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Jennifer S. Gewandter, Ph.D., M.P.H.

Jennifer S. Gewandter, Ph.D., M.P.H.

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About Me

Faculty Appointments

Associate Professor - Department of Anesthesiology and Perioperative Medicine, Research (SMD)

Associate Professor - Department of Dentistry (SMD) - Joint

Associate Professor - Department of Neurology (SMD) - Joint

Associate Professor - Department of Neurosurgery (SMD) - Joint

Credentials

Post-doctoral Training & Residency

R25 Cancer Control Fellowship, UR 2011 - 2012

Education

MPH | University of Rochester. Public health. 2014

PhD | University of Rochester School of Medicine & Dentistry. Biochemistry. 2011

MS | University of Rochester. Biochemistry. 2008

BS | SUNY, College at Geneseo. Biochemistry. 2004

Awards

Early Career Women Faculty Leadership Development workshop. 2018

Distributed Research Network Demonstration Project Award,. 2017

Marvel-dare F. Nutting Award. 2012

APS National Meeting Travel Award. 2012

University of Rochester Pulmonary Training Grant (T32 HL66988-09) Predoctoral Award. 2007 - 2009

CTSI Travel Award. 2007

Elmer Stotz Fellowship. 2005 - 2011

Jackson-Ulmer Biochemistry Award. 2004

Phi Beta Kappa Inductee. 2004

Pre Intramural Research Training. 2004 - 2005

Michael LoMonaco '81 Excellence in Biochemistry. 2003

Geneseo Alumni Fellows Scholarship. 2002 - 2003

Research

Clinical Trials

A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled, Phase 2 Study to Assess the Efficacy and Safety of ATX01 (Topical Amitriptyline Hydrochloride 10% and 15% w/w) in Comparison to Placebo, in Cancer Survivor Adult Patients With Chemotherapy-induced Peripheral Neuropathy (CIPN)

Lead Researcher: Jennifer Gewandter

The purpose of this clinical trial is to compare the efficacy of twice daily applications of ATX01 (10% \& 15%) versus placebo during a 12-week treatment period in treating chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer survivor pa...

Publications

Journal Articles

Personalized Outcomes in Neuropathic Pain: A Clinical Relevance and Assay Sensitivity Analysis from a Randomized Controlled Trial.

Saab K, Gada U, Culakova E, Burnette B, Jorgensen C, Shah D, Morrow G, Mustian K, Sohn MB, Edwards RR, Freeman R, Langford DJ, McDermott MP, Gewandter JS

Pain medicine : the official journal of the American Academy of Pain Medicine.. 2024 October 4 Epub 10/04/2024.

Multidevice spinal cord stimulation trials: shared decision making in the era of multiple neuromodulation paradigms.

Sheen S, Markman J, Sohn M, Bhatia A, Haddas R, Geha P, Gewandter J

Pain management.. 2024 September 26 :1-8. Epub 09/26/2024.

Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system.

Kleckner IR, Manuweera T, Lin PJ, Chung KH, Kleckner AS, Gewandter JS, Culakova E, Tivarus ME, Dunne RF, Loh KP, Mohile NA, Kesler SR, Mustian KM

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2024 September 2132 (10):677. Epub 09/21/2024.

Exploring the reliability and validity of clinically-relevant outcome measures for chemotherapy-induced peripheral neuropathy.

Knoerl R, Sohn MB, Spath K, Burnette B, Francar L, Mustian KM, Shah D, Gauthier L, Gewandter JS

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2024 September 1932 (10):675. Epub 09/19/2024.

Exploring Analgesic Use Patterns Among Cancer Survivors With Chronic Chemotherapy-Induced Peripheral Neuropathy.

Knoerl R, Sohn MB, Foust M, Francar L, O'Rourke MA, Morrow GM, Mustian KM, Gauthier L, Gewandter JS

Oncology nursing forum.. 2024 August 1551 (5):445-450. Epub 1900 01 01.

Non-inferiority study assessing the utility of postcervical and lumbar radiofrequency ablation steroid use.

Williams MR, Philip A, Sheen S, Aujla S, Feng C, Gao S, Kralovic S, Poli J, Ortiz T, Stefanos T, Pennella-Vaughan J, Gewandter JS

Regional anesthesia and pain medicine.. 2024 August 3 Epub 08/03/2024.

Mean of daily vs. single week recall-based pain quality assessments in neuropathic pain trials: Implications for assay sensitivity.

Rangel M, Besharat S, Sohn MB, Foust M, Francar L, Jorgensen C, Mustian K, Morrow G, Culakova E, Jensen MP, Langford DJ, Gewandter JS

The journal of pain.. 2024 July 25 :104643. Epub 07/25/2024.

Use of patient-reported global assessment measures in clinical trials of chronic pain treatments: ACTTION systematic review and considerations.

Langford DJ, Mark RP, France FO, Nishtar M, Park M, Sharma S, Shklyar IC, Schnitzer TJ, Conaghan PG, Amtmann D, Reeve BB, Turk DC, Dworkin RH, Gewandter JS

Pain.. 2024 May 14 Epub 05/14/2024.

Evaluating the balance of benefits and harms in chronic pain clinical trials: prioritizing individual participants over individual outcomes.

Nishtar M, Mark R, Langford DJ, McDermott MP, Markman JD, Evans SR, France FO, Park M, Sharma S, Turk DC, Dworkin RH, Gewandter JS

Regional anesthesia and pain medicine.. 2024 May 749 (5):363-367. Epub 05/07/2024.

Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement.

Hohenschurz-Schmidt D, Cherkin D, Rice ASC, Dworkin RH, Turk DC, McDermott MP, Bair MJ, DeBar LL, Edwards RR, Evans SR, Farrar JT, Kerns RD, Rowbotham MC, Wasan AD, Cowan P, Ferguson M, Freeman R, Gewandter JS, Gilron I, Grol-Prokopczyk H, Iyengar S, Kamp C, Karp BI, Kleykamp BA, Loeser JD, Mackey S, Malamut R, McNicol E, Patel KV, Schmader K, Simon L, Steiner DJ, Veasley C, Vollert J

Pain.. 2024 May 3 Epub 05/03/2024.

Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations.

Haroutounian S, Holzer KJ, Kerns RD, Veasley C, Dworkin RH, Turk DC, Carman KL, Chambers CT, Cowan P, Edwards RR, Eisenach JC, Farrar JT, Ferguson M, Forsythe LP, Freeman R, Gewandter JS, Gilron I, Goertz C, Grol-Prokopczyk H, Iyengar S, Jordan I, Kamp C, Kleykamp BA, Knowles RL, Langford DJ, Mackey S, Malamut R, Markman J, Martin KR, McNicol E, Patel KV, Rice ASC, Rowbotham M, Sandbrink F, Simon LS, Steiner DJ, Vollert J

Pain.. 2024 May 1165 (5):1013-1028. Epub 12/19/2023.

Wireless Transcutaneous Electrical Nerve Stimulation (TENS) for Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Proof-of-Concept Randomized Clinical Trial.

Gewandter JS, Culakova E, Davis JN, Gada U, Guido JJ, Bearden JD, Burnette B, Shah D, Morrow G, Mustian K, Sluka K, Mohile N

The journal of pain.. 2024 May 25 (5):104431. Epub 11/21/2023.

Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system.

Kleckner IR, Manuweera T, Lin PJ, Chung KH, Kleckner AS, Gewandter JS, Culakova E, Tivarus ME, Dunne RF, Loh KP, Mohile NA, Kesler SR, Mustian KM

Research square.. 2024 March 13 Epub 03/13/2024.

What should be the entry pain intensity criteria for chronic pain clinical trials? An IMMPACT update.

Langford DJ, Baron R, Edwards RR, Gewandter JS, Gilron I, Griffin R, Kamerman PR, Katz NP, McDermott MP, Rice ASC, Turk DC, Vollert J, Dworkin RH

Pain.. 2023 September 1164 (9):1927-1930. Epub 06/07/2023.

Covariate Adjustment in Chronic Pain Trials: An Oft-Missed Opportunity.

Langford DJ, Sharma S, McDermott MP, Beeram A, Besherat S, France FO, Mark R, Park M, Nishtar M, Turk DC, Dworkin RH, Gewandter JS

The journal of pain.. 2023 September 24 (9):1555-1569. Epub 06/14/2023.

Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.

Hohenschurz-Schmidt DJ, Cherkin D, Rice ASC, Dworkin RH, Turk DC, McDermott MP, Bair MJ, DeBar LL, Edwards RR, Farrar JT, Kerns RD, Markman JD, Rowbotham MC, Sherman KJ, Wasan AD, Cowan P, Desjardins P, Ferguson M, Freeman R, Gewandter JS, Gilron I, Grol-Prokopczyk H, Hertz SH, Iyengar S, Kamp C, Karp BI, Kleykamp BA, Loeser JD, Mackey S, Malamut R, McNicol E, Patel KV, Sandbrink F, Schmader K, Simon L, Steiner DJ, Veasley C, Vollert J

Pain.. 2023 July 1164 (7):1457-1472. Epub 03/22/2023.

Cannabinoid Therapy: Attitudes and Experiences of People With Chronic Pain.

Gewandter JS, Edwards RR, Hill KP, Wasan AD, Hooker JE, Lape EC, Besharat S, Cowan P, Le Foll B, Ditre JW, Freeman R

The Clinical journal of pain.. 2023 June 139 (6):249-258. Epub 06/01/2023.

Exploring Patients' Understanding of Chemotherapy-Induced Peripheral Neuropathy.

Knoerl R, Berry DL, Meyerhardt J, Reyes K, Salehi E, Gewandter JS

Journal of cancer education : the official journal of the American Association for Cancer Education.. 2023 June 38 (3):906-912. Epub 08/05/2022.

Expectations for Improvement: A Neglected but Potentially Important Covariate or Moderator for Chronic Pain Clinical Trials.

Langford DJ, Lou R, Sheen S, Amtmann D, Colloca L, Edwards RR, Farrar JT, Katz NP, McDermott MP, Reeve BB, Wasan AD, Turk DC, Dworkin RH, Gewandter JS

The journal of pain.. 2023 April 24 (4):575-581. Epub 12/26/2022.

Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations.

Edwards RR, Schreiber KL, Dworkin RH, Turk DC, Baron R, Freeman R, Jensen TS, Latremoliere A, Markman JD, Rice ASC, Rowbotham M, Staud R, Tate S, Woolf CJ, Andrews NA, Carr DB, Colloca L, Cosma-Roman D, Cowan P, Diatchenko L, Farrar J, Gewandter JS, Gilron I, Kerns RD, Marchand S, Niebler G, Patel KV, Simon LS, Tockarshewsky T, Vanhove GF, Vardeh D, Walco GA, Wasan AD, Wesselmann U

The journal of pain.. 2023 February 24 (2):204-225. Epub 10/02/2022.

Identifying participants' preferences for modifiable chemotherapy-induced peripheral neuropathy prevention clinical trial factors: an adaptive choice-based conjoint analysis.

Knoerl R, Berry D, Meyerhardt JA, Reyes K, Salehi E, Thornton K, Gewandter JS

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2022 December 30 (12):9963-9973. Epub 11/10/2022.

Initial Content Validation and Roadmap for a New Patient-Reported Outcome Measure of Pain Intensity.

Langford DJ, Gewandter JS, Amtmann D, Reeve BB, Corneli A, McKenna K, Swezey T, McFatrich M, Jensen MP, Turk DC, Dworkin RH

The journal of pain.. 2022 November 23 (11):1945-1957. Epub 07/19/2022.

Partnering with patients in clinical trials of pain treatments: a narrative review.

Holzer KJ, Veasley C, Kerns RD, Edwards RR, Gewandter JS, Langford DJ, Yaeger LH, McNicol E, Ferguson M, Turk DC, Dworkin RH, Haroutounian S

Pain.. 2022 October 1163 (10):1862-1873. Epub 01/28/2022.

Predicting Treatment Response with Sensory Phenotyping in Post-Traumatic Neuropathic Pain.

Gewandter JS, Sohn MB, De Guzman R, Frazer ME, Chiodo V, Sharma S, Geha P, Markman JD

Pain medicine : the official journal of the American Academy of Pain Medicine.. 2022 September 3023 (10):1726-1732. Epub 1900 01 01.

Patient-Reported Chronic Pain Intensity: More Than Meets the Eye.

Langford DJ, Gewandter JS, Amtmann D, Reeve BB, Hertz S, Loeser JD, Veasley C, Turk DC, Dworkin RH

The patient.. 2022 July 15 (4):383-387. Epub 06/09/2022.

Benefit-risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations.

Kleykamp BA, Dworkin RH, Turk DC, Bhagwagar Z, Cowan P, Eccleston C, Ellenberg SS, Evans SR, Gewandter JS, Goli V, Farrar JT, Freeman RL, Garrison LP, Iyengar S, Jadad AR, Jensen MP, Junor R, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, McDermott MP, Mease PJ, O'Connor AB, Patel KV, Raja SN, Rowbotham MC, Sampaio C, Singh JA, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD

Pain.. 2022 June 1163 (6):1006-1018. Epub 09/09/2021.

Evaluation of the psychometric properties of patient-reported and clinician-reported outcome measures of chemotherapy-induced peripheral neuropathy: a COSMIN systematic review protocol.

Bérubé-Mercier P, Tapp D, Cimon MÈ, Li T, Park SB, Bouhêlier É, McGarragle K, Robichaud LA, Gewandter JS, Bouchard M, Gauthier LR

BMJ open.. 2022 April 612 (4):e057950. Epub 04/06/2022.

Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials recommendations.

Gewandter JS, Smith SM, Dworkin RH, Turk DC, Gan TJ, Gilron I, Hertz S, Katz NP, Markman JD, Raja SN, Rowbotham MC, Stacey BR, Strain EC, Ward DS, Farrar JT, Kroenke K, Rathmell JP, Rauck R, Brown C, Cowan P, Edwards RR, Eisenach JC, Ferguson M, Freeman R, Gray R, Giblin K, Grol-Prokopczyk H, Haythornthwaite J, Jamison RN, Martel M, McNicol E, Oshinsky M, Sandbrink F, Scholz J, Scranton R, Simon LS, Steiner D, Verburg K, Wasan AD, Wentworth K

Pain.. 2021 November 1162 (11):2669-2681. Epub 1900 01 01.

Evaluating predictors of pain reduction after genicular nerve radiofrequency ablation for chronic knee pain.

Philip A, Williams M, Davis J, Beeram A, Feng C, Poli J, Vangellow A, Gewandter J

Pain management.. 2021 November 11 (6):669-677. Epub 06/09/2021.

Composite outcomes for pain clinical trials: considerations for design and interpretation.

Gewandter JS, McDermott MP, Evans S, Katz NP, Markman JD, Simon LS, Turk DC, Dworkin RH

Pain.. 2021 July 1162 (7):1899-1905. Epub 1900 01 01.

Research design considerations for randomized controlled trials of spinal cord stimulation for pain: Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials/Institute of Neuromodulation/International Neuromodulation Society recommendations.

Katz N, Dworkin RH, North R, Thomson S, Eldabe S, Hayek SM, Kopell BH, Markman J, Rezai A, Taylor RS, Turk DC, Buchser E, Fields H, Fiore G, Ferguson M, Gewandter J, Hilker C, Jain R, Leitner A, Loeser J, McNicol E, Nurmikko T, Shipley J, Singh R, Trescot A, van Dongen R, Venkatesan L

Pain.. 2021 July 1162 (7):1935-1956. Epub 1900 01 01.

Systematic Review of Research Methods and Reporting Quality of Randomized Clinical Trials of Spinal Cord Stimulation for Pain.

McNicol E, Ferguson M, Bungay K, Rowe EL, Eldabe S, Gewandter JS, Hayek SM, Katz N, Kopell BH, Markman J, Rezai A, Taylor RS, Turk DC, Dworkin RH, North RB, Thomson S

The journal of pain.. 2021 February 22 (2):127-142. Epub 06/20/2020.

Diagnostic criteria for idiopathic small fiber neuropathy: A systematic review.

Haroutounian S, Todorovic MS, Leinders M, Campagnolo M, Gewandter JS, Dworkin RH, Freeman R

Muscle & nerve.. 2021 February 63 (2):170-177. Epub 09/29/2020.

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H, Kitt RA, Kopecky EA, Malamut R, McDermott MP, Palmer P, Rappaport BA, Rauschkolb C, Steigerwald I, Tobias J, Walco GA

Pain reports.. 2021 6 (1):e895. Epub 01/21/2021.

Peripheral edema: A common and persistent health problem for older Americans.

Besharat S, Grol-Prokopczyk H, Gao S, Feng C, Akwaa F, Gewandter JS

PloS one.. 2021 16 (12):e0260742. Epub 12/16/2021.

Brain Imaging Biomarkers for Chronic Pain.

Zhang Z, Gewandter JS, Geha P

Frontiers in neurology. 2021 12 :734821. Epub 01/03/2022.

Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria.

Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, Levine T, Malik RA, Singleton JR, Smith AG, Bell J, Dworkin RH, Feldman E, Herrmann DN, Hoke A, Kolb N, Mansikka H, Oaklander AL, Peltier A, Polydefkis M, Ritt E, Russell JW, Sainati S, Steiner D, Treister R, Üçeyler N

Neurology.. 2020 December 195 (22):1005-1014. Epub 10/14/2020.

Estimands and missing data in clinical trials of chronic pain treatments: advances in design and analysis.

Cai X, Gewandter JS, He H, Turk DC, Dworkin RH, McDermott MP

Pain.. 2020 October 161 (10):2308-2320. Epub 1900 01 01.

Utility of topical agents for radiation dermatitis and pain: a randomized clinical trial.

Ryan Wolf J, Gewandter JS, Bautista J, Heckler CE, Strasser J, Dyk P, Anderson T, Gross H, Speer T, Dolohanty L, Bylund K, Pentland AP, Morrow GR

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2020 July 28 (7):3303-3311. Epub 11/22/2019.

Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data.

Gewandter JS, Kleckner AS, Marshall JH, Brown JS, Curtis LH, Bautista J, Dworkin RH, Kleckner IR, Kolb N, Mohile SG, Mustian KM

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2020 June 28 (6):2553-2562. Epub 09/07/2019.

Comparison of a Pain Tolerability Question With the Numeric Rating Scale for Assessment of Self-reported Chronic Pain.

Markman JD, Gewandter JS, Frazer ME

JAMA network open.. 2020 April 13 (4):e203155. Epub 04/01/2020.

When should non-significant results influence clinical decisions?: Interpreting confidence intervals.

Gewandter JS, McDermott MP

BJOG : an international journal of obstetrics and gynaecology.. 2020 April 127 (5):548-549. Epub 01/07/2020.

Are there really only 2 kinds of people in the world? Evaluating the distribution of change from baseline in pain clinical trials.

Mbowe OB, Gewandter JS, Turk DC, Dworkin RH, McDermott MP

Pain.. 2020 January 161 (1):195-201. Epub 1900 01 01.

Improving Study Conduct and Data Quality in Clinical Trials of Chronic Pain Treatments: IMMPACT Recommendations.

Gewandter JS, Dworkin RH, Turk DC, Devine EG, Hewitt D, Jensen MP, Katz NP, Kirkwood AA, Malamut R, Markman JD, Vrijens B, Burke L, Campbell JN, Carr DB, Conaghan PG, Cowan P, Doyle MK, Edwards RR, Evans SR, Farrar JT, Freeman R, Gilron I, Juge D, Kerns RD, Kopecky EA, McDermott MP, Niebler G, Patel KV, Rauck R, Rice ASC, Rowbotham M, Sessler NE, Simon LS, Singla N, Skljarevski V, Tockarshewsky T, Vanhove GF, Wasan AD, Witter J

The journal of pain.. 2020 21 (9-10):931-942. Epub 12/13/2019.

Overview and critical revision of clinical assessment tools in chemotherapy-induced peripheral neurotoxicity.

Park SB, Alberti P, Kolb NA, Gewandter JS, Schenone A, Argyriou AA

Journal of the peripheral nervous system : JPNS.. 2019 October 24 Suppl 2 :S13-S25. Epub 1900 01 01.

Clinician-rated measures for distal symmetrical axonal polyneuropathy: ACTTION systematic review.

Gewandter JS, Gibbons CH, Campagnolo M, Lee J, Chaudari J, Ward N, Burke L, Cavaletti G, Herrmann DN, McArthur JC, Russell JW, Smith AG, Smith SM, Turk DC, Dworkin RH, Freeman R

Neurology.. 2019 August 2093 (8):346-360. Epub 07/18/2019.

Demonstrating Heterogeneity of Treatment Effects Among Patients: An Overlooked but Important Step Toward Precision Medicine.

Gewandter JS, McDermott MP, He H, Gao S, Cai X, Farrar JT, Katz NP, Markman JD, Senn S, Turk DC, Dworkin RH

Clinical pharmacology and therapeutics.. 2019 July 106 (1):204-210. Epub 03/12/2019.

Navigating trials of personalized pain treatments: we're going to need a bigger boat.

Gewandter JS, McDermott MP, Mbowe O, Edwards RR, Katz NP, Turk DC, Dworkin RH

Pain.. 2019 June 160 (6):1235-1239. Epub 1900 01 01.

Wireless transcutaneous electrical nerve stimulation device for chemotherapy-induced peripheral neuropathy: an open-label feasibility study.

Gewandter JS, Chaudari J, Ibegbu C, Kitt R, Serventi J, Burke J, Culakova E, Kolb N, Sluka KA, Tejani MA, Mohile NA

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2019 May 27 (5):1765-1774. Epub 08/27/2018.

Extended-release gabapentin for failed back surgery syndrome: results from a randomized double-blind cross-over study.

Gewandter JS, Frazer ME, Cai X, Chiodo VF, Rast SA, Dugan M, Carter HA, Rahmani R, Stone JJ, Markman JD

Pain.. 2019 May 160 (5):1029-1036. Epub 1900 01 01.

Design and Reporting Characteristics of Clinical Trials of Select Chronic and Recurrent Pediatric Pain Conditions: An Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks Systematic Review.

Connolly MR, Chaudari JY, Yang X, Ward N, Kitt RA, Herrmann RS, Krane EJ, LeBel AA, Smith SM, Walco GA, Weisman SJ, Turk DC, Dworkin RH, Gewandter JS

The journal of pain.. 2019 April 20 (4):394-404. Epub 09/13/2018.

Response to Crevenna and Ashbury, Vallance and Bolam, and Crevenna and Keilani regarding the effects of exercise on chemotherapy-induced peripheral neuropathy.

Kleckner IR, Kamen C, Gewandter JS, Mohile NA, Heckler CE, Culakova E, Fung C, Janelsins MC, Asare M, Lin PJ, Reddy PS, Giguere J, Berenberg J, Kesler SR, Mustian KM

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2019 January 27 (1):7-8. Epub 10/29/2018.

Checklist for the preparation and review of pain clinical trial publications: a pain-specific supplement to CONSORT.

Gewandter JS, Eisenach JC, Gross RA, Jensen MP, Keefe FJ, Lee DA, Turk DC

Pain reports.. 2019 4 (3):e621. Epub 09/13/2017.

Why are there no drugs indicated for sciatica, the most common chronic neuropathic syndrome of all?

Markman JD, Baron R, Gewandter JS

Drug discovery today.. 2018 November 23 (11):1904-1909. Epub 06/09/2018.

Evaluation of composite responder outcomes of pain intensity and physical function in neuropathic pain clinical trials: an ACTTION individual patient data analysis.

Patel KV, Allen R, Burke L, Farrar JT, Gewandter JS, Gilron I, Katz NP, Markman JD, Marshall SF, Resnick M, Rice ASC, Rowbotham MC, Smith SM, Vanhove GF, Wasan AD, Zhang S, Dworkin RH, Turk DC

Pain.. 2018 November 159 (11):2245-2254. Epub 1900 01 01.

Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations.

Gewandter JS, Brell J, Cavaletti G, Dougherty PM, Evans S, Howie L, McDermott MP, O'Mara A, Smith AG, Dastros-Pitei D, Gauthier LR, Haroutounian S, Jarpe M, Katz NP, Loprinzi C, Richardson P, Lavoie-Smith EM, Wen PY, Turk DC, Dworkin RH, Freeman R

Neurology.. 2018 August 2891 (9):403-413. Epub 07/27/2018.

Research Design Characteristics of Published Pharmacologic Randomized Clinical Trials for Irritable Bowel Syndrome and Chronic Pelvic Pain Conditions: An ACTTION Systematic Review.

Gewandter JS, Chaudari J, Iwan KB, Kitt R, As-Sanie S, Bachmann G, Clemens Q, Lai HH, Tu F, Verne GN, Vincent K, Wesselmann U, Zhou Q, Turk DC, Dworkin RH, Smith SM

The journal of pain.. 2018 July 19 (7):717-726. Epub 02/02/2018.

Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients.

Ryan Wolf J, Heckler CE, Guido JJ, Peoples AR, Gewandter JS, Ling M, Vinciguerra VP, Anderson T, Evans L, Wade J, Pentland AP, Morrow GR

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2018 May 26 (5):1543-1552. Epub 12/01/2017.

Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial.

Kleckner IR, Kamen C, Gewandter JS, Mohile NA, Heckler CE, Culakova E, Fung C, Janelsins MC, Asare M, Lin PJ, Reddy PS, Giguere J, Berenberg J, Kesler SR, Mustian KM

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2018 April 26 (4):1019-1028. Epub 12/14/2017.

Chemotherapy-induced peripheral neuropathy clinical trials: Review and recommendations.

Gewandter JS, Freeman R, Kitt RA, Cavaletti G, Gauthier LR, McDermott MP, Mohile NA, Mohlie SG, Smith AG, Tejani MA, Turk DC, Dworkin RH

Neurology.. 2017 August 2289 (8):859-869. Epub 07/26/2017.

Interpretation of CIs in clinical trials with non-significant results: systematic review and recommendations.

Gewandter JS, McDermott MP, Kitt RA, Chaudari J, Koch JG, Evans SR, Gross RA, Markman JD, Turk DC, Dworkin RH

BMJ open.. 2017 July 187 (7):e017288. Epub 07/18/2017.

The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.

Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G

Pain medicine : the official journal of the American Academy of Pain Medicine.. 2017 May 118 (5):947-958. Epub 1900 01 01.

The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.

Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G

The journal of pain.. 2017 May 18 (5):479-489. Epub 1900 01 01.

Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy.

Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, McArthur Mb JC, McDermott MP, Rappaport BA, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R

Muscle & nerve.. 2017 March 55 (3):366-372. Epub 12/23/2016.

Reporting of data monitoring boards in publications of randomized clinical trials is often deficient: ACTTION systematic review.

Gewandter JS, Kitt RA, Hunsinger MR, Poku J, Lozano J, Chaudari J, Evans S, Gross RA, McDermott MP, Rowbotham MC, Turk DC, Dworkin RH

Journal of clinical epidemiology.. 2017 March 83 :101-107. Epub 01/23/2017.

Painful chemotherapy-induced peripheral neuropathy: lack of treatment efficacy or the wrong clinical trial methodology?

Gewandter JS, Dworkin RH, Finnerup NB, Mohile NA

Pain.. 2017 January 158 (1):30-33. Epub 1900 01 01.

Reply.

Gewandter JS, Dworkin RH, Finnerup NB, Freeman R, Mohile NA

Pain.. 2017 January 158 (1):182-183. Epub 1900 01 01.

Reporting of Design Features and Analysis Details in Randomized Clinical Trials of Procedural Treatments for Cancer Pain: An ACTTION Systematic Review.

Rothstein D, Kitt RA, Smith SM, Abdi S, Engle MP, McDermott MP, Raja SN, Turk DC, Dworkin RH, Gewandter JS

Regional anesthesia and pain medicine.. 2017 42 (3):392-399. Epub 1900 01 01.

Reporting of cross-over clinical trials of analgesic treatments for chronic pain: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review and recommendations.

Gewandter JS, McDermott MP, McKeown A, Hoang K, Iwan K, Kralovic S, Rothstein D, Gilron I, Katz NP, Raja SN, Senn S, Smith SM, Turk DC, Dworkin RH

Pain.. 2016 November 157 (11):2544-2551. Epub 1900 01 01.

Participant Preferences for Pharmacologic Chronic Pain Treatment Trial Characteristics: An ACTTION Adaptive Choice-Based Conjoint Study.

Smith SM, Gewandter JS, Kitt RA, Markman JD, Vaughan JA, Cowan P, Kopecky EA, Malamut R, Sadosky A, Tive L, Turk DC, Dworkin RH

The journal of pain.. 2016 November 17 (11):1198-1206. Epub 08/20/2016.

Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations.

Taylor AM, Phillips K, Patel KV, Turk DC, Dworkin RH, Beaton D, Clauw DJ, Gignac M, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH, Conaghan PG, Cowan P, Farrar JT, Freeman R, Gewandter J, Gilron I, Goli V, Gover TD, Haddox JD, Kerns RD, Kopecky EA, Lee DA, Malamut R, Mease P, Rappaport BA, Simon LS, Singh JA, Smith SM, Strand V, Tugwell P, Vanhove GF, Veasley C, Walco GA, Wasan AD, Witter J

Pain.. 2016 September 157 (9):1836-1850. Epub 1900 01 01.

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations.

Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice AS, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D

Pain.. 2016 September 157 (9):1851-1871. Epub 1900 01 01.

Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review.

Dworkin JD, McKeown A, Farrar JT, Gilron I, Hunsinger M, Kerns RD, McDermott MP, Rappaport BA, Turk DC, Dworkin RH, Gewandter JS

Journal of clinical epidemiology.. 2016 April 72 :56-65. Epub 11/18/2015.

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.

Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G

Pain.. 2016 April 157 (4):901-909. Epub 1900 01 01.

Measures of outcome for stimulant trials: ACTTION recommendations and research agenda.

Kiluk BD, Carroll KM, Duhig A, Falk DE, Kampman K, Lai S, Litten RZ, McCann DJ, Montoya ID, Preston KL, Skolnick P, Weisner C, Woody G, Chandler R, Detke MJ, Dunn K, Dworkin RH, Fertig J, Gewandter J, Moeller FG, Ramey T, Ryan M, Silverman K, Strain EC

Drug and alcohol dependence.. 2016 January 1158 :1-7. Epub 11/21/2015.

Associations between a patient-reported outcome (PRO) measure of sarcopenia and falls, functional status, and physical performance in older patients with cancer.

Gewandter JS, Dale W, Magnuson A, Pandya C, Heckler CE, Lemelman T, Roussel B, Ifthikhar R, Dolan J, Noyes K, Mohile SG

Journal of geriatric oncology.. 2015 November 6 (6):433-41. Epub 09/11/2015.

Evaluation of outcome measures for neurogenic claudication: A patient-centered approach.

Markman JD, Gewandter JS, Frazer ME, Pittman C, Cai X, Patel KV, Jahromi BS, Dworkin RH, Burke LB, Farrar JT

Neurology.. 2015 October 685 (14):1250-6. Epub 09/09/2015.

Reliability is Necessary but Far From Sufficient: How Might the Validity of Pain Ratings be Improved?

Dworkin RH, Laurie B B, Gewandter JS, Smith SM

The Clinical journal of pain.. 2015 July 31 (7):599-602. Epub 1900 01 01.

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H, Kitt RA, Kopecky EA, Malamut R, McDermott MP, Palmer P, Rappaport BA, Rauschkolb C, Steigerwald I, Tobias J, Walco GA

Pain.. 2015 July 156 (7):1184-1197. Epub 1900 01 01.

Interpretation of urine drug testing results in patients using transdermal buprenorphine preparations for the treatment of chronic noncancer pain.

Markman JD, Barbosa WA, Gewandter JS, Frazer M, Rast S, Dugan M, Nandigam K, Villareal A, Kwong TC

Pain medicine : the official journal of the American Academy of Pain Medicine.. 2015 June 16 (6):1132-6. Epub 03/20/2015.

A Randomized, Double-blind, Placebo-Controlled Crossover Trial of Oxymorphone Hydrochloride and Propoxyphene/Acetaminophen Combination for the Treatment of Neurogenic Claudication Associated With Lumbar Spinal Stenosis.

Markman JD, Gewandter JS, Frazer ME, Murray NM, Rast SA, McDermott MP, Chowdhry AK, Tompkinson E, Pilcher WH, Walter KA, Dworkin RH

Spine.. 2015 May 1540 (10):684-91. Epub 1900 01 01.

The effect of YOCAS©® yoga for musculoskeletal symptoms among breast cancer survivors on hormonal therapy.

Peppone LJ, Janelsins MC, Kamen C, Mohile SG, Sprod LK, Gewandter JS, Kirshner JJ, Gaur R, Ruzich J, Esparaz BT, Mustian KM

Breast cancer research and treatment.. 2015 April 150 (3):597-604. Epub 03/27/2015.

Reporting of adverse events and statistical details of efficacy estimates in randomized clinical trials of pain in temporomandibular disorders: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review.

Gewandter JS, Smith SM, McKeown A, Edwards K, Narula A, Pawlowski JR, Rothstein D, Desjardins PJ, Dworkin SF, Gross RA, Ohrbach R, Rappaport BA, Sessle BJ, Turk DC, Dworkin RH

The Journal of the American Dental Association.. 2015 April 146 (4):246-54.e6. Epub 1900 01 01.

Reporting of sample size calculations in analgesic clinical trials: ACTTION systematic review.

McKeown A, Gewandter JS, McDermott MP, Pawlowski JR, Poli JJ, Rothstein D, Farrar JT, Gilron I, Katz NP, Lin AH, Rappaport BA, Rowbotham MC, Turk DC, Dworkin RH, Smith SM

The journal of pain.. 2015 March 16 (3):199-206.e1-7. Epub 12/04/2014.

Double-blind, randomized, controlled, crossover trial of pregabalin for neurogenic claudication.

Markman JD, Frazer ME, Rast SA, McDermott MP, Gewandter JS, Chowdhry AK, Czerniecka K, Pilcher WH, Simon LS, Dworkin RH

Neurology.. 2015 January 2084 (3):265-72. Epub 12/10/2014.

Data interpretation in analgesic clinical trials with statistically nonsignificant primary analyses: an ACTTION systematic review.

Gewandter JS, McKeown A, McDermott MP, Dworkin JD, Smith SM, Gross RA, Hunsinger M, Lin AH, Rappaport BA, Rice AS, Rowbotham MC, Williams MR, Turk DC, Dworkin RH

The journal of pain.. 2015 January 16 (1):3-10. Epub 10/23/2014.

Reporting of intention-to-treat analyses in recent analgesic clinical trials: ACTTION systematic review and recommendations.

Gewandter JS, McDermott MP, McKeown A, Smith SM, Pawlowski JR, Poli JJ, Rothstein D, Williams MR, Bujanover S, Farrar JT, Gilron I, Katz NP, Rowbotham MC, Turk DC, Dworkin RH

Pain.. 2014 December 155 (12):2714-2719. Epub 10/02/2014.

DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells.

Kalifa L, Gewandter JS, Staversky RJ, Sia EA, Brookes PS, O'Reilly MA

Free radical biology & medicine.. 2014 October 75 :30-9. Epub 07/15/2014.

Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations.

Gewandter JS, Dworkin RH, Turk DC, McDermott MP, Baron R, Gastonguay MR, Gilron I, Katz NP, Mehta C, Raja SN, Senn S, Taylor C, Cowan P, Desjardins P, Dimitrova R, Dionne R, Farrar JT, Hewitt DJ, Iyengar S, Jay GW, Kalso E, Kerns RD, Leff R, Leong M, Petersen KL, Ravina BM, Rauschkolb C, Rice AS, Rowbotham MC, Sampaio C, Sindrup SH, Stauffer JW, Steigerwald I, Stewart J, Tobias J, Treede RD, Wallace M, White RE

Pain.. 2014 September 155 (9):1683-1695. Epub 05/24/2014.

Reporting of missing data and methods used to accommodate them in recent analgesic clinical trials: ACTTION systematic review and recommendations.

Gewandter JS, McDermott MP, McKeown A, Smith SM, Williams MR, Hunsinger M, Farrar J, Turk DC, Dworkin RH

Pain.. 2014 September 155 (9):1871-1877. Epub 06/30/2014.

A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study of 462 cancer survivors.

Gewandter JS, Mohile SG, Heckler CE, Ryan JL, Kirshner JJ, Flynn PJ, Hopkins JO, Morrow GR

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2014 July 22 (7):1807-14. Epub 02/16/2014.

Reporting of primary analyses and multiplicity adjustment in recent analgesic clinical trials: ACTTION systematic review and recommendations.

Gewandter JS, Smith SM, McKeown A, Burke LB, Hertz SH, Hunsinger M, Katz NP, Lin AH, McDermott MP, Rappaport BA, Williams MR, Turk DC, Dworkin RH

Pain.. 2014 March 155 (3):461-466. Epub 11/23/2013.

The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions.

Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, Mantyh PW, Markman J, Neogi T, Ohrbach R, Paice JA, Porreca F, Rappaport BA, Smith SM, Smith TJ, Sullivan MD, Verne GN, Wasan AD, Wesselmann U

The journal of pain.. 2014 March 15 (3):241-9. Epub 1900 01 01.

Characterization of skin reactions and pain reported by patients receiving radiation therapy for cancer at different sites.

Gewandter JS, Walker J, Heckler CE, Morrow GR, Ryan JL

The journal of supportive oncology.. 2013 December 11 (4):183-9. Epub 1900 01 01.

Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study.

Gewandter JS, Fan L, Magnuson A, Mustian K, Peppone L, Heckler C, Hopkins J, Tejani M, Morrow GR, Mohile SG

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2013 July 21 (7):2059-66. Epub 02/28/2013.

Cancer-related stress and complementary and alternative medicine: a review.

Chandwani KD, Ryan JL, Peppone LJ, Janelsins MM, Sprod LK, Devine K, Trevino L, Gewandter J, Morrow GR, Mustian KM

Evidence-based complementary and alternative medicine : eCAM.. 2012 2012 :979213. Epub 07/15/2012.

Interventions to Alleviate Symptoms Related to Breast Cancer Treatments and Areas of Needed Research.

Janelsins MC, Mustian KM, Peppone LJ, Sprod LK, Shayne M, Mohile S, Chandwani K, Gewandter JS, Morrow GR

Journal of cancer science & therapy. 2011 September 29S2 Epub 1900 01 01.

The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.

Gewandter JS, Bambara RA, O'Reilly MA

Cell cycle.. 2011 August 110 (15):2561-7. Epub 08/01/2011.

Hyperoxia augments ER-stress-induced cell death independent of BiP loss.

Gewandter JS, Staversky RJ, O'Reilly MA

Free radical biology & medicine.. 2009 December 1547 (12):1742-52. Epub 09/26/2009.

Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis.

Hom JR, Gewandter JS, Michael L, Sheu SS, Yoon Y

Journal of cellular physiology.. 2007 August 212 (2):498-508. Epub 1900 01 01.

Residual cholesterol synthesis and simvastatin induction of cholesterol synthesis in Smith-Lemli-Opitz syndrome fibroblasts.

Wassif CA, Krakowiak PA, Wright BS, Gewandter JS, Sterner AL, Javitt N, Yergey AL, Porter FD

Molecular genetics and metabolism.. 2005 June 85 (2):96-107. Epub 02/05/2005.

Novel methodology for the synthesis of N-alkoxyamines.

Braslau R, Tsimelzon A, Gewandter J

Organic letters.. 2004 June 246 (13):2233-5. Epub 1900 01 01.