Associate Professor - Department of Medicine (SMD)
Associate Professor - Department of Biomedical Engineering (SMD) - Joint
Associate Professor - Department of Pharmacology and Physiology (SMD) - Joint
Post-doctoral Training & Residency
UT Southwestern Medical Center at Dallas, Dallas, TX (Mentor: Eric N. Olson) 2005 - 2011
Hospital for Sick Children, Toronto, ON (Mentor: Benoit Bruneau) 2004 - 2005
PhD | Univ Texas-Austin. Molecular Biology. 2003
BS | University of Michigan. Cell and Molecular Biology. 1995
Established Investigator Award. 2023
Excellence in Postdoctoral Mentoring Award. 2013
Scientist Development Grant. 2010 - 2014
Ruth L. Kirschstein NRSA Post-Doctoral Fellowship. 2004 - 2007
Best Poster Presentation Award. 2002
1. Cardiac fibroblast plasticity and the development of cardiac fibrosis. The transition to heart failure following cardiac insult is the result of irreversible cardiomyocyte loss and the development of cardiac fibrosis, which impedes contractility and can initiate lethal arrhythmias. Cardiac fibrosis arises from the aberrant and persistent stimulation of fibroblasts, the main source of extracellular matrix in the heart, in a pathological attempt to repair damaged tissue. We utilize gene expression profiling in animal models of heart disease and human heart failure patient samples to identify novel regulators of cardiac fibroblast accumulation and myofibroblast activation in health and disease. We also utilize high-throughput screening and pre-clinical animal studies to develop novel pharmacological and gene-targeting strategies to block or reverse cardiac scarring and the progression of heart failure.
2. Epicardium-derived progenitor cell mobilization. Epicardium-derived progenitor cells (EPDCs) can differentiate into cardiac fibroblasts and coronary blood vessels, and secrete signals that stimulate cardiac growth during embryonic development. We are striving to understand how EPDCs interpret developmental signals and differentiate into the appropriate cell type based upon their location within the heart. We have identified a mechanosensitive gene program that is essential for EPDC migration and subsequent differentiation into fibroblasts and perivascular cells. Ongoing studies are aimed at evaluating whether disruption of mechanosensitive transcriptional programs within the epicardium might contribute to cardiomyopathy. Our long-term goal is to harness the regenerative potential of the epicardium to improve cardiac repair.
Liu X, Burke RM, Lighthouse JK, Baker CD, Dirkx RA, Kang B, Chakraborty Y, Mickelsen DM, Twardowski J, Mello SS, Ashton JM, Small EM
Circulation research.. 2023 July 6 Epub 07/06/2023.
Quijada P, Park S, Zhao P, Kolluri KS, Wong D, Shih KD, Fang K, Pezhouman A, Wang L, Daraei A, Tran MD, Rathbun EM, Burgos Villar KN, Garcia-Hernandez ML, Pham TT, Lowenstein CJ, Iruela-Arispe ML, Carmichael ST, Small EM, Ardehali R
The Journal of clinical investigation.. 2023 May 15133 (10)Epub 05/15/2023.
Lighthouse JK, Small EM
Circulation research.. 2023 January 6132 (1):30-33. Epub 01/05/2023.
Wu X, Liu H, Brooks A, Xu S, Luo J, Steiner R, Mickelsen DM, Moravec CS, Jeffrey AD, Small EM, Jin ZG
Circulation research.. 2022 October 24 Epub 10/24/2022.
Pérez-Hernández M, van Opbergen CJM, Bagwan N, Rasmus Vissing C, Marrón-Liñares GM, Zhang M, Torres Vega E, Sorrentino A, Drici L, Sulek K, Zhai R, Hansen FB, Hørby Christensen A, Boesgaard S, Gustafsson F, Rossing K, Small EM, Davies MJ, Rothenberg E, Sato P, Cerrone M, Jensen THL, Qvortrup K, Bundgaard H, Delmar M, Lundby A
Circulation.. 2022 August 12 :101161CIRCULATIONAHA122060454. Epub 08/12/2022.
Burgos Villar KN, Liu X, Small EM
Current opinion in physiology.. 2022 August 28 Epub 06/03/2022.
Misra A, Baker CD, Pritchett EM, Burgos Villar KN, Ashton JM, Small EM
Journal of cardiovascular development and disease.. 2021 December 219 (1)Epub 12/21/2021.
Quijada P, Trembley MA, Misra A, Myers JA, Baker CD, Pérez-Hernández M, Myers JR, Dirkx RA, Cohen ED, Delmar M, Ashton JM, Small EM
Nature communications.. 2021 July 612 (1):4155. Epub 07/06/2021.
Burke RM, Dirkx RA, Quijada P, Lighthouse JK, Mohan A, O'Brien M, Wojciechowski W, Woeller C, Phipps RP, Alexis JD, Ashton J, Small EM
Circulation research.. 2021 April 7 Epub 04/07/2021.
Guo Y, Cao Y, Jardin BD, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, Pu WT
Proceedings of the National Academy of Sciences of the United States of America.. 2021 January 12118 (2)Epub 1900 01 01.
Burke RM, Burgos Villar KN, Small EM
Cellular signalling.. 2020 October 31 :109824. Epub 10/31/2020.
Small EM, Brooks AC
JACC. Basic to translational science.. 2020 September 5 (9):946-948. Epub 09/28/2020.
Quijada P, Trembley MA, Small EM
Circulation research.. 2020 January 31126 (3):377-394. Epub 01/30/2020.
Chen S, Zhang Y, Lighthouse JK, Mickelsen DM, Wu J, Yao P, Small EM, Yan C
Circulation.. 2019 December 5 Epub 12/05/2019.
Liu H, Zhang S, Xu S, Koroleva M, Small EM, Jin ZG
Biochemical and biophysical research communications.. 2019 June 30514 (3):913-918. Epub 05/10/2019.
Burke RM, Lighthouse JK, Mickelsen DM, Small EM
Circulation. Heart failure.. 2019 April 12 (4):e005565. Epub 1900 01 01.
Quijada P, Misra A, Velasquez LS, Burke RM, Lighthouse JK, Mickelsen DM, Dirkx RA, Small EM
Journal of molecular and cellular cardiology.. 2019 February 13129 :92-104. Epub 02/13/2019.
Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante A, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN
JCI insight.. 2019 January 31 Epub 01/31/2019.
Lighthouse JK, Burke RM, Velasquez LS, Dirkx RA, Aiezza A, Moravec CS, Alexis JD, Rosenberg A, Small EM
JCI insight.. 2019 January 104 (1)Epub 01/10/2019.
Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K
Proceedings of the National Academy of Sciences of the United States of America.. 2019 January 8116 (2):556-565. Epub 12/24/2018.
Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA, Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM
Circulation.. 2018 October 23138 (17):1864-1878. Epub 1900 01 01.
Lacy SH, Woeller CF, Thatcher TH, Pollock SJ, Small EM, Sime PJ, Phipps RP
American journal of respiratory cell and molecular biology.. 2018 September 28 Epub 09/28/2018.
Burke RM, Lighthouse JK, Quijada P, Dirkx RA, Rosenberg A, Moravec CS, Alexis JD, Small EM
Proceedings of the National Academy of Sciences of the United States of America.. 2018 April 10115 (15):E3436-E3445. Epub 03/26/2018.
Guo B, Lyu Q, Slivano OJ, Dirkx R, Christie CK, Czyzyk J, Hezel AF, Gharavi AG, Small EM, Miano JM
Journal of the American Society of Nephrology : JASN.. 2018 February 29 (2):416-422. Epub 11/07/2017.
Cao J, Wang J, Jackman CP, Cox AH, Trembley MA, Balowski JJ, Cox BD, De Simone A, Dickson AL, Di Talia S, Small EM, Kiehart DP, Bursac N, Poss KD
Developmental cell.. 2017 September 2542 (6):600-615.e4. Epub 1900 01 01.
Small EM, Burke RM
Journal of the American College of Cardiology.. 2017 August 2270 (8):972-974. Epub 1900 01 01.
Knight WE, Chen S, Zhang Y, Oikawa M, Wu M, Zhou Q, Miller CL, Cai Y, Mickelsen DM, Moravec C, Small EM, Abe J, Yan C
Proceedings of the National Academy of Sciences of the United States of America.. 2016 November 8113 (45):E7116-E7125. Epub 10/20/2016.
Trembley MA, Velasquez LS, Small EM
Journal of visualized experiments : JoVE.. 2016 March 18 (109)Epub 03/18/2016.
Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG
Cell.. 2016 February 25164 (5):999-1014. Epub 02/11/2016.
Lighthouse JK, Small EM
Journal of molecular and cellular cardiology.. 2016 February 91 :52-60. Epub 12/22/2015.
Trembley MA, Velasquez LS, de Mesy Bentley KL, Small EM
Development.. 2015 January 1142 (1):21-30. Epub 1900 01 01.
Rodés-Cabau J, Dauerman HL, Cohen MG, Mehran R, Small EM, Smyth SS, Costa MA, Mega JL, O'Donoghue ML, Ohman EM, Becker RC
Journal of the American College of Cardiology.. 2013 December 2462 (25):2349-2359. Epub 04/10/2013.
Velasquez LS, Sutherland LB, Liu Z, Grinnell F, Kamm KE, Schneider JW, Olson EN, Small EM
Proceedings of the National Academy of Sciences of the United States of America.. 2013 October 15110 (42):16850-5. Epub 09/30/2013.
Journal of cardiovascular translational research.. 2012 December 5 (6):794-804. Epub 08/17/2012.
Miano JM, Small EM
Circulation research.. 2011 September 30109 (8):825-7. Epub 1900 01 01.
Small EM, Olson EN
Nature.. 2011 January 20469 (7330):336-42. Epub 1900 01 01.
Small EM, Sutherland LB, Rajagopalan KN, Wang S, Olson EN
Circulation research.. 2010 November 26107 (11):1336-44. Epub 10/14/2010.
Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, Richardson JA, Dimaio JM, Sadek H, Kuwahara K, Olson EN
Circulation research.. 2010 July 23107 (2):294-304. Epub 06/17/2010.
Small EM, O'Rourke JR, Moresi V, Sutherland LB, McAnally J, Gerard RD, Richardson JA, Olson EN
Proceedings of the National Academy of Sciences of the United States of America.. 2010 March 2107 (9):4218-23. Epub 02/08/2010.
Small EM, Frost RJ, Olson EN
Circulation.. 2010 March 2121 (8):1022-32. Epub 1900 01 01.
Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN
Genes & development.. 2009 September 1523 (18):2166-78. Epub 08/31/2009.
Meadows SM, Warkman AS, Salanga MC, Small EM, Krieg PA
Proceedings of the National Academy of Sciences of the United States of America.. 2008 February 5105 (5):1545-50. Epub 01/29/2008.
Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, Nakagawa O, Olson EN
Proceedings of the National Academy of Sciences of the United States of America.. 2007 May 8104 (19):7975-80. Epub 04/27/2007.
Small EM, Warkman AS, Wang DZ, Sutherland LB, Olson EN, Krieg PA
Development.. 2005 March 132 (5):987-97. Epub 01/26/2005.
Small EM, Krieg PA
Trends in cardiovascular medicine.. 2004 January 14 (1):13-8. Epub 1900 01 01.
Small EM, Krieg PA
Developmental biology.. 2003 September 1261 (1):116-31. Epub 1900 01 01.
Small EM, Krieg PA
Cold Spring Harbor symposia on quantitative biology.. 2002 67 :71-9. Epub 1900 01 01.
Wang D, Passier R, Liu ZP, Shin CH, Wang Z, Li S, Sutherland LB, Small E, Krieg PA, Olson EN
Cold Spring Harbor symposia on quantitative biology.. 2002 67 :97-105. Epub 1900 01 01.
Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN
Cell.. 2001 June 29105 (7):851-62. Epub 1900 01 01.
Garriock RJ, Vokes SA, Small EM, Larson R, Krieg PA
Development genes and evolution.. 2001 May 211 (5):257-60. Epub 1900 01 01.
Small EM, Krieg PA
Development genes and evolution.. 2000 December 210 (12):638-40. Epub 1900 01 01.
Small EM, Vokes SA, Garriock RJ, Li D, Krieg PA
Mechanisms of development.. 2000 September 96 (2):259-62. Epub 1900 01 01.