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Bin Zhang, Ph.D.

Bin Zhang, Ph.D.

Contact

Office (585) 275-1796

About Me

Dr. Bin Zhang is an Associate Professor in the Department of Pathology & Laboratory Medicine and the Department of Pediatrics at University of Rochester. He serves as a clinical genomicist in the cytogenetics laboratory at Strong Memorial Hospital. He earned his PhD in Molecular Genetics and Ge...
Dr. Bin Zhang is an Associate Professor in the Department of Pathology & Laboratory Medicine and the Department of Pediatrics at University of Rochester. He serves as a clinical genomicist in the cytogenetics laboratory at Strong Memorial Hospital. He earned his PhD in Molecular Genetics and Genomics and obtained his Clinical Genomics Fellowship at Washington University in Saint Louis. He is board certified in Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics. Prior to his doctoral studies, he earned his BS in Biology from Sichuan University in China and MS in Biology from Truman State University. He also completed his post-doctoral training at Cold Spring Harbor Laboratory.

Dr. Zhang' clinical responsibilities include the genetic diagnostic evaluation of blood, bone marrow, lymph nodes, amniotic fluid, chorionic villus, product of conception, and tissues for other malignancies. This includes analysis and interpretation of molecular genetic and cytogenetic, and genomic data from sequencing, karyotyping, FISH, microarray and optical genome mapping. His research focuses on centromere biology and chromosome instability.

Faculty Appointments

Associate Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Post-doctoral Training & Residency

Clinical Genomics Fellowship at Washington University in Saint Louis 2012 - 2015

Postdoctoral Fellowship at Cold Spring Harbor Laboratory 2009 - 2012

Education

PhD | Washington University in Saint Louis. 2007

Research

His graduate study focused on human genetics and mouse models of cohesinopathies and cohesin biology, and his postdoctoral work on the function, regulation, and evolution of long (MALAT1 and NEAT1) and small (piRNAs) non-coding RNAs (ncRNAs). He maintains active research interests in chromosome bio...
His graduate study focused on human genetics and mouse models of cohesinopathies and cohesin biology, and his postdoctoral work on the function, regulation, and evolution of long (MALAT1 and NEAT1) and small (piRNAs) non-coding RNAs (ncRNAs). He maintains active research interests in chromosome biology and centromere biology. In particular, his research program at University of Rochester focuses on the formation, plasticity, and epigenetic inheritance of human centromeres. He created a unique cell model to interrogate a two-step mechanism (seeding and expansion of CENP-A chromatin) regulating human centromere formation via direct genetic manipulation of chromatin followed by chromatin fiber analysis (IF/FISH and DiMeLo-seq). He is also exploring the potential clinical applications of de novo centromere construction in gene therapy and synthetic biology.

Email address: bin_zhang@urmc.rochester.edu.

Publications

Journal Articles

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation.

McGrath KE, Koniski AD, Murphy K, Getman M, An HH, Schulz VP, Kim AR, Zhang B, Schofield TL, Papoin J, Blanc L, Kingsley PD, Westhoff CM, Gallagher PG, Chou ST, Steiner LA, Palis J

bioRxiv : the preprint server for biology.. 2024 February 6 Epub 02/06/2024.

Clinicopathologic and Molecular Characterization of Anorectal Neuroendocrine Carcinomas Reveals Human Papillomavirus, p53, and c-Myc as Alternative Mechanisms of Carcinogenesis.

Cox AJ, Crowe WE, Yang Q, Zhang B, Oltvai ZN, Liao X

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2023 November 36 (11):100295. Epub 07/29/2023.

The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors.

Wang H, Li B, Zuo L, Wang B, Yan Y, Tian K, Zhou R, Wang C, Chen X, Jiang Y, Zheng H, Qin F, Zhang B, Yu Y, Liu CP, Xu Y, Gao J, Qi Z, Deng W, Ji X

Nature communications.. 2022 September 2813 (1):5703. Epub 09/28/2022.

NR4A3 fluorescence in situ hybridization analysis in cytologic and surgical specimens of acinic cell carcinoma.

Shi Q, Zhang B, Bsirini C, Li L, Giampoli EJ, Magliocca KR, Reid M, Zhou Z

Human pathology.. 2022 September 127 :86-91. Epub 06/11/2022.

MEIS2 (15q14) gene deletions in siblings with mild developmental phenotypes and bifid uvula: documentation of mosaicism in an unaffected parent.

Zhang B, Liu M, Fong CT, Iqbal MA

Molecular cytogenetics.. 2021 December 2014 (1):58. Epub 12/20/2021.

Allelic and dosage effects of NHS in X-linked cataract and Nance-Horan syndrome: a family study and literature review.

Miller C, Gertsen BG, Schroeder AL, Fong CT, Iqbal MA, Zhang B

Molecular cytogenetics.. 2021 October 714 (1):48. Epub 10/07/2021.

Transplacental transfer of congenital B-cell acute lymphoblastic leukemia to the maternal vasculature.

Fries C, Noronha SA, Metlay L, Zhang B

Pediatric blood & cancer.. 2021 September 68 (9):e29142. Epub 06/14/2021.

A Case of Acute Eosinophilic Leukemia with a Novel 6 Mutation.

Lipof JJ, Huselton EJ, Zent CS, Evans A, Zhang B, Rothberg PG, Bennett JM

Case reports in hematology.. 2021 2021 :5574766. Epub 07/03/2021.

Diagnosis of FOXG1 syndrome caused by recurrent balanced chromosomal rearrangements: case study and literature review.

Craig CP, Calamaro E, Fong CT, Iqbal AM, Paciorkowski AR, Zhang B

Molecular cytogenetics.. 2020 September 313 (1):40. Epub 09/03/2020.

A case of Burkitt Leukemia: Revisiting the prognostic value of lactate dehydrogenase.

Bodrog A, Zhang B, Liu L, Casulo C, Bennett JM

Leukemia research.. 2020 February 89 :106295. Epub 12/28/2019.

Novel 1.3 Mb germline duplication in chromosome 8q21.11 by microarray comparative genomic hybridization plus single nucleotide polymorphism analysis in an adult patient with pancytopenia and urinary bladder complications.

Reyes Barron C, Evans AG, Miyamoto H, Zhang B, Iqbal MA

Clinical case reports.. 2018 October 6 (10):1947-1952. Epub 08/16/2018.

Chorionic Histiocytic Hyperplasia is Associated With Chronic Inflammatory Lesions in the Placenta.

Katzman PJ, Metlay LA, McMahon LA, LiQiong L, Zhang B

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2017 June 20 (3):197-205. Epub 02/08/2017.

Identification and Characterization of a Class of MALAT1-like Genomic Loci.

Zhang B, Mao YS, Diermeier SD, Novikova IV, Nawrocki EP, Jones TA, Lazar Z, Tung CS, Luo W, Eddy SR, Sanbonmatsu KY, Spector DL

Cell reports.. 2017 May 2319 (8):1723-1738. Epub 1900 01 01.

Domestic chickens activate a piRNA defense against avian leukosis virus.

Sun YH, Xie LH, Zhuo X, Chen Q, Ghoneim D, Zhang B, Jagne J, Yang C, Li XZ

eLife.. 2017 April 66 Epub 04/06/2017.

Multigenerational autosomal dominant inheritance of 5p chromosomal deletions.

Zhang B, Willing M, Grange DK, Shinawi M, Manwaring L, Vineyard M, Kulkarni S, Cottrell CE

American journal of medical genetics. Part A.. 2016 March 170 (3):583-93. Epub 11/24/2015.

The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult.

Zhang B, Arun G, Mao YS, Lazar Z, Hung G, Bhattacharjee G, Xiao X, Booth CJ, Wu J, Zhang C, Spector DL

Cell reports.. 2012 July 262 (1):111-23. Epub 06/28/2012.

Biogenesis and function of nuclear bodies.

Mao YS, Zhang B, Spector DL

Trends in genetics : TIG.. 2011 August 27 (8):295-306. Epub 06/15/2011.

Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.

Mao YS, Sunwoo H, Zhang B, Spector DL

Nature cell biology.. 2011 January 13 (1):95-101. Epub 12/19/2010.

Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus.

Chang J, Zhang B, Heath H, Galjart N, Wang X, Milbrandt J

Proceedings of the National Academy of Sciences of the United States of America.. 2010 December 14107 (50):21836-41. Epub 11/24/2010.

Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.

Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO

Development.. 2010 February 137 (4):631-40. Epub 1900 01 01.

Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis.

Song H, Zhang B, Watson MA, Humphrey PA, Lim H, Milbrandt J

Oncogene.. 2009 September 1728 (37):3307-19. Epub 07/13/2009.

Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.

Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Shashikant K, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, Krantz I, Milbrandt J

PloS one.. 2009 4 (5):e5232. Epub 05/01/2009.

Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.

Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J

Development.. 2007 September 134 (17):3191-201. Epub 07/25/2007.

Books

Clinical Genomics (2014)

Chapter: Single Nucleotide Variant Detection Using Next Generation Sequencing

Authors: David H. Spencer, Bin Zhang and John Pfeifer

Publisher: Elsevier 2014