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Houhui Xia, M.Sc., Ph.D.

Houhui Xia, M.Sc., Ph.D.

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Call Center (585) 276-3000

Research Lab

About Me

Faculty Appointments

Associate Professor - Department of Pharmacology and Physiology (SMD)

Associate Professor - Department of Neuroscience (SMD) - Joint

Research

Publications

Journal Articles

PP1? opposes classic PP1 function, inhibiting spine maturation and promoting LTP.

Foley K, McKee C, Ganguly A, Barnett D, Ward N, Mayer A, Zhang Y, Nairn AC, Xia H

bioRxiv : the preprint server for biology.. 2023 January 27 Epub 01/27/2023.

Regulation of PP1 interaction with I-2, neurabin, and F-actin.

Foley K, Ward N, Hou H, Mayer A, McKee C, Xia H

Molecular and cellular neurosciences.. 2022 November 25 :103796. Epub 11/25/2022.

Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development.

McKee C, Shrager P, Mazumder AG, Ganguly A, Mayer A, Foley K, Ward N, Youngman M, Hou H, Xia H

Molecular neurobiology.. 2022 October 6 Epub 10/06/2022.

Protein phosphatase-1 inhibitor-2 promotes PP1 positive regulation of synaptic transmission.

Foley K, Altimimi H, Hou H, Zhang Y, McKee C, Papasergi-Scott MM, Yang H, Mayer A, Ward N, MacLean DM, Nairn AC, Stellwagen D, Xia H

Frontiers in synaptic neuroscience.. 2022 14 :1021832. Epub 10/06/2022.

Early Low-Level Arsenic Exposure Impacts Post-Synaptic Hippocampal Function in Juvenile Mice.

Foley KFW, Barnett D, Cory-Slechta DA, Xia H

Toxics.. 2021 August 319 (9)Epub 08/31/2021.

Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons.

Hou H, Wang L, Fu T, Papasergi M, Yule DI, Xia H

Molecular neurobiology.. 2020 March 25 Epub 03/25/2020.

Distinct Roles of Protein Phosphatase 1 Bound on Neurabin and Spinophilin and Its Regulation in AMPA Receptor Trafficking and LTD Induction.

Gao J, Hu XD, Yang H, Xia H

Molecular neurobiology.. 2018 September 55 (9):7179-7186. Epub 01/30/2018.

Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor.

Yang H, Hou H, Pahng A, Gu H, Nairn AC, Tang YP, Colombo PJ, Xia H

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 November 1135 (45):15082-7. Epub 1900 01 01.

Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity.

Siddoway B, Hou H, Yang J, Sun L, Yang H, Wang GY, Xia H

Neuroscience letters.. 2014 November 7583 :142-7. Epub 09/08/2014.

The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function.

Hou H, Chávez AE, Wang CC, Yang H, Gu H, Siddoway BA, Hall BJ, Castillo PE, Xia H

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 October 1534 (42):14006-12. Epub 1900 01 01.

Molecular mechanisms of homeostatic synaptic downscaling.

Siddoway B, Hou H, Xia H

Neuropharmacology.. 2014 March 78 :38-44. Epub 08/02/2013.

Synaptic activity bidirectionally regulates a novel sequence-specific S-Q phosphoproteome in neurons.

Siddoway B, Hou H, Yang H, Petralia R, Xia H

Journal of neurochemistry.. 2014 March 128 (6):841-51. Epub 11/13/2013.

Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5.

Hou H, Sun L, Siddoway BA, Petralia RS, Yang H, Gu H, Nairn AC, Xia H

The Journal of cell biology.. 2013 November 11203 (3):521-35. Epub 11/04/2013.

An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.

Siddoway BA, Altimimi HF, Hou H, Petralia RS, Xu B, Stellwagen D, Xia H

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 July 333 (27):11206-11. Epub 1900 01 01.

Rab8 interacts with distinct motifs in alpha2B- and beta2-adrenergic receptors and differentially modulates their transport.

Dong C, Yang L, Zhang X, Gu H, Lam ML, Claycomb WC, Xia H, Wu G

The Journal of biological chemistry.. 2010 June 25285 (26):20369-80. Epub 04/27/2010.

Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase.

Gao J, Siddoway B, Huang Q, Xia H

Biochemical and biophysical research communications.. 2009 January 30379 (1):1-5. Epub 12/12/2008.

Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus.

Hu XD, Huang Q, Yang X, Xia H

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 April 2527 (17):4674-86. Epub 1900 01 01.

Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.

Hu XD, Huang Q, Roadcap DW, Shenolikar SS, Xia H

Journal of neurochemistry.. 2006 September 98 (6):1841-51. Epub 08/08/2006.

Signaling from synapse to nucleus: the logic behind the mechanisms.

Deisseroth K, Mermelstein PG, Xia H, Tsien RW

Current opinion in neurobiology.. 2003 June 13 (3):354-65. Epub 1900 01 01.

A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors.

Xia H, von Zastrow M, Malenka RC

The Journal of biological chemistry.. 2002 December 6277 (49):47765-9. Epub 10/03/2002.

Differential roles for NSF and GRIP/ABP in AMPA receptor cycling.

Braithwaite SP, Xia H, Malenka RC

Proceedings of the National Academy of Sciences of the United States of America.. 2002 May 1499 (10):7096-101. Epub 1900 01 01.