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Jennetta W. Hammond, Ph.D.

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About Me
Credentials
Research
Publications

About Me

Faculty Appointments

Assistant Professor - Department of Neurology, Neuroimmunology (SMD)

Assistant Professor - Department of Neuroscience (SMD) - Joint

Credentials

Post-doctoral Training & Residency

University of Rochester Medical Center; Center for Neurotherapeutics Discovery. Advisor: Harris Gelbard 2012 - 2018

Education

PhD | University of Michigan. Cell and Developmental Biology. 2008

BS | Brigham Young University. Zoology. 2002

Awards

Trainee Professional Development Award. 2015

Research

My research interests are focused on uncovering neuro-immune mechanisms driving synapse and neuron turnover as well as microglia dysregulation throughout the lifespan. Most of my current projects focus on regulation of the complement pathway in the CNS. I have identified and begun characterizing novel complement inhibitory proteins that are specifically expressed in neurons, namely the Sez6 family and Srpx2. These complement inhibitors may serve as protective factors to preserve neurons and neuronal connections during critical windows in brain development when complement is engaged to prune away excess connections. These same complement inhibitors also appear to play a protective role in aging and are likely very important in pathological conditions with heightened inflammation and complement activation like multiple sclerosis.

Publications

Journal Articles

Quantum Dots for Improved Single-Molecule Localization Microscopy.

Urban JM, Chiang W, Hammond JW, Cogan NMB, Litzburg A, Burke R, Stern HA, Gelbard HA, Nilsson BL, Krauss TD

The journal of physical chemistry. B. 2021 March 8 Epub 03/08/2021.

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases.

Qiu WQ, Luo S, Ma SA, Saminathan P, Li H, Gunnersen JM, Gelbard HA, Hammond JW

Frontiers in immunology.. 2021 12 :607641. Epub 04/15/2021.

Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.

Nguyen L, Laboissonniere LA, Guo S, Pilotto F, Scheidegger O, Oestmann A, Hammond JW, Li H, Hyysalo A, Peltola R, Pattamatta A, Zu T, Voutilainen MH, Gelbard HA, Saxena S, Ranum LPW

Neuron.. 2020 October 1 Epub 10/01/2020.

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis.

Hammond JW, Bellizzi MJ, Ware C, Qiu WQ, Saminathan P, Li H, Luo S, Ma SA, Li Y, Gelbard HA

Brain, behavior, and immunity.. 2020 March 6 Epub 03/06/2020.

HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q.

Hammond JW, Qiu WQ, Marker DF, Chamberlain JM, Greaves-Tunnell W, Bellizzi MJ, Lu SM, Gelbard HA

Glia.. 2018 October 16 Epub 10/16/2018.

The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis.

Bellizzi MJ, Hammond JW, Li H, Gantz Marker, Marker DF, Freeman RS, Gelbard HA

eNeuro.. 2018 5 (6)Epub 12/03/2018.

Corrigendum: Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation.

Hammond JW, Lu SM, Gelbard HA