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Brian J. Altman, Ph.D.

Brian J. Altman, Ph.D.

Research Lab

About Me

Faculty Appointments

Assistant Professor - Department of Biomedical Genetics (SMD)



PhD | Duke University. Molecular Cancer Biology. 2011

BA | University of Pennsylvania. Biology. 2005



Journal Articles

Circadian rhythms of macrophages are altered by the acidic pH of the tumor microenvironment.

Knudsen-Clark AM, Mwangi D, Cazarin J, Hablitz LM, Kim M, Altman BJ

bioRxiv : the preprint server for biology.. 2024 February 16 Epub 02/16/2024.

Chewing the fat for good health: ACSM3 deficiency exacerbates metabolic syndrome.

Cazarin J, Altman BJ

The EMBO journal.. 2024 January 23 Epub 01/23/2024.

MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.

Cazarin J, DeRollo RE, Shahidan SNABA, Burchett JB, Mwangi D, Krishnaiah S, Hsieh AL, Walton ZE, Brooks R, Mello SS, Weljie AM, Dang CV, Altman BJ

PLoS genetics.. 2023 August 2819 (8):e1010904. Epub 08/28/2023.

MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.

DeRollo RE, Cazarin J, Ahmad Shahidan SNAB, Burchett JB, Mwangi D, Krishnaiah S, Hsieh AL, Walton ZE, Brooks R, Mello SS, Weljie AM, Dang CV, Altman BJ

bioRxiv : the preprint server for biology.. 2023 January 4 Epub 01/04/2023.

Circadian disruption enhances HSF1 signaling and tumorigenesis in -driven lung cancer.

Pariollaud M, Ibrahim LH, Irizarry E, Mello RM, Chan AB, Altman BJ, Shaw RJ, Bollong MJ, Wiseman RL, Lamia KA

Science advances.. 2022 September 308 (39):eabo1123. Epub 09/28/2022.

Neonatal Hyperoxia Activates ATF4 to Stimulate Folate Metabolism and AT2 Cell Proliferation.

Yee M, McDavid AN, Cohen ED, Huyck HL, Poole C, Altman BJ, Maniscalco WM, Deutsch GH, Pryhuber GS, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2022 January 19 Epub 01/19/2022.

Time-restricted Eating to Address Cancer-related Fatigue among Cancer Survivors: A Single-arm Pilot Study.

Kleckner AS, Altman BJ, Reschke JE, Kleckner IR, Culakova E, Dunne RF, Mustian KM, Peppone LJ

Journal of integrative oncology.. 2022 11 (4)Epub 05/30/2022.

MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer.

Burchett JB, Knudsen-Clark AM, Altman BJ

International journal of molecular sciences.. 2021 July 2022 (14)Epub 07/20/2021.

A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.

Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA

Nature cell biology.. 2018 January 20 (1):104-115. Epub 12/11/2017.

Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.

Krishnaiah SY, Wu G, Altman BJ, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U, Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM

Cell metabolism.. 2017 April 425 (4):961-974.e4. Epub 1900 01 01.

Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERB?.

Altman BJ, Hsieh AL, Gouw AM, Dang CV

Nature communications.. 2017 March 238 :14862. Epub 03/23/2017.

From Krebs to clinic: glutamine metabolism to cancer therapy.

Altman BJ, Stine ZE, Dang CV

Nature reviews. Cancer.. 2016 October 16 (10):619-34. Epub 07/29/2016.

Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer.

Altman BJ

Frontiers in cell and developmental biology.. 2016 4 :62. Epub 06/24/2016.

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV

Cell metabolism.. 2015 December 122 (6):1009-19. Epub 09/17/2015.

MYC, Metabolism, and Cancer.

Stine ZE, Walton ZE, Altman BJ, Hsieh AL, Dang CV

Cancer discovery.. 2015 October 5 (10):1024-39. Epub 09/17/2015.

MYC and metabolism on the path to cancer.

Hsieh AL, Walton ZE, Altman BJ, Stine ZE, Dang CV

Seminars in cell & developmental biology.. 2015 July 43 :11-21. Epub 08/12/2015.

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

Xiang Y, Stine ZE, Xia J, Lu Y, O'Connor RS, Altman BJ, Hsieh AL, Gouw AM, Thomas AG, Gao P, Sun L, Song L, Yan B, Slusher BS, Zhuo J, Ooi LL, Lee CG, Mancuso A, McCallion AS, Le A, Milone MC, Rayport S, Felsher DW, Dang CV

The Journal of clinical investigation.. 2015 June 125 (6):2293-306. Epub 04/27/2015.

Metabolic stress in autophagy and cell death pathways.

Altman BJ, Rathmell JC

Cold Spring Harbor perspectives in biology.. 2012 September 14 (9):a008763. Epub 09/01/2012.

Normal and cancer cell metabolism: lymphocytes and lymphoma.

Altman BJ, Dang CV

The FEBS journal.. 2012 August 279 (15):2598-609. Epub 07/03/2012.

ER stress modulates cellular metabolism.

Wang X, Eno CO, Altman BJ, Zhu Y, Zhao G, Olberding KE, Rathmell JC, Li C

The Biochemical journal.. 2011 April 1435 (1):285-96. Epub 1900 01 01.

Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.

Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC

The Journal of biological chemistry.. 2011 February 18286 (7):5921-33. Epub 12/15/2010.

Autophagy: not good OR bad, but good AND bad.

Altman BJ, Rathmell JC

Autophagy.. 2009 May 5 (4):569-70. Epub 1900 01 01.

An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking.

Wieman HL, Horn SR, Jacobs SR, Altman BJ, Kornbluth S, Rathmell JC

The Biochemical journal.. 2009 March 1418 (2):345-67. Epub 1900 01 01.

Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.

Altman BJ, Wofford JA, Zhao Y, Coloff JL, Ferguson EC, Wieman HL, Day AE, Ilkayeva O, Rathmell JC

Molecular biology of the cell.. 2009 February 20 (4):1180-91. Epub 12/24/2008.

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC

Molecular and cellular biology.. 2007 June 27 (12):4328-39. Epub 03/19/2007.

Telomerase can act as a template- and RNA-independent terminal transferase.

Lue NF, Bosoy D, Moriarty TJ, Autexier C, Altman B, Leng S

Proceedings of the National Academy of Sciences of the United States of America.. 2005 July 12102 (28):9778-83. Epub 06/30/2005.

Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor.

Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D

The Journal of biological chemistry.. 2005 February 25280 (8):7346-58. Epub 11/23/2004.


Annual Review of Cancer Biology (2018)

Chapter: Circadian Clock's Cancer Connections

Authors: Walton ZE, Altman BJ, Brooks RC, and Dang CV

Publisher: Annual Reviews 2018

Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanism (2014)

Chapter: Deregulation of the cellular energetics of cancer cells

Authors: Stine ZE, Altman BJ, Hsieh AL, Gouw AM, and Dang CV

Publisher: Elsevier 2014