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Paula M. Vertino, Ph.D.

Paula M. Vertino, Ph.D.

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About Me

Faculty Appointments

Professor - Department of Biomedical Genetics (SMD)

Wilmot Distinguished Professorship in Cancer Genomics - Cancer Center

Senior Associate Dean, Basic Research - Dean's Office M&D - Administration (SMD)

Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Research

Dr. Vertino's research interests are focused on the areas of cancer epigenetics and novel mechanisms of gene silencing in cancer.

Publications

Journal Articles

Transposon DNA sequences facilitate the tissue-specific gene transfer of circulating tumor DNA between human cells.

Cinar M, Martinez-Medina L, Puvvula PK, Arakelyan A, Vardarajan BN, Anthony N, Nagaraju GP, Park D, Feng L, Sheff F, Mosunjac M, Saxe D, Flygare S, Alese OB, Kaufman JL, Lonial S, Sarmiento JM, Lossos IS, Vertino PM, Lopez JA, El-Rayes B, Bernal-Mizrachi L

Nucleic acids research.. 2024 May 23 Epub 05/23/2024.

Arid1a mutation suppresses TGF-? signaling and induces cholangiocarcinoma.

Guo B, Friedland SC, Alexander W, Myers JA, Wang W, O'Dell MR, Getman M, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Mello SS, Vertino PM, Land HK, Steiner LA, Hezel AF

Cell reports.. 2022 August 3040 (9):111253. Epub 1900 01 01.

Combined inhibition of G9a and EZH2 suppresses tumor growth via synergistic induction of IL24-mediated apoptosis.

Casciello F, Kelly GM, Ramarao-Milne P, Kamal N, Stewart TA, Mukhopadhyay P, Kazakoff SH, Miranda M, Kim D, Davis FM, Hayward NK, Vertino PM, Waddell N, Gannon F, Lee JS

Cancer research.. 2022 February 11 Epub 02/11/2022.

Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation.

Ruff GL, Murphy KE, Smith ZR, Vertino PM, Murphy PJ

BMC cancer.. 2021 December 1821 (1):1342. Epub 12/18/2021.

Ten-eleven translocation protein 1 modulates medulloblastoma progression.

Kim H, Kang Y, Li Y, Chen L, Lin L, Johnson ND, Zhu D, Robinson MH, McSwain L, Barwick BG, Yuan X, Liao X, Zhao J, Zhang Z, Shu Q, Chen J, Allen EG, Kenney AM, Castellino RC, Van Meir EG, Conneely KN, Vertino PM, Jin P, Li J

Genome biology.. 2021 April 2922 (1):125. Epub 04/29/2021.

Chromatin accessibility identifies regulatory elements predictive of gene expression and disease outcome in multiple myeloma.

Barwick BG, Gupta VA, Matulis SM, Patton JC, Powell DR, Gu Y, Jaye DL, Conneely KN, Lin Y, Hofmeister CC, Nooka AK, Keats JJ, Lonial S, Vertino PM, Boise LH

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2021 March 17 Epub 03/17/2021.

Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer.

Zhang B, Li Y, Wu Q, Xie L, Barwick B, Fu C, Li X, Wu D, Xia S, Chen J, Qian WP, Yang L, Osunkoya AO, Boise L, Vertino PM, Zhao Y, Li M, Chen HR, Kowalski J, Kucuk O, Zhou W, Dong JT

Nature communications.. 2021 March 1712 (1):1714. Epub 03/17/2021.

Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score???7.

Miyauchi T, Takahashi M, Mitsuzuka K, Saiki Y, Okubo T, Vertino PM, Goto A, Arai Y, Horii A, Fukushige S

Disease markers.. 2021 2021 :8858905. Epub 02/04/2021.

Prognostic significance of an invasive leader cell-derived mutation cluster on chromosome 16q.

Pedro B, Rupji M, Dwivedi B, Kowalski J, Konen JM, Owonikoko TK, Ramalingam SS, Vertino PM, Marcus AI

Cancer.. 2020 July 1126 (13):3140-3150. Epub 04/21/2020.

Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning.

Summerbell ER, Mouw JK, Bell JSK, Knippler CM, Pedro B, Arnst JL, Khatib TO, Commander R, Barwick BG, Konen J, Dwivedi B, Seby S, Kowalski J, Vertino PM, Marcus AI

Science advances.. 2020 July 6 (30):eaaz6197. Epub 07/24/2020.

Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.

Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM

Journal of cell science.. 2019 October 9132 (19)Epub 10/09/2019.

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis.

Barwick BG, Neri P, Bahlis NJ, Nooka AK, Dhodapkar MV, Jaye DL, Hofmeister CC, Kaufman JL, Gupta VA, Auclair D, Keats JJ, Lonial S, Vertino PM, Boise LH

Nature communications.. 2019 April 2310 (1):1911. Epub 04/23/2019.

Cell of Origin and Genetic Alterations in the Pathogenesis of Multiple Myeloma.

Barwick BG, Gupta VA, Vertino PM, Boise LH

Frontiers in immunology.. 2019 10 :1121. Epub 05/21/2019.

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X

Journal of medicinal chemistry.. 2018 November 15 Epub 11/15/2018.

Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.

Kennedy EM, Powell DR, Li Z, Bell JSK, Barwick BG, Feng H, McCrary MR, Dwivedi B, Kowalski J, Dynan WS, Conneely KN, Vertino PM

Scientific reports.. 2018 April 308 (1):6709. Epub 04/30/2018.

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X

Journal of medicinal chemistry.. 2018 April 1261 (7):3193-3208. Epub 03/23/2018.

Orphan CpG islands define a novel class of highly active enhancers.

Bell JSK, Vertino PM

Epigenetics.. 2017 June 312 (6):449-464. Epub 04/27/2017.

MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.

Wang D, Hashimoto H, Zhang X, Barwick BG, Lonial S, Boise LH, Vertino PM, Cheng X

Nucleic acids research.. 2017 March 1745 (5):2396-2407. Epub 1900 01 01.

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.

Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JSK, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X

Cell chemical biology.. 2016 July 2123 (7):769-781. Epub 07/14/2016.

A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer.

Scott EC, Gardner EJ, Masood A, Chuang NT, Vertino PM, Devine SE

Genome research.. 2016 June 26 (6):745-55. Epub 05/10/2016.

Gene integrated set profile analysis: a context-based approach for inferring biological endpoints.

Kowalski J, Dwivedi B, Newman S, Switchenko JM, Pauly R, Gutman DA, Arora J, Gandhi K, Ainslie K, Doho G, Qin Z, Moreno CS, Rossi MR, Vertino PM, Lonial S, Bernal-Mizrachi L, Boise LH

Nucleic acids research.. 2016 April 2044 (7):e69. Epub 01/29/2016.

Factors affecting the persistence of drug-induced reprogramming of the cancer methylome.

Bell JS, Kagey JD, Barwick BG, Dwivedi B, McCabe MT, Kowalski J, Vertino PM

Epigenetics.. 2016 April 211 (4):273-87. Epub 04/15/2016.

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X

The Journal of biological chemistry.. 2016 February 5291 (6):2631-46. Epub 12/08/2015.

GC skew defines distinct RNA polymerase pause sites in CpG island promoters.

Kellner WA, Bell JS, Vertino PM

Genome research.. 2015 November 25 (11):1600-9. Epub 08/14/2015.

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer.

Brodie SA, Li G, Harvey D, Khuri FR, Vertino PM, Brandes JC

Oncotarget.. 2015 October 136 (31):30773-86. Epub 1900 01 01.

The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations.

Hashimoto H, Zhang X, Vertino PM, Cheng X

The Journal of biological chemistry.. 2015 August 21290 (34):20723-33. Epub 07/07/2015.

HNF4? regulates claudin-7 protein expression during intestinal epithelial differentiation.

Farkas AE, Hilgarth RS, Capaldo CT, Gerner-Smidt C, Powell DR, Vertino PM, Koval M, Parkos CA, Nusrat A

The American journal of pathology.. 2015 August 185 (8):2206-18. Epub 1900 01 01.

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis.

Stoyanov E, Ludwig G, Mizrahi L, Olam D, Schnitzer-Perlman T, Tasika E, Sass G, Tiegs G, Jiang Y, Nie T, Kohler J, Schinazi RF, Vertino PM, Cedar H, Galun E, Goldenberg D

Oncotarget.. 2015 May 106 (13):11047-60. Epub 1900 01 01.

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences.

Lin Y, Cradick TJ, Brown MT, Deshmukh H, Ranjan P, Sarode N, Wile BM, Vertino PM, Stewart FJ, Bao G

Nucleic acids research.. 2014 June 42 (11):7473-85. Epub 05/16/2014.

Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy.

Smith AK, Conneely KN, Pace TW, Mister D, Felger JC, Kilaru V, Akel MJ, Vertino PM, Miller AH, Torres MA

Brain, behavior, and immunity.. 2014 May 38 :227-36. Epub 02/28/2014.

A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.

Kapoor-Vazirani P, Vertino PM

The Journal of biological chemistry.. 2014 March 14289 (11):7425-37. Epub 01/23/2014.

Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer.

Brodie SA, Li G, El-Kommos A, Kang H, Ramalingam SS, Behera M, Gandhi K, Kowalski J, Sica GL, Khuri FR, Vertino PM, Brandes JC

Cancer prevention research.. 2014 March 7 (3):351-61. Epub 01/17/2014.

Aberrant promoter methylation of caveolin-1 is associated with favorable response to taxane-platinum combination chemotherapy in advanced NSCLC.

Brodie SA, Lombardo C, Li G, Kowalski J, Gandhi K, You S, Khuri FR, Marcus A, Vertino PM, Brandes JC

PloS one.. 2014 9 (9):e107124. Epub 09/15/2014.

Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma.

Yang R, Chen L, Newman S, Gandhi K, Doho G, Moreno CS, Vertino PM, Bernal-Mizarchi L, Lonial S, Boise LH, Rossi M, Kowalski J, Qin ZS

Cancer informatics.. 2014 13 (Suppl 2):49-53. Epub 09/21/2014.

Dysregulation of mTOR activity through LKB1 inactivation.

Zhou W, Marcus AI, Vertino PM

Chinese journal of cancer.. 2013 August 32 (8):427-33. Epub 05/14/2013.

Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition.

Yang Z, Garcia A, Xu S, Powell DR, Vertino PM, Singh S, Marcus AI

PloS one.. 2013 8 (9):e75069. Epub 09/12/2013.

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

Duncan CG, Barwick BG, Jin G, Rago C, Kapoor-Vazirani P, Powell DR, Chi JT, Bigner DD, Vertino PM, Yan H

Genome research.. 2012 December 22 (12):2339-55. Epub 08/16/2012.

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.

Hashimoto H, Liu Y, Upadhyay AK, Chang Y, Howerton SB, Vertino PM, Zhang X, Cheng X

Nucleic acids research.. 2012 June 40 (11):4841-9. Epub 02/22/2012.

R loops: lassoing DNA methylation at CpGi.

Vertino PM, Wade PA

Molecular cell.. 2012 March 3045 (6):708-9. Epub 1900 01 01.

Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.

Thaiparambil JT, Bender L, Ganesh T, Kline E, Patel P, Liu Y, Tighiouart M, Vertino PM, Harvey RD, Garcia A, Marcus AI

International journal of cancer.. 2011 December 1129 (11):2744-55. Epub 05/02/2011.

Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.

Zhu D, Hunter SB, Vertino PM, Van Meir EG

Cancer research.. 2011 September 171 (17):5859-70. Epub 07/01/2011.

SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.

Kapoor-Vazirani P, Kagey JD, Vertino PM

Molecular and cellular biology.. 2011 April 31 (8):1594-609. Epub 02/14/2011.

Molecular coupling of DNA methylation and histone methylation.

Hashimoto H, Vertino PM, Cheng X

Epigenomics.. 2010 October 2 (5):657-69. Epub 1900 01 01.

Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.

Kagey JD, Kapoor-Vazirani P, McCabe MT, Powell DR, Vertino PM

Molecular cancer research : MCR.. 2010 July 8 (7):1048-59. Epub 06/29/2010.

Natural mutagenesis of human genomes by endogenous retrotransposons.

Iskow RC, McCabe MT, Mills RE, Torene S, Pittard WS, Neuwald AF, Van Meir EG, Vertino PM, Devine SE

Cell.. 2010 June 25141 (7):1253-61. Epub 1900 01 01.

Age/race differences in HER2 testing and in incidence rates for breast cancer triple subtypes: a population-based study and first report.

Lund MJ, Butler EN, Hair BY, Ward KC, Andrews JH, Oprea-Ilies G, Bayakly AR, O'Regan RM, Vertino PM, Eley JW

Cancer.. 2010 June 1116 (11):2549-59. Epub 1900 01 01.

Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.

McCabe MT, Powell DR, Zhou W, Vertino PM

Cancer genetics and cytogenetics.. 2010 March 197 (2):130-41. Epub 1900 01 01.

Cancer DNA methylation: molecular mechanisms and clinical implications.

McCabe MT, Brandes JC, Vertino PM

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2009 June 1515 (12):3927-37. Epub 06/09/2009.

Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.

Lucas ME, Crider KS, Powell DR, Kapoor-Vazirani P, Vertino PM

The Journal of biological chemistry.. 2009 May 29284 (22):14698-709. Epub 03/25/2009.

Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.

Parsons MJ, Patel P, Brat DJ, Colbert L, Vertino PM

Cancer research.. 2009 March 169 (5):1706-11. Epub 02/17/2009.

A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation.

McCabe MT, Lee EK, Vertino PM

Cancer research.. 2009 January 169 (1):282-91. Epub 1900 01 01.

LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.

Zhong D, Liu X, Khuri FR, Sun SY, Vertino PM, Zhou W

Cancer research.. 2008 September 1568 (18):7270-7. Epub 1900 01 01.

Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.

Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM, Moreno CS, Varma V, Dong JT, Zhou W

Molecular cancer research : MCR.. 2008 September 6 (9):1421-30. Epub 1900 01 01.

Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.

Kapoor-Vazirani P, Kagey JD, Powell DR, Vertino PM

Cancer research.. 2008 August 1568 (16):6810-21. Epub 1900 01 01.

Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.

Subramanian K, Jia D, Kapoor-Vazirani P, Powell DR, Collins RE, Sharma D, Peng J, Cheng X, Vertino PM

Molecular cell.. 2008 May 930 (3):336-47. Epub 1900 01 01.

The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.

Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI

Cancer research.. 2008 February 168 (3):740-8. Epub 1900 01 01.

Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses.

Evans CO, Moreno CS, Zhan X, McCabe MT, Vertino PM, Desiderio DM, Oyesiku NM

Pituitary.. 2008 11 (3):231-45. Epub 1900 01 01.

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.

Saxena NK, Vertino PM, Anania FA, Sharma D

The Journal of biological chemistry.. 2007 May 4282 (18):13316-25. Epub 03/07/2007.

Infrequent mutation of ATBF1 in human breast cancer.

Sun X, Zhou Y, Otto KB, Wang M, Chen C, Zhou W, Subramanian K, Vertino PM, Dong JT

Journal of cancer research and clinical oncology.. 2007 February 133 (2):103-5. Epub 08/24/2006.

Dual role of TMS1/ASC in death receptor signaling.

Parsons MJ, Vertino PM

Oncogene.. 2006 November 225 (52):6948-58. Epub 05/22/2006.

LKB1 mutation in large cell carcinoma of the lung.

Zhong D, Guo L, de Aguirre I, Liu X, Lamb N, Sun SY, Gal AA, Vertino PM, Zhou W

Lung cancer : journal of the International Association for the Study of Lung Cancer.. 2006 September 53 (3):285-94. Epub 07/05/2006.

Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways.

Sharma D, Saxena NK, Vertino PM, Anania FA

Endocrine-related cancer.. 2006 June 13 (2):629-40. Epub 1900 01 01.

DNA motifs associated with aberrant CpG island methylation.

Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM

Genomics.. 2006 May 87 (5):572-9. Epub 02/17/2006.

Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.

Stone AR, Bobo W, Brat DJ, Devi NS, Van Meir EG, Vertino PM

The American journal of pathology.. 2004 October 165 (4):1151-61. Epub 1900 01 01.

Epigenetic regulation of MDR1 gene in breast cancer: CpG methylation status dominates the stable maintenance of a silent gene.

Sharma D, Vertino PM

Cancer biology & therapy.. 2004 June 3 (6):549-50. Epub 06/24/2004.

TMS1/ASC: the cancer connection.

McConnell BB, Vertino PM

Apoptosis : an international journal on programmed cell death.. 2004 January 9 (1):5-18. Epub 1900 01 01.

Predicting aberrant CpG island methylation.

Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM

Proceedings of the National Academy of Sciences of the United States of America.. 2003 October 14100 (21):12253-8. Epub 09/30/2003.

Effects of methylation on expression of TMS1/ASC in human breast cancer cells.

Levine JJ, Stimson-Crider KM, Vertino PM

Oncogene.. 2003 May 2922 (22):3475-88. Epub 1900 01 01.

Methylation matters: a new spin on maspin.

Costello JF, Vertino PM

Nature genetics.. 2002 June 31 (2):123-4. Epub 1900 01 01.

Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture.

Stimson KM, Vertino PM

The Journal of biological chemistry.. 2002 February 15277 (7):4951-8. Epub 12/03/2001.

DNMT1 is a component of a multiprotein DNA replication complex.

Vertino PM, Sekowski JA, Coll JM, Applegren N, Han S, Hickey RJ, Malkas LH

Cell cycle.. 2002 1 (6):416-23. Epub 1900 01 01.

Identification and characterization of the human MOG1 gene.

Marfatia KA, Harreman MT, Fanara P, Vertino PM, Corbett AH

Gene.. 2001 March 21266 (1-2):45-56. Epub 1900 01 01.

TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers.

Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST, Vertino PM

Cancer research.. 2000 November 1560 (22):6236-42. Epub 1900 01 01.

Alterations in DNA methylation: a fundamental aspect of neoplasia.

Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP

Advances in cancer research.. 1998 72 :141-96. Epub 1900 01 01.

Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.

Ferguson AT, Vertino PM, Spitzner JR, Baylin SB, Muller MT, Davidson NE

The Journal of biological chemistry.. 1997 December 19272 (51):32260-6. Epub 1900 01 01.

Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.

Graff JR, Herman JG, Myöhänen S, Baylin SB, Vertino PM

The Journal of biological chemistry.. 1997 August 29272 (35):22322-9. Epub 1900 01 01.

New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.

Yoder JA, Yen RW, Vertino PM, Bestor TH, Baylin SB

The Journal of biological chemistry.. 1996 December 6271 (49):31092-7. Epub 1900 01 01.

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

Issa JP, Vertino PM, Boehm CD, Newsham IF, Baylin SB

Proceedings of the National Academy of Sciences of the United States of America.. 1996 October 1593 (21):11757-62. Epub 1900 01 01.

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase.

Vertino PM, Yen RW, Gao J, Baylin SB

Molecular and cellular biology.. 1996 August 16 (8):4555-65. Epub 1900 01 01.

Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts.

Vertino PM, Issa JP, Pereira-Smith OM, Baylin SB

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.. 1994 December 5 (12):1395-402. Epub 1900 01 01.

Increased cytosine DNA-methyltransferase activity during colon cancer progression.

Issa JP, Vertino PM, Wu J, Sazawal S, Celano P, Nelkin BD, Hamilton SR, Baylin SB

Journal of the National Cancer Institute.. 1993 August 485 (15):1235-40. Epub 1900 01 01.

Isolation of polyadenylated RNA from cultured cells and intact tissues.

Celano P, Vertino PM, Casero RA

BioTechniques.. 1993 July 15 (1):26-8. Epub 1900 01 01.

Altered chromosomal methylation patterns accompany oncogene-induced transformation of human bronchial epithelial cells.

Vertino PM, Spillare EA, Harris CC, Baylin SB

Cancer research.. 1993 April 153 (7):1684-9. Epub 1900 01 01.

Isolation and characterization of the cDNA encoding human DNA methyltransferase.

Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB

Nucleic acids research.. 1992 May 1120 (9):2287-91. Epub 1900 01 01.

Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.

Vertino PM, Beerman TA, Kelly EJ, Bergeron RJ, Porter CW

Molecular pharmacology.. 1991 April 39 (4):487-94. Epub 1900 01 01.

Structural determinants of spermidine-DNA interactions.

Vertino PM, Bergeron RJ, Cavanaugh PF, Porter CW

Biopolymers.. 1987 May 26 (5):691-703. Epub 1900 01 01.