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Heng Lin, Ph.D.

Heng Lin, Ph.D.


Research Lab

Gail Johnson Lab

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About Me

Faculty Appointments

Research Assistant Professor - Department of Anesthesiology and Perioperative Medicine (SMD)


Post-doctoral Training & Residency

Postdoc Associate, Department of Anesthesiology, Medical Center, University of Rochester, Rochester, NY 2019 - 2021

Postdoc Associate, Center for Oral Biology, Medical Center, University of Rochester, Rochester, NY 2015 - 2018

Attending Dentist in Orthodontics, Department of Orthodontics,
School and Hospital of Stomatology, Wuhan University, Wuhan, China 2013 - 2015


PhD | School of Stomatology, Wuhan University, China. Oral Biology. 2013

BDS | Central South University, China. Dentistry. 2008


Alzheimer's Association International Research Grant. 2021 - 2024

URMC IDDRC micro-grant. 2021

Outstanding Postdoctoral Mentor Award. 2020

Tau2020 Global Conference Travel award. 2020

William H. Bowen award.. 2017

National Institutes of Health R90 Postdoctoral training Grant. 2015 - 2017



Journal Articles

Commentary: BAG3 as a mediator of endosome function and tau clearance.

Lin H, Deaton CA, Johnson GVW

Neuroscience.. 2022 May 9 Epub 05/09/2022.

BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.

Lin H, Tang M, Ji C, Girardi P, Cvetojevic G, Chen D, Koren SA, Johnson GVW

Biological psychiatry.. 2021 November 10 Epub 11/10/2021.

The role of BAG3 in health and disease: A "Magic BAG of Tricks".

Lin H, Koren SA, Cvetojevic G, Girardi P, Johnson GVW

Journal of cellular biochemistry.. 2021 May 14 Epub 05/14/2021.

CREB activation affects mesenchymal stem cell migration and differentiation in periodontal tissues due to orthodontic force.

Chang M, Lin H, Fu H, Wang J, Yang Y, Wan Z, Han G

The international journal of biochemistry & cell biology.. 2020 December 129 :105862. Epub 10/10/2020.

Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF-? Signaling Pathway and Interaction With Histone Acetylation.

Tao H, Lin H, Sun Z, Pei F, Zhang J, Chen S, Liu H, Chen Z

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2019 August 34 (8):1502-1516. Epub 05/21/2019.

MicroRNA-195-5p Regulates Osteogenic Differentiation of Periodontal Ligament Cells Under Mechanical Loading.

Chang M, Lin H, Fu H, Wang B, Han G, Fan M

Journal of cellular physiology.. 2017 December 232 (12):3762-3774. Epub 05/03/2017.

Sp1 is a competitive endogenous RNA of Klf4 during odontoblast differentiation.

Zhang J, Liu H, Lin H, Li S, Tao H, Zhang L, Yuan G, Chen Z

The international journal of biochemistry & cell biology.. 2017 April 85 :159-165. Epub 02/24/2017.

Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation.

Fu HD, Wang BK, Wan ZQ, Lin H, Chang ML, Han GL

Journal of molecular histology.. 2016 October 47 (5):455-66. Epub 07/25/2016.

The Dentin Sialoprotein (DSP) Domain Regulates Dental Mesenchymal Cell Differentiation through a Novel Surface Receptor.

Wan C, Yuan G, Luo D, Zhang L, Lin H, Liu H, Chen L, Yang G, Chen S, Chen Z

Scientific reports.. 2016 July 196 :29666. Epub 07/19/2016.

Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development.

Maruyama EO, Lin H, Chiu SY, Yu HM, Porter GA, Hsu W

Scientific reports.. 2016 February 176 :20999. Epub 02/17/2016.

Integrated miRNA and mRNA expression profiling of tension force-induced bone formation in periodontal ligament cells.

Chang M, Lin H, Luo M, Wang J, Han G

In vitro cellular & developmental biology. Animal.. 2015 September 51 (8):797-807. Epub 06/20/2015.

SP1 promotes the odontoblastic differentiation of dental papilla cells.

Zhang J, Lin H, Liu H, Zhang L, Yuan G, Chen Z

Development, growth & differentiation.. 2015 June 57 (5):400-407. Epub 05/24/2015.

Dual role of autophagy in lipopolysaccharide-induced preodontoblastic cells.

Pei F, Lin H, Liu H, Li L, Zhang L, Chen Z

Journal of dental research.. 2015 January 94 (1):175-82. Epub 10/08/2014.

KLF4 promoted odontoblastic differentiation of mouse dental papilla cells via regulation of DMP1.

Lin H, Liu H, Sun Q, Yuan G, Zhang L, Chen Z

Journal of cellular physiology.. 2013 October 228 (10):2076-85. Epub 1900 01 01.

Adenosine monophosphate-activated protein kinase/mammalian target of rapamycin-dependent autophagy protects human dental pulp cells against hypoxia.

Zhou Q, Liu H, Sun Q, Zhang L, Lin H, Yuan G, Zhang L, Chen Z

Journal of endodontics.. 2013 June 39 (6):768-73. Epub 03/16/2013.

MicroRNA-338-3p promotes differentiation of mDPC6T into odontoblast-like cells by targeting Runx2.

Sun Q, Liu H, Lin H, Yuan G, Zhang L, Chen Z

Molecular and cellular biochemistry.. 2013 May 377 (1-2):143-9. Epub 02/05/2013.

miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop.

Liu H, Lin H, Zhang L, Sun Q, Yuan G, Zhang L, Chen S, Chen Z

The Journal of biological chemistry.. 2013 March 29288 (13):9261-71. Epub 02/19/2013.

Establishment and characterization of a tamoxifen-mediated reversible immortalized mouse dental papilla cell line.

Lin H, Liu H, Sun Q, Yuan G, Zhang L, Chen Z

In vitro cellular & developmental biology. Animal.. 2013 February 49 (2):114-21. Epub 01/09/2013.

Identification of microRNA-RNA interactions using tethered RNAs and streptavidin aptamers.

Liu H, Zhang S, Lin H, Jia R, Chen Z

Biochemical and biophysical research communications.. 2012 June 8422 (3):405-10. Epub 05/07/2012.

Expression pattern of Sox2 during mouse tooth development.

Zhang L, Yuan G, Liu H, Lin H, Wan C, Chen Z

Gene expression patterns : GEP.. 2012 12 (7-8):273-81. Epub 07/24/2012.

KLF4 promotes the odontoblastic differentiation of human dental pulp cells.

Lin H, Xu L, Liu H, Sun Q, Chen Z, Yuan G, Chen Z

Journal of endodontics.. 2011 July 37 (7):948-54. Epub 05/13/2011.