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Christopher S. Anderson, Ph.D.

Christopher S. Anderson, Ph.D.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Assistant Professor - Department of Medicine, Infectious Diseases (SMD)

Research

Research Overview:
The Anderson Laboratory develops and investigates next generation vaccines. Traditional vaccine approaches have led to over 20 human vaccines, one of the greatest preventative medical achievements of the last century. Unfortunately, these classic approaches have been ineffectiv...
Research Overview:
The Anderson Laboratory develops and investigates next generation vaccines. Traditional vaccine approaches have led to over 20 human vaccines, one of the greatest preventative medical achievements of the last century. Unfortunately, these classic approaches have been ineffective in inducing long-lasting, protective immunity against the remaining majority of human pathogens. Exciting new approaches have recently emerged in the world of vaccine research including novel delivery techniques (e.g. mRNA Lipid-nanoparticles and viral-vector) and regimens (e.g. bivalent vaccines and heterologous-prime-boost). The Anderson Laboratory incorporates novel computational modeling and state-of-the-art experimental approaches to develop and understand next generation vaccines with an aim to induce long-lasting, broadly-neutralizing, humoral immunity to viruses such as Respiratory Syncytial Virus (RSV), Influenza, Human immunodeficiency virus (HIV), and SARS-CoV-2.

Publications

Journal Articles

Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection.

Zhou T, Gilliam NJ, Li S, Spandau S, Osborn RM, Connor S, Anderson CS, Mariani TJ, Thakar J, Dewhurst S, Mathews DH, Huang L, Sun Y

mBio.. 2023 April 19 :e0025023. Epub 04/19/2023.

CX3CR1 Engagement by Respiratory Syncytial Virus Leads to Induction of Nucleolin and Dysregulation of Cilia-related Genes.

Anderson CS, Chirkova T, Slaunwhite CG, Qiu X, Walsh EE, Anderson LJ, Mariani TJ

Journal of virology.. 2021 March 17 Epub 03/17/2021.

Implementing sequence-based antigenic distance calculation into immunological shape space model.

Anderson CS, Sangster MY, Yang H, Mariani TJ, Chaudhury S, Topham DJ

BMC bioinformatics.. 2020 June 1921 (1):256. Epub 06/19/2020.

Characterizing Emerging Canine H3 Influenza Viruses.

Martinez-Sobrido L, Blanco-Lobo P, Rodriguez L, Fitzgerald T, Zhang H, Nguyen P, Anderson CS, Holden-Wiltse J, Bandyopadhyay S, Nogales A, DeDiego ML, Wasik BR, Miller BL, Henry C, Wilson PC, Sangster MY, Treanor JJ, Topham DJ, Byrd-Leotis L, Steinhauer DA, Cummings RD, Luczo JM, Tompkins SM, Sakamoto K, Jones CA, Steel J, Lowen AC, Danzy S, Tao H, Fink AL, Klein SL, Wohlgemuth N, Fenstermacher KJ, El Najjar F, Pekosz A, Sauer L, Lewis MK, Shaw-Saliba K, Rothman RE, Liu ZY, Chen KF, Parrish CR, Voorhees IEH, Kawaoka Y, Neumann G, Chiba S, Fan S, Hatta M, Kong H, Zhong G, Wang G, Uccellini MB, García-Sastre A, Perez DR, Ferreri LM, Herfst S, Richard M, Fouchier R, Burke D, Pattinson D, Smith DJ, Meliopoulos V, Freiden P, Livingston B, Sharp B, Cherry S, Dib JC, Yang G, Russell CJ, Barman S, Webby RJ, Krauss S, Danner A, Woodard K, Peiris M, Perera RAPM, Chan MCW, Govorkova EA, Marathe BM, Pascua PNQ, Smith G, Li YT, Thomas PG, Schultz-Cherry S

PLoS pathogens.. 2020 April 16 (4):e1008409. Epub 04/14/2020.

Collagen VI Deficiency Results in Structural Abnormalities in the Mouse Lung.

Mereness JA, Bhattacharya S, Ren Y, Wang Q, Anderson CS, Donlon K, Dylag AM, Haak J, Angelin A, Bonaldo P, Mariani TJ

The American journal of pathology.. 2019 December 13 Epub 12/13/2019.

CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung.

Anderson CS, Chu CY, Wang Q, Mereness JA, Ren Y, Donlon K, Bhattacharya S, Misra RS, Walsh EE, Pryhuber GS, Mariani TJ

Pediatric research.. 2019 November 14 Epub 11/14/2019.

Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.

Gaylo-Moynihan A, Prizant H, Popovic M, Fernandes NRJ, Anderson CS, Chiou KK, Bell H, Schrock DC, Schumacher J, Capece T, Walling BL, Topham DJ, Miller J, Smrcka AV, Kim M, Hughson A, Fowell DJ

Immunity.. 2019 August 2051 (2):298-309.e6. Epub 08/06/2019.

Mutation of Respiratory Syncytial Virus G Protein's CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells.

Ha B, Chirkova T, Boukhvalova MS, Sun HY, Walsh EE, Anderson CS, Mariani TJ, Anderson LJ

Vaccines.. 2019 July 197 (3)Epub 07/19/2019.

Broad Hemagglutinin-Specific Memory B Cell Expansion by Seasonal Influenza Virus Infection Reflects Early-Life Imprinting and Adaptation to the Infecting Virus.

Tesini BL, Kanagaiah P, Wang J, Hahn M, Halliley JL, Chaves FA, Nguyen PQT, Nogales A, DeDiego ML, Anderson CS, Ellebedy AH, Strohmeier S, Krammer F, Yang H, Bandyopadhyay S, Ahmed R, Treanor JJ, Martinez-Sobrido L, Golding H, Khurana S, Zand MS, Topham DJ, Sangster MY

Journal of virology.. 2019 April 1593 (8)Epub 04/03/2019.

Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza.

Zhang H, Henry C, Anderson CS, Nogales A, DeDiego ML, Bucukovski J, Martinez-Sobrido L, Wilson PC, Topham DJ, Miller BL

Analytical chemistry.. 2018 August 790 (15):9583-9590. Epub 07/20/2018.

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML

Scientific reports.. 2018 March 68 (1):4265. Epub 03/06/2018.

Antigenic cartography of H1N1 influenza viruses using sequence-based antigenic distance calculation.

Anderson CS, McCall PR, Stern HA, Yang H, Topham DJ

BMC bioinformatics.. 2018 February 1219 (1):51. Epub 02/12/2018.

Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML

Scientific reports.. 2018 January 58 (1):276. Epub 01/05/2018.

Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML

Scientific reports.. 2017 November 67 (1):14614. Epub 11/06/2017.

Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins.

Clark AM, DeDiego ML, Anderson CS, Wang J, Yang H, Nogales A, Martinez-Sobrido L, Zand MS, Sangster MY, Topham DJ

PloS one.. 2017 12 (11):e0188267. Epub 11/16/2017.

Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection.

DeDiego ML, Anderson CS, Yang H, Holden-Wiltse J, Fitzgerald T, Treanor JJ, Topham DJ

Immunology.. 2016 June 148 (2):160-73. Epub 03/30/2016.

Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection.

Anderson CS, DeDiego ML, Topham DJ, Thakar J

Computational and mathematical methods in medicine.. 2016 2016 :7686081. Epub 02/14/2016.

Novel Sequence-Based Mapping of Recently Emerging H5NX Influenza Viruses Reveals Pandemic Vaccine Candidates.

Anderson CS, DeDiego ML, Thakar J, Topham DJ

PloS one.. 2016 11 (8):e0160510. Epub 08/05/2016.

Essential role of Elmo1 in Dock2-dependent lymphocyte migration.

Stevenson C, de la Rosa G, Anderson CS, Murphy PS, Capece T, Kim M, Elliott MR

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 June 15192 (12):6062-70. Epub 05/12/2014.