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Xi Lin, Ph.D.

Xi Lin, Ph.D.

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About Me

Faculty Appointments

Research Assistant Professor - Department of Pathology and Laboratory Medicine (SMD)

Research

Dr. Lin's research focuses on the pathology and mechanisms of osteoarthritis. She is interested in how changes in the synovial tissues surrounding the joint modulate osteoarthritis pathology post-injury or during natural aging. She has expertise in genetic and surgical murine models of osteoarthriti...
Dr. Lin's research focuses on the pathology and mechanisms of osteoarthritis. She is interested in how changes in the synovial tissues surrounding the joint modulate osteoarthritis pathology post-injury or during natural aging. She has expertise in genetic and surgical murine models of osteoarthritis, in vivo imaging techniques, in vivo and in vitro cellular and molecular biology techniques, and histology/immunohistochemistry/immunocytology. She also utilizes bioinformatics analysis as a tool to generate novel hypotheses and validate experimental findings by analyzing independent published datasets.

Publications

Journal Articles

Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice.

Lin X, Bell RD, Catheline SE, Takano T, McDavid A, Jonason JH, Schwarz EM, Xing L

Arthritis & rheumatology.. 2023 January 10 Epub 01/10/2023.

Molecular signatures distinguish senescent cells from inflammatory cells in aged mouse callus stromal cells.

Liu J, Lin X, McDavid A, Yang Y, Zhang H, Boyce BF, Xing L

Frontiers in endocrinology.. 2023 14 :1090049. Epub 02/16/2023.

Age-associated callus senescent cells produce TGF-?1 that inhibits fracture healing in aged mice.

Liu J, Zhang J, Lin X, Boyce BF, Zhang H, Xing L

The Journal of clinical investigation.. 2022 April 15132 (8)Epub 1900 01 01.

Proteasome inhibition-enhanced fracture repair is associated with increased mesenchymal progenitor cells in mice.

Zhang H, Li X, Liu J, Lin X, Pei L, Boyce BF, Xing L

PloS one.. 2022 17 (2):e0263839. Epub 02/25/2022.

Aged Callus Skeletal Stem/Progenitor Cells Contain an Inflammatory Osteogenic Population With Increased IRF and NF-?B Pathways and Reduced Osteogenic Potential.

Lin X, Zhang H, Liu J, Wu CL, McDavid A, Boyce BF, Xing L

Frontiers in molecular biosciences.. 2022 9 :806528. Epub 06/09/2022.

Bone-targeted Bortezomib Inhibits Bortezomib-Resistant Multiple Myeloma in Mice by Providing Higher Levels of Bortezomib in Bone.

Tao J, Srinivasan V, Yi X, Zhao Y, Zhang H, Lin X, Zhou X, Boyce BF, Villalta PW, Ebetino FH, Ho KK, Boeckman RK, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2021 December 30 Epub 12/30/2021.

TNF-polarized macrophages produce insulin like 6 peptide to stimulate bone formation in rheumatoid arthritis in mice.

Yi X, Liu X, Kenney HM, Duan R, Lin X, Schwarz E, Yao Z

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2021 September 29 Epub 09/29/2021.

The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization.

Lin X, Wang W, McDavid A, Xu H, Boyce BF, Xing L

Osteoarthritis and cartilage. 2021 April 30 Epub 04/30/2021.

Ubiquitination of interleukin-1? is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH.

Lin X, Zhang H, Boyce BF, Xing L

The Journal of biological chemistry.. 2020 June 25 Epub 06/25/2020.

Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model.

Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q

Frontiers in pharmacology.. 2020 11 :45. Epub 02/14/2020.

Targeting Bortezomib to Bone Increases its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice.

Wang H, Zhang H, Srinivasan V, Tao J, Sun W, Lin X, Wu T, Boyce BF, Ebetino FH, Boeckman RK, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2019 October 14 Epub 10/14/2019.

Attenuated Joint Tissue Damage Associated With Improved Synovial Lymphatic Function Following Treatment With Bortezomib in a Mouse Model of Experimental Posttraumatic Osteoarthritis.

Wang W, Lin X, Xu H, Sun W, Bouta EM, Zuscik MJ, Chen D, Schwarz EM, Xing L

Arthritis & rheumatology.. 2019 February 71 (2):244-257. Epub 01/05/2019.

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.

Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT

Cancer cell.. 2018 October 834 (4):659-673.e6. Epub 09/27/2018.