Assistant Professor - Department of Microbiology and Immunology (SMD)
Post-doctoral Training & Residency
Rockefeller University 2014 - 2022
PhD | Icahn School of Medicine at Mount Sinai. Biomedical Sciences. 2014
BS | Rochester Institute of Technology. Biotechnology. 2008
To investigate this dynamic we study Staphylococcus and Streptococcus, the phage that infects them, and the systems used to defend against infection. We have a particular focus on a bacterial adaptive immune system called CRISPR, best known for its genome editing capabilities, and how this system interacts with phage. By gaining a better understanding of the mediators and barriers of horizontal gene transfer we hope to gain insight into how pathogenesis and antibiotic resistance develops, while also further developing molecular tools for genetic manipulation.
Maguin P, Varble A, Modell JW, Marraffini LA
Molecular cell.. 2022 March 382 (5):907-919.e7. Epub 02/07/2022.
Varble A, Campisi E, Euler CW, Maguin P, Kozlova A, Fyodorova J, Rostøl JT, Fischetti VA, Marraffini LA
Nature microbiology.. 2021 December 6 (12):1516-1525. Epub 11/24/2021.
Chen V, Griffin ME, Maguin P, Varble A, Hang HC
Applied and environmental microbiology.. 2021 August 2687 (18):e0084421. Epub 08/26/2021.
Mo CY, Mathai J, Rostøl JT, Varble A, Banh DV, Marraffini LA
Nature.. 2021 April 592 (7855):611-615. Epub 04/07/2021.
Varble A, Meaden S, Barrangou R, Westra ER, Marraffini LA
Nature microbiology.. 2019 June 4 (6):956-963. Epub 03/18/2019.
Varble A, Marraffini LA
Trends in genetics : TIG.. 2019 June 35 (6):446-456. Epub 04/27/2019.
Goldberg GW, McMillan EA, Varble A, Modell JW, Samai P, Jiang W, Marraffini LA
Nature communications.. 2018 January 49 (1):61. Epub 01/04/2018.
Pyenson NC, Gayvert K, Varble A, Elemento O, Marraffini LA
Cell host & microbe.. 2017 September 1322 (3):343-353.e3. Epub 08/17/2017.
Varble AJ, Ried CD, Hammond WJ, Marquis KA, Woodruff MC, Ferran MC
Virology.. 2016 December 499 :99-104. Epub 09/17/2016.
Benitez AA, Panis M, Xue J, Varble A, Shim JV, Frick AL, López CB, Sachs D, tenOever BR
Cell reports.. 2015 June 2311 (11):1714-26. Epub 06/11/2015.
Varble A, Albrecht RA, Backes S, Crumiller M, Bouvier NM, Sachs D, García-Sastre A, tenOever BR
Cell host & microbe.. 2014 November 1216 (5):691-700. Epub 10/23/2014.
Moy RH, Cole BS, Yasunaga A, Gold B, Shankarling G, Varble A, Molleston JM, tenOever BR, Lynch KW, Cherry S
Cell.. 2014 August 14158 (4):764-777. Epub 1900 01 01.
Backes S, Langlois RA, Schmid S, Varble A, Shim JV, Sachs D, tenOever BR
Cell reports.. 2014 July 108 (1):114-25. Epub 06/19/2014.
Varble A, Benitez AA, Schmid S, Sachs D, Shim JV, Rodriguez-Barrueco R, Panis M, Crumiller M, Silva JM, Sachidanandam R, tenOever BR
Cell host & microbe.. 2013 September 1114 (3):346-56. Epub 1900 01 01.
Langlois RA, Varble A, Chua MA, García-Sastre A, tenOever BR
Proceedings of the National Academy of Sciences of the United States of America.. 2012 July 24109 (30):12117-22. Epub 07/09/2012.
Varble A, ten Oever BR
RNA biology.. 2011 8 (2):190-4. Epub 03/01/2011.
Shapiro JS, Varble A, Pham AM, Tenoever BR
RNA.. 2010 November 16 (11):2068-74. Epub 09/14/2010.
Perez JT, Varble A, Sachidanandam R, Zlatev I, Manoharan M, García-Sastre A, tenOever BR
Proceedings of the National Academy of Sciences of the United States of America.. 2010 June 22107 (25):11525-30. Epub 06/01/2010.
Varble A, Chua MA, Perez JT, Manicassamy B, García-Sastre A, tenOever BR
Proceedings of the National Academy of Sciences of the United States of America.. 2010 June 22107 (25):11519-24. Epub 06/07/2010.
Streptococcus pyogenes: Basic Biology to Clinical Manifestations (2022)
Chapter: The CRISPR-Cas system of Streptococcus pyogenes: function and applications
Authors: Andrew Varble, Luciano Marraffini, Joseph J. Ferretti, Dennis L. Stevens, Vincent A. Fischetti
Publisher: The University of Oklahoma Health Sciences Center 2022