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Marlies P. Rossmann, M.D., Ph.D.

Marlies P. Rossmann, M.D., Ph.D.

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Office (585) 274-1586
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Administrative (585) 273-1440

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About Me

Marlies was born and raised in Berlin, Germany. As a medical student at the Free University and Humboldt University of Berlin, she performed her M.D. thesis work with Prof. Detlev Ganten at the Max Delbru?ck Center for Molecular Medicine and Max Planck Institute for Molecular Genetics. After her med...
Marlies was born and raised in Berlin, Germany. As a medical student at the Free University and Humboldt University of Berlin, she performed her M.D. thesis work with Prof. Detlev Ganten at the Max Delbru?ck Center for Molecular Medicine and Max Planck Institute for Molecular Genetics. After her medical residency in Neurology and Internal Medicine, Marlies joined the State University of New York at Stony Brook, where she completed her Ph.D. thesis in the group of Dr. Bruce Stillman at Cold Spring Harbor Laboratory with the discovery of a novel mechanism linking epigenetic silencing and nucleotide metabolism. Motivated by her interest in transcription and chromatin, and the power of unbiased screens, Marlies then joined Dr. Leonard Zon's lab as a postdoctoral fellow at the Department of Stem Cell and Regenerative Biology of Harvard University. There, through a chemical suppressor screen in zebrafish and subsequent genetic, genomic and metabolomic analysis also involving human cell models, she elucidated that a transcriptional program drives erythroid lineage differentiation by instructing critical metabolic activities. Marlies joined the University of Rochester as Assistant Professor of Biomedical Genetics in January 2023. Her lab focuses on the instructive role of metabolism during cell fate decisions in hematopoietic lineage differentiation.

Faculty Appointments

Assistant Professor - Department of Biomedical Genetics (SMD)

Assistant Professor - Department of Microbiology and Immunology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 2011 - 2022

Education

Post-doctoral training | | Harvard University. Molecular Hematopoiesis. 2022

PhD | State University of New York at Stony Brook. 2010

MD | Free University and Humboldt University Berlin, Germany. 1999

Awards

Award, Howard Hughes Medical Institute, for Metabolomics Course at Cold Spring Harbor Laboratory. 2022

Intersections Science Fellow, Yale School of Medicine, CT. 2021 - 2022

The Eugene Cronkite New Investigator Award, 1st Place Postdoctoral Fellow. 2020

Abstract Achievement Award, 61st American Society of Hematology Annual Meeting. 2019

Trainee Leadership Award, Department of Stem Cell and Regenerative Biology, Harvard University. 2019

Postdoctoral Award for Professional Development, Faculty of Arts and Sciences, Harvard University. 2017

Best Poster Award, 20th Hemoglobin Switching Conference, Pacific Grove. 2016

Merit Award, Red Cells Gordon Research Seminar. 2015

Scholarship for Eukaryotic Gene Expression Course at Cold Spring Harbor Laboratory. 2009

Research

Lineage differentiation depends on gene expression programs that regulate changes in cell fate, including metabolic changes. However, we poorly understand if, when and how metabolism actively promotes lineage specification and differentiation and how gene expression, in turn, adapts to the metaboli...
Lineage differentiation depends on gene expression programs that regulate changes in cell fate, including metabolic changes. However, we poorly understand if, when and how metabolism actively promotes lineage specification and differentiation and how gene expression, in turn, adapts to the metabolic state. The Rossmann lab studies hematopoiesis as a paradigm to elucidate the crosstalk between transcription, specific metabolic activities, and the epigenetic landscape during cell fate decisions. We use zebrafish as a powerful genetically tractable vertebrate model that amenable to screening and in-vivo imaging, but also integrate it with mouse and human stem cell differentiation models. We strive to leverage key insights from these studies to elucidate the metabolic origins of a variety of diseases, facilitate novel metabolism-centered differentiation therapies for hematological malignancies, and combat the decline in lymphoid cell production by the aging hematopoietic system.

Publications

Journal Articles

Developmental regulation of primitive erythropoiesis.

Rossmann MP, Palis J

Current opinion in hematology.. 2024 May 131 (3):71-81. Epub 02/27/2024.

Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.

García-Castillo J, Alcaraz-Pérez F, Martínez-Balsalobre E, García-Moreno D, Rossmann MP, Fernández-Lajarín M, Bernabé-García M, Pérez-Oliva AB, Rodríguez-Cortez VC, Bueno C, Adatto I, Agarwal S, Menéndez P, Zon LI, Mulero V, Cayuela ML

Proceedings of the National Academy of Sciences of the United States of America.. 2021 August 10118 (32)Epub 1900 01 01.

Mitochondrial function in development and disease.

Rossmann MP, Dubois SM, Agarwal S, Zon LI

Disease models & mechanisms.. 2021 June 114 (6)Epub 06/11/2021.

Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis.

Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI

Science.. 2021 May 14372 (6543):716-721. Epub 1900 01 01.

'Enhancing' red cell fate through epigenetic mechanisms.

Rossmann MP, Zon LI

Current opinion in hematology.. 2021 May 128 (3):129-137. Epub 1900 01 01.

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.

Tyrkalska SD, Pérez-Oliva AB, Rodríguez-Ruiz L, Martínez-Morcillo FJ, Alcaraz-Pérez F, Martínez-Navarro FJ, Lachaud C, Ahmed N, Schroeder T, Pardo-Sánchez I, Candel S, López-Muñoz A, Choudhuri A, Rossmann MP, Zon LI, Cayuela ML, García-Moreno D, Mulero V

Immunity.. 2019 July 1651 (1):50-63.e5. Epub 06/04/2019.

Development: For cloche the Bell Tolls.

Rossmann MP, Zhou Y, Zon LI

Current biology : CB.. 2016 October 1026 (19):R890-R892. Epub 10/10/2016.

Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes.

Yang S, Ott CJ, Rossmann MP, Superdock M, Zon LI, Zhou Y

Methods in cell biology.. 2016 135 :387-412. Epub 06/20/2016.

Immunoblotting histones from yeast whole-cell protein extracts.

Rossmann MP, Stillman B

Cold Spring Harbor protocols.. 2013 July 12013 (7):625-30. Epub 07/01/2013.

A common telomeric gene silencing assay is affected by nucleotide metabolism.

Rossmann MP, Luo W, Tsaponina O, Chabes A, Stillman B

Molecular cell.. 2011 April 842 (1):127-36. Epub 1900 01 01.

The harlequin mouse mutation downregulates apoptosis-inducing factor.

Klein JA, Longo-Guess CM, Rossmann MP, Seburn KL, Hurd RE, Frankel WN, Bronson RT, Ackerman SL

Nature.. 2002 September 26419 (6905):367-74. Epub 1900 01 01.

High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers.

Gösele C, Hong L, Kreitler T, Rossmann M, Hieke B, Gross U, Kramer M, Himmelbauer H, Bihoreau MT, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, Ganten D, Lehrach H, Knoblauch M

Genomics.. 2000 November 169 (3):287-94. Epub 1900 01 01.

Books

Hematology: Basic Principles and Practice (2022)

Chapter: Hematopoietic stem cell biology

Authors: Rossmann, M.P., Chute, J.H.

Publisher: Elsevier 2022

Hematology: Basic Principles and Practice (2018)

Chapter: Hematopoietic stem cell biology

Authors: Rossmann, M.P., Orkin, S.H., Chute, J.H.

Publisher: Elsevier 2018