Andrei Seluanov, Ph.D.

African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile.

Athar F, Morandini F, Fatima I, Silvestri I, Kim SB, Lee M, Liao X, Sharov A, Botchkarev V, Seluanov A, Gorbunova V

Protein & cell.. 2025 October 3116 (10):896-904. Epub 1900 01 01.

Evidence for improved DNA repair in long-lived bowhead whale.

Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov AY, Sun S, Wu Z, Gigas J, Hillpot EC, Martinez JC, Lee M, Williams A, Gilman A, Hamilton N, Strelkova E, Haseljic E, Patel A, Straight ME, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopmann MR, Moritz RL, Fujii S, Pelletier A, Hayman DJ, Liu H, Cai Y, Leung AKL, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Maley CC, Modesti M, Genovese G, Simons MJP, Vijg J, Seluanov A, Gorbunova V

Nature.. 2025 October 29 Epub 10/29/2025.

Longevity steps on the cGAS.

Martinez JC, Seluanov A, Gorbunova V

Science.. 2025 October 9390 (6769):126-127. Epub 10/09/2025.

Advancing cancer research via comparative oncology.

Vincze O, Spada B, Bilder D, Cagan A, DeGregori J, Gorbunova V, Maley CC, Schiffman JD, Seluanov A, Giraudeau M, Pradeu T

Nature reviews. Cancer.. 2025 September 25 (9):740-748. Epub 06/27/2025.

Unlocking longevity through the comparative biology of aging.

Rechsteiner C, Morandini F, Kim SJ, Seluanov A, Gorbunova V

Nature aging.. 2025 September 5 (9):1686-1703. Epub 08/28/2025.

Structures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes-Is rRNA Fragmentation Linked to Translational Fidelity?

Gutierrez-Vargas C, De S, Maji S, Liu Z, Ke Z, Nieß M, Seluanov A, Gorbunova V, Frank J

bioRxiv : the preprint server for biology.. 2025 August 2 Epub 08/02/2025.

Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes.

Gilbert MB, Glastad KM, Fioriti M, Sorek M, Scarpa T, Purnell FS, Xu D, Pino LK, Korotkov A, Biashad A, Baeza J, Lauman R, Filippova A, Kacsoh BZ, Bonasio R, Mathis MW, Garcia BA, Seluanov A, Gorbunova V, Berger SL

Cell.. 2025 July 24188 (15):3974-3991.e21. Epub 06/11/2025.

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair.

Robbins P, Zhang L, Elsallabi O, Soto-Palma C, Bartz J, Salekeen R, Nunes A, Xu W, Lee K, Hughes B, Zhang B, Mohamed A, McGowan S, Angelini L, O'Kelly R, Biashad SA, Hillpot E, Morandini F, Seluanov A, Gorbunova V, Dong X, Niedernhofer L

Research square.. 2025 June 6 Epub 06/06/2025.

Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and "Protein Age".

Meadow ME, Broas S, Hoare M, Ahmed M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Jain A, Martinez JC, Seluanov A, Gorbunova V, Buchwalter A, Ghaemmaghami S

Bio-protocol.. 2025 May 515 (9):e5296. Epub 05/05/2025.

Limited cell-autonomous anticancer mechanisms in long-lived bats.

Athar F, Zheng Z, Riquier S, Zacher M, Lu JY, Zhao Y, Volobaev V, Alcock D, Galazyuk A, Cooper LN, Schountz T, Wang LF, Teeling EC, Seluanov A, Gorbunova V

Nature communications.. 2025 May 316 (1):4125. Epub 05/03/2025.

From geroscience to precision geromedicine: Understanding and managing aging.

Kroemer G, Maier AB, Cuervo AM, Gladyshev VN, Ferrucci L, Gorbunova V, Kennedy BK, Rando TA, Seluanov A, Sierra F, Verdin E, López-Otín C

Cell.. 2025 April 17188 (8):2043-2062. Epub 1900 01 01.

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells.

Miller KN, Li B, Pierce-Hoffman HR, Patel S, Lei X, Rajesh A, Teneche MG, Havas AP, Gandhi A, Macip CC, Lyu J, Victorelli SG, Woo SH, Lagnado AB, LaPorta MA, Liu T, Dasgupta N, Li S, Davis A, Korotkov A, Hultenius E, Gao Z, Altman Y, Porritt RA, Garcia G, Mogler C, Seluanov A, Gorbunova V, Kaech SM, Tian X, Dou Z, Chen C, Passos JF, Adams PD

Nature communications.. 2025 March 516 (1):2229. Epub 03/05/2025.

SIRT5 slows skeletal muscle ageing by alleviating inflammation.

Gorbunova V, Seluanov A

Nature metabolism.. 2025 March 7 (3):447-449. Epub 1900 01 01.

Transposable element 5mC methylation state of blood cells predicts age and disease.

Morandini F, Lu JY, Rechsteiner C, Shadyab AH, Casanova R, Snively BM, Seluanov A, Gorbunova V

Nature aging.. 2025 February 5 (2):193-204. Epub 11/27/2024.

Henipavirus in Northern Short-Tailed Shrew, Alabama, USA.

Parry RH, Yamada KYH, Hood WR, Zhao Y, Lu JY, Seluanov A, Gorbunova V, Modhiran N, Watterson D, Isaacs A

Emerging infectious diseases.. 2025 February 31 (2):392-394. Epub 1900 01 01.

Disagreement on foundational principles of biological aging.

Gladyshev VN, Anderson B, Barlit H, Barré B, Beck S, Behrouz B, Belsky DW, Chaix A, Chamoli M, Chen BH, Cheng K, Chuprin J, Churchill GA, Cipriano A, Colville A, Deelen J, Deigin Y, Edmonds KK, English BW, Fang R, Florea M, Gershteyn IM, Gill D, Goetz LH, Gorbunova V, Griffin PT, Horvath S, Borch Jensen M, Jin X, Jovanovska S, Kajderowicz KM, Kasahara T, Kerepesi C, Kulkarni S, Labunskyy VM, Levine ME, Libert S, Lu JY, Lu YR, Marioni RE, McCoy BM, Mitchell W, Moqri M, Nasirian F, Niimi P, Oh HS, Okundaye B, Parkhitko AA, Peshkin L, Petljak M, Poganik JR, Pridham G, Promislow DEL, Prusisz W, Quiniou M, Raj K, Richard D, Ricon JL, Rutledge J, Scheibye-Knudsen M, Schork NJ, Seluanov A, Shadpour M, Shindyapina AV, Shuken SR, Sivakumar S, Stoeger T, Sugiura A, Sutton NR, Suvorov A, Tarkhov AE, Teeling EC, Trapp A, Tyshkovskiy A, Unfried M, Ward-Caviness CK, Yim SH, Ying K, Yunes J, Zhang B, Zhavoronkov A

PNAS nexus.. 2024 December 3 (12):pgae499. Epub 12/03/2024.

Neuropeptides specify and reprogram division of labor in the leafcutter ant .

Gilbert MB, Glastad KM, Fioriti M, Sorek M, Gannon T, Xu D, Pino LK, Korotkov A, Biashad A, Baeza J, Lauman R, Filippova A, Kacsoh BZ, Bonasio R, Mathis MW, Garcia BA, Seluanov A, Gorbunova V, Berger SL

bioRxiv : the preprint server for biology.. 2024 November 8 Epub 11/08/2024.

DNA repair and anti-cancer mechanisms in the long-lived bowhead whale.

Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov A, Sun S, Wu Z, Gigas J, Hillpot E, Martinez J, Lee M, Williams A, Gilman A, Hamilton N, Haseljic E, Patel A, Straight M, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopman M, Moritz R, Fujii S, Hayman DJ, Liu H, Cai Y, Leung AKL, Simons MJP, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Modesti M, Genovese G, Vijg J, Seluanov A, Gorbunova V

bioRxiv : the preprint server for biology.. 2024 November 5 Epub 11/05/2024.

cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation.

Martinez JC, Morandini F, Fitzgibbons L, Sieczkiewicz N, Bae SJ, Meadow ME, Hillpot E, Cutting J, Paige V, Biashad SA, Simon M, Sedivy J, Seluanov A, Gorbunova V

bioRxiv : the preprint server for biology.. 2024 October 11 Epub 10/11/2024.

An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation.

Takasugi M, Nonaka Y, Takemura K, Yoshida Y, Stein F, Schwarz JJ, Adachi J, Satoh J, Ito S, Tombline G, Biashad SA, Seluanov A, Gorbunova V, Ohtani N

Nature communications.. 2024 October 215 (1):8520. Epub 10/02/2024.

Linked regulation of genome integrity and senescence-associated inflammation by p53.

Miller KN, Li B, Pierce-Hoffman HR, Patel S, Lei X, Rajesh A, Teneche MG, Havas AP, Gandhi A, Macip CC, Lyu J, Victorelli SG, Woo SH, Lagnado AB, LaPorta MA, Liu T, Dasgupta N, Li S, Davis A, Korotkov A, Hultenius E, Gao Z, Altman Y, Porritt RA, Garcia G, Mogler C, Seluanov A, Gorbunova V, Kaech SM, Tian X, Dou Z, Chen C, Passos JF, Adams PD

bioRxiv : the preprint server for biology.. 2024 September 19 Epub 09/19/2024.

LINE1 and its host: one cell's junk is another cell's treasure.

Martinez JC, Seluanov A, Gorbunova V

The EMBO journal.. 2024 September 43 (17):3547-3549. Epub 07/29/2024.

Proteome Birthdating Reveals Age-Selectivity of Protein Ubiquitination.

Meadow ME, Broas S, Hoare M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Martinez JC, Biashad SA, Seluanov A, Gorbunova V, Buchwalter A, Ghaemmaghami S

Molecular & cellular proteomics : MCP.. 2024 July 23 (7):100791. Epub 05/24/2024.

Hyaluronidase inhibitor delphinidin inhibits cancer metastasis.

McGuire J, Taguchi T, Tombline G, Paige V, Janelsins M, Gilmore N, Seluanov A, Gorbunova V

Scientific reports.. 2024 June 2814 (1):14958. Epub 06/28/2024.

Epigenetic predictors of species maximum life span and other life-history traits in mammals.

Li CZ, Haghani A, Yan Q, Lu AT, Zhang J, Fei Z, Ernst J, Yang XW, Gladyshev VN, Robeck TR, Chavez AS, Cook JA, Dunnum JL, Raj K, Seluanov A, Gorbunova V, Horvath S

Science advances.. 2024 June 710 (23):eadm7273. Epub 06/07/2024.

Invariant ??TCR natural killer-like effector T cells in the naked mole-rat.

Sanchez Sanchez G, Emmrich S, Georga M, Papadaki A, Kossida S, Seluanov A, Gorbunova V, Vermijlen D

Nature communications.. 2024 May 1815 (1):4248. Epub 05/18/2024.

Slow and steady lives the longest.

Morandini F, Seluanov A, Gorbunova V

Nature aging.. 2024 January 4 (1):7-9. Epub 1900 01 01.

Evolution of high-molecular-mass hyaluronic acid is associated with subterranean lifestyle.

Zhao Y, Zheng Z, Zhang Z, Xu Y, Hillpot E, Lin YS, Zakusilo FT, Lu JY, Ablaeva J, Biashad SA, Miller RA, Nevo E, Seluanov A, Gorbunova V

Nature communications.. 2023 December 514 (1):8054. Epub 12/05/2023.

Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging.

Brochard T, McIntyre RL, Houtkooper RH, Seluanov A, Gorbunova V, Janssens GE

Ageing research reviews.. 2023 December 92 :102132. Epub 11/19/2023.

Integration of fluorescence in situ hybridization and chromosome-length genome assemblies revealed synteny map for guinea pig, naked mole-rat, and human.

Romanenko SA, Kliver SF, Serdyukova NA, Perelman PL, Trifonov VA, Seluanov A, Gorbunova V, Azpurua J, Pereira JC, Ferguson-Smith MA, Graphodatsky AS

Scientific reports.. 2023 November 2913 (1):21055. Epub 11/29/2023.

Author Correction: Universal DNA methylation age across mammalian tissues.

Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG, Zhang B, Zhang Z, Zhao P, Zhao Y, Zhou W, Zimmermann J, Ernst J, Raj K, Horvath S

Nature aging.. 2023 November 3 (11):1462. Epub 1900 01 01.

Reuniting philosophy and science to advance cancer research.

Pradeu T, Daignan-Fornier B, Ewald A, Germain PL, Okasha S, Plutynski A, Benzekry S, Bertolaso M, Bissell M, Brown JS, Chin-Yee B, Chin-Yee I, Clevers H, Cognet L, Darrason M, Farge E, Feunteun J, Galon J, Giroux E, Green S, Gross F, Jaulin F, Knight R, Laconi E, Larmonier N, Maley C, Mantovani A, Moreau V, Nassoy P, Rondeau E, Santamaria D, Sawai CM, Seluanov A, Sepich-Poore GD, Sisirak V, Solary E, Yvonnet S, Laplane L

Biological reviews of the Cambridge Philosophical Society.. 2023 October 98 (5):1668-1686. Epub 05/08/2023.

CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance.

Takasugi M, Ohtani N, Takemura K, Emmrich S, Zakusilo FT, Yoshida Y, Kutsukake N, Mariani JN, Windrem MS, Chandler-Militello D, Goldman SA, Satoh J, Ito S, Seluanov A, Gorbunova V

Cell reports.. 2023 September 2642 (9):113130. Epub 09/13/2023.

Universal DNA methylation age across mammalian tissues.

Lu AT, Fei Z, Haghani A, Robeck TR, Zoller JA, Li CZ, Lowe R, Yan Q, Zhang J, Vu H, Ablaeva J, Acosta-Rodriguez VA, Adams DM, Almunia J, Aloysius A, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter GG, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke SM, Cooper LN, Cossette ML, Day J, DeYoung J, DiRocco S, Dold C, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Gorbunova V, Goya RG, Grant MJ, Green CB, Hales EN, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaitre JF, Levine AJ, Li C, Li X, Lim AR, Lin DTS, Lindemann DM, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, O'Brien JK, O'Tierney Ginn P, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pellegrini M, Peters KJ, Pedersen AB, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Seluanov A, Shafer ABA, Shanmuganayagam D, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmaohammadi E, Spangler ML, Spriggs MC, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Wallingford MC, Wang N, Wayne RK, Wilkinson GS, Williams CK, Williams RW, Yang XW, Yao M, Young BG, Zhang B, Zhang Z, Zhao P, Zhao Y, Zhou W, Zimmermann J, Ernst J, Raj K, Horvath S

Nature aging.. 2023 September 3 (9):1144-1166. Epub 08/10/2023.

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice.

Zhang Z, Tian X, Lu JY, Boit K, Ablaeva J, Zakusilo FT, Emmrich S, Firsanov D, Rydkina E, Biashad SA, Lu Q, Tyshkovskiy A, Gladyshev VN, Horvath S, Seluanov A, Gorbunova V

Nature.. 2023 September 621 (7977):196-205. Epub 08/23/2023.

DNA methylation networks underlying mammalian traits.

Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, Acosta-Rodríguez VA, Adams DM, Alagaili AN, Almunia J, Aloysius A, Amor NMS, Ardehali R, Arneson A, Baker CS, Banks G, Belov K, Bennett NC, Black P, Blumstein DT, Bors EK, Breeze CE, Brooke RT, Brown JL, Carter G, Caulton A, Cavin JM, Chakrabarti L, Chatzistamou I, Chavez AS, Chen H, Cheng K, Chiavellini P, Choi OW, Clarke S, Cook JA, Cooper LN, Cossette ML, Day J, DeYoung J, Dirocco S, Dold C, Dunnum JL, Ehmke EE, Emmons CK, Emmrich S, Erbay E, Erlacher-Reid C, Faulkes CG, Fei Z, Ferguson SH, Finno CJ, Flower JE, Gaillard JM, Garde E, Gerber L, Gladyshev VN, Goya RG, Grant MJ, Green CB, Hanson MB, Hart DW, Haulena M, Herrick K, Hogan AN, Hogg CJ, Hore TA, Huang T, Izpisua Belmonte JC, Jasinska AJ, Jones G, Jourdain E, Kashpur O, Katcher H, Katsumata E, Kaza V, Kiaris H, Kobor MS, Kordowitzki P, Koski WR, Krützen M, Kwon SB, Larison B, Lee SG, Lehmann M, Lemaître JF, Levine AJ, Li X, Li C, Lim AR, Lin DTS, Lindemann DM, Liphardt SW, Little TJ, Macoretta N, Maddox D, Matkin CO, Mattison JA, McClure M, Mergl J, Meudt JJ, Montano GA, Mozhui K, Munshi-South J, Murphy WJ, Naderi A, Nagy M, Narayan P, Nathanielsz PW, Nguyen NB, Niehrs C, Nyamsuren B, O'Brien JK, Ginn PO, Odom DT, Ophir AG, Osborn S, Ostrander EA, Parsons KM, Paul KC, Pedersen AB, Pellegrini M, Peters KJ, Petersen JL, Pietersen DW, Pinho GM, Plassais J, Poganik JR, Prado NA, Reddy P, Rey B, Ritz BR, Robbins J, Rodriguez M, Russell J, Rydkina E, Sailer LL, Salmon AB, Sanghavi A, Schachtschneider KM, Schmitt D, Schmitt T, Schomacher L, Schook LB, Sears KE, Seifert AW, Shafer ABA, Shindyapina AV, Simmons M, Singh K, Sinha I, Slone J, Snell RG, Soltanmohammadi E, Spangler ML, Spriggs M, Staggs L, Stedman N, Steinman KJ, Stewart DT, Sugrue VJ, Szladovits B, Takahashi JS, Takasugi M, Teeling EC, Thompson MJ, Van Bonn B, Vernes SC, Villar D, Vinters HV, Vu H, Wallingford MC, Wang N, Wilkinson GS, Williams RW, Yan Q, Yao M, Young BG, Zhang B, Zhang Z, Zhao Y, Zhao P, Zhou W, Zoller JA, Ernst J, Seluanov A, Gorbunova V, Yang XW, Raj K, Horvath S

Science.. 2023 August 11381 (6658):eabq5693. Epub 08/11/2023.

Distinct longevity mechanisms across and within species and their association with aging.

Tyshkovskiy A, Ma S, Shindyapina AV, Tikhonov S, Lee SG, Bozaykut P, Castro JP, Seluanov A, Schork NJ, Gorbunova V, Dmitriev SE, Miller RA, Gladyshev VN

Cell.. 2023 June 22186 (13):2929-2949.e20. Epub 06/03/2023.

Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle.

Zhao Y, Zheng Z, Zhang Z, Hillpot E, Lin YS, Zakusilo FT, Lu JY, Ablaeva J, Miller RA, Nevo E, Seluanov A, Gorbunova V

bioRxiv : the preprint server for biology.. 2023 May 9 Epub 05/09/2023.

Bat crazy iPSCs.

Athar F, Seluanov A, Gorbunova V

Cell.. 2023 March 2186 (5):901-903. Epub 1900 01 01.

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.

Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V

The EMBO journal.. 2023 February 142 (3):e113326. Epub 1900 01 01.

DNA damage and repair in age-related inflammation.

Zhao Y, Simon M, Seluanov A, Gorbunova V

Nature reviews. Immunology.. 2023 February 23 (2):75-89. Epub 07/13/2022.

Introduction: Progression of the Science of Ageing.

Gorbunova V, Seluanov A

Sub-cellular biochemistry.. 2023 102 :1-6. Epub 1900 01 01.

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging.

Paine PT, Rechsteiner C, Morandini F, Desdín-Micó G, Mrabti C, Parras A, Haghani A, Brooke R, Horvath S, Seluanov A, Gorbunova V, Ocampo A

Frontiers in aging.. 2023 4 :1323194. Epub 01/23/2024.

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.

Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Thomas DD, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V

The EMBO journal.. 2022 November 241 (21):e110393. Epub 10/10/2022.

Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes.

Fatima I, Chen G, Botchkareva NV, Sharov AA, Thornton D, Wilkinson HN, Hardman MJ, Grutzkau A, Pedro de Magalhaes J, Seluanov A, Smith ESJ, Gorbunova V, Mardaryev AN, Faulkes CG, Botchkarev VA

The Journal of investigative dermatology.. 2022 November 142 (11):2853-2863.e4. Epub 06/09/2022.

Correlation of cell mechanics with the resistance to malignant transformation in naked mole rat fibroblasts.

Makarova N, Kalaparthi V, Seluanov A, Gorbunova V, Dokukin ME, Sokolov I

Nanoscale.. 2022 October 1314 (39):14594-14602. Epub 10/13/2022.

Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits.

Emmrich S, Trapp A, Tolibzoda Zakusilo F, Straight ME, Ying AK, Tyshkovskiy A, Mariotti M, Gray S, Zhang Z, Drage MG, Takasugi M, Klusmann JH, Gladyshev VN, Seluanov A, Gorbunova V

The EMBO journal.. 2022 August 141 (15):e109694. Epub 06/13/2022.

Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation.

Lu JY, Simon M, Zhao Y, Ablaeva J, Corson N, Choi Y, Yamada KYH, Schork NJ, Hood WR, Hill GE, Miller RA, Seluanov A, Gorbunova V

Cell metabolism.. 2022 June 734 (6):836-856.e5. Epub 05/16/2022.

Accurate Proteomewide Measurement of Methionine Oxidation in Aging Mouse Brains.

Bettinger JQ, Simon M, Korotkov A, Welle KA, Hryhorenko JR, Seluanov A, Gorbunova V, Ghaemmaghami S

Journal of proteome research.. 2022 June 321 (6):1495-1509. Epub 05/18/2022.

Sirt6 regulates lifespan in .

Taylor JR, Wood JG, Mizerak E, Hinthorn S, Liu J, Finn M, Gordon S, Zingas L, Chang C, Klein MA, Denu JM, Gorbunova V, Seluanov A, Boeke JD, Sedivy JM, Helfand SL

Proceedings of the National Academy of Sciences of the United States of America.. 2022 February 1119 (5)Epub 1900 01 01.

The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.

Buffenstein R, Amoroso V, Andziak B, Avdieiev S, Azpurua J, Barker AJ, Bennett NC, Brieño-Enríquez MA, Bronner GN, Coen C, Delaney MA, Dengler-Crish CM, Edrey YH, Faulkes CG, Frankel D, Friedlander G, Gibney PA, Gorbunova V, Hine C, Holmes MM, Jarvis JUM, Kawamura Y, Kutsukake N, Kenyon C, Khaled WT, Kikusui T, Kissil J, Lagestee S, Larson J, Lauer A, Lavrenchenko LA, Lee A, Levitt JB, Lewin GR, Lewis Hardell KN, Lin TD, Mason MJ, McCloskey D, McMahon M, Miura K, Mogi K, Narayan V, O'Connor TP, Okanoya K, O'Riain MJ, Park TJ, Place NJ, Podshivalova K, Pamenter ME, Pyott SJ, Reznick J, Ruby JG, Salmon AB, Santos-Sacchi J, Sarko DK, Seluanov A, Shepard A, Smith M, Storey KB, Tian X, Vice EN, Viltard M, Watarai A, Wywial E, Yamakawa M, Zemlemerova ED, Zions M, Smith ESJ

Biological reviews of the Cambridge Philosophical Society.. 2022 February 97 (1):115-140. Epub 09/03/2021.

Epigenetic aging of the demographically non-aging naked mole-rat.

Kerepesi C, Meer MV, Ablaeva J, Amoroso VG, Lee SG, Zhang B, Gerashchenko MV, Trapp A, Yim SH, Lu AT, Levine ME, Seluanov A, Horvath S, Park TJ, Gorbunova V, Gladyshev VN

Nature communications.. 2022 January 1713 (1):355. Epub 01/17/2022.

DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders.

Horvath S, Haghani A, Macoretta N, Ablaeva J, Zoller JA, Li CZ, Zhang J, Takasugi M, Zhao Y, Rydkina E, Zhang Z, Emmrich S, Raj K, Seluanov A, Faulkes CG, Gorbunova V

Nature aging.. 2022 January 2 (1):46-59. Epub 12/23/2021.

Sirtuin 6: linking longevity with genome and epigenome stability.

Korotkov A, Seluanov A, Gorbunova V

Trends in cell biology.. 2021 December 31 (12):994-1006. Epub 07/17/2021.

Matters of size: Roles of hyaluronan in CNS aging and disease.

Zakusilo FT, Gelbard HA, Seluanov A, Kerry O'Banion M, Gorbunova V

Ageing research reviews.. 2021 December 72 :101485. Epub 10/09/2021.

Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms.

Zhao Y, Seluanov A, Gorbunova V

Annual review of genetics. 2021 November 2355 :135-159. Epub 08/20/2021.

Long-lived fish in a big pond.

Lu JY, Seluanov A, Gorbunova V

Science.. 2021 November 12374 (6569):824-825. Epub 11/11/2021.

Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.

Zhang Q, Tombline G, Ablaeva J, Zhang L, Zhou X, Smith Z, Zhao Y, Xiaoli AM, Wang Z, Lin JR, Jabalameli MR, Mitra J, Nguyen N, Vijg J, Seluanov A, Gladyshev VN, Gorbunova V, Zhang ZD

Cell reports.. 2021 November 937 (6):109965. Epub 1900 01 01.

Maintenance of genome sequence integrity in long- and short-lived rodent species.

Zhang L, Dong X, Tian X, Lee M, Ablaeva J, Firsanov D, Lee SG, Maslov AY, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J

Science advances.. 2021 October 297 (44):eabj3284. Epub 10/27/2021.

Transposon-triggered innate immune response confers cancer resistance to the blind mole rat.

Zhao Y, Oreskovic E, Zhang Q, Lu Q, Gilman A, Lin YS, He J, Zheng Z, Lu JY, Lee J, Ke Z, Ablaeva J, Sweet MJ, Horvath S, Zhang Z, Nevo E, Seluanov A, Gorbunova V

Nature immunology.. 2021 October 22 (10):1219-1230. Epub 09/23/2021.

Ectopic cervical thymi and no thymic involution until midlife in naked mole rats.

Emmrich S, Tolibzoda Zakusilo F, Trapp A, Zhou X, Zhang Q, Irving EM, Drage MG, Zhang Z, Gladyshev VN, Seluanov A, Gorbunova V

Aging cell.. 2021 October 20 (10):e13477. Epub 10/01/2021.

The role of retrotransposable elements in ageing and age-associated diseases.

Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, Woodham TA, Taylor JR, Helfand SL, Sedivy JM

Nature.. 2021 August 596 (7870):43-53. Epub 08/04/2021.

Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.

Swovick K, Firsanov D, Welle KA, Hryhorenko JR, Wise JP, George C, Sformo TL, Seluanov A, Gorbunova V, Ghaemmaghami S

Molecular & cellular proteomics : MCP.. 2021 20 :100041. Epub 01/07/2021.

The conundrum of human immune system "senescence".

Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA

Mechanisms of ageing and development.. 2020 December 192 :111357. Epub 09/17/2020.

Naked mole-rats are extremely resistant to post-traumatic osteoarthritis.

Taguchi T, Kotelsky A, Takasugi M, Chang M, Ke Z, Betancourt M, Buckley MR, Zuscik M, Seluanov A, Gorbunova V

Aging cell.. 2020 November 19 (11):e13255. Epub 10/28/2020.

A hairy tale: SIRT7 safeguards skin stem cells during aging.

Simon M, Emmrich S, Seluanov A, Gorbunova V

The EMBO journal.. 2020 September 1539 (18):e106294. Epub 08/16/2020.

Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity.

Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN

Cell reports.. 2020 July 2832 (4):107949. Epub 1900 01 01.

Hyaluronan goes to great length.

Gorbunova V, Takasugi M, Seluanov A

Cell stress.. 2020 July 174 (9):227-229. Epub 07/17/2020.

The World Goes Bats: Living Longer and Tolerating Viruses.

Gorbunova V, Seluanov A, Kennedy BK

Cell metabolism.. 2020 July 732 (1):31-43. Epub 1900 01 01.

Reply to: Transformation of naked mole-rat cells.

Zhao J, Tian X, Zhu Y, Zhang Z, Rydkina E, Yuan Y, Zhang H, Roy B, Cornwell A, Nevo E, Shang X, Huang R, Kristiansen K, Seluanov A, Fang X, Gorbunova V

Nature.. 2020 July 583 (7814):E8-E13. Epub 1900 01 01.

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.

Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A, Gorbunova V

Aging.. 2020 June 2512 (12):11165-11184. Epub 06/25/2020.

Compromised DNA repair is responsible for diabetes-associated fibrosis.

Kumar V, Agrawal R, Pandey A, Kopf S, Hoeffgen M, Kaymak S, Bandapalli OR, Gorbunova V, Seluanov A, Mall MA, Herzig S, Nawroth PP

The EMBO journal.. 2020 June 239 (11):e103477. Epub 04/27/2020.

Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.

Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V

Nature communications.. 2020 May 1211 (1):2376. Epub 05/12/2020.

Proteomics of Long-Lived Mammals.

Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V

Proteomics.. 2020 March 20 (5-6):e1800416. Epub 01/09/2020.

A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites.

Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z

Nucleic acids research.. 2019 September 1947 (16):8563-8580. Epub 1900 01 01.

Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma.

Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, Kondo A, Wadhwani NR, Lulla R, Goldman S, Venneti S, Becher OJ, Zou L, Shilatifard A, Hashizume R

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2019 September 1525 (18):5572-5583. Epub 06/21/2019.

SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170.

Rezazadeh S, Yang D, Tombline G, Simon M, Regan SP, Seluanov A, Gorbunova V

Nucleic acids research.. 2019 September 547 (15):7914-7928. Epub 1900 01 01.

Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM

Nature.. 2019 August 572 (7767):E5. Epub 1900 01 01.

Publisher Correction: Lipidome determinants of maximal lifespan in mammals.

Bozek K, Khrameeva EE, Reznick J, Omerbašic D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P

Scientific reports.. 2019 May 19 (1):6972. Epub 05/01/2019.

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V

Cell.. 2019 April 18177 (3):622-638.e22. Epub 1900 01 01.

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V

Cell metabolism.. 2019 April 229 (4):871-885.e5. Epub 03/07/2019.

L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM

Nature.. 2019 February 566 (7742):73-78. Epub 02/06/2019.

Ten things you should know about transposable elements.

Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, Imbeault M, Izsvák Z, Levin HL, Macfarlan TS, Mager DL, Feschotte C

Genome biology.. 2018 November 1919 (1):199. Epub 11/19/2018.

Mechanisms of cancer resistance in long-lived mammals.

Seluanov A, Gladyshev VN, Vijg J, Gorbunova V

Nature reviews. Cancer.. 2018 July 18 (7):433-441. Epub 1900 01 01.

Naked mole rat cells display more efficient excision repair than mouse cells.

Evdokimov A, Kutuzov M, Petruseva I, Lukjanchikova N, Kashina E, Kolova E, Zemerova T, Romanenko S, Perelman P, Prokopov D, Seluanov A, Gorbunova V, Graphodatsky A, Trifonov V, Khodyreva S, Lavrik O

Aging.. 2018 June 2010 (6):1454-1473. Epub 1900 01 01.

Cross-species Comparison of Proteome Turnover Kinetics.

Swovick K, Welle KA, Hryhorenko JR, Seluanov A, Gorbunova V, Ghaemmaghami S

Molecular & cellular proteomics : MCP.. 2018 April 17 (4):580-591. Epub 01/10/2018.

Accurate translation is important for longevity.

Ke Z, Seluanov A, Gorbunova V

Aging.. 2018 March 1210 (3):297-298. Epub 1900 01 01.

Evolution of telomere maintenance and tumour suppressor mechanisms across mammals.

Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V

Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2018 March 5373 (1741)Epub 1900 01 01.

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence.

Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V

Proceedings of the National Academy of Sciences of the United States of America.. 2018 February 20115 (8):1801-1806. Epub 02/05/2018.

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.

Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, Seluanov A, Gillespie DA, Adams PD

Oncogene.. 2018 January 2537 (4):427-438. Epub 10/02/2017.

Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming.

Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V

Stem cell reports.. 2017 November 149 (5):1721-1734. Epub 10/26/2017.

Translation fidelity coevolves with longevity.

Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V

Aging cell.. 2017 October 16 (5):988-993. Epub 07/13/2017.

Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species.

Tian X, Seluanov A, Gorbunova V

Trends in endocrinology and metabolism : TEM.. 2017 October 28 (10):722-734. Epub 09/07/2017.

Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging.

Tian X, Seluanov A, Gorbunova V

Cell metabolism.. 2017 May 225 (5):991-992. Epub 1900 01 01.

Non-canonical aging model systems and why we need them.

Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V

The EMBO journal.. 2017 April 1336 (8):959-963. Epub 03/20/2017.

Lipidome determinants of maximal lifespan in mammals.

Bozek K, Khrameeva EE, Reznick J, Omerbašic D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P

Scientific reports.. 2017 January 317 (1):5. Epub 01/31/2017.

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity.

Ma S, Upneja A, Galecki A, Tsai YM, Burant CF, Raskind S, Zhang Q, Zhang ZD, Seluanov A, Gorbunova V, Clish CB, Miller RA, Gladyshev VN

eLife.. 2016 November 225 Epub 11/22/2016.

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.

Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI

Autophagy.. 2016 October 212 (10):1917-1930. Epub 07/08/2016.

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A

Cell reports.. 2016 September 616 (10):2641-2650. Epub 08/25/2016.

Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM.

Dokukin M, Ablaeva Y, Kalaparthi V, Seluanov A, Gorbunova V, Sokolov I

Biophysical journal.. 2016 July 12111 (1):236-46. Epub 1900 01 01.

Dangerous Entrapment for NRF2.

Gorbunova V, Rezazadeh S, Seluanov A

Cell.. 2016 June 2165 (6):1312-1313. Epub 1900 01 01.

DNA double strand break repair, aging and the chromatin connection.

Gorbunova V, Seluanov A

Mutation research.. 2016 June 788 :2-6. Epub 02/15/2016.

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coskun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V

Aging.. 2016 May 8 (5):841-7. Epub 1900 01 01.

DNA repair in species with extreme lifespan differences.

MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J

Aging.. 2015 December 7 (12):1171-84. Epub 1900 01 01.

Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity.

Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN

Cell reports.. 2015 November 1713 (7):1319-1326. Epub 11/05/2015.

Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, Lewin HA, Ma J, Band M, Bicker A, Kranz A, Mattheus T, Schmidt H, Seluanov A, Azpurua J, McGowen MR, Ben Jacob E, Li K, Peng S, Zhu X, Liao X, Li S, Krogh A, Zhou X, Brodsky L, Wang J

Nature communications.. 2015 August 126 :8051. Epub 08/12/2015.

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.

MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD

Aging cell.. 2015 April 14 (2):288-91. Epub 01/28/2015.

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.

Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A

Proceedings of the National Academy of Sciences of the United States of America.. 2015 January 27112 (4):1053-8. Epub 12/30/2014.

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner.

Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z

Cell cycle.. 2015 14 (2):269-76. Epub 1900 01 01.

The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.

Keane M, Craig T, Alföldi J, Berlin AM, Johnson J, Seluanov A, Gorbunova V, Di Palma F, Lindblad-Toh K, Church GM, de Magalhães JP

Bioinformatics.. 2014 December 1530 (24):3558-60. Epub 08/28/2014.

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.

Van Meter M, Kashyap M, Rezazadeh S, Geneva AJ, Morello TD, Seluanov A, Gorbunova V

Nature communications.. 2014 September 235 :5011. Epub 09/23/2014.

Comparative genetics of longevity and cancer: insights from long-lived rodents.

Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J

Nature reviews. Genetics.. 2014 August 15 (8):531-40. Epub 07/01/2014.

Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age.

Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V

PLoS genetics.. 2014 July 10 (7):e1004511. Epub 07/17/2014.

Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.

Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, Huang Z, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong Y, Gudkov A, Zheng Q, Rechavi G, Liu S, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, Lewin HA, Ma J, Band M, Bicker A, Kranz A, Mattheus T, Schmidt H, Seluanov A, Azpurua J, McGowen MR, Ben Jacob E, Li K, Peng S, Zhu X, Liao X, Li S, Krogh A, Zhou X, Brodsky L, Wang J

Nature communications.. 2014 June 35 :3966. Epub 06/03/2014.

Utilization of Rad51C promoter for transcriptional targeting of cancer cells.

Cao Y, Xu Y, Zhang L, Li Z, Jiang Y, Tian X, Seluanov A, Gorbunova V, Mao Z

Oncotarget.. 2014 April 155 (7):1805-11. Epub 1900 01 01.

Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups.

Ke Z, Vaidya A, Ascher J, Seluanov A, Gorbunova V

Journal of the American Association for Laboratory Animal Science : JAALAS.. 2014 January 53 (1):89-91. Epub 1900 01 01.

Regulation of Rad51 promoter.

Hine CM, Li H, Xie L, Mao Z, Seluanov A, Gorbunova V

Cell cycle.. 2014 13 (13):2038-45. Epub 04/29/2014.

SIRT6: a promising target for cancer prevention and therapy.

Van Meter M, Gorbunova V, Seluanov A

Advances in experimental medicine and biology.. 2014 818 :181-96. Epub 1900 01 01.

Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage.

Azpurua J, Ke Z, Chen IX, Zhang Q, Ermolenko DN, Zhang ZD, Gorbunova V, Seluanov A

Proceedings of the National Academy of Sciences of the United States of America.. 2013 October 22110 (43):17350-5. Epub 09/30/2013.

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.

Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A

Nature.. 2013 July 18499 (7458):346-9. Epub 06/19/2013.

IGF1R levels in the brain negatively correlate with longevity in 16 rodent species.

Azpurua J, Yang JN, Van Meter M, Liu Z, Kim J, Lobo Ladd AA, Coppi AA, Gorbunova V, Seluanov A

Aging.. 2013 April 5 (4):304-14. Epub 1900 01 01.

Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging.

Yang JN, Seluanov A, Gorbunova V

PloS one.. 2013 8 (9):e73318. Epub 09/17/2013.

Forever young? Exploring the link between rapamycin, longevity and cancer.

Van Meter M, Seluanov A, Gorbunova V

Cell cycle.. 2012 December 111 (23):4296-7. Epub 11/14/2012.

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism.

Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A

Proceedings of the National Academy of Sciences of the United States of America.. 2012 November 20109 (47):19392-6. Epub 11/05/2012.

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A

Proceedings of the National Academy of Sciences of the United States of America.. 2012 July 17109 (29):11800-5. Epub 07/02/2012.

Replicatively senescent cells are arrested in G1 and G2 phases.

Mao Z, Ke Z, Gorbunova V, Seluanov A

Aging.. 2012 June 4 (6):431-5. Epub 1900 01 01.

The second international conference "genetics of aging and longevity".

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P

Aging.. 2012 May 4 (5):305-17. Epub 1900 01 01.

Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.

Hine CM, Seluanov A, Gorbunova V

Molecular therapy : the journal of the American Society of Gene Therapy.. 2012 February 20 (2):347-55. Epub 10/18/2011.

Long-lived cancer-resistant rodents as new model species for cancer research.

Azpurua J, Seluanov A

Frontiers in genetics.. 2012 3 :319. Epub 01/09/2013.

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.

Van Meter M, Mao Z, Gorbunova V, Seluanov A

Cell cycle.. 2011 September 1510 (18):3153-8. Epub 09/15/2011.

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.

Van Meter M, Mao Z, Gorbunova V, Seluanov A

Aging.. 2011 September 3 (9):829-35. Epub 1900 01 01.

SIRT6 promotes DNA repair under stress by activating PARP1.

Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V

Science.. 2011 June 17332 (6036):1443-6. Epub 1900 01 01.

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S

PloS one.. 2011 6 (12):e28714. Epub 12/09/2011.

Establishing primary adult fibroblast cultures from rodents.

Seluanov A, Vaidya A, Gorbunova V

Journal of visualized experiments : JoVE.. 2010 October 5 (44)Epub 10/05/2010.

Analysis of DNA double-strand break (DSB) repair in mammalian cells.

Seluanov A, Mao Z, Gorbunova V

Journal of visualized experiments : JoVE.. 2010 September 8 (43)Epub 09/08/2010.

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat.

Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V

Proceedings of the National Academy of Sciences of the United States of America.. 2009 November 17106 (46):19352-7. Epub 10/26/2009.

DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells.

Mao Z, Jiang Y, Liu X, Seluanov A, Gorbunova V

Neoplasia : an international journal for oncology research.. 2009 July 11 (7):683-91. Epub 1900 01 01.

Coevolution of telomerase activity and body mass in mammals: from mice to beavers.

Gorbunova V, Seluanov A

Mechanisms of ageing and development.. 2009 130 (1-2):3-9. Epub 02/23/2008.

Use of the Rad51 promoter for targeted anti-cancer therapy.

Hine CM, Seluanov A, Gorbunova V

Proceedings of the National Academy of Sciences of the United States of America.. 2008 December 30105 (52):20810-5. Epub 12/23/2008.

Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan.

Seluanov A, Hine C, Bozzella M, Hall A, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V

Aging cell.. 2008 December 7 (6):813-23. Epub 09/05/2008.

Comparison of nonhomologous end joining and homologous recombination in human cells.

Mao Z, Bozzella M, Seluanov A, Gorbunova V

DNA repair.. 2008 October 17 (10):1765-71. Epub 08/20/2008.

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells.

Mao Z, Bozzella M, Seluanov A, Gorbunova V

Cell cycle.. 2008 September 157 (18):2902-6. Epub 1900 01 01.

Rodents for comparative aging studies: from mice to beavers.

Gorbunova V, Bozzella MJ, Seluanov A

Age.. 2008 September 30 (2-3):111-9. Epub 06/25/2008.

Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination.

Dion V, Lin Y, Price BA, Fyffe SL, Seluanov A, Gorbunova V, Wilson JH

DNA repair.. 2008 February 17 (2):313-20. Epub 1900 01 01.

Changes in the level and distribution of Ku proteins during cellular senescence.

Seluanov A, Danek J, Hause N, Gorbunova V

DNA repair.. 2007 December 16 (12):1740-8. Epub 08/07/2007.

TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination.

Mao Z, Seluanov A, Jiang Y, Gorbunova V

Proceedings of the National Academy of Sciences of the United States of America.. 2007 August 7104 (32):13068-73. Epub 08/01/2007.

Cell divisions are required for L1 retrotransposition.

Shi X, Seluanov A, Gorbunova V

Molecular and cellular biology.. 2007 February 27 (4):1264-70. Epub 12/04/2006.

Telomerase activity coevolves with body mass not lifespan.

Seluanov A, Chen Z, Hine C, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V

Aging cell.. 2007 February 6 (1):45-52. Epub 12/14/2006.

Changes in DNA repair during aging.

Gorbunova V, Seluanov A, Mao Z, Hine C

Nucleic acids research.. 2007 35 (22):7466-74. Epub 10/02/2007.

Making ends meet in old age: DSB repair and aging.

Gorbunova V, Seluanov A

Mechanisms of ageing and development.. 2005 126 (6-7):621-8. Epub 03/24/2005.

Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells.

Gorbunova V, Seluanov A, Mittelman D, Wilson JH

Human molecular genetics.. 2004 December 113 (23):2979-89. Epub 09/30/2004.

DNA end joining becomes less efficient and more error-prone during cellular senescence.

Seluanov A, Mittelman D, Pereira-Smith OM, Wilson JH, Gorbunova V

Proceedings of the National Academy of Sciences of the United States of America.. 2004 May 18101 (20):7624-9. Epub 04/28/2004.

Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells.

Gorbunova V, Seluanov A, Dion V, Sandor Z, Meservy JL, Wilson JH

Molecular and cellular biology.. 2003 July 23 (13):4485-93. Epub 1900 01 01.

Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts.

Gorbunova V, Seluanov A, Pereira-Smith OM

The Journal of biological chemistry.. 2003 February 28278 (9):7692-8. Epub 12/19/2002.

Telomerase as a growth-promoting factor.

Gorbunova V, Seluanov A

Cell cycle.. 2003 2 (6):534-7. Epub 1900 01 01.

Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis.

Gorbunova V, Seluanov A, Pereira-Smith OM

The Journal of biological chemistry.. 2002 October 11277 (41):38540-9. Epub 07/24/2002.

CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA.

Gorbunova V, Seluanov A

FEBS letters.. 2002 April 10516 (1-3):279-84. Epub 1900 01 01.

Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY.

Herskovits AA, Seluanov A, Rajsbaum R, ten Hagen-Jongman CM, Henrichs T, Bochkareva ES, Phillips GJ, Probst FJ, Nakae T, Ehrmann M, Luirink J, Bibi E

EMBO reports.. 2001 November 2 (11):1040-6. Epub 1900 01 01.

Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

Seluanov A, Gorbunova V, Falcovitz A, Sigal A, Milyavsky M, Zurer I, Shohat G, Goldfinger N, Rotter V

Molecular and cellular biology.. 2001 March 21 (5):1552-64. Epub 1900 01 01.

The NG domain of the prokaryotic signal recognition particle receptor, FtsY, is fully functional when fused to an unrelated integral membrane polypeptide.

Zelazny A, Seluanov A, Cooper A, Bibi E

Proceedings of the National Academy of Sciences of the United States of America.. 1997 June 1094 (12):6025-9. Epub 1900 01 01.

Andrei Seluanov, Ph.D.

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