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Peter C. Keng, Ph.D.

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About Me

Faculty Appointments

Professor Emeritus - Department of Radiation Oncology (SMD)

Credentials

Post-doctoral Training & Residency

Tumor biology at the University of Rochester Cancer Center 1978 - 1979

Education

PhD | Colorado State University. Radiation Biology. 1978

BS | Tunghai University. Biology. 1968

Publications

Journal Articles

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.

Gehen SC, Staversky RJ, Bambara RA, Keng PC, O'Reilly MA

Oncogene.. 2008 July 327 (29):4065-74. Epub 03/10/2008.

Tumor response kinetics after schedule-dependent Paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization.

Zhang, H.; Hyrien, O.; Pandya, K.; Keng, PC.; and Chen, Y.

J Thoracic Oncology. 2008; .

PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of Bax death.

Vitiello, PF.; Staversky, RJ.; Keng, PC.; and O'Reilly, MA.

Biochem. 2008; .

Phase II study of one-cycle induction docetaxel/cisplatin with rhG-CSF and sensitizing docetaxel chemoradiation for stage III non-small cell lung cancer.

Chen, Y.; Pandya, KJ.; Keng, PC.; Smudzin, T.; Anderson, J.; Qazi, R.; Smith, B.; Watson, TJ.; Johnston, DW.; Feins, RH.

J Thoracic Oncology. 2008; .

Identification of label-retaining Type II cells with limited ability to undergo transdifferentiation.

Yee, M.; Vitiello, PF.; Keng, PC.; Palis, J.; Panoskaltsis-Mortari, A.; Blazar, BR.; Finkelstein, JN.; and O'Reilly, MA.

Am J Physiol. 2008; .

Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment.

Sun W, Wang W, Kim J, Keng P, Yang S, Zhang H, Liu C, Okunieff P, Zhang L

Advances in experimental medicine and biology.. 2008 614 :179-86. Epub 1900 01 01.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry.

Dertinger SD, Tsai Y, Nowak I, Hyrien O, Sun H, Bemis JC, Torous DK, Keng P, Palis J, Chen Y

Mutation research.. 2007 December 1634 (1-2):119-25. Epub 07/05/2007.

Hypertonicity induced apoptosis in HL-60 cells in the presence of intracellular potassium.

Ghosh A, Keng PC, Knauf PA

Apoptosis : an international journal on programmed cell death.. 2007 July 12 (7):1281-8. Epub 1900 01 01.

Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia.

Gehen SC, Vitiello PF, Bambara RA, Keng PC, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2007 March 292 (3):L716-24. Epub 11/03/2006.

Enhanced anti-tumor effect of combined triptolide and ionizing radiation.

Wang, W.; Yang, S., Su, Y.; Xiao, Z.; Wang, C.; Li, X.; Lin, L.; Fenton, BM.; Paoni, SF.; Ding, I.; Keng, P.; Okunieff, P.; and Zhang, L.

Clin Cancer Res. 2007; .

p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L).

Staversky RJ, Vitiello PF, Gehen SC, Helt CE, Rahman A, Keng PC, O'Reilly MA

Free radical biology & medicine.. 2006 August 1541 (4):601-9. Epub 05/23/2006.

Norepinephrine-induced oxidative stress causes PC-12 cell apoptosis by both endoplasmic reticulum stress and mitochondrial intrinsic pathway: inhibition of phosphatidylinositol 3-kinase survival pathway.

Mao W, Iwai C, Keng PC, Vulapalli R, Liang CS

American journal of physiology. Cell physiology.. 2006 May 290 (5):C1373-84. Epub 12/07/2005.

Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression.

Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L

The Journal of biological chemistry.. 2006 April 28281 (17):11846-55. Epub 02/06/2006.

Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression.

Chen MF, Keng PC, Shau H, Wu CT, Hu YC, Liao SK, Chen WC

International journal of radiation oncology, biology, physics.. 2006 February 164 (2):581-91. Epub 1900 01 01.

The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation.

Brandt, PD.; Helt, CE.; Keng, PC.; Bambara, RA.

Biochemical & Biophysical Research Communications. 2006; 347(1): 232-7.

Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells.

Tsai MH. Chen X. Chandramouli GV. Chen Y. Yan H. Zhao S. Keng P. Liber HL. Coleman CN. Mitchell JB. Chuang EY.

Oncogene. 25(4):622-32, 2006 Jan 26. 2006; 25(4): 622-32.

Evidence that DNA damage detection machinery participates in DNA repair.

Helt CE, Wang W, Keng PC, Bambara RA

Cell cycle.. 2005 April 4 (4):529-32. Epub 04/10/2005.

p53 modulates radiation sensitivity independent of p21 transcriptional activation.

Mazzatti DJ, Lee YJ, Helt CE, O'Reilly MA, Keng PC

American journal of clinical oncology.. 2005 February 28 (1):43-50. Epub 1900 01 01.

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA

The Journal of biological chemistry.. 2005 January 14280 (2):1186-92. Epub 11/08/2004.

Inhibition of invasiveness of human lung cancer cell line H1299 by over-expression of cofilin.

Lee YJ. Mazzatti DJ. Yun Z. Keng PC.

Cell Biology International. 29(11):877-83, 2005 Nov. 2005; 29(11).

Caffeic acid phenethyl ester decreases acute pneumonitis after irradiation in vitro and in vivo.

Chen MF. Keng PC. Lin PY. Yang CT. Liao SK. Chen WC.

BMC Cancer. 5:158, 2005. 2005; 5: 158-68.

Studying the effects of actin cytoskeletal destabilization on cell cycle by cofilin overexpression.

Lee YJ. Keng PC.

Molecular Biotechnology. 31(1):1-10, 2005 Sep. 2005; 31(1): 1-10.

Enhancement of radiosensitivity in H1299 cancer cells by actin-associated protein cofilin.

Lee YJ. Sheu TJ. Keng PC.

Biochemical & Biophysical Research Communications. 335(2):286-91, 2005 Sep 23. 2005; 335(2): 286-91.

Arsenite delays progression through each cell cycle phase and induces apoptosis following G2/M arrest in U937 myeloid leukemia cells.

McCollum G. Keng PC. States JC. McCabe MJ Jr.

Journal of Pharmacology & Experimental Therapeutics. 313(2):877-87, 2005 May. 2005; 313(2): 877-87.

Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells.

Chen MF, Wu CT, Chen YJ, Keng PC, Chen WC

Journal of radiation research.. 2004 June 45 (2):253-60. Epub 1900 01 01.

Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells.

Chen MF. Wu CT. Chen YJ. Keng PC. Chen WC.

Journal of Radiation Research. 45(2):253-60, 2004 Jun. 2004; 45(2): 253-60.

Extracellular norepinephrine reduces neuronal uptake of norepinephrine by oxidative stress in PC12 cells.

Mao W. Qin F. Iwai C. Vulapalli R. Keng PC. Liang CS.

American Journal of Physiology - Heart & Circulatory Physiology. 2004; 287(1): H29-39.

The role of the THY1 gene in human ovarian cancer suppression based on transfection studies.

Abeysinghe HR. Pollock SJ. Guckert NL. Veyberman Y. Keng P. Halterman M. Federoff HJ. Rosenblatt JP. Wang N.

Cancer Genetics & Cytogenetics. 149(1):1-10, 2004 Feb. 2004; 149(1): 1-10.

In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells.

Roper JM. Mazzatti DJ. Watkins RH. Maniscalco WM. Keng PC. O'Reilly MA.

American Journal of Physiology - Lung Cellular & Molecular Physiology. 286(5):L1045-54, 2004 May. 2004; 286(5): L1045-54.

Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells.

Wang L. Hsu CL. Ni J. Wang PH. Yeh S. Keng P. Chang C.

Molecular & Cellular Biology. 24(5):2202-13, 2004 Mar. 2004; 24(5): 2202-13.

The Cdk and PCNA domains on p21Cip1 both function to inhibit G1/S progression during hyperoxia.

Helt CE. Staversky RJ. Lee YJ. Bambara RA. Keng PC. O'Reilly MA.

American Journal of Physiology - Lung Cellular & Molecular Physiology. 286(3):L506-13, 2004 Mar. 2004; 286(3): L506-13.

The Cdk and PCNA domains on p21Cip1 both function to inhibit G1/S progression during hyperoxia.

Helt CE. Staversky RJ. Lee YJ. Bambara RA. Keng PC. O'Reilly MA.

American Journal of Physiology - Lung Cellular & Molecular Physiology. 286(3):L506-13, 2004 Mar. 2004; 286(3): L506-13.

Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth.

Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I

American journal of clinical oncology.. 2003 August 26 (4):S103-9. Epub 1900 01 01.

Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines.

Chen Y, Pandya K, Keng PC, Johnstone D, Li J, Lee YJ, Smudzin T, Okunieff P

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2003 March 9 (3):969-75. Epub 1900 01 01.

Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption.

Xing L. Carlson L. Story B. Tai Z. Keng P. Siebenlist U. Boyce BF.

Journal of Bone & Mineral Research. 18(2):260-9, 2003 Feb. 2003; 18(2): 260-9.

Identification and isolation of mouse type II cells on the basis of intrinsic expression of enhanced green fluorescent protein.

Roper JM. Staversky RJ. Finkelstein JN. Keng PC. O'Reilly MA.

American Journal of Physiology - Lung Cellular & Molecular Physiology. 2003; 285(3): L691-700.

THY1 expression is associated with tumor suppression of human ovarian cancer.

Abeysinghe HR. Cao Q. Xu J. Pollock S. Veyberman Y. Guckert NL. Keng P. Wang N.

Cancer Genetics & Cytogenetics. 2003; 143(2): 125-32.

Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia.

O'Reilly MA. Staversky RJ. Finkelstein JN. Keng PC.

American Journal of Physiology - Lung Cellular & Molecular Physiology. 2003; 284(2): L368-75.

Growth arrest in G1 protects against oxygen-induced DNA damage and cell death.

Rancourt RC, Hayes DD, Chess PR, Keng PC, O'Reilly MA

Journal of cellular physiology.. 2002 October 193 (1):26-36. Epub 1900 01 01.

Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans.

Baev D. Li XS. Dong J. Keng P. Edgerton M.

Infection & Immunity. 2002; 70(9): 4777-84.

Effects of p53 mutations on cellular sensitivity to ionizing radiation.

Matsui Y, Tsuchida Y, Keng PC

American journal of clinical oncology.. 2001 October 24 (5):486-90. Epub 1900 01 01.

Suppression of tumorigenicity in human ovarian carcinoma cell line SKOV-3 by microcell-mediated transfer of chromosome 11.

Cao Q. Abeysinghe H. Chow O. Xu J. Kaung H. Fong C. Keng P. Insel RA. Lee WM. Barrett JC. Wang N.

Cancer Genetics & Cytogenetics. 2001; 129(2): 131-7.

The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress.

O'Reilly MA. Staversky RJ. Watkins RH. Reed CK. de Mesy Jensen KL. Finkelstein JN. Keng PC.

American Journal of Respiratory Cell & Molecular Biology. 2001; 24(6): 703-10.

The role of p21(CIP1/WAF1) in growth of epithelial cells exposed to hyperoxia.

Rancourt RC. Keng PC. Helt CE. O'Reilly MA.

American Journal of Physiology - Lung Cellular & Molecular Physiology. 2001; 280(4): L617-26.

Sigma-2 receptors as a biomarker of proliferation in solid tumours.

Wheeler KT, Wang LM, Wallen CA, Childers SR, Cline JM, Keng PC, Mach RH

British journal of cancer.. 2000 March 82 (6):1223-32. Epub 1900 01 01.

Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow.

Chen YG. Mantalaris A. Bourne P. Keng P. Wu JH.

Biochemical & Biophysical Research Communications. 2000; 276(2): 724-8.

Alteration of tumour response to radiation by interleukin-2 gene transfer.

Lee J. Moran JP. Fenton BM. Koch CJ. Frelinger JG. Keng PC. Lord EM.

British Journal of Cancer. 82(4):937-44, 2000 Feb. 2000; 82(4): 937-44.

p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia.

O'Reilly MA. Staversky RJ. Watkins RH. Maniscalco WM. Keng PC.

American Journal of Physiology - Lung Cellular & Molecular Physiology. 2000; 278(3): L552-9.

Hyperoxia inhibits proliferation of Mv1Lu epithelial cells independent of TGF-beta signaling.

Rancourt RC, Staversky RJ, Keng PC, O'Reilly MA

The American journal of physiology.. 1999 December 277 (6):L1172-8. Epub 1900 01 01.

Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumour cells.

Al-Nabulsi I, Mach RH, Wang LM, Wallen CA, Keng PC, Sten K, Childers SR, Wheeler KT

British journal of cancer.. 1999 November 81 (6):925-33. Epub 1900 01 01.

Hypoxia significantly reduces aminolaevulinic acid-induced protoporphyrin IX synthesis in EMT6 cells.

Georgakoudi I, Keng PC, Foster TH

British journal of cancer.. 1999 March 79 (9-10):1372-7. Epub 1900 01 01.

Passive mechanical behavior of human neutrophils: effects of colchicine and paclitaxel.

Tsai MA, Waugh RE, Keng PC

Biophysical journal.. 1998 June 74 (6):3282-91. Epub 1900 01 01.

Absence of a radiation-induced first-cycle G1-S arrest in p53+ human tumor cells synchronized by mitotic selection.

Nagasawa H, Keng P, Maki C, Yu Y, Little JB

Cancer research.. 1998 May 158 (9):2036-41. Epub 1900 01 01.

Regulation by ionizing radiation of CDC2, cyclin A, cyclin B, thymidine kinase, topoisomerase IIalpha, and RAD51 expression in normal human diploid fibroblasts is dependent on p53/p21Waf1.

de Toledo SM. Azzam EI. Keng P. Laffrenier S. Little JB.

Cell Growth & Differentiation. 1998; 9(11): 887-96.

Engineering a human bone marrow model: a case study on ex vivo erythropoiesis.

Mantalaris A, Keng P, Bourne P, Chang AY, Wu JH

Biotechnology progress.. 1998 14 (1):126-33. Epub 1900 01 01.

Measurement of proliferation activities in human tumor models: a comparison of flow cytometric methods.

Keng PC, Siemann DW

Radiation oncology investigations. 1998 6 (3):120-7. Epub 1900 01 01.

Lack of uncoupling of S phase and mitosis after irradiation in p53- human lymphoblast cell lines.

Wenz F. Yu Y. Nagasawa H. Imrich AC. Keng P. Little JB.

Radiation Research. 148(2):129-34, 1997 Aug. 1997; 148(2): 129-34.

Toxicity of cadmium in human trophoblast cells (JAr choriocarcinoma): role of calmodulin and the calmodulin inhibitor, zaldaride maleate.

Powlin SS. Keng PC. Miller RK.

Toxicology & Applied Pharmacology. 144(2):C, 1997 Jun.

The effect of bcr-abl antisense oligonucleotide on DNA synthesis and apoptosis in K562 chronic myeloid leukemia cells.

Rowley PT, Keng PC, Kosciolek BA

Leukemia research.. 1996 June 20 (6):473-80. Epub 1900 01 01.

Cell cycle-dependence of HL-60 cell deformability.

Tsai MA, Waugh RE, Keng PC

Biophysical journal.. 1996 April 70 (4):2023-9. Epub 1900 01 01.

Changes in HL-60 cell deformability during differentiation induced by DMSO.

Tsai MA, Waugh RE, Keng PC

Biorheology. 1996 33 (1):1-15. Epub 1900 01 01.

Effect of caffeine on gamma-ray induced G2 arrest in well-synchronized Chinese hamster ovary cells in vitro.

Masunaga S, Keng PC

Radiation medicine.. 1996 14 (6):309-13. Epub 1900 01 01.

Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status.

Little JB, Nagasawa H, Keng PC, Yu Y, Li CY

The Journal of biological chemistry.. 1995 May 12270 (19):11033-6. Epub 1900 01 01.

In vitro radiation sensitivity of mouse lung fibroblasts isolated by flow cytometry.

Keng PC, Phipps R, Penney DP

International journal of radiation oncology, biology, physics.. 1995 February 131 (3):519-23. Epub 1900 01 01.

Relationship between gamma-ray-induced G2/M delay and cellular radiosensitivity.

Nagasawa H, Keng P, Harley R, Dahlberg W, Little JB

International journal of radiation biology.. 1994 October 66 (4):373-9. Epub 1900 01 01.

Effects of GM-CSF on Ki67 expression and cell cycle traverse in acute myelogenous leukemia specimens and cell lines.

Liesveld JL, Keng PC, Rowe JM, DiPersio JF, Abboud CN

Leukemia research.. 1994 August 18 (8):609-16. Epub 1900 01 01.

Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats.

Grota LJ, Reiter RJ, Keng P, Michaelson S

Bioelectromagnetics.. 1994 15 (5):427-37. Epub 1900 01 01.

Combined Betaseron R (recombinant human interferon beta) and radiation for inoperable non-small cell lung cancer.

McDonald S, Chang AY, Rubin P, Wallenberg J, Kim IS, Sobel S, Smith J, Keng P, Muhs A

International journal of radiation oncology, biology, physics.. 1993 October 2027 (3):613-9. Epub 1900 01 01.

Reduction of radiation cytotoxicity by human apurinic endonuclease in a radiation-sensitive Escherichia coli mutant.

Chen DS, Law C, Keng P

Radiation research.. 1993 September 135 (3):405-10. Epub 1900 01 01.

A "trans-acting" factor for activation of transcription is defective in the xrs-5 mutant of the Chinese hamster ovary cell line.

Zhu W, Kriajevskaia M, Keng PC, Chou WG

Mutation research.. 1993 August 294 (2):101-8. Epub 1900 01 01.

Oncogene elements within an endogenous retrovirus.

Whartenby KA. Insel RA. Freeman SM. Keng P. Abraham GN.

Acta Virologica. 37(2-3):113-22, 1993 Apr-Jun. 1993; 37(2-3): 113-22.

Reduction of radiation cytotoxicity by human apurinic endonuclease in a radiation-sensitive Escherichia coli mutant.

Chen DS. Law C. Keng P.

Radiation Research. 135(3):405-10, 1993 Sep. 1993; 135(3): 405-10.

Oncogene elements within an endogenous retrovirus.

Whartenby KA, Insel RA, Freeman SM, Keng P, Abraham GN

Acta virologica. 1993 37 (2-3):113-22. Epub 1900 01 01.

Differential gene expression in wild-type and X-ray-sensitive mutants of Chinese hamster ovary cell lines.

Zhu W, Keng PC, Chou WG

Mutation research.. 1992 September 274 (3):237-45. Epub 1900 01 01.

Differential collagen and fibronectin production by Thy 1+ and Thy 1- lung fibroblast subpopulations.

Derdak S, Penney DP, Keng P, Felch ME, Brown D, Phipps RP

The American journal of physiology.. 1992 August 263 (2 Pt 1):L283-90. Epub 1900 01 01.

Activity of etoposide (VP-16) and teniposide (VM-26) in exponential and plateau phase human tumor cell cultures.

Chapuis JC, Keng PC, Siemann DW

Anti-cancer drugs.. 1992 June 3 (3):245-52. Epub 1900 01 01.

Centrifugal elutriation of large fragile cells: isolation of RNA from fixed embryonic blastomeres.

Nasir A, Reynolds SD, Keng PC, Angerer LM, Angerer RC

Analytical biochemistry.. 1992 May 15203 (1):22-6. Epub 1900 01 01.

Morphologic and functional characteristics of subpopulations of murine lung fibroblasts grown in vitro.

Penney DP, Keng PC, Derdak S, Phipps RP

The Anatomical record.. 1992 March 232 (3):432-43. Epub 1900 01 01.

Interleukin 1 alpha stimulates hemopoiesis but not tumor cell proliferation and protects mice from lethal total body irradiation.

Constine LS, Harwell S, Keng P, Lee F, Rubin P, Siemann D

International journal of radiation oncology, biology, physics.. 1991 March 20 (3):447-56. Epub 1900 01 01.

Activity of etoposide (VP-16) in human tumor cells under different growth conditions.

Chapuis JC, Keng PC, Siemann DW

International journal of radiation oncology, biology, physics.. 1991 February 20 (2):373-5. Epub 1900 01 01.

Differentiation patterns in two- and three-dimensional culture systems of human squamous carcinoma cell lines.

Knuechel R, Keng P, Hofstaedter F, Langmuir V, Sutherland RM, Penney DP

The American journal of pathology.. 1990 September 137 (3):725-36. Epub 1900 01 01.

Differential expression of interleukin 1 alpha by Thy-1+ and Thy-1- lung fibroblast subpopulations: enhancement of interleukin 1 alpha production by tumor necrosis factor-alpha.

Phipps RP, Baecher C, Frelinger JG, Penney DP, Keng P, Brown D

European journal of immunology.. 1990 August 20 (8):1723-7. Epub 1900 01 01.

Evaluation of cell subpopulations isolated from human tumor xenografts by centrifugal elutriation.

Keng PC, Allalunis-Turner J, Siemann DW

International journal of radiation oncology, biology, physics.. 1990 May 18 (5):1061-7. Epub 1900 01 01.

Erratum: Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia.

Wilson RE, Keng PC, Sutherland RM

Journal of the National Cancer Institute.. 1990 February 782 (3):239. Epub 1900 01 01.

Changes in growth characteristics and macromolecular synthesis on recovery from severe hypoxia.

Wilson RE, Keng PC, Sutherland RM

British journal of cancer.. 1990 January 61 (1):14-21. Epub 1900 01 01.

Lymphocytic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor.

Loeffler DA. Keng PC. Baggs RB. Lord EM.

International Journal of Cancer. 1990; 45(3): 462-7.

[Proliferation-associated antigens PCNA and Ki-67 in two- and three-dimensional experimental systems of human squamous epithelial carcinomas].

Knüchel R, Hofstaedter F, Sutherland RM, Keng PC

Verhandlungen der Deutschen Gesellschaft für Pathologie. 1990 74 :275-8. Epub 1900 01 01.

Immune functions of subpopulations of lung fibroblasts.

Phipps RP, Penney DP, Keng P, Silvera M, Harkins S, Derdak S

Immunologic research.. 1990 9 (4):275-86. Epub 1900 01 01.

Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia.

Wilson RE, Keng PC, Sutherland RM

Journal of the National Cancer Institute.. 1989 August 1681 (16):1235-40. Epub 1900 01 01.

Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle.

Liu YC, Marraccino RL, Keng PC, Bambara RA, Lord EM, Chou WG, Zain SB

Biochemistry.. 1989 April 428 (7):2967-74. Epub 1900 01 01.

Radiation-induced DNA damage and repair in quiescent and proliferating human tumor cells in vitro.

Wilson KM, Keng PC

International journal of radiation biology.. 1989 March 55 (3):385-95. Epub 1900 01 01.

Early identification and retrieval or deletion of human lymphocyte subpopulations responding to influenza virus or respiratory syncytial virus challenge.

Domurat FM. Keng P. Mock DJ. Roberts NJ Jr.

Cell Biophysics. 15(3):173-88, 1989 Dec. 1989; 15(3): 173-88.

Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHC.

Phipps RP. Penney DP. Keng P. Quill H. Paxhia A. Derdak S. Felch ME.

American Journal of Respiratory Cell & Molecular Biology. 1989; 1(1): 65-74.

Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (II). Cell sorting.

Siemann DW, Keng PC

British journal of cancer.. 1988 September 58 (3):296-300. Epub 1900 01 01.

Glutathione contents in human and rodent tumor cells in various phases of the cell cycle.

Lee FY, Siemann DW, Allalunis-Turner MJ, Keng PC

Cancer research.. 1988 July 148 (13):3661-5. Epub 1900 01 01.

Stabilization of myc proto-oncogene proteins during Friend murine erythroleukemia cell differentiation.

Wingrove TG, Watt R, Keng P, Macara IG

The Journal of biological chemistry.. 1988 June 25263 (18):8918-24. Epub 1900 01 01.

Growth phase related variation in the radiation sensitivity of human colon adenocarcinoma cells.

West CM, Keng PC, Sutherland RM

International journal of radiation oncology, biology, physics.. 1988 June 14 (6):1213-9. Epub 1900 01 01.

Effects of bleomycins on synchronized cells by centrifugal elutriation.

Wu DZ, Keng P

Zhongguo yao li xue bao = Acta pharmacologica Sinica.. 1988 March 9 (2):170-4. Epub 1900 01 01.

Analysis of human tumor cell kinetics using anti BrdUrd antibody and flow cytometry

Keng, P.C.,.

Proceedings of the Third Symposium on Recent Advances in Biological and Medical Sciences, Academia Sinica. 1988; 18: 32-43.

Responses of tumor cell subpopulations to single modality and combined modality therapies.

Siemann DW, Keng PC

NCI monographs : a publication of the National Cancer

Human choriocarcinoma (JAr) cells grown as multicellular spheroids.

White TE, Saltzman RA, Di Sant'Agnese PA, Keng PC, Sutherland RM, Miller RK

Placenta.. 1988 9 (6):583-98. Epub 1900 01 01.

Separation of spontaneously differentiating and cell cycle-specific populations of HL-60 cells.

Palis J, King B, Keng P

Leukemia research.. 1988 12 (4):339-44. Epub 1900 01 01.

Cell cycle dependent activities of DNA polymerases alpha and delta in Chinese hamster ovary cells.

Marraccino RL, Wahl AF, Keng PC, Lord EM, Bambara RA

Biochemistry.. 1987 December 126 (24):7864-70. Epub 1900 01 01.

Comparison of fluorescence intensity of Hoechst 33342-stained EMT6 tumour cells and tumour-infiltrating host cells.

Loeffler DA, Keng PC, Wilson KM, Lord EM

British journal of cancer.. 1987 November 56 (5):571-6. Epub 1900 01 01.

Characterization of radiation sensitivity of human squamous carcinoma A431 cells.

Ng CE, Keng PC, Sutherland RM

British journal of cancer.. 1987 September 56 (3):301-7. Epub 1900 01 01.

Interactions of dimethyl sulfoxide and granulocyte-macrophage colony-stimulating factors on the growth and maturation of HL-60 cells.

Brennan JK, Lee KS, Abboud CN, Erickson-Miller CL, Keng PC

Journal of cellular physiology.. 1987 August 132 (2):246-54. Epub 1900 01 01.

A human colon adenocarcinoma xenograft--radiation response, cellular composition, and tumor disaggregation.

West CM, Keng PC, Siemann DW, Sutherland RM

Journal of the National Cancer Institute.. 1987 February 78 (2):371-6. Epub 1900 01 01.

Macrophages are required for influenza virus infection of human lymphocytes.

Mock DJ, Domurat F, Roberts NJ, Walsh EE, Licht MR, Keng P

The Journal of clinical investigation.. 1987 February 79 (2):620-4. Epub 1900 01 01.

Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (I). Centrifugal elutriation.

Siemann DW, Keng PC

British journal of cancer.. 1987 January 55 (1):33-6. Epub 1900 01 01.

Macrophages are required for influenza virus infection of human lymphocytes.

Mock DJ. Domurat F. Roberts NJ Jr. Walsh EE. Licht MR. Keng P.

Journal of Clinical Investigation. 79(2):620-4, 1987 Feb. 1987; 79(2): 620-4.

Effects of heavy ions on rabbit tissues: induction of DNA strand breaks in retinal photoreceptor cells by high doses of radiation.

Lett JT. Keng PC. Bergtold DS. Howard J.

Radiation & Environmental Biophysics. 1987; 26(1): 23-36.

Use of flow cytometry in the measurement of cell mitotic cycle.

Keng PC

International journal of cell cloning.. 1986 September 4 (5):295-311. Epub 1900 01 01.

Lymphoma models for B cell activation and tolerance. III. Cell cycle dependence for negative signalling of WEHI-231 B lymphoma cells by anti-mu.

Scott DW, Livnat D, Pennell CA, Keng P

The Journal of experimental medicine.. 1986 July 1164 (1):156-64. Epub 1900 01 01.

Cell cycle specific toxicity of the Hoechst 33342 stain in untreated or irradiated murine tumor cells.

Siemann DW, Keng PC

Cancer research.. 1986 July 46 (7):3556-9. Epub 1900 01 01.

Radiation response of proliferating and quiescent subpopulations isolated from multicellular spheroids.

Luk CK, Keng PC, Sutherland RM

British journal of cancer.. 1986 July 54 (1):25-32. Epub 1900 01 01.

Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate.

Bodenner DL, Dedon PC, Keng PC, Katz JC, Borch RF

Cancer research.. 1986 June 46 (6):2751-5. Epub 1900 01 01.

Survival characteristics of normal differentiated rat thyroid cells maintained in vitro.

Brosing JW, Keng PC, Mulcahy RT

Radiation research.. 1986 February 105 (2):138-46. Epub 1900 01 01.

Density distributions of human squamous carcinoma cells: influence of growth conditions, proliferative status and DNA content.

Ng CE. Keng PC. Sutherland RM.

International Journal of Cancer. 1986; 38(3): 413-8.

Effects of LET infinity on the fate of DNA damage induced in rabbit sensory cells in situ: fundamental aspects.

Lett JT, Bertold DS, Keng PC

Basic life sciences.. 1986 38 :139-50. Epub 1900 01 01.

The interaction between bleomycin and radiation on cell survival and DNA damage in mammalian cell cultures.

Wu DZ, Zhang YQ, Keng P, Sutherland RM, Lasagna L

International journal of radiation oncology, biology, physics.. 1985 December 11 (12):2125-31. Epub 1900 01 01.

Lymphoma models for B-cell activation and tolerance. II. Growth inhibition by anti-mu of WEHI-231 and the selection and properties of resistant mutants.

Scott DW, Tuttle J, Livnat D, Haynes W, Cogswell JP, Keng P

Cellular immunology.. 1985 June 93 (1):124-31. Epub 1900 01 01.

Regrowth and radiation sensitivity of quiescent cells isolated from EMT6/Ro-fed plateau monolayers.

Luk CK, Keng PC, Sutherland RM

Cancer research.. 1985 March 45 (3):1020-5. Epub 1900 01 01.

In vivo interaction between radiation and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the absence or presence of misonidazole in mice.

Siemann DW, Maddison K, Wolf K, Hill SA, Keng PC

Cancer research.. 1985 January 45 (1):198-202. Epub 1900 01 01.

Characterization of the biophysical properties of human tumor and bone marrow cells as a preliminary step to the use of centrifugal elutriation in autologous bone marrow transplantation.

Keng PC, Rubin P, Constine LS, Frantz C, Nakissa N, Gregory P

International journal of radiation oncology, biology, physics.. 1984 October 10 (10):1913-22. Epub 1900 01 01.

Comparison of tumour age response to radiation for cells derived from tissue culture or solid tumours.

Keng PC, Siemann DW, Wheeler KT

British journal of cancer.. 1984 October 50 (4):519-26. Epub 1900 01 01.

In situ radiation response and oxygen enhancement ratio of KHT sarcoma cells in various phases of the cell cycle.

Siemann DW, Keng PC

The British journal of radiology.. 1984 September 57 (682):823-7. Epub 1900 01 01.

Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO.

Hill SA, Keng PC, Siemann DW

International journal of radiation oncology, biology, physics.. 1984 September 10 (9):1615-8. Epub 1900 01 01.

The effect in the KHT sarcoma of CCNU and MISO on cell cycle progression evaluated by flow-cytometry.

Hill SA, Bauer KD, Keng PC, Siemann DW

International journal of radiation oncology, biology, physics.. 1984 September 10 (9):1619-22. Epub 1900 01 01.

Methods for using centrifugal elutriation to separate malignant and lymphoid cell populations.

Lord EM, Keng PC

Journal of immunological methods.. 1984 March 3068 (1-2):147-55. Epub 1900 01 01.

Further evidence that the survival of irradiated mammalian cells is controlled by temporal processes.

Lett JT, Bergtold DS, Cox AB, Keng PC, Okayasu R

The British journal of cancer. Supplement.. 1984 6 :163-8. Epub 1900 01 01.

Effects of heavy ions on rabbit tissues: analysis of low levels of DNA damage in retinal photoreceptor cells.

Keng PC. Bergtold DS. Lett JT.

International Journal of Radiation Biology & Related Studies in Physics, Chemistry & Medicine. 1983; 43(3): 219-29.

Inhibition of cell growth in synchronous human hypernephroma cells by recombinant interferon alpha-D and irradiation.

Chang AY, Keng PC

Journal of interferon research. 1983 3 (4):379-85. Epub 1900 01 01.

Isolation of quiescent cells from multicellular tumor spheroids using centrifugal elutriation.

Bauer KD, Keng PC, Sutherland RM

Cancer research.. 1982 January 42 (1):72-8. Epub 1900 01 01.

Effects of heavy ions on rabbit tissues: damage to the forebrain.

Cox AB. Keng PC. Lee AC. Lett JT.

International Journal of Radiation Biology & Related Studies in Physics, Chemistry & Medicine. 1982; 42(4): 355-67.

Effects of heavy ions on rabbit tissues: cataractogenesis.

Keng PC. Lee AC. Cox AB. Bergtold DS. Lett JT.

International Journal of Radiation Biology & Related Studies in Physics, Chemistry & Medicine. 1982; 41(2): 127-37.

In vitro hypoxic cytotoxicity of nitroimidazoles: uptake and cell cycle phase specificity.

Sutherland RM, Keng P, Conroy PJ, McDermott D, Bareham BJ, Passalacqua W

International journal of radiation oncology, biology, physics.. 1982 8 (3-4):745-8. Epub 1900 01 01.

The separation of a mixture of bone marrow stem cells from tumor cells: an essential step for autologous bone marrow transplantation.

Rubin P, Wheeler KT, Keng PC, Gregory PK, Croizat H

International journal of radiation oncology, biology, physics.. 1981 October 7 (10):1405-11. Epub 1900 01 01.

Direct synchronization of cells from solid tumors by centrifugal elutriation.

Keng PC, Wheeler KT, Siemann DW, Lord EM

Experimental cell research.. 1981 July 134 (1):15-22. Epub 1900 01 01.

Cell subpopulations dispersed from solid tumours and separated by centrifugal elutriation.

Siemann DW, Lord EM, Keng PC, Wheeler KT

British journal of cancer.. 1981 July 44 (1):100-8. Epub 1900 01 01.

Characterization of the separation properties of the Beckman elutriator system.

Keng PC, Li CK, Wheeler KT

Cell biophysics. 1981 March 3 (1):41-56. Epub 1900 01 01.

Effects of heavy ions on rabbit tissues: alopecia.

Cox AB. Keng PC. Glass NL. Lett JT.

International Journal of Radiation Biology & Related Studies in Physics, Chemistry & Medicine. 1981; 40(6): 645-57.

Effects of heavy ions on rabbit tissues: loss of electroretinogram and DNA repair in retinal photoreceptor cells.

Keng PC. Lett JT.

International Journal of Radiation Biology & Related Studies in Physics, Chemistry & Medicine. 1981; 39(6): 655-64.

Synchronization of 9L rat brain tumor cells by centrifugal elutriation.

Keng PC, Li CK, Wheeler KT

Cell biophysics. 1980 September 2 (3):191-206. Epub 1900 01 01.

Radiation response of synchronized 9L rat brain tumor cells separated by centrifugal elutriation.

Keng PC, Wheeler KT

Radiation research.. 1980 September 83 (3):633-43. Epub 1900 01 01.

Late degeneration in rabbit tissues after irradiation by heavy ions.

Lett JT. Cox AB. Keng PC. Lee AC. Su CM. Bergtold DS.

Life Sciences & Space Research. 1980; 18: 131-42.

DNA Damage and Repair in Nondividing Cells. In P.C. Hanawalt, E.C. Freidberg, and C.F. Fox (eds.),

Lett, J.T., Keng, P.C. and Sun, C.,.

DNA Repair Mechanism, Academic Press, New York. 1978; : 481-4.

Books

Cell Cycle: Materials and Methods (1995)

Chapter: Centrifugal Elutriation

Authors: Marraccino, R.; Keng, PC.

Publisher: Springer-Verlag Press, Germany 1995

Pulmonary Fibroblast Heterogeneity (1992)

Chapter: Morphologic and Functional Characteristics of Subpopulations of Murine Lung Fibroblasts Grown In Vitro.

Authors: Penney, DP.; Phipps, R.; Keng, PC., and Maltby, K.

Publisher: CRC Press 1992

Synergism and Antagonism in Chemotherapy (1991)

Chapter: Synergistic Interactions at the Solid Tumor Level through Targeting of Therapies against Two or More Different Tumor Cell Subpopulations.

Authors: Siemann, DW.; Keng, PC.

Publisher: Academic Press, New York 1991

Cell Separation Science and Technology (1991)

Chapter: High Capacity Separation of Homogeneous Cell Subpopulations by Centrifugal Elutriation

Authors: Keng, PC.

Publisher: Academic Press, New York 1991

Cell Separation Methods and Selected Applications (1987)

Chapter: Separation of Malignant Cells from Host Cells Using Centrifugal Elutriation

Authors: Keng, PC.; Siemann, DW.; Lord, EM.

Publisher: Academic Press, New York 1987

Life Sciences and Space Research (1980)

Chapter: Late Degeneration in Rabbit Tissues after Irradiation by Heavy Ions.

Authors: Lett, JT.; Cox, AB.; Keng, PC.; Lee, AC., Su, CM.; Bergtold, DS.

Publisher: Pergamon Press, Oxford 1980

DNA Repair Mechanism (1978)

Chapter: DNA Damage and Repair in Nondividing Cells

Authors: Lett, JT.; Keng, PC.; Sun, C.

Publisher: Academic Press, New York 1978