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Jennifer Jonason, Ph.D.

Jennifer Jonason, Ph.D.

About Me

Faculty Appointments

Research Associate Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Credentials

Post-doctoral Training & Residency

Post-doctoral Fellowship | Center for Musculoskeletal Research, University of Rochester | Mentor: Regis O'Keefe 2007 - 2011

Education

PhD | Yale University. Genetics. 2006

BS | Otterbein College. Molecular Biology. 1999

Awards

Young Investigator Travel Award. 2011

Forum on Metabolic Bone Disease Travel Award. 2008

National Research Service Award. 2007 - 2010

Outstanding Honor's Thesis. 1999

Outstanding Senior Research Project. 1999

Mortar Board National College Senior Honor Society. 1998 - 1999

Otterbein Scholar Award. 1995 - 1999

Endowed Scholar Award. 1995 - 1999

Research

The Jonason laboratory is interested in the signaling mechanisms that govern mesenchymal stem cell differentiation as well as maturation of committed chondrocytes and osteoblasts during skeletal development. Additionally, we have a strong interest in those mechanisms that function to maintain artic...
The Jonason laboratory is interested in the signaling mechanisms that govern mesenchymal stem cell differentiation as well as maturation of committed chondrocytes and osteoblasts during skeletal development. Additionally, we have a strong interest in those mechanisms that function to maintain articular chondrocytes and the integrity of the articular cartilage matrix. We combine in vivo genetic mouse models with in vitro tissue culture and molecular biology techniques to better understand the role of specific signaling pathways and transcription factors in regulation of bone and joint development as well as in the onset and progression of osteoarthritis.

Publications

Journal Articles

NF-?B activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival.

Best KT, Nichols AEC, Knapp E, Hammert WC, Ketonis C, Jonason JH, Awad HA, Loiselle AE

Science signaling.. 2020 November 1713 (658)Epub 11/17/2020.

Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice.

Catheline SE, Hoak D, Chang M, Ketz JP, Hilton MJ, Zuscik MJ, Jonason JH

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2019 September 34 (9):1676-1689. Epub 06/12/2019.

Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.

Feigenson M, Jonason JH, Shen J, Loiselle AE, Awad HA, O'Keefe RJ

Annals of biomedical engineering.. 2019 April 12 Epub 04/12/2019.

Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice.

Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2018 May 110 :150-159. Epub 02/03/2018.

Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2014 May 62 :79-89. Epub 02/12/2014.

Isolation and culture of neonatal mouse calvarial osteoblasts.

Jonason JH, O'Keefe RJ

Methods in molecular biology.. 2014 1130 :295-305. Epub 1900 01 01.

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH

Journal of cell science.. 2013 December 15126 (Pt 24):5704-13. Epub 10/21/2013.

The role of muscle in bone repair: the cells, signals, and tissue responses to injury.

Shah K, Majeed Z, Jonason J, O'Keefe RJ

Current osteoporosis reports.. 2013 June 11 (2):130-5. Epub 1900 01 01.

Cartilage-specific ?-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development.

Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 August 27 (8):1680-94. Epub 1900 01 01.

TRIP-1: a regulator of osteoblast function.

Metz-Estrella D, Jonason JH, Sheu TJ, Mroczek-Johnston RM, Puzas JE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 July 27 (7):1576-84. Epub 1900 01 01.

EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair.

Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 April 26 (4):792-802. Epub 1900 01 01.

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.

Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2010 August 25 (8):1784-97. Epub 1900 01 01.

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ

Arthritis and rheumatism.. 2010 August 62 (8):2359-69. Epub 1900 01 01.

Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice.

Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D

Journal of cell science.. 2009 October 1122 (Pt 19):3566-78. Epub 09/08/2009.

Post-translational Regulation of Runx2 in Bone and Cartilage.

Jonason JH, Xiao G, Zhang M, Xing L, Chen D

Journal of dental research.. 2009 August 88 (8):693-703. Epub 1900 01 01.

PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation.

Zhang M, Xie R, Hou W, Wang B, Shen R, Wang X, Wang Q, Zhu T, Jonason JH, Chen D

Journal of cell science.. 2009 May 1122 (Pt 9):1382-9. Epub 04/07/2009.

Regulation of SCF(SKP2) ubiquitin E3 ligase assembly and p27(KIP1) proteolysis by the PTEN pathway and cyclin D1.

Jonason JH, Gavrilova N, Wu M, Zhang H, Sun H

Cell cycle.. 2007 April 156 (8):951-61. Epub 04/05/2007.

p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.

Hulit J, Lee RJ, Li Z, Wang C, Katiyar S, Yang J, Quong AA, Wu K, Albanese C, Russell R, Di Vizio D, Koff A, Thummala S, Zhang H, Harrell J, Sun H, Muller WJ, Inghirami G, Lisanti MP, Pestell RG

Cancer research.. 2006 September 166 (17):8529-41. Epub 1900 01 01.

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.

Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, Lykke-Andersen K, Wei N, Sun H, Kobayashi R, Zhang H

Molecular cell.. 2002 December 10 (6):1519-26. Epub 1900 01 01.