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Scott Earley, Ph.D.

Scott Earley, Ph.D.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Professor - Department of Pharmacology and Physiology (SMD)

Publications

Journal Articles

TRPM4 Couples Mechanical Force to Myogenic Constriction Throughout the Resistance Vasculature.

Zhu W, Sanchez-Solano A, Lavanderos B, Pan S, Feng Earley Y, Earley S

bioRxiv : the preprint server for biology.. 2026 June 11 Epub 06/11/2026.

Guidelines for evaluating endothelial function in vascular tissue.

McCarthy CG, Aalkjær C, Bagher P, Beyer AM, Boedtkjer E, Bomfim GF, Breslin JW, Briones AM, Castorena-Gonzalez JA, Costa TJ, Dai Z, Davel AP, Earley S, Freed JK, Garland C, Isakson BE, Jepps TA, Kalucka J, Lavanderos B, Makino A, Norton CE, Segal SS, Tan W, Trask AJ, Wilson C, Zawieja SD, Wenceslau CF

American journal of physiology. Heart and circulatory physiology.. 2026 May 1330 (5):H1600-H1672. Epub 03/09/2026.

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model.

Santana LF, Earley S

The Journal of physiology.. 2026 January 29 Epub 01/29/2026.

Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels.

Davis MJ, Kim HJ, Li M, Castorena-Gonzalez JA, Pal S, Domeier TL, Scallan JP, Earley S, Zawieja SD

bioRxiv : the preprint server for biology.. 2025 October 7 Epub 10/07/2025.

Pericytes under pressure: TRPC3 channels as gatekeepers of capillary flow.

Earley S

Science signaling.. 2025 April 2918 (884):eadw7185. Epub 04/29/2025.

Understanding Vascular Reactivity.

Navedo MF, Earley S, Isakson BE

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2025 April 32 (3):e70008. Epub 1900 01 01.

Mitochondrial Small RNA Alterations Associated with Increased Lysosome Activity in an Alzheimer's Disease Mouse Model Uncovered by PANDORA-seq.

Zhang X, Shi J, Thakore P, Gonzales AL, Earley S, Chen Q, Zhou T, Feng Earley Y

International journal of molecular sciences.. 2025 March 2626 (7)Epub 03/26/2025.

Shocking insights for neurovascular coupling: Electrical signals ignite calcium dynamics in brain capillaries.

Lavanderos B, Saldias MP, Earley S

Cell calcium.. 2025 March 126 :103001. Epub 02/01/2025.

Transient Receptor Potential Channels in Vascular Mechanotransduction.

Solano AS, Lavanderos B, Metwally E, Earley S

American journal of hypertension.. 2025 February 1838 (3):151-160. Epub 1900 01 01.

Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome.

Metwally E, Sanchez Solano A, Lavanderos B, Yamasaki E, Thakore P, McClenaghan C, Rios N, Radi R, Feng Earley Y, Nichols CG, Earley S

JCI insight.. 2024 August 19 (17)Epub 08/01/2024.

Impaired intracellular Ca signaling contributes to age-related cerebral small vessel disease in mutant mice.

Yamasaki E, Thakore P, Ali S, Sanchez Solano A, Wang X, Gao X, Labelle-Dumais C, Chaumeil MM, Gould DB, Earley S

Science signaling.. 2023 November 1416 (811):eadi3966. Epub 11/14/2023.

ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle.

Akin EJ, Aoun J, Jimenez C, Mayne K, Baeck J, Young MD, Sullivan B, Sanders KM, Ward SM, Bulley S, Jaggar JH, Earley S, Greenwood IA, Leblanc N

The Journal of general physiology.. 2023 November 6155 (11)Epub 09/13/2023.

PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease.

Thakore P, Yamasaki E, Ali S, Sanchez Solano A, Labelle-Dumais C, Gao X, Chaumeil MM, Gould DB, Earley S

Proceedings of the National Academy of Sciences of the United States of America.. 2023 August 29120 (35):e2306479120. Epub 08/22/2023.

Vascular mechanotransduction.

Davis MJ, Earley S, Li YS, Chien S

Physiological reviews.. 2023 April 1103 (2):1247-1421. Epub 01/05/2023.

PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease.

Thakore P, Yamasaki E, Ali S, Solano AS, Labelle-Dumais C, Gao X, Chaumeil MM, Gould DB, Earley S

bioRxiv : the preprint server for biology.. 2023 March 6 Epub 03/06/2023.

Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome.

Yamasaki E, Ali S, Sanchez Solano A, Thakore P, Smith M, Wang X, Labelle-Dumais C, Gould DB, Earley S

Proceedings of the National Academy of Sciences of the United States of America.. 2023 January 31120 (5):e2217327120. Epub 01/24/2023.

Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.

Sullivan MN, Thakore P, Krishnan V, Alphonsa S, Li W, Feng Earley Y, Earley S

Frontiers in molecular biosciences.. 2023 10 :1129435. Epub 01/30/2023.

STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma.

Thakore P, Earley S

Cell calcium.. 2022 June 104 :102589. Epub 04/09/2022.

The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021.

Earley S, Santana LF, Lederer WJ

Physiological reviews.. 2022 April 1102 (2):1153-1158. Epub 02/07/2022.

Reply to De Mey et al.

Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, Webb RC

American journal of physiology. Heart and circulatory physiology.. 2022 April 1322 (4):H683-H684. Epub 1900 01 01.

Reply to Boedtkjer and Aalkjaer.

Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, Webb RC

American journal of physiology. Heart and circulatory physiology.. 2022 April 1322 (4):H687-H688. Epub 1900 01 01.

STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells.

Krishnan V, Ali S, Gonzales AL, Thakore P, Griffin CS, Yamasaki E, Alvarado MG, Johnson MT, Trebak M, Earley S

eLife.. 2022 February 1111 Epub 02/11/2022.

Guidelines for the measurement of vascular function and structure in isolated arteries and veins.

Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, Webb RC

American journal of physiology. Heart and circulatory physiology.. 2021 July 1321 (1):H77-H111. Epub 05/14/2021.

PIP as the "coin of the realm" for neurovascular coupling.

Earley S, Kleinfeld D

Proceedings of the National Academy of Sciences of the United States of America.. 2021 May 25118 (21)Epub 1900 01 01.

Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function.

Alvarado MG, Thakore P, Earley S

Cells.. 2021 May 1110 (5)Epub 05/11/2021.

Brain endothelial cell TRPA1 channels initiate neurovascular coupling.

Thakore P, Alvarado MG, Ali S, Mughal A, Pires PW, Yamasaki E, Pritchard HA, Isakson BE, Tran CHT, Earley S

eLife.. 2021 February 2610 Epub 02/26/2021.

Nitric Oxide Signals Through IRAG to Inhibit TRPM4 Channels and Dilate Cerebral Arteries.

Ali S, Solano AS, Gonzales AL, Thakore P, Krishnan V, Yamasaki E, Earley S

Function.. 2021 2 (6):zqab051. Epub 10/09/2021.

Metabolic Control of Cardiac Pacemaking.

Earley S, Lederer WJ

Function.. 2021 2 (5):zqab043. Epub 08/23/2021.

The intracellular Ca release channel TRPML1 regulates lower urinary tract smooth muscle contractility.

Griffin CS, Alvarado MG, Yamasaki E, Drumm BT, Krishnan V, Ali S, Nagle EM, Sanders KM, Earley S

Proceedings of the National Academy of Sciences of the United States of America.. 2020 December 1117 (48):30775-30786. Epub 11/16/2020.

TRPML1 channels initiate Ca sparks in vascular smooth muscle cells.

Thakore P, Pritchard HAT, Griffin CS, Yamasaki E, Drumm BT, Lane C, Sanders KM, Feng Earley Y, Earley S

Science signaling.. 2020 June 2313 (637)Epub 06/23/2020.

Differential expression of angiotensin II type 1 receptor subtypes within the cerebral microvasculature.

Yamasaki E, Thakore P, Krishnan V, Earley S

American journal of physiology. Heart and circulatory physiology.. 2020 February 1318 (2):H461-H469. Epub 12/30/2019.

Regulation of vascular tone by transient receptor potential ankyrin 1 channels.

Thakore P, Ali S, Earley S

Current topics in membranes.. 2020 85 :119-150. Epub 02/29/2020.

Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility.

Pritchard HAT, Griffin CS, Yamasaki E, Thakore P, Lane C, Greenstein AS, Earley S

Proceedings of the National Academy of Sciences of the United States of America.. 2019 October 22116 (43):21874-21881. Epub 10/07/2019.

Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling.

Thakore P, Earley S

Comprehensive physiology.. 2019 June 129 (3):1249-1277. Epub 06/12/2019.

Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy.

Pritchard HAT, Pires PW, Yamasaki E, Thakore P, Earley S

Proceedings of the National Academy of Sciences of the United States of America.. 2018 October 9115 (41):E9745-E9752. Epub 09/04/2018.

Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke.

Pires PW, Earley S

eLife.. 2018 September 217 Epub 09/21/2018.

SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract.

Zheng H, Drumm BT, Earley S, Sung TS, Koh SD, Sanders KM

Science signaling.. 2018 June 1211 (534)Epub 06/12/2018.

Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system.

Peng H, Jensen DD, Li W, Sullivan MN, Buller SA, Worker CJ, Cooper SG, Zheng S, Earley S, Sigmund CD, Feng Y

American journal of physiology. Heart and circulatory physiology.. 2018 March 1314 (3):H580-H592. Epub 12/15/2017.

Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility.

Pritchard HAT, Gonzales AL, Pires PW, Drumm BT, Ko EA, Sanders KM, Hennig GW, Earley S

Science signaling.. 2017 September 1910 (497)Epub 09/19/2017.

The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells.

Pires PW, Ko EA, Pritchard HAT, Rudokas M, Yamasaki E, Earley S

The Journal of physiology.. 2017 July 15595 (14):4735-4753. Epub 06/01/2017.

Redox regulation of transient receptor potential channels in the endothelium.

Pires PW, Earley S

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2017 April 24 (3)Epub 1900 01 01.

Isolation and Cannulation of Cerebral Parenchymal Arterioles.

Pires PW, Dabertrand F, Earley S

Journal of visualized experiments : JoVE.. 2016 May 23 (111)Epub 05/23/2016.

No Static at All: Tuning Into the Complexities of Ca2+ Signaling in the Endothelium.

Pires PW, Earley S

Circulation research.. 2016 April 1118 (7):1042-4. Epub 1900 01 01.

A TRPC3 signalling complex promotes cerebral artery remodelling during hypertension.

Pires PW, Earley S

Cardiovascular research.. 2016 January 1109 (1):4-5. Epub 11/27/2015.

Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles.

Pires PW, Sullivan MN, Pritchard HA, Robinson JJ, Earley S

American journal of physiology. Heart and circulatory physiology.. 2015 December 15309 (12):H2031-41. Epub 10/09/2015.

Transient receptor potential channels in the vasculature.

Earley S, Brayden JE

Physiological reviews.. 2015 April 95 (2):645-90. Epub 1900 01 01.

TRPs in the kidney - location, location, location.

Pires PW, Earley S

Acta physiologica. 2015 February 213 (2):296-7. Epub 10/18/2014.

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation.

Sullivan MN, Gonzales AL, Pires PW, Bruhl A, Leo MD, Li W, Oulidi A, Boop FA, Feng Y, Jaggar JH, Welsh DG, Earley S

Science signaling.. 2015 January 68 (358):ra2. Epub 01/06/2015.

Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries.

Harraz OF, Abd El-Rahman RR, Bigdely-Shamloo K, Wilson SM, Brett SE, Romero M, Gonzales AL, Earley S, Vigmond EJ, Nygren A, Menon BK, Mufti RE, Watson T, Starreveld Y, Furstenhaupt T, Muellerleile PR, Kurjiaka DT, Kyle BD, Braun AP, Welsh DG

Circulation research.. 2014 September 12115 (7):650-61. Epub 08/01/2014.

Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferation.

Zhao L, Sullivan MN, Chase M, Gonzales AL, Earley S

American journal of respiratory cell and molecular biology.. 2014 June 50 (6):1064-75. Epub 1900 01 01.

A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries.

Gonzales AL, Yang Y, Sullivan MN, Sanders L, Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S

Science signaling.. 2014 May 277 (327):ra49. Epub 05/27/2014.

Endothelial control of vasodilation: integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids.

Ellinsworth DC, Earley S, Murphy TV, Sandow SL

Pflu?gers Archiv : European journal of physiology.. 2014 March 466 (3):389-405. Epub 06/08/2013.

Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension.

Li W, Peng H, Mehaffey EP, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A, Feng Y

Hypertension.. 2014 February 63 (2):316-23. Epub 11/18/2013.

Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes.

Streifel KM, Gonzales AL, De Miranda B, Mouneimne R, Earley S, Tjalkens R

PloS one.. 2014 9 (11):e110996. Epub 11/03/2014.

TRP channel Ca(2+) sparklets: fundamental signals underlying endothelium-dependent hyperpolarization.

Sullivan MN, Earley S

American journal of physiology. Cell physiology.. 2013 November 15305 (10):C999-C1008. Epub 09/11/2013.

Serotonin receptors take the TRiPV4 highway in chronic hypoxic pulmonary hypertension. Focus on "TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension".

Earley S, Leblanc N

American journal of physiology. Cell physiology.. 2013 October 1305 (7):C690-2. Epub 07/24/2013.

TRPM4 channels in smooth muscle function.

Earley S

Pflu?gers Archiv : European journal of physiology.. 2013 September 465 (9):1223-31. Epub 02/27/2013.

Regulation of cerebral artery smooth muscle membrane potential by Ca²⁺-activated cation channels.

Gonzales AL, Earley S

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2013 May 20 (4):337-47. Epub 1900 01 01.

Smooth muscle cell Ca²⁺: think locally, act globally.

Earley S

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2013 May 20 (4):279-80. Epub 1900 01 01.

TRPM4 channel: a new player in urinary bladder smooth muscle function in rats.

Smith AC, Parajuli SP, Hristov KL, Cheng Q, Soder RP, Afeli SA, Earley S, Xin W, Malysz J, Petkov GV

American journal of physiology. Renal physiology.. 2013 April 1304 (7):F918-29. Epub 01/02/2013.

Novel role for the transient potential receptor melastatin 4 channel in guinea pig detrusor smooth muscle physiology.

Smith AC, Hristov KL, Cheng Q, Xin W, Parajuli SP, Earley S, Malysz J, Petkov GV

American journal of physiology. Cell physiology.. 2013 March 1304 (5):C467-77. Epub 01/09/2013.

Recruitment of dynamic endothelial Ca2+ signals by the TRPA1 channel activator AITC in rat cerebral arteries.

Qian X, Francis M, Solodushko V, Earley S, Taylor MS

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2013 February 20 (2):138-48. Epub 1900 01 01.

Robust internal elastic lamina fenestration in skeletal muscle arteries.

Kirby BS, Bruhl A, Sullivan MN, Francis M, Dinenno FA, Earley S

PloS one.. 2013 8 (1):e54849. Epub 01/24/2013.

Control of urinary bladder smooth muscle excitability by the TRPM4 channel modulator 9-phenanthrol.

Parajuli SP, Hristov KL, Sullivan MN, Xin W, Smith AC, Earley S, Malysz J, Petkov GV

Channels.. 2013 7 (6):537-40. Epub 09/13/2013.

TRPA1 channels in the vasculature.

Earley S

British journal of pharmacology.. 2012 September 167 (1):13-22. Epub 1900 01 01.

Optical recording reveals novel properties of GSK1016790A-induced vanilloid transient receptor potential channel TRPV4 activity in primary human endothelial cells.

Sullivan MN, Francis M, Pitts NL, Taylor MS, Earley S

Molecular pharmacology.. 2012 September 82 (3):464-72. Epub 06/11/2012.

Endogenous cytosolic Ca(2+) buffering is necessary for TRPM4 activity in cerebral artery smooth muscle cells.

Gonzales AL, Earley S

Cell calcium.. 2012 January 51 (1):82-93. Epub 12/07/2011.

Endothelium-dependent cerebral artery dilation mediated by transient receptor potential and Ca2+-activated K+ channels.

Earley S

Journal of cardiovascular pharmacology.. 2011 February 57 (2):148-53. Epub 1900 01 01.

Basal protein kinase Cδ activity is required for membrane localization and activity of TRPM4 channels in cerebral artery smooth muscle cells.

Garcia ZI, Bruhl A, Gonzales AL, Earley S

Channels.. 2011 5 (3):210-4. Epub 05/01/2011.

Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle.

Gonzales AL, Garcia ZI, Amberg GC, Earley S

American journal of physiology. Cell physiology.. 2010 November 299 (5):C1195-202. Epub 09/08/2010.

Local regulation of arterial L-type calcium channels by reactive oxygen species.

Amberg GC, Earley S, Glapa SA

Circulation research.. 2010 October 15107 (8):1002-10. Epub 08/26/2010.

(Sub)family feud: crosstalk between TRPC channels in vascular smooth muscle cells during vasoconstrictor agonist stimulation.

Earley S, Gonzales AL

The Journal of physiology.. 2010 October 1588 (Pt 19):3637-8. Epub 1900 01 01.

Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells.

Crnich R, Amberg GC, Leo MD, Gonzales AL, Tamkun MM, Jaggar JH, Earley S

American journal of physiology. Cell physiology.. 2010 September 299 (3):C682-94. Epub 07/07/2010.

Ca2+ release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells.

Gonzales AL, Amberg GC, Earley S

American journal of physiology. Cell physiology.. 2010 August 299 (2):C279-88. Epub 04/28/2010.

Vanilloid and melastatin transient receptor potential channels in vascular smooth muscle.

Earley S

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2010 May 17 (4):237-49. Epub 1900 01 01.

Transient receptor potential channels and vascular function.

Earley S, Brayden JE

Clinical science.. 2010 April 7119 (1):19-36. Epub 04/07/2010.

A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation.

Earley S, Gonzales AL, Garcia ZI

Molecular pharmacology.. 2010 April 77 (4):612-20. Epub 01/19/2010.

TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure.

Earley S, Pauyo T, Drapp R, Tavares MJ, Liedtke W, Brayden JE

American journal of physiology. Heart and circulatory physiology.. 2009 September 297 (3):H1096-102. Epub 07/17/2009.

Reduction in TRPC4 expression specifically attenuates G-protein coupled receptor-stimulated increases in intracellular calcium in human myometrial cells.

Ulloa A, Gonzales AL, Zhong M, Kim YS, Cantlon J, Clay C, Ku CY, Earley S, Sanborn BM

Cell calcium.. 2009 July 46 (1):73-84. Epub 06/11/2009.

Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca2+-Activated K+ channels.

Earley S, Gonzales AL, Crnich R

Circulation research.. 2009 April 24104 (8):987-94. Epub 03/19/2009.

Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow.

Brayden JE, Earley S, Nelson MT, Reading S

Clinical and experimental pharmacology & physiology.. 2008 September 35 (9):1116-20. Epub 01/21/2008.

Phosphorylation of focal adhesion kinase promotes extravasation of breast cancer cells.

Earley S, Plopper GE

Biochemical and biophysical research communications.. 2008 February 8366 (2):476-82. Epub 12/10/2007.

Protein kinase C regulates vascular myogenic tone through activation of TRPM4.

Earley S, Straub SV, Brayden JE

American journal of physiology. Heart and circulatory physiology.. 2007 June 292 (6):H2613-22. Epub 02/09/2007.