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Nicholas M. Adams, Ph.D.

Contact

Call Center (585) 276-3000

About Me
Credentials
Publications

About Me

Faculty Appointments

Assistant Professor - Department of Microbiology and Immunology (SMD)

Credentials

Education

PhD | Gerstner Sloan Kettering. Biomedical Engineering. 2018

BSc | Yale University. Biomedical Engineering. 2013

Publications

Journal Articles

Transcription factor Etv3 controls the tolerogenic function of dendritic cells.

Adams NM, Martinez-Krams D, Esteva E, Ra AC, Alexiou AI, Jin H, Yun TJ, Tellaoui RS, Mudianto T, Vollmer E, Novikova E, Tan Y, Huntley W, Krichevsky O, Dolgalev I, Izmirly P, Buyon JP, Moreira AL, Lund AW, Reizis B

Science.. 2026 February 12391 (6786):eads1246. Epub 02/12/2026.

Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells.

Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Ullrich S, Yeung ST, Tan Y, Pucella JN, Dolgalev I, Levy DE, Khanna KM, Solovei I, Mirny LA, Reizis B

Immunity.. 2026 February 1059 (2):270-287.e11. Epub 1900 01 01.

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells.

Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Martinez-Krams D, Lau CM, Reyes J, Abdennur N, Shkolikov A, Yap GS, Khodadadi-Jamayran A, Dolgalev I, Mirny LA, Reizis B

Science immunology.. 2026 February 611 (116):eadx4622. Epub 02/06/2026.

Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection.

Santosa EK, Zhang JM, Sauter JC, Lee ME, Ng BD, Stulz SV, Takizawa M, Grassmann S, Weizman OE, Adams NM, Chaligné R, Oxenius A, Gasteiger G, Lau CM, Sun JC

The Journal of experimental medicine.. 2025 August 4222 (8)Epub 05/19/2025.

Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability.

Wethington D, Ahmad S, Potempa M, Giuliani G, Aguilar OA, Poudel M, Grassmann S, Stewart W, Adams NM, Sun JC, Lanier LL, Das J

bioRxiv : the preprint server for biology.. 2025 July 18 Epub 07/18/2025.

Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells.

Adams NM, Galitsyna A, Tiniakou I, Esteva E, Lau CM, Reyes J, Abdennur N, Shkolikov A, Yap GS, Khodadadi-Jamayran A, Mirny LA, Reizis B

bioRxiv : the preprint server for biology.. 2024 October 30 Epub 10/30/2024.

Ontogeny and Function of Plasmacytoid Dendritic Cells.

Adams NM, Das A, Yun TJ, Reizis B

Annual review of immunology.. 2024 June 42 (1):347-373. Epub 1900 01 01.

Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.

Tiniakou I, Hsu PF, Lopez-Zepeda LS, Garipler G, Esteva E, Adams NM, Jang G, Soni C, Lau CM, Liu F, Khodadadi-Jamayran A, Rodrick TC, Jones D, Tsirigos A, Ohler U, Bedford MT, Nimer SD, Kaartinen V, Mazzoni EO, Reizis B

Science immunology.. 2024 April 129 (94):eadi1023. Epub 04/12/2024.

Clonal barcoding of endogenous adult hematopoietic stem cells reveals a spectrum of lineage contributions.

Feng J, Jang G, Esteva E, Adams NM, Jin H, Reizis B

Proceedings of the National Academy of Sciences of the United States of America.. 2024 January 23121 (4):e2317929121. Epub 01/16/2024.

Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses.

Sulczewski FB, Maqueda-Alfaro RA, Alcántara-Hernández M, Perez OA, Saravanan S, Yun TJ, Seong D, Arroyo Hornero R, Raquer-McKay HM, Esteva E, Lanzar ZR, Leylek RA, Adams NM, Das A, Rahman AH, Gottfried-Blackmore A, Reizis B, Idoyaga J

Nature immunology.. 2023 August 24 (8):1265-1280. Epub 07/06/2023.

Stem cell decoupling underlies impaired lymphoid development during aging.

Jang G, Contreras Castillo S, Esteva E, Upadhaya S, Feng J, Adams NM, Richard E, Awatramani R, Sawai CM, Reizis B

Proceedings of the National Academy of Sciences of the United States of America.. 2023 May 30120 (22):e2302019120. Epub 05/22/2023.

Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells.

Feng J, Pucella JN, Jang G, Alcántara-Hernández M, Upadhaya S, Adams NM, Khodadadi-Jamayran A, Lau CM, Stoeckius M, Hao S, Smibert P, Tsirigos A, Idoyaga J, Reizis B

Immunity.. 2022 March 855 (3):405-422.e11. Epub 02/17/2022.

Deconvoluting global cytokine signaling networks in natural killer cells.

Wiedemann GM, Santosa EK, Grassmann S, Sheppard S, Le Luduec JB, Adams NM, Dang C, Hsu KC, Sun JC, Lau CM

Nature immunology.. 2021 May 22 (5):627-638. Epub 04/15/2021.

Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells.

Adams NM, Diaz-Salazar C, Dang C, Lanier LL, Sun JC

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 February 1206 (3):465-470. Epub 12/21/2020.

Clonal expansion of innate and adaptive lymphocytes.

Adams NM, Grassmann S, Sun JC

Nature reviews. Immunology.. 2020 November 20 (11):694-707. Epub 05/18/2020.

Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.

Weizman OE, Song E, Adams NM, Hildreth AD, Riggan L, Krishna C, Aguilar OA, Leslie CS, Carlyle JR, Sun JC, O'Sullivan TE

Nature immunology.. 2019 August 20 (8):1004-1011. Epub 07/01/2019.

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc.

Dong H, Adams NM, Xu Y, Cao J, Allan DSJ, Carlyle JR, Chen X, Sun JC, Glimcher LH

Nature immunology.. 2019 July 20 (7):865-878. Epub 05/13/2019.

Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells.

Adams NM, Geary CD, Santosa EK, Lumaquin D, Le Luduec JB, Sottile R, van der Ploeg K, Hsu J, Whitlock BM, Jackson BT, Weizman OE, Huse M, Hsu KC, Sun JC

Immunity.. 2019 June 1850 (6):1381-1390.e5. Epub 05/15/2019.

Spatial and temporal coordination of antiviral responses by group 1 ILCs.

Adams NM, Sun JC

Immunological reviews.. 2018 November 286 (1):23-36. Epub 1900 01 01.

Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection.

Seelige R, Saddawi-Konefka R, Adams NM, Picarda G, Sun JC, Benedict CA, Bui JD

Scientific reports.. 2018 September 128 (1):13670. Epub 09/12/2018.

Epigenetic control of innate and adaptive immune memory.

Lau CM, Adams NM, Geary CD, Weizman OE, Rapp M, Pritykin Y, Leslie CS, Sun JC

Nature immunology.. 2018 September 19 (9):963-972. Epub 08/06/2018.

Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection.

Geary CD, Krishna C, Lau CM, Adams NM, Gearty SV, Pritykin Y, Thomsen AR, Leslie CS, Sun JC

Cell reports.. 2018 August 2124 (8):1949-1957.e6. Epub 1900 01 01.

Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response.

Adams NM, Lau CM, Fan X, Rapp M, Geary CD, Weizman OE, Diaz-Salazar C, Sun JC

Immunity.. 2018 June 1948 (6):1172-1182.e6. Epub 05/29/2018.

Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses.

Rapp M, Lau CM, Adams NM, Weizman OE, O'Sullivan TE, Geary CD, Sun JC

Science immunology.. 2017 December 82 (18)Epub 1900 01 01.

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection.

Weizman OE, Adams NM, Schuster IS, Krishna C, Pritykin Y, Lau C, Degli-Esposti MA, Leslie CS, Sun JC, O'Sullivan TE

Cell.. 2017 November 2171 (4):795-808.e12. Epub 10/19/2017.

NK Cell Responses Redefine Immunological Memory.

Adams NM, O'Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC

The Journal of immunology : official journal of the American Association of Immunologists.. 2016 October 15197 (8):2963-2970. Epub 1900 01 01.

Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance.

O'Sullivan TE, Rapp M, Fan X, Weizman OE, Bhardwaj P, Adams NM, Walzer T, Dannenberg AJ, Sun JC

Immunity.. 2016 August 1645 (2):428-41. Epub 08/02/2016.

Quantitative evaluation and optimization of co-drugging to improve anti-HIV latency therapy.

Wong VC, Fong LE, Adams NM, Xue Q, Dey SS, Miller-Jensen K

Cellular and molecular bioengineering.. 2014 September 17 (3):320-333. Epub 1900 01 01.