Jacob N. Finkelstein, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5220

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Faculty Appointments

Professor - Department of Pediatrics , Neonatology (SMD)
Professor - Department of Environmental Medicine (SMD) - Joint

Biography

Research

Dr. Finkelstein's laboratory research emphasizes the role of the alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli. This includes studies of oxidant induced signaling in the pulmonary epithelium and macrophages and epithelial production of cytokines and chemokines in the regulation of the inflammatory functions of alveolar macrophages. His previous research effort focused on the pulmonary alveolar type II cell as the site of pulmonary surfactant synthesis and secretion, and studies on the basic cell and molecular biology of these processes are still an important facet of his work. In addition, the type II cell also plays an important role as the stem cell for renewal of the alveolar epithelium both in the normal lung development and during epithelial repair and renewal following lung injury. The most recent data suggest that type II cells may also be involved in regulating the inflammatory functions of alveolar macrophages, as well as the actions of interstitial fibroblasts during lung growth or pulmonary fibrosis.
The overall goal of the current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants. This work is funded by grants from NIH, EPA and DoD.

The overall goal of some of their additional current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants.

Credentials

Education

1971
BS | Carnegie-Mellon University
Chemistry

1976
PhD | Northwestern University
Biochemistry

Post-doctoral Training & Residency

1977 - 1978
NIH Postdoctoral Fellowship, Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY

1976 - 1977
NSF Postdoctoral Fellowship, Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY

Awards

2006
March of Dimes Health Leadership Award

1986
Elected member, Perinatal Research Society

1974
Sigma Xi Graduate Research Symposium Award

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Publications

Journal Articles

7/1/2021
Bennett TD, Moffitt RA, Hajagos JG, Amor B, Anand A, Bissell MM, Bradwell KR, Bremer C, Byrd JB, Denham A, DeWitt PE, Gabriel D, Garibaldi BT, Girvin AT, Guinney J, Hill EL, Hong SS, Jimenez H, Kavuluru R, Kostka K, Lehmann HP, Levitt E, Mallipattu SK, Manna A, McMurry JA, Morris M, Muschelli J, Neumann AJ, Palchuk MB, Pfaff ER, Qian Z, Qureshi N, Russell S, Spratt H, Walden A, Williams AE, Wooldridge JT, Yoo YJ, Zhang XT, Zhu RL, Austin CP, Saltz JH, Gersing KR, Haendel MA, Chute CG, . "Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative." JAMA network open.. 2021 Jul 1; 4(7):e2116901. Epub 2021 Jul 01.

5/24/2021
Wang J, Kim SY, House E, Olson HM, Johnston CJ, Chalupa D, Hernady E, Mariani TJ, Clair G, Ansong C, Qian WJ, Finkelstein JN, McGraw MD. "Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology." Archives of toxicology.. 2021 May 24; Epub 2021 May 24.

10/15/2020
Fleg JL, Keteyian SJ, Peterson PN, Benzo R, Finkelstein J, Forman DE, Gaalema DE, Cooper LS, Punturieri A, Joseph L, Shero S, Zieman S. "Increasing Use of Cardiac and Pulmonary Rehabilitation in Traditional and Community Settings: OPPORTUNITIES TO REDUCE HEALTH CARE DISPARITIES." Journal of cardiopulmonary rehabilitation and prevention.. 2020 Oct 15; Epub 2020 Oct 15.

Books & Chapters

2005
Chapter Title: Cell and animal models of lung injury
Book Title: Lung Injury: Mechanisms, Pathophysiology, and Therapy
Author List: Finkelstein JN, O'Reilly M, Holm BA, Chess PR, Notter RH
Edited By: Notter RH, Finkelstein JN, Holm BA
Published By: Taylor & Francis Group 2005 in Boca Raton, FL

2005
Chapter Title: Surfactant replacement therapy in lung injury.
Book Title: Lung Injury: Mechanisms, Pathophysiology, and Therapy
Author List: Chess PR, Finkelstein JN, Holm BA, Notter RH
Edited By: Notter RH, Finkelstein JN, Holm BA
Published By: Taylor & Francis Group 2005 in Boca Raton, FL

2005
Chapter Title: Combined-modality therapies for lung Injury
Book Title: Lung Injury: Mechanisms, Pathophysiology, and Therapy
Author List: Pryhuber GS, D'Angio CT, Finkelstein JN, Notter RH
Edited By: Notter RH, Finkelstein JN, Holm BA
Published By: Taylor & Francis Group 2005 in Boca Raton, FL

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