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Patricia M. Hinkle, Ph.D.

Patricia M. Hinkle, Ph.D.

Contact

Call Center (585) 276-3000

Research Lab

About Me

Faculty Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD)

Credentials

Education

PhD | Univ of Cal Berkeley. Biochemistry. 1970

BA | Mount Holyoke College. Chemistry. 1965

Research

Publications

Journal Articles

siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor.

Gehret AU, Hinkle PM

ACS chemical biology.. 2013 March 158 (3):588-98. Epub 12/18/2012.

Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, Tesmer JJ

ACS chemical biology.. 2012 November 167 (11):1830-9. Epub 08/21/2012.

?-Subunit of the Ost?-Ost? organic solute transporter is required not only for heterodimerization and trafficking but also for function.

Christian WV, Li N, Hinkle PM, Ballatori N

The Journal of biological chemistry.. 2012 June 15287 (25):21233-43. Epub 04/25/2012.

Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor.

Hinkle PM, Gehret AU, Jones BW

Frontiers in neuroscience.. 2012 6 :180. Epub 12/13/2012.

Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.

Liang L, Sebag JA, Eagelston L, Serasinghe MN, Veo K, Reinick C, Angleson J, Hinkle PM, Dores RM

General and comparative endocrinology.. 2011 October 1174 (1):5-14. Epub 08/09/2011.

Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.

Gehret AU, Hinkle PM

The Biochemical journal.. 2010 May 13428 (2):235-45. Epub 05/13/2010.

Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.

Sebag JA, Hinkle PM

Science signaling.. 2010 April 63 (116):ra28. Epub 04/06/2010.

Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.

Gehret AU, Jones BW, Tran PN, Cook LB, Greuber EK, Hinkle PM

Molecular pharmacology.. 2010 February 77 (2):288-97. Epub 11/11/2009.

Subcellular trafficking of the TRH receptor: effect of phosphorylation.

Jones BW, Hinkle PM

Molecular endocrinology.. 2009 September 23 (9):1466-78. Epub 06/18/2009.

Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.

Sebag JA, Hinkle PM

The Journal of biological chemistry.. 2009 August 21284 (34):22641-8. Epub 06/17/2009.

Structure and function of the melanocortin2 receptor accessory protein (MRAP).

Hinkle PM, Sebag JA

Molecular and cellular endocrinology.. 2009 March 5300 (1-2):25-31. Epub 11/06/2008.

Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling.

Sebag JA, Hinkle PM

The Journal of biological chemistry.. 2009 January 2284 (1):610-8. Epub 11/03/2008.

Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.

Jones BW, Hinkle PM

Molecular pharmacology.. 2008 July 74 (1):195-202. Epub 04/15/2008.

A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2.

Hogan N, O'Boyle KM, Hinkle PM, Kelly JA

Neuroscience letters.. 2008 January 24431 (1):26-30. Epub 11/17/2007.

Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers.

Sebag JA, Hinkle PM

Proceedings of the National Academy of Sciences of the United States of America.. 2007 December 18104 (51):20244-9. Epub 12/12/2007.

Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation.

Song GJ, Jones BW, Hinkle PM

Proceedings of the National Academy of Sciences of the United States of America.. 2007 November 13104 (46):18303-8. Epub 11/07/2007.

Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone.

Scalabrino GA, Hogan N, O'Boyle KM, Slator GR, Gregg DJ, Fitchett CM, Draper SM, Bennett GW, Hinkle PM, Bauer K, Williams CH, Tipton KF, Kelly JA

Neuropharmacology.. 2007 June 52 (7):1472-81. Epub 02/28/2007.

Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies.

Jones BW, Song GJ, Greuber EK, Hinkle PM

The Journal of biological chemistry.. 2007 April 27282 (17):12893-906. Epub 02/28/2007.

Regulation of endogenous melanocortin-4 receptor expression and signaling by glucocorticoids.

Sebag JA, Hinkle PM

Endocrinology.. 2006 December 147 (12):5948-55. Epub 09/14/2006.

Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor.

Jones BW, Hinkle PM

The Journal of biological chemistry.. 2005 November 18280 (46):38346-54. Epub 09/23/2005.

Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling.

Song GJ, Hinkle PM

Molecular endocrinology.. 2005 November 19 (11):2859-70. Epub 07/14/2005.

Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.

Cook LB, Hinkle PM

Endocrinology.. 2004 July 145 (7):3095-100. Epub 04/29/2004.

Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein.

Cook LB, Hinkle PM

The Biochemical journal.. 2004 June 15380 (Pt 3):815-21. Epub 1900 01 01.

Detection of G protein-coupled receptors by immunofluorescence microscopy.

Hinkle PM, Puskas JA

Methods in molecular biology.. 2004 237 :127-34. Epub 1900 01 01.

TRH and related peptides: homeostatic regulators of glutamate transmission?

Sattin A, Pekary AE, Lloyd RL, Paulson M, Meyerhoff JA, Hinkle PM, Faull K

Annals of the New York Academy of Sciences.. 2003 November 1003 :458-60. Epub 1900 01 01.

Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.

Cook LB, Zhu CC, Hinkle PM

Molecular endocrinology.. 2003 September 17 (9):1777-91. Epub 06/12/2003.

Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release.

Graves TK, Hinkle PM

Endocrinology.. 2003 August 144 (8):3565-74. Epub 1900 01 01.

Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.

Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV

The Journal of biological chemistry.. 2003 May 30278 (22):19634-41. Epub 03/20/2003.

Endoplasmic reticulum calcium storage and release in cells expressing misfolded growth hormone.

Graves TK, Hinkle PM

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.. 2003 February 13 (1):36-43. Epub 1900 01 01.

Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.

Zhu CC, Cook LB, Hinkle PM

The Journal of biological chemistry.. 2002 August 2277 (31):28228-37. Epub 05/22/2002.

Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides.

Hinkle PM, Pekary AE, Senanayaki S, Sattin A

Brain research.. 2002 May 10935 (1-2):59-64. Epub 1900 01 01.

Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic.

Graves TK, Patel S, Dannies PS, Hinkle PM

Journal of cell science.. 2001 October 114 (Pt 20):3685-94. Epub 1900 01 01.

Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis.

Smith J, Yu R, Hinkle PM

Molecular endocrinology.. 2001 September 15 (9):1539-48. Epub 1900 01 01.

Calcium responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone and somatostatin in phospholipase css3 knockout mice.

Romoser VA, Graves TK, Wu D, Jiang H, Hinkle PM

Molecular endocrinology.. 2001 January 15 (1):125-35. Epub 1900 01 01.

Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.

Rapoport AP, Simons-Evelyn M, Chen T, Sidell R, Luhowskyj S, Rosell K, Obrig T, Hicks D, Hinkle PM, Nahm M, Insel RA, Abboud CN

Blood cells, molecules & diseases.. 2001 27 (3):610-24. Epub 1900 01 01.

Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicators.

Yu R, Hinkle PM

The Journal of biological chemistry.. 2000 August 4275 (31):23648-53. Epub 1900 01 01.

Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids.

Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D

Proceedings of the National Academy of Sciences of the United States of America.. 1999 August 3196 (18):10385-90. Epub 1900 01 01.

Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11.

Yu R, Hinkle PM

The Journal of biological chemistry.. 1999 May 28274 (22):15745-50. Epub 1900 01 01.

Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity.

Fliss MS, Hinkle PM, Bancroft C

Molecular endocrinology.. 1999 April 13 (4):644-57. Epub 1900 01 01.

Receptors for thyrotropin-releasing hormone on rat lactotropes and thyrotropes.

Yu R, Ashworth R, Hinkle PM

Thyroid : official journal of the American Thyroid Association.. 1998 October 8 (10):887-94. Epub 1900 01 01.

Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization.

Yu R, Hinkle PM

Molecular endocrinology.. 1998 May 12 (5):737-49. Epub 1900 01 01.

Fluorescence methods to assess multidrug resistance in individual cells.

Nelson EJ, Zinkin NT, Hinkle PM

Cancer chemotherapy and pharmacology.. 1998 42 (4):292-9. Epub 1900 01 01.

Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps.

Yu R, Hinkle PM

The Journal of biological chemistry.. 1997 November 7272 (45):28301-7. Epub 1900 01 01.

Lead uptake in brain capillary endothelial cells: activation by calcium store depletion.

Kerper LE, Hinkle PM

Toxicology and applied pharmacology.. 1997 September 146 (1):127-33. Epub 1900 01 01.

Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. A new class of fluorescent indicators.

Romoser VA, Hinkle PM, Persechini A

The Journal of biological chemistry.. 1997 May 16272 (20):13270-4. Epub 1900 01 01.

Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor.

Yu R, Hinkle PM

Molecular pharmacology.. 1997 May 51 (5):785-93. Epub 1900 01 01.

Cellular uptake of lead is activated by depletion of intracellular calcium stores.

Kerper LE, Hinkle PM

The Journal of biological chemistry.. 1997 March 28272 (13):8346-52. Epub 1900 01 01.

Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs.

Ashworth R, Hinkle PM

Endocrinology.. 1996 December 137 (12):5205-12. Epub 1900 01 01.

Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C.

Shupnik MA, Weck J, Hinkle PM

Molecular endocrinology.. 1996 January 10 (1):90-9. Epub 1900 01 01.

Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.

Ashworth R, Yu R, Nelson EJ, Dermer S, Gershengorn MC, Hinkle PM

Proceedings of the National Academy of Sciences of the United States of America.. 1995 January 1792 (2):512-6. Epub 1900 01 01.

Thyrotropin-releasing hormone activates Ca2+ efflux. Evidence suggesting that a plasma membrane Ca2+ pump is an effector for a G-protein-coupled Ca(2+)-mobilizing receptor.

Nelson EJ, Hinkle PM

The Journal of biological chemistry.. 1994 December 9269 (49):30854-60. Epub 1900 01 01.

Characteristics of the Ca2+ spike and oscillations induced by different doses of thyrotropin-releasing hormone (TRH) in individual pituitary cells and nonexcitable cells transfected with TRH receptor complementary deoxyribonucleic acid.

Nelson EJ, Hinkle PM

Endocrinology.. 1994 September 135 (3):1084-92. Epub 1900 01 01.

Inhibition of L-type calcium-channel activity by thapsigargin and 2,5-t-butylhydroquinone, but not by cyclopiazonic acid.

Nelson EJ, Li CC, Bangalore R, Benson T, Kass RS, Hinkle PM

The Biochemical journal.. 1994 August 15302 ( Pt 1) :147-54. Epub 1900 01 01.

Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool. Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer.

Gershengorn MC, Heinflink M, Nussenzveig DR, Hinkle PM, Falck-Pedersen E

The Journal of biological chemistry.. 1994 March 4269 (9):6779-83. Epub 1900 01 01.

Cadmium toxicity in rat pheochromocytoma cells: studies on the mechanism of uptake.

Hinkle PM, Osborne ME

Toxicology and applied pharmacology.. 1994 January 124 (1):91-8. Epub 1900 01 01.

Saturable, stereospecific transport of 3,5,3'-triiodo-L-thyronine and L-thyroxine into GH4C1 pituitary cells.

Yan Z, Hinkle PM

The Journal of biological chemistry.. 1993 September 25268 (27):20179-84. Epub 1900 01 01.

The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes.

Straight SW, Hinkle PM, Jewers RJ, McCance DJ

Journal of virology.. 1993 August 67 (8):4521-32. Epub 1900 01 01.

Regulation of L-type voltage-gated calcium channels by epidermal growth factor.

Hinkle PM, Nelson EJ, Haymes AA

Endocrinology.. 1993 July 133 (1):271-6. Epub 1900 01 01.

Activation of protein kinase C increases Ca2+ sensitivity of secretory response of GH3 pituitary cells.

Haymes AA, Hinkle PM

The American journal of physiology.. 1993 April 264 (4 Pt 1):C1020-8. Epub 1900 01 01.

Measurement of intracellular cadmium with fluorescent dyes. Further evidence for the role of calcium channels in cadmium uptake.

Hinkle PM, Shanshala ED, Nelson EJ

The Journal of biological chemistry.. 1992 December 15267 (35):25553-9. Epub 1900 01 01.

Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels.

Li P, Thaw CN, Sempowski GD, Gershengorn MC, Hinkle PM

Molecular endocrinology.. 1992 September 6 (9):1393-402. Epub 1900 01 01.

Characterization of multidrug-resistant pituitary tumor cells.

Nelson EJ, Hinkle PM

Endocrinology.. 1992 June 130 (6):3246-56. Epub 1900 01 01.

Prolactin and secretogranin-II, a marker for the regulated pathway, are secreted in parallel by pituitary GH4C1 cells.

Hinkle PM, Scammell JG, Shanshala ED

Endocrinology.. 1992 June 130 (6):3503-11. Epub 1900 01 01.

Activation of protein kinase C reduces L-type calcium channel activity of GH3 pituitary cells.

Haymes AA, Kwan YW, Arena JP, Kass RS, Hinkle PM

The American journal of physiology.. 1992 May 262 (5 Pt 1):C1211-9. Epub 1900 01 01.

Studies on the biological activity of triiodothyronine sulfate.

Spaulding SW, Smith TJ, Hinkle PM, Davis FB, Kung MP, Roth JA

The Journal of clinical endocrinology and metabolism.. 1992 May 74 (5):1062-7. Epub 1900 01 01.

Epidermal growth factor decreases the concentration of thyrotropin-releasing hormone (TRH) receptors and TRH responses in pituitary GH4C1 cells.

Hinkle PM, Shanshala ED, Yan ZF

Endocrinology.. 1991 September 129 (3):1283-8. Epub 1900 01 01.

Pituitary thyrotropin-releasing hormone (TRH) receptors: effects of TRH, drugs mimicking TRH action, and chlordiazepoxide.

Hinkle PM, Shanshala ED

Molecular endocrinology.. 1989 September 3 (9):1337-44. Epub 1900 01 01.

Pituitary thyrotropin-releasing hormone receptors: local anesthetic effects on binding and responses.

Phillips WJ, Enyeart JJ, Hinkle PM

Molecular endocrinology.. 1989 September 3 (9):1345-51. Epub 1900 01 01.

Solubilization and characterization of pituitary thyrotropin-releasing hormone receptors.

Phillips WJ, Hinkle PM

Molecular pharmacology.. 1989 April 35 (4):533-40. Epub 1900 01 01.

Attenuation of thyroid hormone action by 1,25-dihydroxyvitamin D3 in pituitary cells.

Kaji H, Hinkle PM

Endocrinology.. 1989 February 124 (2):930-6. Epub 1900 01 01.

Pituitary TRH receptors.

Hinkle PM

Annals of the New York Academy of Sciences.. 1989 553 :176-87. Epub 1900 01 01.

Prolactin synthesis in cultured pituitary cells is chloride-dependent.

Day RN, Hinkle PM

The Journal of biological chemistry.. 1988 November 5263 (31):15922-7. Epub 1900 01 01.

Osmotic regulation of prolactin secretion. Possible role of chloride.

Day RN, Hinkle PM

The Journal of biological chemistry.. 1988 November 5263 (31):15915-21. Epub 1900 01 01.

Calcium channel agonists and antagonists: effects of chronic treatment on pituitary prolactin synthesis and intracellular calcium.

Hinkle PM, Jackson AE, Thompson TM, Zavacki AM, Coppola DA, Bancroft C

Molecular endocrinology.. 1988 November 2 (11):1132-8. Epub 1900 01 01.

Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.

Kaji H, Casnellie JE, Hinkle PM

The Journal of biological chemistry.. 1988 September 25263 (27):13588-93. Epub 1900 01 01.

Transient dopaminergic inhibition of prolactin release from hybrid cells derived by fusion of normal rat pituitary and GH4C1 tumor cells.

Day RN, Hinkle PM

Endocrinology.. 1988 May 122 (5):2165-73. Epub 1900 01 01.

Cadmium uptake and toxicity via voltage-sensitive calcium channels.

Hinkle PM, Kinsella PA, Osterhoudt KC

The Journal of biological chemistry.. 1987 December 5262 (34):16333-7. Epub 1900 01 01.

Regulation of thyroid hormone receptors and responses by thyrotropin-releasing hormone in GH4C1 cells.

Kaji H, Hinkle PM

Endocrinology.. 1987 November 121 (5):1697-704. Epub 1900 01 01.

Pituitary Ca2+ channels: blockade by conventional and novel Ca2+ antagonists.

Enyeart JJ, Sheu SS, Hinkle PM

The American journal of physiology.. 1987 July 253 (1 Pt 1):C162-70. Epub 1900 01 01.

Dihydropyridine modulators of voltage-sensitive Ca2+ channels specifically regulate prolactin production by GH4C1 pituitary tumor cells.

Enyeart JJ, Sheu SS, Hinkle PM

The Journal of biological chemistry.. 1987 March 5262 (7):3154-9. Epub 1900 01 01.

Epidermal growth factor decreases thyroid hormone receptors and attenuates thyroid hormone responses in GH4C1 cells.

Kaji H, Hinkle PM

Endocrinology.. 1987 February 120 (2):537-43. Epub 1900 01 01.

Thyroid hormone induction of an autocrine growth factor secreted by pituitary tumor cells.

Hinkle PM, Kinsella PA

Science.. 1986 December 19234 (4783):1549-52. Epub 1900 01 01.

Thyroliberin action in pituitary cells is not inhibited by pertussis toxin.

Hinkle PM, Hewlett EL, Gershengorn MC

The Biochemical journal.. 1986 July 1237 (1):181-6. Epub 1900 01 01.

Interaction of dihydropyridine Ca2+ agonist Bay K 8644 with normal and transformed pituitary cells.

Enyeart JJ, Aizawa T, Hinkle PM

The American journal of physiology.. 1986 January 250 (1 Pt 1):C95-102. Epub 1900 01 01.

Dihydropyridine Ca2+ antagonists: potent inhibitors of secretion from normal and transformed pituitary cells.

Enyeart JJ, Aizawa T, Hinkle PM

The American journal of physiology.. 1985 May 248 (5 Pt 1):C510-9. Epub 1900 01 01.

Differential effects of thyrotropin-releasing hormone, vasoactive intestinal peptide, phorbol ester, and depolarization in GH4C1 rat pituitary cells.

Aizawa T, Hinkle PM

Endocrinology.. 1985 March 116 (3):909-19. Epub 1900 01 01.

Thyrotropin-releasing hormone rapidly stimulates a biphasic secretion of prolactin and growth hormone in GH4C1 rat pituitary tumor cells.

Aizawa T, Hinkle PM

Endocrinology.. 1985 January 116 (1):73-82. Epub 1900 01 01.

Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes from GH4C1 rat pituitary tumor cells.

Hinkle PM, Phillips WJ

Proceedings of the National Academy of Sciences of the United States of America.. 1984 October 81 (19):6183-7. Epub 1900 01 01.

The calcium agonist Bay K 8644 stimulates secretion from a pituitary cell line.

Enyeart JJ, Hinkle PM

Biochemical and biophysical research communications.. 1984 August 16122 (3):991-6. Epub 1900 01 01.

Characterization of thyroid hormone stimulation of uridine uptake by rat pituitary tumor cells.

Halpern J, Hinkle PM

Endocrinology.. 1984 July 115 (1):95-101. Epub 1900 01 01.

Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides.

Hinkle PM, Kinsella PA

The Journal of biological chemistry.. 1984 March 25259 (6):3445-9. Epub 1900 01 01.

Binding and internalization of epidermal growth factor by rat pituitary tumor cells.

Halpern J, Hinkle PM

Molecular and cellular endocrinology.. 1983 December 33 (2-3):183-96. Epub 1900 01 01.

Rapid temperature-dependent transformation of the thyrotropin-releasing hormone-receptor complex in rat pituitary tumor cells.

Hinkle PM, Kinsella PA

The Journal of biological chemistry.. 1982 May 25257 (10):5462-70. Epub 1900 01 01.

Regulation of thyrotropin-releasing hormone receptors and responses by L-triiodothyronine in dispersed rat pituitary cell cultures.

Hinkle PM, Goh KB

Endocrinology.. 1982 May 110 (5):1725-31. Epub 1900 01 01.

Evidence for an active step in thyroid hormone transport to nuclei: drug inhibition of L-125I-triiodothyronine binding to nuclear receptors in rat pituitary tumor cells.

Halpern J, Hinkle PM

Endocrinology.. 1982 March 110 (3):1070-2. Epub 1900 01 01.

Purification of a stimulator of microtubule assembly from bovine thyroid.

Berk BC, Hinkle PM

The Journal of biological chemistry.. 1981 November 25256 (22):11859-65. Epub 1900 01 01.

Mechanism of thyroid hormone inhibition of thyrotropin-releasing hormone action.

Hinkle PM, Perrone MH, Schonbrunn A

Endocrinology.. 1981 January 108 (1):199-205. Epub 1900 01 01.

Direct visualization of receptors for thyrotropin-releasing hormone with a fluorescein-labeled analog.

Halpern J, Hinkle PM

Proceedings of the National Academy of Sciences of the United States of America.. 1981 January 78 (1):587-91. Epub 1900 01 01.

Evidence for a thyrotropin-releasing hormone inhibitor in the pineal gland.

Vriend J, Hinkle PM, Knigge KM

Endocrinology.. 1980 December 107 (6):1791-7. Epub 1900 01 01.

Thyroid and brain microtubules: a comparison.

Berk BC, Hinkle PM

The Journal of biological chemistry.. 1980 April 10255 (7):3186-93. Epub 1900 01 01.

Thyrotropin-releasing hormone-receptor interaction in GH3 pituitary cells.

Hinkle PM, Lewis DG, Greer TL

Endocrinology.. 1980 March 106 (3):1000-5. Epub 1900 01 01.

Relationships between thyroid hormone and glucocorticoid effects in GH3 pituitary cells.

Perrone MH, Greer TL, Hinkle PM

Endocrinology.. 1980 February 106 (2):600-5. Epub 1900 01 01.

A macromolecule which gives rise to thyrotropin releasing-hormone.

Rupnow JH, Hinkle PM, Dixon JE

Biochemical and biophysical research communications.. 1979 July 2789 (2):721-8. Epub 1900 01 01.

Thyroid hormone action in pituitary cells. Differences in the regulation of thyrotropin-releasing hormone receptors and growth hormone synthesis.

Hinkle PM, Perrone MH, Greer TL

The Journal of biological chemistry.. 1979 May 25254 (10):3907-11. Epub 1900 01 01.

Regulation of pituitary receptors for thyrotropin-releasing hormone by thyroid hormones.

Perrone MH, Hinkle PM

The Journal of biological chemistry.. 1978 July 25253 (14):5168-73. Epub 1900 01 01.

Solubilization of pituitary receptors for thyrotropin-releasing hormone.

Hinkle PM, Lewis DG

Biochimica et biophysica acta.. 1978 July 3541 (3):347-59. Epub 1900 01 01.

Adenylyl cyclase and cyclic nucleotide phosphodiesterases in GH-Strains of rat pituitary cells.

Hinkle PM, Tashjian AH

Endocrinology.. 1977 April 100 (4):934-44. Epub 1900 01 01.

Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture.

Hinkle PM, Tashjian AH

Biochemistry.. 1975 August 2614 (17):3845-51. Epub 1900 01 01.

Degradation of thyrotropin-releasing hormone by the GH3 strain of pituitary cells in culture.

Hinkle PM, Tashjian AH

Endocrinology.. 1975 August 97 (2):324-31. Epub 1900 01 01.

Intrinsic tryptophan fluorescence of membranes of GH3 pituitary cells: quenching by thyrotropin-releasing hormone.

Imae T, Fasman GD, Hinkle PM, Tashjian AH

Biochemical and biophysical research communications.. 1975 February 1762 (4):923-32. Epub 1900 01 01.

Uses of prolactin- and growth hormone-producing rat pituitary tumor cells in culture.

Hinkle PM

Lloydia.. 1974 June 37 (2):192-5. Epub 1900 01 01.

Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture.

Hinkle PM, Woroch EL, Tashjian AH

The Journal of biological chemistry.. 1974 May 25249 (10):3085-90. Epub 1900 01 01.

Receptors for thyrotropin-releasing hormone in prolactin producing rat pituitary cells in culture.

Hinkle PM, Tashjian AH

The Journal of biological chemistry.. 1973 September 10248 (17):6180-6. Epub 1900 01 01.

Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin.

Levine L, Hinkle PM, Voelkel EF, Tashjian AH

Biochemical and biophysical research communications.. 1972 May 2647 (4):888-96. Epub 1900 01 01.

Demonstration of a change in the rate-determining step in papain- and ficin-catalyzed acyl-transfer reactions.

Hinkle PM, Kirsch JF

Biochemistry.. 1971 July 610 (14):2717-26. Epub 1900 01 01.