Robert H. Notter, M.D., Ph.D.

Robert H. Notter, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Appointment: (585) 276-3000

Professional Bio

Robert H. Notter, M.D. (1980, with distinction in research, University of Rochester)
Ph.D. (1969, Chemical Engineering, University of Washington)
M.S. (1965, Chemical Engineering, Stanford University)
B.S. (1964, Chemical Engineering, Stanford University)

Professor of Pediatrics and Environmental Medicine, University of Rochester (1989-present)

Past positions:
Professor of Chemical Engineering, University of Rochester (1983-2003)
Professor of Biomedical Engineering, University of Rochester (2001-2004)
Director of Research, Division of Neonatology, University of Rochester (1990-2000) Director of University-wide Program in Biomedical Engineering, University of Rochester (1984-1995)

Research awards:
*Health Leadership Award in Research, March of Dimes (2005)
*Two time principal investigator and program director for National Institutes of Health (NIH) Special Center of Research (SCOR) in Lung Biology and Disease in Infants and Children at Rochester (1989-1997)
*Research Career Development Award, National Heart, Lung, Blood Institute (NHLBI) of NIH (1981-1986)
*Principal investigator of multiple individual NIH RO1 research grants on lung surfactant activity, inhibition and replacement (1980-present)
*NIH young investigator award, NHLBI (1975-1976)
*NIH Postdoctoral Fellowship award in Bioengineering (1969-1971)
*American Society for Testing Materials (ASTM) research award, Stanford University (1964)
*NSF undergraduate research award, Stanford University (1962)

Teaching awards: Outstanding Teacher in the College of Engineering, Penn State University (1976)

Other activities:
*Associate Editor, American Journal of Physiology: Lung Cellular and Molecular Biology (1997)
*Member of NIH Working Group on Lung Development (1992)
*Elected to Perinatal Research Society, Society for Pediatric Research, Sigma Xi, Tau Beta Pi
*Author of over 250 scientific papers and abstracts, plus the book Lung Surfactants: Basic Science and Clinical Applications (Marcel Dekker, 2000)
*Senior editor of Lung Injury: Mechanisms, Pathophysiology, and Therapy (Taylor Francis, 2005)
*Co-editor of Surfactant Replacement Therapy (Wiley Interscience, 1989)

Research interests:
Pulmonary surfactant; bioengineering; lung injury
Molecular Biophysics of Phospholipids and Proteins
Biomedical Engineering

Patient Care Bio

Dr. Notter's main area of research focuses on pulmonary surfactant, a substance in the lungs of humans and other air-breathing organisms that is essential for normal respiration. His clinical interests emphasize severe pulmonary diseases where lung surfactant is deficient or becomes dysfunctional. These diseases include the respiratory distress syndrome (RDS) of premature infants, plus the lethal and widespread syndromes of clinical acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) that can affect patients of all ages ranging from infants to adults. A major component of research is on the development and optimization of lung surfactant-based therapies for RDS, ALI, and ARDS. Research from Dr. Notter's laboratory over the past three decades has helped to establish clinically-effective surfactant replacement therapy for RDS in premature infants, and this is now being extended to patients with surfactant dysfunction and ALI/ARDS through the development of novel synthetic exogenous lung surfactants.

Key Words:
Development of Surfactant-based Therapies for Lung Disease and Injury in Infants,
Children, and Adults
Molecular Biophysics of Phospholipids and Proteins
Biomedical Engineering

Awards & Honors (National)

Two time NIH Pulmonary SCOR Director (NHLBI) 1989 - 1997
Elected to Perinatal Research Society 1985
Research Career Development Award, National Lung Institute 1981 - 1986
Above the 95th percentile for total NIH research funding over the 25 year period 1980 - 2005. 1980 - 2005
NIH Young Investigator (National Lung Institute) 1975 - 1977

Awards & Honors (Local)

Health Leadership Award in Research | March of Dimes 2005
Dinstinction in MD Research, University of Rochester School of Medicine 1980
Outstanding Teacher in College of Engineering, Penn State University, PA 1975 - 1976
Outstanding Senior Chemical Engineer, Stanford University 1964
American Society for Testing Materials Award, Stanford University 1964
NSF Undergarduate Research Award, Stanford University 1962 - 1963


Novel Synthetic SP-B and SP-C Peptides and Their Use in Synthetic Exogenous Lipid/Peptide Lung Surfactants

United States Serial NO.: 14/376,726
Filed Date: February 11, 2013
Title: Novel SP-B and SP-C Peptides, Synthetic Lung Surfactants, and Use Thereof
Invented by: Robert Notter, Alan Waring, Adrian Schwan, Zhengdong Wang, Larry Gordon, Frans Walther

Current Appointments

Professor Emeritus - Department of Pediatrics, Neonatology (SMD) - Primary
Professor Emeritus - Department of Environmental Medicine (SMD)


MD | Medicine | University of Rochester School of Medicine and Dentistry1980
PhD | Chemical Engineering | University of Washington1969
MS | Chemical Engineering | Stanford University1965
BS | Chemical Engineering | Stanford University1964

Post-Doctoral Training & Residency

Bioengineering Postdoctoral Fellowship, NIH (NHLBI), University of Washington, Seattle, WA 1971