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Ingrid H. Sarelius, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-7729

Fax: (585) 273-2652

Biography

Research

My research focus is on vascular cell communication and signaling. Our lab is specifically interested in how the cells of the blood vessel wall communicate with each other, with the surrounding tissue, and with the blood itself. Basically, we're interested in figuring out how microvessels work! Since cardiovascular disease is a major killer of adult populations, and since much of this is vascular disease or disorder, understanding normal blood vessel function seems like a good place to start.
The major tool that we use to ask our questions is confocal immunofluorescent intravital microscopy; we are one of a handful of labs worldwide that is able to image local events in cells of the vascular wall in real time in blood perfused microvessels in living animals. We also use single microparticle tracking to define the local fluid dynamic environment in vivo, and confocal imaging of signaling molecules and leukocyte populations in the in situ blood vessel.

Credentials

Faculty Appointments

Education

1978
PhD | University of Auckland, New Zealand
Physiology

1972
MSc(Hons) | Massey University
Physiology

1968
BSc | Massey University
Physiology

Publications

Journal Articles

2/1/2016
Sarelius IH, Titus PA, Maimon N, Okech W, Wilke-Mounts SJ, Brennan JR, Hocking DC. "Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin." The Journal of physiology.. 2016 Feb 1; 594(3):687-97. Epub 2016 Jan 15.

11/1/2015
Murrant CL, Sarelius IH. "Local control of blood flow during active hyperaemia: what kinds of integration are important?" The Journal of physiology.. 2015 Nov 1; 593(21):4699-711. Epub 2015 Sep 29.

2015
Sarelius IH, Glading AJ. "Control of vascular permeability by adhesion molecules." Tissue barriers. 2015 3(1-2):e985954. Epub 2015 Apr 03.

Books & Chapters

2005
Chapter Title: Vascular control mechanisms in skeletal muscle.
Book Title: Microvascular Research: Biology and Pathology
Author List: Sarelius, I.H.
Edited By: D. Shepro
Published By: Academic Press2005

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