Ingrid H. Sarelius, Ph.D.

Ingrid H. Sarelius, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-7729
Fax: (585) 273-2652

Research Bio

My research focus is on vascular cell communication and signaling. Our lab is specifically interested in how the cells of the blood vessel wall communicate with each other, with the surrounding tissue, and with the blood itself. Basically, we're interested in figuring out how microvessels work! Since cardiovascular disease is a major killer of adult populations, and since much of this is vascular disease or disorder, understanding normal blood vessel function seems like a good place to start.
The major tool that we use to ask our questions is confocal immunofluorescent intravital microscopy; we are one of a handful of labs worldwide that is able to image local events in cells of the vascular wall in real time in blood perfused microvessels in living animals.

We also use single microparticle tracking to define the local fluid dynamic environment in vivo, and confocal imaging of signaling molecules and leukocyte populations in the in situ blood vessel.

Recent Journal Articles

Showing the 5 most recent journal articles. 84 available »

2016 Feb 1
Sarelius IH, Titus PA, Maimon N, Okech W, Wilke-Mounts SJ, Brennan JR, Hocking DC. "Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin." The Journal of physiology. 2016 Feb 1; 594(3):687-97. Epub 2016 Jan 15.
2015 Nov 1
Murrant CL, Sarelius IH. "Local control of blood flow during active hyperaemia: what kinds of integration are important?" The Journal of physiology. 2015 Nov 1; 593(21):4699-711. Epub 2015 Sep 29.
2015
Sarelius IH, Glading AJ. "Control of vascular permeability by adhesion molecules." Tissue barriers. 2015 3(1-2):e985954. Epub 2015 Apr 03.
2015
Rocheleau AD, Sumagin R, Sarelius IH, King MR. "Simulation and Analysis of Tethering Behavior of Neutrophils with Pseudopods." PloS one. 2015 10(6):e0128378. Epub 2015 Jun 19.
2014 Nov 21
Distefano PV, Kuebel JM, Sarelius IH, Glading AJ. "KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling." The Journal of biological chemistry. 2014 Nov 21; 289(47):33054-65. Epub 2014 Oct 15.

Education

PhD | Physiology | University of Auckland, New Zealand1978
MSc(Hons) | Physiology | Massey University1972
BSc | Physiology | Massey University1968