Skip to main content
Explore URMC

William M. Maniscalco, M.D.

Contact Information

Phone Numbers

Office: (585) 275-2972

Fax: (585) 461-3614

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting



Bronchopulmonary Dysplasia


Dr. Maniscalco studies pulmonary microvascular development in lung injury. Using various animal models, including a non-human primate model of BPD, this work examines the effects of oxygen and ventilation of immature lung on the development of alveolar capillaries. The major goals of the research are to characterize microvascular development in lung injury and investigate angiogenic and angiostatic regulators in normal and injured lung. Recent work has linked expression of inflammatory CXC chemokine mediators, which regulate angiogenesis and are part of the pathophysiology of BPD, to impaired lung microangiogenesis.



MD | Johns Hopkins University School of Medicine

Post-doctoral Training & Residency

07/01/1975 - 06/30/1978
Fellowship in Neonatal-Perinatal Medicine at Yale New Haven Hospital

07/01/1973 - 06/30/1975
Residency in Pediatrics at Children's Hospital Boston - Harvard University

07/01/1972 - 06/30/1973
Internship in Pediatrics at Children's Hospital Boston - Harvard University

VIEW ALL expand_more


America's Top Doctors
Sponsor: Castle Connolly Medical, Ltd.

1980 - 1982
Buswell Faculty Research Award
Sponsor: University of Rochester School of Medicine
Location: Rochester, NY


Journal Articles

Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ. "Murine mechanical ventilation stimulates alveolar epithelial cell proliferation." Experimental lung research.. 2010 Aug 0; 36(6):331-41.

Chess P, Benson R, Maniscalco WM, Wright T, O'Reilly M, Johnston C. "Murine mechanical ventilation stimulates alveolar epithelial cell proliferation". Exp Lung Research. 2010; 36(6): 331-341.

McCurnin, DC.; Willis, B.; Pierce, RA.; Chang, Ly.; Yoder, BA.; Yuhanna, IS.; Ballard, PA.; Pepe, JK.; Maniscalco, WM.; Crapo, JD.; Grubb, PH.; Shaul, PW. "Postnatal estradiol administration upregulates pulmonary NO synthase, improves pulmonary function, and lowers ventilatory support requirements in a primate model of neonatal chronic lung disease of Prematurity." Am J Respir Crit Care Med. 2009; .

Books & Chapters

Chapter Title: Respiratory Distress Syndrome/Bronchopulmonary Dysplasia
Book Title: Avery's Neonatology Board Review
Author List: Maniscalco WM, Chess P
Published By: Elsevier 2019 in Philadelphia

Chapter Title: Disruption of Lung Vascular Development in BPD
Book Title: Informa Healthcare
Author List: Maniscalco, WM.; Bhandari, V.
Published By: Abman (In Press) 2009 in New York

Chapter Title: Vascular endothelial growth factor.
Book Title: Encyclopedia of Respiratory Medicine
Author List: D'Angio CT, Maniscalco WM
Edited By: Laurent GJ, Shapiro SD
Published By: Elsevier 2006 in London, England