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William M. Maniscalco, M.D.

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Office: (585) 275-2972

Fax: (585) 461-3614

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Bronchopulmonary Dysplasia


Dr. Maniscalco studies pulmonary microvascular development in lung injury. Using various animal models, including a non-human primate model of BPD, this work examines the effects of oxygen and ventilation of immature lung on the development of alveolar capillaries. The major goals of the research are to characterize microvascular development in lung injury and investigate angiogenic and angiostatic regulators in normal and injured lung. Recent work has linked expression of inflammatory CXC chemokine mediators, which regulate angiogenesis and are part of the pathophysiology of BPD, to impaired lung microangiogenesis.



MD | Johns Hopkins University School of Medicine (USA)

Post-doctoral Training & Residency

07/01/1975 - 06/30/1978
Fellowship in Neonatal-Perinatal Medicine at Yale New Haven Hospital

07/01/1973 - 06/30/1975
Residency in Pediatrics at Boston Children's Hospital (USA)

07/01/1972 - 06/30/1973
Internship in Pediatrics at Boston Children's Hospital (USA)

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America's Top Doctors
Sponsor: Castle Connolly Medical, Ltd.

1980 - 1982
Buswell Faculty Research Award
Sponsor: University of Rochester School of Medicine
Location: Rochester, NY


Journal Articles

Yee M, McDavid AN, Cohen ED, Huyck HL, Poole C, Altman BJ, Maniscalco WM, Deutsch GH, Pryhuber GS, O'Reilly MA. "Neonatal Hyperoxia Activates ATF4 to Stimulate Folate Metabolism and AT2 Cell Proliferation." American journal of respiratory cell and molecular biology.. 2022 Jan 19; Epub 2022 Jan 19.

Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ. "Murine mechanical ventilation stimulates alveolar epithelial cell proliferation." Experimental lung research.. 2010 Aug; 36(6):331-41.

Chess P, Benson R, Maniscalco WM, Wright T, O'Reilly M, Johnston C. "Murine mechanical ventilation stimulates alveolar epithelial cell proliferation". Exp Lung Research. 2010; 36(6): 331-341.

Books & Chapters

Chapter Title: Respiratory Distress Syndrome/Bronchopulmonary Dysplasia
Book Title: Avery's Neonatology Board Review
Author List: Maniscalco WM, Chess P
Published By: Elsevier 2019 in Philadelphia

Chapter Title: Disruption of Lung Vascular Development in BPD
Book Title: Informa Healthcare
Author List: Maniscalco, WM.; Bhandari, V.
Published By: Abman (In Press) 2009 in New York

Chapter Title: Pathogenesis of bronchopulmonary dysplasia (BPD)
Book Title: Sem Perinatol
Author List: Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM
Edited By: Bhandari V
Published By: TBD 2006