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William M. Maniscalco, M.D.

Contact Information

Phone Numbers

Office: (585) 275-2972

Fax: (585) 461-3614

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting

Pediatrics

Biography

Bronchopulmonary Dysplasia

Research

Dr. Maniscalco studies pulmonary microvascular development in lung injury. Using various animal models, including a non-human primate model of BPD, this work examines the effects of oxygen and ventilation of immature lung on the development of alveolar capillaries. The major goals of the research are to characterize microvascular development in lung injury and investigate angiogenic and angiostatic regulators in normal and injured lung. Recent work has linked expression of inflammatory CXC chemokine mediators, which regulate angiogenesis and are part of the pathophysiology of BPD, to impaired lung microangiogenesis.

Credentials

Education

1968
BA | University of Massachusetts
Pre-Medical

1972
MD | Johns Hopkins University School of Medicine
Medicine

Post-doctoral Training & Residency

07/01/1975 - 06/30/1978
Fellowship in Neonatal-Perinatal Medicine at Yale New Haven Hospital

07/01/1973 - 06/30/1975
Residency in Pediatrics at Children's Hospital Boston - Harvard University

07/01/1972 - 06/30/1973
Internship in Pediatrics at Children's Hospital Boston - Harvard University

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Awards

2016
America's Top Doctors
Sponsor: Castle Connolly Medical, Ltd.

1980 - 1982
Buswell Faculty Research Award
Sponsor: University of Rochester School of Medicine
Location: Rochester, NY

Publications

Journal Articles

2010
Chess P, Benson R, Maniscalco WM, Wright T, O'Reilly M, Johnston C. "Murine mechanical ventilation stimulates alveolar epithelial cell proliferation". Exp Lung Research. 2010; 36(6): 331-341.

2009
McCurnin, DC.; Willis, B.; Pierce, RA.; Chang, Ly.; Yoder, BA.; Yuhanna, IS.; Ballard, PA.; Pepe, JK.; Maniscalco, WM.; Crapo, JD.; Grubb, PH.; Shaul, PW. "Postnatal estradiol administration upregulates pulmonary NO synthase, improves pulmonary function, and lowers ventilatory support requirements in a primate model of neonatal chronic lung disease of Prematurity." Am J Respir Crit Care Med. 2009; .

6/2007
Pierce RA, Joyce B, Officer S, Heintz C, Moore C, McCurnin D, Johnston C, Maniscalco W. "Retinoids increase lung elastin expression but fail to alter morphology or angiogenesis genes in premature ventilated baboons." Pediatric research.. 2007 Jun 0; 61(6):703-9.

Books & Chapters

2019
Chapter Title: Respiratory Distress Syndrome/Bronchopulmonary Dysplasia
Book Title: Avery's Neonatology Board Review
Author List: Maniscalco WM, Chess P
Published By: Elsevier 2019 in Philadelphia

2009
Chapter Title: Disruption of Lung Vascular Development in BPD
Book Title: Informa Healthcare
Author List: Maniscalco, WM.; Bhandari, V.
Published By: Abman (In Press) 2009 in New York

2006
Chapter Title: Vascular endothelial growth factor.
Book Title: Encyclopedia of Respiratory Medicine
Author List: D'Angio CT, Maniscalco WM
Edited By: Laurent GJ, Shapiro SD
Published By: Elsevier 2006 in London, England

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