William M. Maniscalco, M.D.

William M. Maniscalco, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 275-5884
Fax: (585) 461-3614
Lab: (585) 275-1492

Research Bio

Dr. Maniscalco's research interests are:
1) Bronchopulmonary Dysplasia
2) Angiogenesis
3) Lung Development.

His laboratory research focuses on injury to the developing lung and the cellular response that is essential to repair the injured alveolus. Oxygen injury to the lungs is a common clinical problem that can result from therapeutic use of oxygen.

Their primary focus is on the development of the microvasculature and the effects of oxidant injury. The factors that regulate development of the pulmonary microvasculature are not known but likely involve vascular endothelial growth factor (VEGF) and its receptors. VEGF is a peptide growth factor that is specifically mitogenic for endothelial cells. It may be a major angiogenic growth factor in several situations, such as lung development and recovery lung injury, in which neovascularization is active. They have determined that alveolar type II cells express VEGF in animals during the recovery phase of lung injury.

Their current studies seek to determine which cells express VEGF in developing lung, the impact of hyperoxic injury on lung vascular development, and the regulation of type II cell VEGF expression in vitro. They are also determining endothelial expression of the major VEGF receptors in lung during development and after oxygen injury. They use standard molecular and protein methods, such as Northern hybridization, in situ hybridization, immunocytochemistry and Western blotting.

Awards & Honors (Local)

Buswell Faculty Research Award | University of Rochester School of Medicine | Rochester, NY 1980 - 1982

Recent Journal Articles

Showing the 5 most recent journal articles. 66 available »

McCurnin, DC.; Willis, B.; Pierce, RA.; Chang, Ly.; Yoder, BA.; Yuhanna, IS.; Ballard, PA.; Pepe, JK.; Maniscalco, WM.; Crapo, JD.; Grubb, PH.; Shaul, PW. "Postnatal estradiol administration upregulates pulmonary NO synthase, improves pulmonary function, and lowers ventilatory support requirements in a primate model of neonatal chronic lung disease of Prematurity." Am J Respir Crit Care Med. 2009; .
2007 Jun
Pierce RA, Joyce B, Officer S, Heintz C, Moore C, McCurnin D, Johnston C, Maniscalco W. "Retinoids increase lung elastin expression but fail to alter morphology or angiogenesis genes in premature ventilated baboons." Pediatric research. 2007 Jun; 61(6):703-9.
2006 Nov
Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. "Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development." American journal of physiology. Lung cellular and molecular physiology. 2006 Nov; 291(5):L1101-11. Epub 2006 Jul 21.
2006 Aug
Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM. "Pathogenesis of bronchopulmonary dysplasia." Seminars in perinatology. 2006 Aug; 30(4):171-8.
2005 Sep
Maniscalco WM, Watkins RH, Roper JM, Staversky R, O'Reilly MA. "Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression." Pediatric research. 2005 Sep; 58(3):549-56.

Current Appointments

Professor - Department of Pediatrics, Neonatology (SMD) - Primary


Pediatrics - American Board of Pediatrics
Neonatal-Perinatal Medicine - American Board of Pediatrics


MD | Medicine | Johns Hopkins University School of Medicine1972
BA | Pre-Medical | University of Massachusetts1968

Post-Doctoral Training & Residency

Fellowship in Neonatal-Perinatal Medicine at Yale New Haven Hospital07/01/1975 - 06/30/1978
Residency in Pediatrics at Children's Hospital Boston07/01/1973 - 06/30/1975
Internship in Pediatrics at Children's Hospital Boston07/01/1972 - 06/30/1973