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Shalom Rackovsky, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-2235

Faculty Appointments

Biography

Research

We are interested in computational studies of protein folding and dynamics, and particularly in the information about protein physics which is available through bioinformatic studies. We have developed a series of novel approaches to protein biophysics based on ideas from information theory and signal processing. In recent work we developed the first bioinformatic representation of protein dynamics, and are currently using this tool, in combination with earlier studies of the static physical properties of amino acid sequences, to elucidate basic mechanisms of protein folding. We have extended our studies to encompass intrinsically disordered proteins, and are using the sequences of those proteins as an added resource in the study of folding and stability in proteins.
In earlier work, we have applied novel bioinformatic methods to the comparison of protein sequences and protein structures, and used the resulting data to address problems at the foundations of bioinformatics. These studies are still ongoing in our group.

Credentials

Education

1967
BA | Yeshiva University
Chemistry

1972
PhD | Massachusetts Institute of Technology
Chemical Physics

Publications

Journal Articles

12/3/2020
Scheraga HA, Rackovsky S. "Dynamic and conformational switching in proteins." Biopolymers.. 2020 Dec 3; :e23411. Epub 2020 Dec 03.

11/19/2020
Maisuradze GG, Montelione GT, Rackovsky S, Skolnick J. "Tribute to Harold A. Scheraga." The journal of physical chemistry. B. 2020 Nov 19; 124(46):10301-10302. Epub 2020 Oct 23.

8/18/2020
Rackovsky S, Scheraga HA. "The structure of protein dynamic space." Proceedings of the National Academy of Sciences of the United States of America.. 2020 Aug 18; 117(33):19938-19942. Epub 2020 Aug 05.

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