Skip to main content
Explore URMC

Kathleen E. McGrath, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5073

Research Labs

Faculty Appointments



Dr. McGrath's research interests are:

1) Emergence of hematopoiesis in murine embryo and ES/iPS cells
2) Recovery of hematopoiesis post radiation
3) Imaging flow cytometry for examination of rare populations
4) Roles of early erythroid-myeloid progenitors during embryogenesis

Dr. McGrath is a Research Assistant Professor working within Jim Palis' research group. Her research interests are in how the hematopoietic system assembled both initially in the embryo and during repair after radiation damage in the adult. She applies that paradigm to the development of the blood system in the mouse embryo where overlapping waves of stem cells emergence, each with different lineage and self-renewal potentials. Similarly, regeneration of hematopoiesis in irradiated adult bone marrow is regulated through compartments of blood cells precursors and progenitors with differential sensitivities and responses to damage. Her work relies on prospectively discriminating these cells with different potentials and understanding the signaling that has determined their fate.

Recently, Dr. McGrath has focused on a unique embryonic hematopoietic progenitor with potential for short term production of erythroid and myeloid cells that can also be identified in embryonic stem cells and can function when transfused in adults. Additionally, her studies of recovery of hematopoietic stem cells as well megakaryocytes after radiation are addressing mitigation of short term thrombocytopenia as well as long term stem cell dysfunction. These studies have benefited from her expertise in flow cytometry including pioneering the use of imaging flow cytometry in analysis of development and repair from the most primitive progenitors to mature blood cells focusing on erythroid and megakaryocyte lineages.



BA | Reed College

MS | University of Rochester

PhD | University of Rochester


Leon Wheeless Innovation in Cytometry Award
Sponsor: Western NY Flow Users Group
Location: University of Rochester Medical School


Journal Articles

Zhang Y, McGrath KE, Ayoub E, Kingsley PD, Yu H, Fegan K, McGlynn KA, Rudzinskas S, Palis J, Perkins AS. "Mds1, an inducible Cre allele specific to adult-repopulating hematopoietic stem cells." Cell reports.. 2021 Aug 17; 36(7):109562.

Saunders J, Niswander LM, McGrath KE, Koniski A, Catherman SC, Ture SK, Medhora M, Kingsley PD, Calvi LM, Williams JP, Morrell CN, Palis J. "Long-acting PGE2 and Lisinopril Mitigate H-ARS." Radiation research.. 2021 Jun 21; Epub 2021 Jun 21.

Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders Ii J, Georas SN, Veazey JM, Madere F, Tesoro Santos L, Arne AM, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons CE, Metcalf Pate KA, McGrath KE, Palis J, Morrell C. "Lung megakaryocytes are immune modulatory cells." The Journal of clinical investigation.. 2020 Oct 20; Epub 2020 Oct 20.

Books & Chapters

Chapter Title: Polyamine Stress: A Variable Nonspecific Component of Disease?
Book Title: Polyamines: Basic Clinical Aspects
Author List: Campbell RA, McGrath KE
Edited By: AE Inahori et al
Published By: VNU Science Press 1984 in The Netherlands