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William H. Merigan, Jr., Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-4872

Research Labs

Faculty Appointments

  • Professor - Department of Ophthalmology (SMD)
  • Professor - Department of Brain/Cognitive Sciences RC (RC) - Joint
  • Professor - Department of Center for Visual Science A&S (RC) - Joint

Biography

Professional Background

Dr. Merigan's research examines the role of retinal ganglion cells in visual perception in the primate (human and macaque). The primate retina contains at least 14 different types of retinal ganglion cells, and each type forms a complete network across the retina. Because the size, shape andprojections of each of the cell types is distinctive, it is thought that they may play quite different and possibly independent roles invisual function,but at present relatively little is known about this question. Some clues about possible functions of different ganglion cell classes comes from their structure (some extend across large swaths of retina, while others get input from tiny regions of retina), their physiology (some ganglion cells respond to color, while others are color blind), and their projections into the brain (some ganglion cells project to visual cortex while others reach the superchiasmatic nucleus, which is thought to be important in diurnal rhythms).

Credentials

Education

1967
BA | Boston College
Psychology

1972
MS | Univ of Maryland
Psychology

1975
PhD | Univ of Maryland
Psychology, All Other

Publications

Journal Articles

1/1/2019
Walters S, Schwarz C, Sharma R, Rossi EA, Fischer WS, DiLoreto DA, Strazzeri J, Nelidova D, Roska B, Hunter JJ, Williams DR, Merigan WH. "Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye." Biomedical optics express.. 2019 Jan 1; 10(1):66-82. Epub 2018 Dec 05.

2018
Cheong SK, Strazzeri JM, Williams DR, Merigan WH. "All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice." PloS one.. 2018 13(3):e0194947. Epub 2018 Mar 29.

2018
Cheong SK, Xiong W, Strazzeri JM, Cepko CL, Williams DR, Merigan WH. "In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators." Advances in experimental medicine and biology.. 2018 1074:135-144.

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