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Daniel H. Ryan, M.D.

Pathology

Contact Information

Phone Numbers

Office: (585) 275-3184

Fax: (585) 276-2802

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Dr. Ryan specializes in hematopathology. He is a former Director of the Hematology and Molecular Diagnostics laboratories and was Director of the URMC Labs until his appointment as Department Chair in 2004. His research established molecular events detremining B lymphoid lineage commitment and early differentiation of human B cell progenitors. He has recently focused on the elucidation of the role of common genetic variants in determining outcome of patients following a coronary event.

Research

We are interested in the molecular events determining B lymphoid lineage commitment and early differentiation of B cell progenitors. Insight into the regulation of B cell development can be applied to studies of childhood lymphoblastic leukemia, a neoplasm derived from an early B lymphoid progenitor which cannot properly commit and/or differentiate into a mature B cell.

Signals for human B cell development are incompletely understood, largely due to difficulties in culturing normal human B cell progenitors. Using a bone marrow stromal dependent culture system, we have identified colony forming human lymphoid progenitors in a very early bone marrow population (CD34+/CD19-/IL-7 receptor -) which expresses early myeloid as well as lymphoid markers, and may therefore represent cells engaged in the earliest steps of commitment to two of the major hematopoietic lineages, lymphoid and myeloid. This experimental system can be used to define critical molecular events determining the commitment of early human hematopoietic progenitors to B lymphoid differentiation.

The goal of my research is to characterize the signals for lineage commitment and B lineage differentiation of these early human lymphoid progenitors. Efforts focus on analysis of immunoglobulin gene rearrangements of individual progenitors as an indicator of early B lineage commitment using advanced cell sorting and micromanipulation techniques, and transfer of B lineage specific regulatory genes directly into normal human hematopoietic progenitors to assess their contribution to B lineage commitment and development.

Credentials

Faculty Appointments

Specialties

  • Clinical Pathology/Laboratory Medicine - American Board of Pathology

Education

1971
BS | University of Notre Dame
Pre-Medical

1975
MD | Johns Hopkins U Sch Medicine
Medicine

Post-doctoral Training & Residency

12/01/1975 - 06/01/1981
Fellowship in Pathology-Anatomic and Clinical at University of Rochester Medical Center

06/01/1975 - 12/01/1975
Residency in Pediatrics at Univ. of Rochester School of Medicine and Dentistry

Awards

2000
My Fifth Award University of Rochester Medical Center

1999
My Fourth Award University of Rochester Medical Center

1998
My Third Award University of Rochester Medical Center

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Publications

Journal Articles

7/2016
Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE. "Influences on plasminogen activator inhibitor-2 polymorphism-associated recurrent cardiovascular disease risk in patients with high HDL cholesterol and inflammation." Atherosclerosis.. 2016 Jul 0; 250:1-8. Epub 2016 Apr 21.

4/2016
Chen L, Oleksyn D, Pulvino M, Sanz I, Ryan D, Ryan C, Lin CS, Poligone B, Pentland AP, Ritchlin C, Zhao J. "A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells." Immunology letters.. 2016 Apr 0; 172:67-78. Epub 2016 Feb 26.

4/2014
Moss AJ, Ryan DH, Yeaney GA. "Ganglionitis and genetic cardiac arrhythmias: more questions than answers." Circulation. Arrhythmia and electrophysiology.. 2014 Apr 0; 7(2):190-1.

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