CONTACT INFORMATIONBIOGRAPHYCREDENTIALSAWARDSPATENTSPUBLICATIONSDaniel H. Ryan, M.D.Contact InformationPhone NumbersOffice: (585) 275-3184Fax: (585) 276-2802assignmentAccepting New PatientsLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 626Rochester, NY 14642Faculty AppointmentsProfessor Emeritus - Department of Pathology and Laboratory Medicine (SMD) Patient Care SettingPathologyBiographyDr. Ryan specializes in hematopathology. He is a former Director of the Hematology and Molecular Diagnostics laboratories and was Director of the URMC Labs until his appointment as Department Chair in 2004. His research established molecular events determining B lymphoid lineage commitment and early differentiation of human B cell progenitors. He has recently focused on the elucidation of the role of common genetic variants in determining outcome of patients following a coronary event.ResearchWe are interested in the molecular events determining B lymphoid lineage commitment and early differentiation of B cell progenitors. Insight into the regulation of B cell development can be applied to studies of childhood lymphoblastic leukemia, a neoplasm derived from an early B lymphoid progenitor which cannot properly commit and/or differentiate into a mature B cell. Signals for human B cell development are incompletely understood, largely due to difficulties in culturing normal human B cell progenitors. Using a bone marrow stromal dependent culture system, we have identified colony forming human lymphoid progenitors in a very early bone marrow population (CD34+/CD19-/IL-7 receptor -) which expresses early myeloid as well as lymphoid markers, and may therefore represent cells engaged in the earliest steps of commitment to two of the major hematopoietic lineages, lymphoid and myeloid. This experimental system can be used to define critical molecular events determining the commitment of early human hematopoietic progenitors to B lymphoid differentiation. The goal of my research is to characterize the signals for lineage commitment and B lineage differentiation of these early human lymphoid progenitors. Efforts focus on analysis of immunoglobulin gene rearrangements of individual progenitors as an indicator of early B lineage commitment using advanced cell sorting and micromanipulation techniques, and transfer of B lineage specific regulatory genes directly into normal human hematopoietic progenitors to assess their contribution to B lineage commitment and development.CredentialsEducation1975MD | Johns Hopkins University School of MedicinePost-doctoral Training & Residency7/1/1976 - 6/30/1981Fellowship in Pathology at University of Rochester Medical Center07/01/1975 - 6/30/1976Residency in Pediatrics at Univ. of Rochester School of Medicine and DentistryAwards2000My Fifth Award University of Rochester Medical Center1999My Fourth Award University of Rochester Medical Center1998My Third Award University of Rochester Medical CenterVIEW ALL expand_morePatentsPatent Title: Identifying Risk of a Medical Event Patent #: 8,979,753 Issue Date: Mar 17, 2015 Country: United States Invented By: James P Corsetti, Arthur J Moss, Daniel H Ryan, Charles E SparksPublicationsJournal Articles7/2016Corsetti JP, Salzman P, Ryan D, Moss AJ, Zareba W, Sparks CE. "Influences on plasminogen activator inhibitor-2 polymorphism-associated recurrent cardiovascular disease risk in patients with high HDL cholesterol and inflammation." Atherosclerosis.. 2016 Jul 0; 250:1-8. Epub 2016 Apr 21. 4/2016Chen L, Oleksyn D, Pulvino M, Sanz I, Ryan D, Ryan C, Lin CS, Poligone B, Pentland AP, Ritchlin C, Zhao J. "A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells." Immunology letters.. 2016 Apr 0; 172:67-78. Epub 2016 Feb 26. 4/2014Moss AJ, Ryan DH, Yeaney GA. "Ganglionitis and genetic cardiac arrhythmias: more questions than answers." Circulation. Arrhythmia and electrophysiology.. 2014 Apr 0; 7(2):190-1. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Daniel H. Ryan, M.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Daniel H. Ryan, M.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.