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Elizabeth Grayhack, Ph.D.


Showing all 43 journal articles & 0 books available

Journal Articles

Houston L, Platten EM, Connelly SM, Wang J, Grayhack EJ. "Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by Integrated Stress Response regulators Gcn1 and Gcn20." RNA.. 2021 Dec 16; Epub 2021 Dec 16.

Ghoneim DH, Zhang X, Brule CE, Mathews DH, Grayhack EJ. "Conservation of location of several specific inhibitory codon pairs in the Saccharomyces sensu stricto yeasts reveals translational selection." Nucleic acids research.. 2018 Dec 21; Epub 2018 Dec 21.

Wang J, Zhou J, Yang Q, Grayhack EJ. "Multi-protein Bridging Factor 1(Mbf1), Rps3 and Asc1 prevent stalled ribosomes from frameshifting." eLife.. 2018 Nov 22; 7Epub 2018 Nov 22.

Coller J, Grayhack EJ. "The analysis of translational mechanisms that modulate gene expression." Methods : a companion to Methods in enzymology.. 2018 Mar 15; 137:1-2.

Brule CE, Grayhack EJ. "Synonymous Codons: Choose Wisely for Expression." Trends in genetics : TIG.. 2017 Apr; 33(4):283-297. Epub 2017 Mar 12.

Patra B, Kon Y, Yadav G, Sevold AW, Frumkin JP, Vallabhajosyula RR, Hintze A, Østman B, Schossau J, Bhan A, Marzolf B, Tamashiro JK, Kaur A, Baliga NS, Grayhack EJ, Adami C, Galas DJ, Raval A, Phizicky EM, Ray A. "A genome wide dosage suppressor network reveals genomic robustness." Nucleic acids research.. 2017 Jan 9; 45(1):255-270. Epub 2016 Nov 29.

Gamble CE, Brule CE, Dean KM, Fields S, Grayhack EJ. "Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast." Cell.. 2016 Jul 28; 166(3):679-690. Epub 2016 Jun 30.

Brule CE, Dean KM, Grayhack EJ. "RNA-ID, a Powerful Tool for Identifying and Characterizing Regulatory Sequences." Methods in enzymology.. 2016 572:237-53. Epub 2016 Mar 11.

Quivey RG, Grayhack EJ, Faustoferri RC, Hubbard CJ, Baldeck JD, Wolf AS, MacGilvray ME, Rosalen PL, Scott-Anne K, Santiago B, Gopal S, Payne J, Marquis RE. "Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants." Molecular oral microbiology.. 2015 Dec; 30(6):474-95. Epub 2015 Jun 19.

Wolf AS, Grayhack EJ. "Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats." RNA.. 2015 May; 21(5):935-45. Epub 2015 Mar 19.

Guy MP, Young DL, Payea MJ, Zhang X, Kon Y, Dean KM, Grayhack EJ, Mathews DH, Fields S, Phizicky EM. "Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis." Genes & development.. 2014 Aug 1; 28(15):1721-32.

Letzring DP, Wolf AS, Brule CE, Grayhack EJ. "Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1." RNA.. 2013 Sep; 19(9):1208-17. Epub 2013 Jul 03.

Grant TD, Luft JR, Wolfley JR, Snell ME, Tsuruta H, Corretore S, Quartley E, Phizicky EM, Grayhack EJ, Snell EH. "The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA." Journal of molecular biology.. 2013 Jul 24; 425(14):2480-93. Epub 2013 Apr 10.

Dean KM, Grayhack EJ. "RNA-ID, a highly sensitive and robust method to identify cis-regulatory sequences using superfolder GFP and a fluorescence-based assay." RNA.. 2012 Dec; 18(12):2335-44. Epub 2012 Oct 24.

Grant TD, Snell EH, Luft JR, Quartley E, Corretore S, Wolfley JR, Elizabeth Snell M, Hadd A, Perona JJ, Phizicky EM, Grayhack EJ. "Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase." Nucleic acids research.. 2012 Apr; 40(8):3723-31. Epub 2011 Dec 17.

Letzring DP, Dean KM, Grayhack EJ. "Control of translation efficiency in yeast by codon-anticodon interactions." RNA.. 2010 Dec; 16(12):2516-28. Epub 2010 Oct 22.

Quartley E, Alexandrov A, Mikucki M, Buckner FS, Hol WG, Detitta GT, Phizicky EM, Grayhack EJ. "Heterologous expression of L. major proteins in S. cerevisiae: a test of solubility, purity, and gene recoding." Journal of structural and functional genomics. 2009 Sep; 10(3):233-47. Epub 2009 Aug 22.

Chernyakov I, Whipple JM, Kotelawala L, Grayhack EJ, Phizicky EM. "Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1." Genes & development.. 2008 May 15; 22(10):1369-80. Epub 2008 Apr 28.

Kotelawala L, Grayhack EJ, Phizicky EM. "Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species." RNA.. 2008 Jan; 14(1):158-69. Epub 2007 Nov 19.

Jackman JE, Grayhack EJ, Phizicky EM. "The use of Saccharomyces cerevisiae proteomic libraries to identify RNA-modifying proteins." Methods in molecular biology.. 2008 488:383-93.

Chernyakov I, Baker MA, Grayhack EJ, Phizicky EM. "Chapter 11. Identification and analysis of tRNAs that are degraded in Saccharomyces cerevisiae due to lack of modifications." Methods in enzymology.. 2008 449:221-37.

Malkowski MG, Quartley E, Friedman AE, Babulski J, Kon Y, Wolfley J, Said M, Luft JR, Phizicky EM, DeTitta GT, Grayhack EJ. "Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing." Proceedings of the National Academy of Sciences of the United States of America.. 2007 Apr 17; 104(16):6678-83. Epub 2007 Apr 10.

Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM. "The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4." RNA.. 2007 Mar; 13(3):404-13. Epub 2007 Jan 22.

White MA, Clark KM, Grayhack EJ, Dumont ME. "Characteristics affecting expression and solubilization of yeast membrane proteins." Journal of molecular biology.. 2007 Jan 19; 365(3):621-36. Epub 2006 Oct 06.

Jackman JE, Kotelawala L, Grayhack EJ, Phizicky EM. "Identification and characterization of modification enzymes by biochemical analysis of the proteome." Methods in enzymology.. 2007 425:139-52.

Alexandrov A, Chernyakov I, Gu W, Hiley SL, Hughes TR, Grayhack EJ, Phizicky EM. "Rapid tRNA decay can result from lack of nonessential modifications." Molecular cell.. 2006 Jan 6; 21(1):87-96.

Phizicky EM, Grayhack EJ. "Proteome-scale analysis of biochemical activity." Critical reviews in biochemistry and molecular biology. 2006 41(5):315-27.

Gelperin DM, White MA, Wilkinson ML, Kon Y, Kung LA, Wise KJ, Lopez-Hoyo N, Jiang L, Piccirillo S, Yu H, Gerstein M, Dumont ME, Phizicky EM, Snyder M, Grayhack EJ. "Biochemical and genetic analysis of the yeast proteome with a movable ORF collection." Genes & development.. 2005 Dec 1; 19(23):2816-26.

Gu W, Hurto RL, Hopper AK, Grayhack EJ, Phizicky EM. "Depletion of Saccharomyces cerevisiae tRNA(His) guanylyltransferase Thg1p leads to uncharged tRNAHis with additional m(5)C." Molecular and cellular biology.. 2005 Sep; 25(18):8191-201.

Ma X, Yang C, Alexandrov A, Grayhack EJ, Behm-Ansmant I, Yu YT. "Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism." The EMBO journal.. 2005 Jul 6; 24(13):2403-13. Epub 2005 Jun 16.

Alexandrov A, Grayhack EJ, Phizicky EM. "tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p." RNA.. 2005 May; 11(5):821-30. Epub 2005 Apr 05.

Alexandrov A, Vignali M, LaCount DJ, Quartley E, de Vries C, De Rosa D, Babulski J, Mitchell SF, Schoenfeld LW, Fields S, Hol WG, Dumont ME, Phizicky EM, Grayhack EJ. "A facile method for high-throughput co-expression of protein pairs." Molecular & cellular proteomics : MCP.. 2004 Sep; 3(9):934-8. Epub 2004 Jul 07.

Van Slyke C, Grayhack EJ. "The essential transcription factor Reb1p interacts with the CLB2 UAS outside of the G2/M control region." Nucleic acids research.. 2003 Aug 1; 31(15):4597-607.

Phizicky EM, Martzen MR, McCraith SM, Spinelli SL, Xing F, Shull NP, Van Slyke C, Montagne RK, Torres FM, Fields S, Grayhack EJ. "Biochemical genomics approach to map activities to genes." Methods in enzymology.. 2002 350:546-59.

Grayhack EJ, Phizicky EM. "Genomic analysis of biochemical function." Current opinion in chemical biology.. 2001 Feb; 5(1):34-9.

Martzen MR, McCraith SM, Spinelli SL, Torres FM, Fields S, Grayhack EJ, Phizicky EM. "A biochemical genomics approach for identifying genes by the activity of their products." Science.. 1999 Nov 5; 286(5442):1153-5.

Kuo MH, Nadeau ET, Grayhack EJ. "Multiple phosphorylated forms of the Saccharomyces cerevisiae Mcm1 protein include an isoform induced in response to high salt concentrations." Molecular and cellular biology.. 1997 Feb; 17(2):819-32.

Kuo MH, Grayhack E. "A library of yeast genomic MCM1 binding sites contains genes involved in cell cycle control, cell wall and membrane structure, and metabolism." Molecular and cellular biology.. 1994 Jan; 14(1):348-59.

Grayhack EJ. "The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site." Molecular and cellular biology.. 1992 Aug; 12(8):3573-82.

Yang XJ, Hart CM, Grayhack EJ, Roberts JW. "Transcription antitermination by phage lambda gene Q protein requires a DNA segment spanning the RNA start site." Genes & development.. 1987 May; 1(3):217-26.

Grayhack EJ, Yang XJ, Lau LF, Roberts JW. "Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site." Cell.. 1985 Aug; 42(1):259-69.

Grayhack EJ, Roberts JW. "Purification of the bacteriophage lambda late gene regulator encoded by gene Q." The Journal of biological chemistry.. 1983 Aug 10; 258(15):9192-6.

Grayhack EJ, Roberts JW. "The phage lambda Q gene product: activity of a transcription antiterminator in vitro." Cell.. 1982 Sep; 30(2):637-48.