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Carl J. Johnston, Ph.D.

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Faculty Appointments



Dr. Carl Johnston's work seeks to understand how the postnatal lung copes with external stress. A critical biological factor that plays a role in childhood pulmonary susceptibility is that a significant portion of lung development takes place postnatally. One of the environmental factors relevant to developmental lung disease is the recent increase in complexity and distribution, if not the levels, of airborne pollutants, including allergens and endotoxins, respirable particulate matter and irritant gases, exposure to which damages various cell types. Among the most important of these are the respiratory epithelium and critical immune effector cell populations. Furthermore; combined exposures to multiple pollutants may activate several unique signaling pathways which are age dependent and depending on the sequence of initiation may result in responses not predicted by evaluating exposures to an individual pollutant. His work depends heavily on mRNA analysis, microarray technology, immuno-histochemistry and in situ hybridization. This work is supported by participation in several NIH grants.



BA | Buffalo State College

MS | University of Rochester

PhD | SUNY at Buffalo
Pharmacology and Toxicology


SOT Meeting, Outstanding Presentation – Mixtures Specialty Section


Journal Articles

Ye J, Gavras NW, Keeley DC, Hughson AL, Hannon G, Vrooman TG, Lesch ML, Johnston CJ, Lord EM, Belt BA, Linehan DC, Eyles J, Gerber SA. "CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models." Journal for immunotherapy of cancer.. 2023 May; 11(5)

Day NJ, Wang J, Johnston CJ, Kim SY, Olson HM, House EL, Attah IK, Clair GC, Qian WJ, McGraw MD. "Rat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures." American journal of physiology. Lung cellular and molecular physiology.. 2023 Mar 7; Epub 2023 Mar 07.

Groves AM, Misra R, Clair G, Hernady E, Olson H, Orton D, Finkelstein J, Marples B, Johnston CJ. "Influence of the irradiated pulmonary microenvironment on macrophage and T cell dynamics." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2023 Feb 20; :109543. Epub 2023 Feb 20.

Books & Chapters

Chapter Title: Ambient ultrafine particles: Inducers of acute injury?
Book Title: Relationships between respiratory disease and exposure to air pollution
Author List: Oberdörster G, Gelein R, Johnston C, Mercer P, Corson N, Finkelstein J.
Edited By: Dungworth et al, U Mohr
Published By: ILSI Monographs, ILSI press 1998 in Washington, DC

Chapter Title: Identification and characterization of a novel phosphatase with a role in the growth plate chondrocyte maturation
Book Title: Skeletal growth and development
Author List: Reynolds PR, Romano PR, Chi H, Wang J, Reynolds SD, Johnston C, Leboy PS, Tiller GE, Dasouk MJ, O'Keefe RJ, Puzas E, Rosier RN
Edited By: JA Buckwalter, MG Ehrlich, LJ Sandell, SB Tripped
Published By: American Academy of Orthopaedic Surgeons 1998 in Rosemont, IL