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Carl J. Johnston, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5948

Biography

Research

Dr. Carl Johnston's work seeks to understand how the postnatal lung copes with external stress. A critical biological factor that plays a role in childhood pulmonary susceptibility is that a significant portion of lung development takes place postnatally. One of the environmental factors relevant to developmental lung disease is the recent increase in complexity and distribution, if not the levels, of airborne pollutants, including allergens and endotoxins, respirable particulate matter and irritant gases, exposure to which damages various cell types. Among the most important of these are the respiratory epithelium and critical immune effector cell populations. Furthermore; combined exposures to multiple pollutants may activate several unique signaling pathways which are age dependent and depending on the sequence of initiation may result in responses not predicted by evaluating exposures to an individual pollutant. His work depends heavily on mRNA analysis, microarray technology, immuno-histochemistry and in situ hybridization. This work is supported by participation in several NIH grants.

Credentials

Faculty Appointments

Education

1987
BA | Buffalo State College
Biology

1993
MS | University of Rochester
Toxicology

2006
PhD | SUNY at Buffalo
Pharmacology and Toxicology

Publications

Journal Articles

2013
Allen JA, Conrad K, Oberdörster G, Johnston CJ, Sleezer B, Cory-Slecta DA. "Developmental exposure to concentrated ambient particles and preference for immediate reward in mice". Env Health Perspect. 2013; 121(1): 32-38.

2013
Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN. "Lung Irradiation Increases Mortality Following Influenza A Virus Challenge Occurring Late After Exposure". International Journal of Radiation Oncology*Biology*Physics. 2013; 86(1): 128-135.

2013
Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP. "Neonatal Irradiation Sensitizes Mice to Delayed Pulmonary Challenge". Radiation Research. 2013; 179(4): 475-484.

Books & Chapters

1998
Chapter Title: Ambient ultrafine particles: Inducers of acute injury?
Book Title: Relationships between respiratory disease and exposure to air pollution
Author List: Oberdörster G, Gelein R, Johnston C, Mercer P, Corson N, Finkelstein J.
Edited By: Dungworth et al, U Mohr
Published By: ILSI Monographs, ILSI press1998 in Washington, DC

1998
Chapter Title: Identification and characterization of a novel phosphatase with a role in the growth plate chondrocyte maturation
Book Title: Skeletal growth and development
Author List: Reynolds PR, Romano PR, Chi H, Wang J, Reynolds SD, Johnston C, Leboy PS, Tiller GE, Dasouk MJ, O'Keefe RJ, Puzas E, Rosier RN
Edited By: JA Buckwalter, MG Ehrlich, LJ Sandell, SB Tripped
Published By: American Academy of Orthopaedic Surgeons1998 in Rosemont, IL

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