Keith Nehrke, Ph.D.

Contact Information

Phone Numbers

Research Labs

Our focus is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism.

Visit Our focus is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism. Lab Website

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 675
Rochester, NY 14642

Faculty Appointments

Professor - Department of Medicine , Nephrology (SMD)
Professor - Department of Pharmacology and Physiology (SMD) - Joint

Biography

Research

The focus of my laboratory is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism. Our goal is to develop a deeper understanding of how these cell physiologic processes are integrated to mediate the environmental sensitivity and functional output exhibited by live animals. Recent focuses have been on mitochondrial ion flux, proteostasis and trans-organelle signaling pathways that regulate hypoxic sensitivity. We believe that combining physiology and genetics provides synergistic value in deciphering mechanisms whereby cells communicate information in their native context. My unique, diverse background has helped my lab to harness the power of new tools such as CRISPR-Cas9 genome editing while translating our findings from the genetic model organism C. elegans to mammalian models such as mice. And collaboration being the heart-and-soul of science, we are pleased to be able to interact with our colleagues in a collegial and inclusive atmosphere where everyone's unique contributions to the team are valued.

Credentials

Education

1989
BS | St Univ at Binghamton
Biochemistry

1992
MS | Univ Rochester Sch Med/Dent
Biochemistry

1994
PhD | Univ Rochester Sch Med/Dent
Biochemistry

Post-doctoral Training & Residency

1994 - 1997
Center for Oral Biology, University of Rochester Medical Center under Dr. Larry Tabak

Publications

Journal Articles

11/9/2020
Guha S, Fischer S, Johnson GVW, Nehrke K. "Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model." Molecular neurodegeneration.. 2020 Nov 9; 15(1):65. Epub 2020 Nov 09.

9/9/2020
Guha S, Fischer S, Cheng A, Johnson GVW, Nehrke K. "A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in touch neurons." . 2020 Sep 9; 2020Epub 2020 Sep 09.

8/26/2020
Guha S, Johnson GVW, Nehrke K. "The Crosstalk Between Pathological Tau Phosphorylation and Mitochondrial Dysfunction as a Key to Understanding and Treating Alzheimer's Disease." Molecular neurobiology.. 2020 Aug 26; Epub 2020 Aug 26.

Books & Chapters

2012
Chapter Title: The inositol 1,4,5-trisphospate receptor in C. elegans
Book Title: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling.
Author List: Allman E., Thyagarajan B., and Nehrke K.
Edited By: M. Nedergaard and A. Verkhratsky
Published By: Wiley 2012

2006
Book Title: Intracellular pH measurements in vivo using green fluorescent protein variants.
Author List: Nehrke K.
Edited By: K. Strange
Published By: Methods Mol Biol. 2006

2002
Chapter Title: Ca2+-Activated Cl- Currents in Salivary and Lacrimal Glands.
Book Title: Current Topics in Membranes
Author List: Melvin J.E., Arreola J., Nehrke K., and Begenisich, T.
Edited By: C.;M. Fuller
Published By: Academic Press 2002 in San Diego

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