Keith Nehrke, Ph.D.

Keith Nehrke, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 675
Rochester, NY 14642

Office: (585) 275-7020
Administrative: (585) 275-1554
Fax: (585) 442-9201
Lab: (585) 275-1625

Lab Information

Our focus is on integrative physiology, and in particular on understanding how membrane electrolyte flux and pH regulation influences viability and behavior in the genetic model organism C. elegans.

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Research Bio

The focus of my laboratory is on integrative physiology, and in particular on understanding how membrane electrolyte flux and pH regulation influences viability and behavior in the genetic model organism C. elegans. Our approach has been to exploit novel, fluorescent biosensors for measuring physiologic outputs such as calcium, pH, and redox status in unrestrained worms. Our goal is to develop a deeper understanding of how these cell physiologic processes are integrated to mediate the environmental sensitivity and functional output exhibited by live animals. We believe that this combination of physiology and genetics will allow us to discover unique mechanisms whereby cells communicate information in their native context.

My background in mammalian physiology and previous work creating mouse transgenics and gene ablations has helped to allow us translate our findings in worms, as has the congenial atmosphere at the University of Rochester which promotes collaborative efforts. Our lab's funding is currently from the NSF to study calcium and pH synergism during a rhythmic behavior and from the NIH, with co-PI Dr. Paul Brookes, to study ischemic preconditioning in worms. These interactions with other faculty are one of the benefits of working in a multidisciplinary area such as Medicine.

Recent Journal Articles

Showing the 5 most recent journal articles. 65 available »

2016 Dec 1
Nehrke K. "H(OH), H(OH), H(OH): a holiday perspective. Focus on "Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH- conductance pathway that is stimulated by rises in intracellular and extracellular pH"." American journal of physiology. Cell physiology. 2016 Dec 1; 311(6):C942-C944. Epub 2016 Oct 26.
2016 Sep 16
Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS. "Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling." The Journal of biological chemistry. 2016 Sep 16; 291(38):20188-97. Epub 2016 Aug 10.
2016 Jul 21
Wojtovich AP, Wei AY, Sherman TA, Foster TH, Nehrke K. "Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans." Scientific reports. 2016 Jul 21; 6:29695. Epub 2016 Jul 21.
2016 May
Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K. "Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning." Anesthesiology. 2016 May; 124(5):1065-76.
2016 Feb 1
Allman E, Wang Q, Walker RL, Austen M, Peters MA, Nehrke K. "Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans." American journal of physiology. Cell physiology. 2016 Feb 1; 310(3):C233-42. Epub 2015 Nov 11.

Current Appointments

Professor - Department of Medicine, Nephrology (SMD) - Primary
Professor - Department of Pharmacology and Physiology (SMD)

Education

PhD | Biochemistry | Univ Rochester Sch Med/Dent1994
MS | Biochemistry | Univ Rochester Sch Med/Dent1992
BS | Biochemistry | St Univ at Binghamton1989

Post-Doctoral Training & Residency

Center for Oral Biology, University of Rochester Medical Center under Dr. Larry Tabak 1997