CONTACT INFORMATIONCREDENTIALSPUBLICATIONSKeith Nehrke, Ph.D.Contact InformationPhone NumbersAdministrative: (585) 275-1554Office: (585) 275-7020Fax: (585) 442-9201Research LabsOur focus is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism.Visit Our focus is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism. Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 675Rochester, NY 14642Faculty AppointmentsProfessor - Department of Medicine , Nephrology (SMD) Professor - Department of Pharmacology and Physiology (SMD) - JointBiographyResearchThe focus of my laboratory is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism. Our goal is to develop a deeper understanding of how these cell physiologic processes are integrated to mediate the environmental sensitivity and functional output exhibited by live animals. Recent focuses have been on mitochondrial ion flux, proteostasis and trans-organelle signaling pathways that regulate hypoxic sensitivity. We believe that combining physiology and genetics provides synergistic value in deciphering mechanisms whereby cells communicate information in their native context. My unique, diverse background has helped my lab to harness the power of new tools such as CRISPR-Cas9 genome editing while translating our findings from the genetic model organism C. elegans to mammalian models such as mice. And collaboration being the heart-and-soul of science, we are pleased to be able to interact with our colleagues in a collegial and inclusive atmosphere where everyone's unique contributions to the team are valued.CredentialsEducation1989BS | St Univ at BinghamtonBiochemistry1992MS | Univ Rochester Sch Med/DentBiochemistry1994PhD | Univ Rochester Sch Med/DentBiochemistryPost-doctoral Training & Residency1994 - 1997Center for Oral Biology, University of Rochester Medical Center under Dr. Larry TabakPublicationsJournal Articles1/8/2021Lim Y, Berry B, Viteri S, McCall M, Park EC, Rongo C, Brookes PS, Nehrke K. "FNDC-1-Mediated Mitophagy and ATFS-1 Coordinate to Protect Against Hypoxia-Reoxygenation." Autophagy.. 2021 Jan 8; Epub 2021 Jan 08. 11/9/2020Guha S, Fischer S, Johnson GVW, Nehrke K. "Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model." Molecular neurodegeneration.. 2020 Nov 9; 15(1):65. Epub 2020 Nov 09. 9/9/2020Guha S, Fischer S, Cheng A, Johnson GVW, Nehrke K. "A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer's disease Causes Activation of the Mitochondrial Unfolded Protein Response in touch neurons." . 2020 Sep 9; 2020Epub 2020 Sep 09. Books & Chapters2012 Chapter Title: The inositol 1,4,5-trisphospate receptor in C. elegans Book Title: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. Author List: Allman E., Thyagarajan B., and Nehrke K. Edited By: M. Nedergaard and A. Verkhratsky Published By: Wiley 20122006 Book Title: Intracellular pH measurements in vivo using green fluorescent protein variants. Author List: Nehrke K. Edited By: K. Strange Published By: Methods Mol Biol. 20062002 Chapter Title: Ca2+-Activated Cl- Currents in Salivary and Lacrimal Glands. Book Title: Current Topics in Membranes Author List: Melvin J.E., Arreola J., Nehrke K., and Begenisich, T. Edited By: C.;M. Fuller Published By: Academic Press 2002 in San DiegoVIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Keith Nehrke, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Keith Nehrke, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.