Keith Nehrke, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-1554

Office: (585) 275-7020

Fax: (585) 442-9201

Research Labs

Our focus is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism.

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Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 675
Rochester, NY 14642

Faculty Appointments

Professor - Department of Medicine , Nephrology (SMD)
Professor - Department of Pharmacology and Physiology (SMD) - Joint

Biography

Research

The focus of my laboratory is on integrative physiology, and in particular on understanding the molecular mechanisms whereby bioenergetic responses influence metabolic plasticity, survival, and behavior in a whole organism. Our goal is to develop a deeper understanding of how these cell physiologic processes are integrated to mediate the environmental sensitivity and functional output exhibited by live animals. Recent focuses have been on mitochondrial ion flux, proteostasis and trans-organelle signaling pathways that regulate hypoxic sensitivity. We believe that combining physiology and genetics provides synergistic value in deciphering mechanisms whereby cells communicate information in their native context. My unique, diverse background has helped my lab to harness the power of new tools such as CRISPR-Cas9 genome editing while translating our findings from the genetic model organism C. elegans to mammalian models such as mice. And collaboration being the heart-and-soul of science, we are pleased to be able to interact with our colleagues in a collegial and inclusive atmosphere where everyone's unique contributions to the team are valued.

Credentials

Education

1989
BS | St Univ at Binghamton
Biochemistry

1992
MS | Univ Rochester Sch Med/Dent
Biochemistry

1994
PhD | Univ Rochester Sch Med/Dent
Biochemistry

Post-doctoral Training & Residency

1994 - 1997
Center for Oral Biology, University of Rochester Medical Center under Dr. Larry Tabak

Publications

Journal Articles

8/2018
Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS. "Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH." Journal of molecular and cellular cardiology.. 2018 Aug 0; 121:155-162. Epub 2018 Jun 26.

6/4/2018
Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS. "Cardiac metabolic effects of K1.2 channel deletion and evidence for its mitochondrial localization." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 Jun 4; :fj201800139R. Epub 2018 Jun 04.

8/10/2017
Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS. "Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation." The Biochemical journal.. 2017 Aug 10; 474(16):2829-2839. Epub 2017 Aug 10.

Books & Chapters

2014
Chapter Title: Membrane ion transport in non-excitable tissues
Book Title: Wombook
Author List: Nehrke, K.
Edited By: The C. elegans Research Community
Published By: Wormbook 2014

2012
Chapter Title: The inositol 1,4,5-trisphospate receptor in C. elegans
Book Title: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling.
Author List: Allman E., Thyagarajan B., and Nehrke K.
Edited By: M. Nedergaard and A. Verkhratsky
Published By: Wiley 2012

2006
Book Title: Intracellular pH measurements in vivo using green fluorescent protein variants.
Author List: Nehrke K.
Edited By: K. Strange
Published By: Methods Mol Biol. 2006

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