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Keith Nehrke, Ph.D.

Publications

Showing all 74 journal articles & 4 books available

Journal Articles

8/2018
Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS. "Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH." Journal of molecular and cellular cardiology.. 2018 Aug 0; 121:155-162. Epub 2018 Jun 26.

6/4/2018
Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS. "Cardiac metabolic effects of K1.2 channel deletion and evidence for its mitochondrial localization." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 Jun 4; :fj201800139R. Epub 2018 Jun 04.

8/10/2017
Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS. "Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation." The Biochemical journal.. 2017 Aug 10; 474(16):2829-2839. Epub 2017 Aug 10.

6/9/2017
Smith CO, Nehrke K, Brookes PS. "The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection." The Biochemical journal.. 2017 Jun 9; 474(12):2067-2094. Epub 2017 Jun 09.

12/1/2016
Nehrke K. "H(OH), H(OH), H(OH): a holiday perspective. Focus on "Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH- conductance pathway that is stimulated by rises in intracellular and extracellular pH"." American journal of physiology. Cell physiology.. 2016 Dec 1; 311(6):C942-C944. Epub 2016 Oct 26.

9/16/2016
Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS. "Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling." The Journal of biological chemistry.. 2016 Sep 16; 291(38):20188-97. Epub 2016 Aug 10.

7/21/2016
Wojtovich AP, Wei AY, Sherman TA, Foster TH, Nehrke K. "Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans." Scientific reports.. 2016 Jul 21; 6:29695. Epub 2016 Jul 21.

5/2016
Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K. "Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning." Anesthesiology.. 2016 May 0; 124(5):1065-76.

2/1/2016
Allman E, Wang Q, Walker RL, Austen M, Peters MA, Nehrke K. "Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans." American journal of physiology. Cell physiology.. 2016 Feb 1; 310(3):C233-42. Epub 2015 Nov 11.

2016
Peña S, Sherman T, Brookes PS, Nehrke K. "The Mitochondrial Unfolded Protein Response Protects against Anoxia in Caenorhabditis elegans." PloS one.. 2016 11(7):e0159989. Epub 2016 Jul 26.

2015
Panitz, D.; Swamy, H.; Nehrke, K.;. "A C. elegans model of electronic cigarette use: Physiological effects of e-liquids in nematodes" . 2015; 16: 32.

2014
Matthews, T. A.; Abel, A.; Demme, C.; Sherman, T.; Pan, P. W.; Halterman, M. W.; Parkkila, S.; Nehrke, K.;. "Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia" . 2014; 1543: 28-37.

2014
Nehrke, K.;. "Membrane ion transport in non-excitable tissues" . 2014; : 1-22.

2014
Queliconi, B. B.; Kowaltowski, A. J.; Nehrke, K.;. "An anoxia-starvation model for ischemia/reperfusion in C. elegans" . 2014; .

2013
Allman, E.; Waters, K.; Ackroyd, S.; Nehrke, K.;. "Analysis of Ca2+ signaling motifs that regulate proton signaling through the Na+/H+ exchanger NHX-7 during a rhythmic behavior in Caenorhabditis elegans" . 2013; 288(8): 5886-95.

2013
Coburn, C.; Allman, E.; Mahanti, P.; Benedetto, A.; Cabreiro, F.; Pincus, Z.; Matthijssens, F.; Araiz, C.; Mandel, A.; Vlachos, M.; Edwards, S. A.; Fischer, G.; Davidson, A.; Pryor, R. E.; Stevens, A.; Slack, F. J.; Tavernarakis, N.; Braeckman, B. P.; Schroeder, F. C.; Nehrke, K.; Gems, D.;. "Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans" . 2013; 11(7): e1001613.

2013
Portal-Celhay, C.; Nehrke, K.; Blaser, M. J.;. "Effect of Caenorhabditis elegans age and genotype on horizontal gene transfer in intestinal bacteria" . 2013; 27(2): 760-8.

2013
Queliconi, B. B.; Marazzi, T. B.; Vaz, S. M.; Brookes, P. S.; Nehrke, K.; Augusto, O.; Kowaltowski, A. J.;. "Bicarbonate modulates oxidative and functional damage in ischemia-reperfusion" . 2013; 55: 46-53.

2013
Wojtovich, A. P.; Nadtochiy, S. M.; Urciuoli, W. R.; Smith, C. O.; Grunnet, M.; Nehrke, K.; Brookes, P. S.;. "A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel" . 2013; 1: e48.

2013
Wojtovich, A. P.; Smith, C. O.; Haynes, C. M.; Nehrke, K. W.; Brookes, P. S.;. "Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel" . 2013; 1827(5): 598-611.

2013
Wojtovich, A. P.; Urciuoli, W. R.; Chatterjee, S.; Fisher, A. B.; Nehrke, K.; Brookes, P. S.;. "Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning" . 2013; 304(11): H1439-45.

2012
Johnson, D.; Allman, E.; Nehrke, K.;. "Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation" . 2012; 302(7): C1045-54.

2012
Kemp, B. J.; Allman, E.; Immerman, L.; Mohnen, M.; Peters, M. A.; Nehrke, K.; Abbott, A. L.;. "miR-786 regulation of a fatty-acid elongase contributes to rhythmic calcium-wave initiation in C. elegans" . 2012; 22(23): 2213-20.

2012
Perry, G. M.; Nehrke, K. W.; Bushinsky, D. A.; Reid, R.; Lewandowski, K. L.; Hueber, P.; Scheinman, S. J.;. "Sex modifies genetic effects on residual variance in urinary calcium excretion in rat (Rattus norvegicus)" . 2012; 191(3): 1003-13.

2012
Sherman, T. A.; Rongali, S. C.; Matthews, T. A.; Pfeiffer, J.; Nehrke, K.;. "Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans" . 2012; 1823(4): 808-17.

2012
Wojtovich, A. P.; DiStefano, P.; Sherman, T.; Brookes, P. S.; Nehrke, K.;. "Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans" . 2012; 586(4): 428-34.

2012
Wojtovich, A. P.; Nadtochiy, S. M.; Brookes, P. S.; Nehrke, K.;. "Ischemic preconditioning: the role of mitochondria and aging" . 2012; 47(1): 1-7.

2011
Wagner, J.; Allman, E.; Taylor, A.; Ulmschneider, K.; Kovanda, T.; Ulmschneider, B.; Nehrke, K.; Peters, M. A.;. "A calcineurin homologous protein is required for sodium-proton exchange events in the C. elegans intestine" . 2011; 301(6): C1389-403.

2011
Wojtovich, A. P.; Sherman, T. A.; Nadtochiy, S. M.; Urciuoli, W. R.; Brookes, P. S.; Nehrke, K.;. "SLO-2 is cytoprotective and contributes to mitochondrial potassium transport" . 2011; 6(12): e28287.

2010
Johnson, D.; Nehrke, K.;. "Mitochondrial fragmentation leads to intracellular acidification in Caenorhabditis elegans and mammalian cells" . 2010; 21(13): 2191-201.

2010
Wojtovich, A. P.; Nehrke, K. W.; Brookes, P. S.;. "The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria" . 2010; 57(4): 431-4.

2010
Wojtovich, A. P.; Williams, D. M.; Karcz, M. K.; Lopes, C. M.; Gray, D. A.; Nehrke, K. W.; Brookes, P. S.;. "A novel mitochondrial K(ATP) channel assay" . 2010; 106(7): 1190-6.

2009
Allman, E.; Johnson, D.; Nehrke, K.;. "Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans" . 2009; 297(5): C1071-81.

2009
Frick, K. K.; Krieger, N. S.; Nehrke, K.; Bushinsky, D. A.;. "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1" . 2009; 24(2): 305-13.

2009
Nehrke, K.;. "On the steady-state properties of actual flip angle imaging (AFI)" . 2009; 61(1): 84-92.

2008
Nehrke, K.; Denton, J.; Mowrey, W.;. "Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program" . 2008; 294(1): C333-44.

2008
Pfeiffer, J.; Johnson, D.; Nehrke, K.;. "Oscillatory transepithelial H(+) flux regulates a rhythmic behavior in C. elegans" . 2008; 18(4): 297-302.

2008
Wojtovich, A. P.; Burwell, L. S.; Sherman, T. A.; Nehrke, K. W.; Brookes, P. S.;. "The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning" . 2008; 376(3): 625-8.

2006
Bushinsky, D. A.; Frick, K. K.; Nehrke, K.;. "Genetic hypercalciuric stone-forming rats" . 2006; 15(4): 403-18.

2006
Denton, J.; Nehrke, K.; Yin, X.; Beld, A. M.; Strange, K.;. "Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte" . 2006; 290(4): C1109-18.

2006
He, L.; Denton, J.; Nehrke, K.; Strange, K.;. "Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity" . 2006; 90(10): 3570-81.

2006
Nehrke, K.;. "Intracellular pH measurements in vivo using green fluorescent protein variants" . 2006; 351: 223-39.

2006
Strange, K.; Denton, J.; Nehrke, K.;. "Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume" . 2006; 21: 61-8.

2006
Yan, X.; Xing, J.; Lorin-Nebel, C.; Estevez, A. Y.; Nehrke, K.; Lamitina, T.; Strange, K.;. "Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis" . 2006; 128(4): 443-59.

2005
de Santiago, J. A.; Nehrke, K.; Arreola, J.;. "Quantitative analysis of the voltage-dependent gating of mouse parotid ClC-2 chloride channel" . 2005; 126(6): 591-603.

2005
Denton, J.; Nehrke, K.; Yin, X.; Morrison, R.; Strange, K.;. "GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel" . 2005; 125(2): 113-25.

2005
Sherman, T.; Chernova, M. N.; Clark, J. S.; Jiang, L.; Alper, S. L.; Nehrke, K.;. "The abts and sulp families of anion transporters from Caenorhabditis elegans" . 2005; 289(2): C341-51.

2004
Begenisich, T.; Nakamoto, T.; Ovitt, C. E.; Nehrke, K.; Brugnara, C.; Alper, S. L.; Melvin, J. E.;. "Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4" . 2004; 279(46): 47681-7.

2004
Chen, Y.; Zhao, Y. H.; Kalaslavadi, T. B.; Hamati, E.; Nehrke, K.; Le, A. D.; Ann, D. K.; Wu, R.;. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues" . 2004; 30(2): 155-65.

2004
Denton, J.; Nehrke, K.; Rutledge, E.; Morrison, R.; Strange, K.;. "Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+" . 2004; 555(Pt 1): 97-114.

2003
Hoffman, J. F.; Joiner, W.; Nehrke, K.; Potapova, O.; Foye, K.; Wickrema, A.;. "The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells" . 2003; 100(12): 7366-71.

2003
Joiner, W. J.; Basavappa, S.; Vidyasagar, S.; Nehrke, K.; Krishnan, S.; Binder, H. J.; Boulpaep, E. L.; Rajendran, V. M.;. "Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon" . 2003; 285(1): G185-96.

2003
Nehrke, K.;. "A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span" . 2003; 278(45): 44657-66.

2003
Nehrke, K.; Quinn, C. C.; Begenisich, T.;. "Molecular identification of Ca2+-activated K+ channels in parotid acinar cells" . 2003; 284(2): C535-46.

2002
Arreola, J.; Begenisich, T.; Nehrke, K.; Nguyen, H. V.; Park, K.; Richardson, L.; Yang, B.; Schutte, B. C.; Lamb, F. S.; Melvin, J. E.;. "Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene" . 2002; 545(1): 207-16.

2002
Dickerson, L. W.; Bonthius, D. J.; Schutte, B. C.; Yang, B.; Barna, T. J.; Bailey, M. C.; Nehrke, K.; Williamson, R. A.; Lamb, F. S.;. "Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels" . 2002; 958(2): 227-50.

2002
Elble, R. C.; Ji, G.; Nehrke, K.; DeBiasio, J.; Kingsley, P. D.; Kotlikoff, M. I.; Pauli, B. U.;. "Molecular and functional characterization of a murine calcium-activated chloride channel expressed in smooth muscle" . 2002; 277(21): 18586-91.

2002
Nehrke, K.; Arreola, J.; Nguyen, H. V.; Pilato, J.; Richardson, L.; Okunade, G.; Baggs, R.; Shull, G. E.; Melvin, J. E.;. "Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice" . 2002; 277(26): 23604-11.

2002
Nehrke, K.; Melvin, J. E.;. "The NHX family of Na+-H+ exchangers in Caenorhabditis elegans" . 2002; 277(32): 29036-44.

2001
Attaphitaya, S.; Nehrke, K.; Melvin, J. E.;. "Acute inhibition of brain-specific Na(+)/H(+) exchanger isoform 5 by protein kinases A and C and cell shrinkage" . 2001; 281(4): C1146-57.

2001
Melvin, J. E.; Nguyen, H. V.; Nehrke, K.; Schreiner, C. M.; Ten Hagen, K. G.; Scott, W.;. "Targeted disruption of the Nhe1 gene fails to inhibit beta(1)-adrenergic receptor-induced parotid gland hypertrophy" . 2001; 280(4): G694-700.

2001
Park, K.; Evans, R. L.; Watson, G. E.; Nehrke, K.; Richardson, L.; Bell, S. M.; Schultheis, P. J.; Hand, A. R.; Shull, G. E.; Melvin, J. E.;. "Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient mice" . 2001; 276(29): 27042-50.

2001
Yan, W.; Nehrke, K.; Choi, J.; Barber, D. L.;. "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor" . 2001; 276(33): 31349-56.

2000
Nehrke, K.; Begenisich, T.; Pilato, J.; Melvin, J. E.;. "Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression" . 2000; 279(6): C2052-66.

1998
Hagen, F. K.; Nehrke, K.;. "cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans" . 1998; 273(14): 8268-77.

1998
Nehrke, K.; Hagen, F. K.; Tabak, L. A.;. "Isoform-specific O-glycosylation by murine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3, in vivo" . 1998; 8(4): 367-71.

1997
Nehrke, K.; Tabak, L. A.;. "Biosynthesis of a low-molecular-mass rat submandibular gland mucin glycoprotein in COS7 cells" . 1997; 323 ( Pt 2): 497-502.

1997
Nehrke, K.; Ten Hagen, K. G.; Hagen, F. K.; Tabak, L. A.;. "Charge distribution of flanking amino acids inhibits O-glycosylation of several single-site acceptors in vivo" . 1997; 7(8): 1053-60.

1996
Nehrke, K.; Hagen, F. K.; Tabak, L. A.;. "Charge distribution of flanking amino acids influences O-glycan acquisition in vivo" . 1996; 271(12): 7061-5.

1995
Russnak, R.; Nehrke, K. W.; Platt, T.;. "REF2 encodes an RNA-binding protein directly involved in yeast mRNA 3'-end formation" . 1995; 15(3): 1689-97.

1994
Nehrke, K. W.; Platt, T.;. "A quaternary transcription termination complex. Reciprocal stabilization by Rho factor and NusG protein" . 1994; 243(5): 830-9.

1993
Nehrke, K. W.; Zalatan, F.; Platt, T.;. "NusG alters rho-dependent termination of transcription in vitro independent of kinetic coupling" . 1993; 3(2): 119-33.

11/25/1992
Nehrke KW, Seifried SE, Platt T. "Overproduced rho factor from p39AS has lysine replacing glutamic acid at residue 155 in the linker region between its RNA and ATP binding domains." Nucleic acids research.. 1992 Nov 25; 20(22):6107.

3/5/1992
Phizicky EM, Consaul SA, Nehrke KW, Abelson J. "Yeast tRNA ligase mutants are nonviable and accumulate tRNA splicing intermediates." The Journal of biological chemistry.. 1992 Mar 5; 267(7):4577-82.

Books & Chapters

2012
Chapter Title: The inositol 1,4,5-trisphospate receptor in C. elegans
Book Title: Wiley Interdisciplinary Reviews: Membrane Transport and Signaling.
Author List: Allman E., Thyagarajan B., and Nehrke K.
Edited By: M. Nedergaard and A. Verkhratsky
Published By: Wiley2012

2006
Book Title: Intracellular pH measurements in vivo using green fluorescent protein variants.
Author List: Nehrke K.
Edited By: K. Strange
Published By: Methods Mol Biol.2006

2002
Chapter Title: Ca2+-Activated Cl- Currents in Salivary and Lacrimal Glands.
Book Title: Current Topics in Membranes
Author List: Melvin J.E., Arreola J., Nehrke K., and Begenisich, T.
Edited By: C.;M. Fuller
Published By: Academic Press2002 in San Diego

1997
Chapter Title: Experimental Approaches to Studying O-Glycosylation In Vivo.
Book Title: Techniques in Glycobiology
Author List: Nehrke K., Hagen F.H., and Tabak, L.A.
Edited By: R. Townsend and A. Hotchkiss
Published By: Marcel Dekker1997 in New York