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Edward E. Walsh, M.D.

Contact Information

Phone Numbers

Office: (585) 922-4003

Fax: (585) 339-5168

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients

Faculty Appointments

Patient Care Setting

Infectious Diseases


Professional Background

Dr Walsh received an undergraduate degree in Chemistry from Manhattan College and an MD degree from SUNY-Downstate Medical Center in 1974. He completed his residency at the URMC Strong Memorial Hospital in 1977 and a fellowship in Infectious Diseases in 1982. Since then he has been faculty in the Department of Medicine and a member Infectious Diseases division at the University of Rochester. Dr Walsh is head of the ID unit at Rochester General Hospital where his clinical activities and research activities are based.


Edward Walsh is Professor of Medicine at the University of Rochester, and Head of Infectious Diseases at the Rochester General Hospital. His research activities since 1980 have revolved around many aspects of RSV infection. These include characterizing the function and antigenic characteristics of the viral proteins, primarily the F and G glycoproteins. This work also involved study of their role as potential vaccines in animal models of RSV infection. Dr. Walsh's clinical research has centered on describing the epidemiology and clinical characteristics of RSV infection in adult populations with an emphasis on high risk and elderly populations. Laboratory work has attempted to describe immune correlates of protection in these groups. Currently, he is completing a three year study on the pathogenesis of disease severity in full term infants with primary RSV infection.

Selected research publications:
Walsh EE, Hruska JF. Monoclonal antibodies to respiratory syncytial virus proteins: Identification of the fusion protein. J Virol 47:171, 1983.
Walsh EE, Hall CB, Schlesinger JJ, Brandriss, MW, Hildreth S, Paradiso P. Comparison of antigenic sites of subtype specific respiratory syncytial virus attachment proteins. J Gen Virol 70:2953, 1989.
Walsh EE, Falsey AR, Sullender WM. Monoclonal antibody neutralization escape mutants of respiratory syncytial virus with unique alterations in the attachment (G) protein. J. Gen. Virol. 69:479-487, 1998.
Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory Syncytial Virus Infection in Elderly and High-Risk Adults. New Engl J Med 2005; 352:1749-1759.
Walsh EE, Peterson DR, Falsey AR. Another piece of the puzzle: Human Metapneumovirus Infection in Adults. Arch Intern Med 2009;168:2489-2496
Walsh EE, Peterson DR, Kalkanoglu A, Lee FE-H, Falsey AR. Viral Shedding and Immune Responses to Respiratory Syncytial Virus Infection in Older Adults. J Infect Dis 2013; 207:1424-32
Johnson AM, McNally BA, Ionnidis I, Flano E, Teng MN, Oomens AG, Walsh EE, Peeples ME. Respiratory Syncytial Virus uses CX3CR1 as a receptor on primary human airway epithelial cultures. (2015) PLoS Pathog 11(12):e1005318.doi:10.1371/journal.ppat1005318



MD | SUNY Downstate Health Sciences University - College of Medicine

Post-doctoral Training & Residency

07/01/1980 - 06/30/1982
Fellowship in Infectious Disease at University of Rochester Medical Center

06/25/1975 - 07/25/1977
Residency in Infectious Disease at University of Rochester Medical Center

06/24/1974 - 06/24/1975
Internship in Internal Medicine at University of Rochester Medical Center

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Journal Articles

Branche AR, Saiman L, Walsh EE, Falsey AR, Jia H, Barrett A, Alba L, Phillips M, Finelli L. "Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults." Influenza and other respiratory viruses.. 2022 Sep 7; Epub 2022 Sep 07.

Anderson LJ, Walsh EE. "The Challenge of Respiratory Syncytial Virus Human Challenge Studies." The New England journal of medicine.. 2022 Feb 17; 386(7):696-697.

Ha B, Chirkova T, Boukhvalova MS, Sun HY, Walsh EE, Anderson CS, Mariani TJ, Anderson LJ. "Mutation of Respiratory Syncytial Virus G Protein's CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells." Vaccines.. 2019 Jul 19; 7(3)Epub 2019 Jul 19.





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