Stephen Dewhurst, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-3402

Office: (585) 275-3216

Research Labs

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Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Faculty Appointments

Professor - Department of Microbiology and Immunology (SMD)
Albert and Phyllis Ritterson Professorship - Department of Microbiology and Immunology (SMD)
Vice Dean for Research, SMD - Dean's Office M&D - Administration (SMD)
Associate Vice President for Health Sciences Research - Office of Sr VP for Research (UR)

Biography

Dr. Dewhurst is interim Vice President for Research for the University of Rochester (UR) and Vice Dean for Research at the UR School of Medicine and Dentistry. He is also the Albert and Phyllis Ritterson Professor of Microbiology & Immunology. His research focuses on pathogenic human viruses, including HIV, influenza and SARS-CoV-2, and he codirects the UR’s HIV Clinical Trials Unit (CTU), which conducts HIV vaccine and treatment trials and engages with communities affected by HIV.

Professional Background

ADMINISTRATIVE EXPERIENCE

Dr. Dewhurst is interim Vice President for Research for the University of Rochester (UR) and Vice Dean for Research at the UR School of Medicine and Dentistry. He joined the faculty of UR in 1990, and previously served as Senior Associate Dean for Basic Research at the URSMD from 2007 to 2009.

EDUCATION AND MENTORING EXPERIENCE

Over the past 10 years, Dr. Dewhurst has mentored 12 doctoral students and 5 post-baccalaureate trainees. He presently mentors 4 doctoral trainees and 2 undergraduates. Many of his former trainees hold prestigious positions in industry and government; others are tenure-track academic faculty members. He has also received several mentoring awards, including the UR’s highest award for graduate education, the William H. Riker University Award for Graduate Teaching (2008), as well as the Graduate Student Society Faculty Teaching Award (1996), the Graduate Alumni Award for Excellence in Graduate Education (2001) and the Graduate Student Society Student Advocacy Award (2021). In addition, he served as the communicating MPI of the UR’s NIH-funded “Broadening Experiences in Scientific Training (BEST)” program (2014-2021); this program has transformed institutional culture and practice in the area of graduate and postdoctoral education, by creating sustainable structures that support the exploration of diverse career options by PhD students and postdocs.

CONTRIBUTIONS TO EQUITY AND INCLUSION

Dr. Dewhurst is the founding Director (and contact MPI) of the UR’s NIH-funded Rochester Partnership for Research and Academic Career Training of Deaf Postdoctoral Scholars. This mentored postdoctoral research training program for Deaf and Hard-of-Hearing (D/HH) Scholars is the only program of its kind in the nation, and is a unique partnership between UR and the National Technical Institute for the Deaf (NTID) at the Rochester Institute of Technology (RIT). Dr. Dewhurst was also the founding Director for the UR's NIH funded Postbaccalaureate Research Education Program (PREP), which has supported over 100 postbacc trainees since its inception - all of whom are members of groups that have been historically excluded from the biomedical research enterprise. Over 75% of these individuals have gone on to successfully complete biomedical Ph.Ds. Finally, he is a member of the UR’s Executive Committee on Diversity and Inclusion.

Research

Dr. Dewhurst has over 30 years’ experience in molecular virology research. He currently codirects the UR’s HIV Clinical Trials Unit (CTU), which conducts HIV vaccine and treatment trials and engages with communities affected by HIV. Other research interests include: (1) understanding the interaction of HIV with glial cells; (2) developing an improved live attenuated influenza vaccine (LAIV); (3) elucidating host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV).

Credentials

Education

1984
BS | Bristol University, UK
Biochemistry

1987
PhD | University of Nebraska
Molecular Biology

Post-doctoral Training & Residency

1988 - 1990
Postdoctoral Fellow, Department of Cancer Biology, Harvard School of Public Health, Boston, MA.

1987 - 1988
Postdoctoral Fellow, Department of Medicine and Pediatrics, Columbia University, New York, NY.

Awards

2021 - 2021
Graduate Student Society Student Advocacy Award, UR School of Medicine and Dentistry

2020 - Present
Member, Scientific Advisory Board, Sensei Biotherapeutics

2020 - Present
Albert and Phyllis Ritterson Professor of Microbiology and Immunology

2018 - Present
Member, Scientific Advisory Board, Vaccitech

2018 - 2021
Member, HIV Immunopathogenesis and Vaccine Development (HIVD) Study Section, NIH

2015
Outstanding Training Program Director
Sponsor: University of Rochester School of Medicine & Dentistry

2008
William H. Riker Award for Graduate Education
Sponsor: University of Rochester

2004 - 2008
Member, NIH Recombinant Advisory Committee (RAC)

2003 - 2004
Chair, NIH/NIAID AIDSRRC Charter Study Section

2003
University Dean's Award for Meritorious Service in Ph.D. Defenses
Sponsor: University of Rochester

2002 - 2019
Dean's Professor of Microbiology & Immunology
Sponsor: University of Rochester School of Medicine & Dentistry

2002
Graduate Alumni Award for Excellence in Graduate Education
Sponsor: University of Rochester

1996
Graduate Student Society (GSS) Faculty Teaching Award
Sponsor: University of Rochester School of Medicine & Dentistry

1995
Friend of Education Award
Sponsor: Rochester City School District

1994 - 1999
Research Career Development Award, NIH

1988 - 1991
AIDS Research Scholar
Sponsor: AmFAR (American Foundation for AIDS Research)

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Patents

Patent Title: avB3 Integrin-Binding Polypeptide Monobodies and Their Use
Patent #: 7,556,925
Issue Date: Jul 07, 2009
Country: United States
Invented By: Stephen Dewhurst, Shohei Koide, Akiko Koide, Michelle L Miller, Julie Richards Gunzler

Patent Title: Substituted Pyrrolo [2,3-b] Pyridines as MLK Inhibitors
Patent #: 9,814,704
Issue Date: Nov 14, 2017
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Substituted Pyrrolo [2,3-B] Pyridines as MLK Inhibitors
Patent #: 9,181,247
Issue Date: Nov 10, 2015
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Substituted Pyrrolo [2,3-B] Pyridines as MLK Inhibitors
Patent #: 8,877,772
Issue Date: Nov 04, 2014
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Modified Phage for Displaying Post-Translationally Modified Proteins and Uses Thereof
Patent #: 8,754,015
Issue Date: Jun 17, 2014
Country: United States
Invented By: Stephen Dewhurst, John J Treanor

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: 10,485,800
Issue Date: Nov 26, 2019
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: 2925319
Issue Date: Jan 09, 2019
Country: Europe
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: FR2925319
Issue Date: Jan 09, 2019
Country: France
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: 602013049719.2
Issue Date: Jan 09, 2019
Country: Germany
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: GB2925319
Issue Date: Jan 09, 2019
Country: United Kingdom
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: ZL201380060736.1
Issue Date: Aug 10, 2018
Country: China, People's Republic of
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Methods and Compositions Related to Increasing the Fidelity of Influenza A Virus for Vaccine Development
Patent #: 10,500,268
Issue Date: Dec 10, 2019
Country: United States
Invented By: Andrew Cox, Stephen Dewhurst

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 2,744,498
Issue Date: Oct 24, 2017
Country: Canada
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 5930278
Issue Date: May 13, 2016
Country: Japan
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 5873544
Issue Date: Jan 22, 2016
Country: Japan
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 2379561
Issue Date: Nov 04, 2015
Country: Europe
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: FR2379561
Issue Date: Nov 04, 2015
Country: France
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: DE2379561
Issue Date: Nov 04, 2015
Country: Germany
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: IT2379561
Issue Date: Nov 04, 2015
Country: Italy
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: ES2379561
Issue Date: Nov 04, 2015
Country: Spain
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: GB2379561
Issue Date: Nov 04, 2015
Country: United Kingdom
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 2009324894
Issue Date: Jul 23, 2015
Country: Australia
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 614904
Issue Date: Jun 30, 2015
Country: New Zealand
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: ZL200980152665.1
Issue Date: Feb 11, 2015
Country: China, People's Republic of
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Helper Virus-Free Herpesvirus Amplicon Particles and Uses Thereof
Patent #: DE1346036
Issue Date: Apr 28, 2010
Country: Germany
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpesvirus Amplicon Particles and Uses Thereof
Patent #: FR1346036
Issue Date: Apr 28, 2010
Country: France
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: 8,119,118
Issue Date: Feb 21, 2012
Country: United States
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: 1346036
Issue Date: Apr 28, 2010
Country: Europe
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: IE1346036
Issue Date: Apr 28, 2010
Country: Ireland
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: GB1346036
Issue Date: Apr 28, 2010
Country: United Kingdom
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: DK1346036
Issue Date: Apr 28, 2010
Country: Denmark
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: BE1346036
Issue Date: Apr 28, 2010
Country: Belgium
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: 2002246625
Issue Date: Apr 24, 2008
Country: Australia
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 2,800,176
Issue Date: Aug 28, 2018
Country: Canada
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 2011258465
Issue Date: Mar 30, 2017
Country: Australia
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 6086326
Issue Date: Feb 10, 2017
Country: Japan
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: ZL201180036376.2
Issue Date: Feb 10, 2016
Country: China, People's Republic of
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 603644
Issue Date: Feb 03, 2015
Country: New Zealand
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 8,846,909
Issue Date: Sep 30, 2014
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 2,918,739
Issue Date: Sep 07, 2021
Country: Canada
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: ZL201480045309.0
Issue Date: Apr 28, 2020
Country: China, People's Republic of
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 3022298
Issue Date: Jun 19, 2019
Country: Europe
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: FR3022298
Issue Date: Jun 19, 2019
Country: France
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 602014048
Issue Date: Jun 19, 2019
Country: Germany
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: GB3022298
Issue Date: Jun 19, 2019
Country: United Kingdom
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 10,323,231
Issue Date: Jun 18, 2019
Country: United States
Invented By: Andrew Cox, Stephen Dewhurst, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 9,878,032
Issue Date: Jan 30, 2018
Country: United States
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Antigenic Mimics of Discontinuous Epitopes of Pathogens Recognized by Broadly Neutralizing Antibodies
Patent #: 8,961,977
Issue Date: Feb 24, 2015
Country: United States
Invented By: Stephen Dewhurst, Mark A Sullivan

Patent Title: AVB3 Integrin-Binding Polypeptide Monobodies and Their Use
Patent #: 2002307146
Issue Date: May 17, 2007
Country: Australia
Invented By: Stephen Dewhurst, Shohei Koide, Akiko Koide, Michelle L Miller, Julie Richards Gunzler

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Publications

Journal Articles

2023
Osborn RM, Leach J, Zanche M, Ashton JM, Chu C, Thakar J, Dewhurst S, Rosenberger S, Pavelka M, Pryhuber GS, Mariani TJ, Anderson CS. "Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells." PloS one.. 2023 18(2):e0281898. Epub 2023 Feb 24.

5/18/2022
Nogales A, Steel J, Liu WC, Lowen AC, Rodriguez L, Chiem K, Cox A, García-Sastre A, Albrecht RA, Dewhurst S, Martínez-Sobrido L. "Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine." Microbiology spectrum.. 2022 May 18; :e0007822. Epub 2022 May 18.

11/27/2021
Raymonda MH, Ciesla JH, Monaghan M, Leach J, Asantewaa G, Smorodintsev-Schiller LA, Lutz MM, Schafer XL, Takimoto T, Dewhurst S, Munger J, Harris IS. "Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro." Virology.. 2021 Nov 27; 566:60-68. Epub 2021 Nov 27.

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