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Stephen Dewhurst, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-3216

Fax: (585) 473-2361

Research Labs

Faculty Appointments

Biography

Dr. Dewhurst is Vice Dean for Research at the School of Medicine and Dentistry (SMD), and Associate Vice President for Health Sciences Research at the University of Rochester (UR). He has over 25 years experience as a molecular virologist, working mainly on HIV/AIDS - with an emphasis in recent years on vaccine development. He serves as Director of the UR's NIH-funded Development Center for AIDS Research, in addition to his own research. Dr. Dewhurst is internationally recognized for his expertise, and is also a former NIH Study Section Chair and a former member of the NIH Recombinant Advisory Committee (RAC). Finally, he has been recognized for his mentoring and training achievements through several awards from the UR.

Professional Background

Dr. Dewhurst is Dean's Professor and Chair of Microbiology & Immunology at the University of Rochester School of Medicine and Dentistry (URSMD). He received his Ph.D. from the University of Nebraska Medical Center in 1987, and then undertook postdoctoral training at Columbia University and at the Harvard School of Public Health. His doctoral and postdoctoral work focused on HIV/AIDS research. He joined the faculty of UR in 1990 and served as Senior Associate Dean for Basic Research at the URSMD from 2007 to 2009. He was appointed as Chair of Microbiology & Immunology in 2009, and Vice Dean for Research at the URSMD in 2013.

Dr. Dewhurst has over 25 years experience as a molecular virologist, working on both DNA and RNA viruses, including HIV and influenza viruses. He has served on many NIH special emphasis and regular grant review panels and is a current member of the NeuroAIDS and other End-organ Diseases Study Section [NAED] study section; he has previously served as a Study Section Chair as well as a past (2004-2008) member of the NIH Recombinant Advisory Committee (RAC), which oversees all recombinant DNA studies in human subjects.

Dr. Dewhurst's educational and training roles include serving as the co-director (with Tracey Baas and Sarah Peyré) of the UR's NIH-funded BEST program (URBEST) - which seeks to broaden scientific training opportunities for graduate students and postdoctoral fellows at the university. He is also the PI of a NIH predoctoral T32 training program in the Pathogenesis of Bacteria and Viruses, and the co-director (and contact PI) of the Rochester Partnership for Research and Academic Career Training of Deaf Postdoctoral Scholars, a unique, transformative mentored postdoctoral research training in biomedical and behavioral sciences for Deaf and Hard-of-Hearing (D/HH) Scholars. This program combines research training at the UR with an opportunity to develop critical academic skills, including teaching, at our partner institution, Rochester Institute of Technology (RIT) and its National Technical Institute for the Deaf (NTID); it is the only program of its kind in the nation.

Finally, Dr. Dewhurst co-directs the UR's Burroughs Wellcome Foundation predoctoral training program (with Dr. Nancy Bennett), entitledInfection and Immunity: From Molecules to Populations, and was the founding director of the UR's Post-Baccalaureate Research and Education Program (PREP), which provides research training for under-represented minority students. He received the UR's Graduate Student Society Faculty Teaching Award in 1996, the Graduate Alumni Award for Excellence in Graduate Education in 2001, the William H. Riker University Award for Graduate Teaching in 2008 (the UR's highest award for education and mentoring) and the outstanding T32 Program Director award in 2015.

Research

Current research interests in our laboratory include the following: HIV VACCINE AND MICROBICIDE DEVELOPMENT: An effective HIV vaccine must elicit protective immune responses at mucosal sites of virus transmission. It is thought that mucosal delivery of vaccines may hold the key to this. We are therefore exploring whether this problem can be solved by delivering nanoparticle-based vaccines by a mucosal route, under the tongue. This "sublingual" route of delivery has been safely used to deliver medicines such as nitroglycerin for decades, but has been little studied in the setting of vaccine administration. Improving the mucosal immune response is only part of the battle, in terms of developing a successful HIV vaccine. Also needed are improved immunogens, capable of evoking virus neutralizing antibodies that recognize diverse virus strains. However, antibodies of this kind have proven hard to generate, in part because the virus structures that they recognize are normally hidden from the immune system. We are therefore also working to develop improved vaccine immunogens, by producing novel "antigenic mimics" of key structures present on the surface of the virus. Finally, we are also exploring new approaches to microbicide development, by targeting amyloid structures in semen, known as SEVI. SEVI enhances infection by allowing HIV particles to stick more efficiently to the immune cells that the virus infects. We are presently examining the normal function of SEVI, which presumably did not evolve to enhance HIV infection! We are also developing novel developing compounds that prevent SEVI from interacting with the virus – thereby reducing the efficiency of HIV infection. This strategy is different from most other antiviral approaches, because it targets an invariant host factor – making it very unlikely that the virus could ever become resistant to SEVI inhibitors. NEUROAIDS RESEARCH: NOVEL THERAPEUTICS and STUDIES OF CEREBRAL BLOOD FLOW: HIV-Associated Neurocognitive Disorders (HAND) continue to affect more than 50% of persons living with HIV, despite the widespread use of effective antiviral drugs. This suggests that chronic, virally-initiated, neuroinflammation may persist over time – leading to neuronal dysfunction and damage. In collaboration with Handy Gelbard, we are therefore working to develop new therapies for HAND, by targeting mixed lineage kinase (MLK)-3, an upstream kinase involved in the regulation of neuroinflammation and cell fate. In separate studies, we are also examining the mechanisms by which HIV infection leads to inhibition of cerebral blood flow (CBF). These experiments include an analysis of how virally-encoded neurotoxins may interact with drugs of abuse (such as methamphetamine) to exacerbate CNS disease and neuroinflammation. ROLE OF CELLULAR FACTORS IN INFLUENZA VIRUS PATHOGENESIS AND HOST ADAPTATION: The influenza A virus (IAV) RNA polymerase complex is known to play an important role in viral pathogenesis and host adaptation, but the underlying reasons for this remain unclear. In collaboration with the Katze laboratory at the University of Washington, our group recently completed an extensive proteomic analysis of host cell factors that interact with the IAV RNA polymerase. This resulted in the identification of a large number of mitochondrial proteins, and other cellular proteins that were previously not recognized to play a role in influenza virus infection. Current studies in our laboratory are examining how these proteins influence virus replication, and pathogenesis, as well as the activity of the viral RNA polymerase.

Credentials

Education

1984
BS | Bristol University, UK
Biochemistry

1987
PhD | University of Nebraska
Molecular Biology

Post-doctoral Training & Residency

1988 - 1990
Postdoctoral Fellow, Department of Cancer Biology, Harvard School of Public Health, Boston, MA.

1987 - 1988
Postdoctoral Fellow, Department of Medicine and Pediatrics, Columbia University, New York, NY.

Awards

2008
William H. Riker Award for Graduate Education
Sponsor: University of Rochester

2004 - Present
Member, NIH Recombinant Advisory Committee (RAC)

2003 - 2004
Chair, NIH/NIAID AIDSRRC Charter Study Section

2003
University Dean's Award for Meritorious Service in Ph.D. Defenses
Sponsor: University of Rochester

2002 - Present
Dean's Professor of Microbiology & Immunology
Sponsor: University of Rochester School of Medicine & Dentistry

2002
Graduate Alumni Award for Excellence in Graduate Education
Sponsor: University of Rochester

1996
Graduate Student Soceity (GSS) Faculty Teaching Award
Sponsor: University of Rochester School of Medicine & Dentistry

1995
Friend of Education Award
Sponsor: Rochester City School District

1994 - 1999
Research Career Development Award, NIH

1988 - 1991
AIDS Research Scholar
Sponsor: AmFAR (American Foundation for AIDS Research)

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Patents

Patent Title: avB3 Integrin-Binding Polypeptide Monobodies and Their Use
Patent #: 7,556,925
Issue Date: Jul 07, 2009
Country: United States
Invented By: Stephen Dewhurst, Shohei Koide, Akiko Koide, Michelle L Miller, Julie Richards Gunzler

Patent Title: Substituted Pyrrolo [2,3-b] Pyridines as MLK Inhibitors
Patent #: 9,814,704
Issue Date: Nov 14, 2017
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Substituted Pyrrolo [2,3-B] Pyridines as MLK Inhibitors
Patent #: 9,181,247
Issue Date: Nov 10, 2015
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Substituted Pyrrolo [2,3-B] Pyridines as MLK Inhibitors
Patent #: 8,877,772
Issue Date: Nov 04, 2014
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Modified Phage for Displaying Post-Translationally Modified Proteins and Uses Thereof
Patent #: 8,754,015
Issue Date: Jun 17, 2014
Country: United States
Invented By: Stephen Dewhurst, John J Treanor

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: 10,485,800
Issue Date: Nov 26, 2019
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: 2925319
Issue Date: Jan 09, 2019
Country: Europe
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: FR2925319
Issue Date: Jan 09, 2019
Country: France
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: 602013049719.2
Issue Date: Jan 09, 2019
Country: Germany
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: GB2925319
Issue Date: Jan 09, 2019
Country: United Kingdom
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: Mixed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Patent #: ZL201380060736.1
Issue Date: Aug 10, 2018
Country: China, People's Republic of
Invented By: Stephen Dewhurst, Harris A Gelbard, Howard E Gendelman

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 2,744,498
Issue Date: Oct 24, 2017
Country: Canada
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 5930278
Issue Date: May 13, 2016
Country: Japan
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 5873544
Issue Date: Jan 22, 2016
Country: Japan
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 2379561
Issue Date: Nov 04, 2015
Country: Europe
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: FR2379561
Issue Date: Nov 04, 2015
Country: France
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 602009034691.1
Issue Date: Nov 04, 2015
Country: Germany
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: IT2379561
Issue Date: Nov 04, 2015
Country: Italy
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: ES2379561
Issue Date: Nov 04, 2015
Country: Spain
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: GB2379561
Issue Date: Nov 04, 2015
Country: United Kingdom
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 2009324894
Issue Date: Jul 23, 2015
Country: Australia
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: 614904
Issue Date: Jun 30, 2015
Country: New Zealand
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: MLK Inhibitors and Methods of Use
Patent #: ZL200980152665.1
Issue Date: Feb 11, 2015
Country: China, People's Republic of
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Torsten Wiemann

Patent Title: Helper Virus-Free Herpesvirus Amplicon Particles and Uses Thereof
Patent #: DE1346036
Issue Date: Apr 28, 2010
Country: Germany
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpesvirus Amplicon Particles and Uses Thereof
Patent #: FR1346036
Issue Date: Apr 28, 2010
Country: France
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: 8,119,118
Issue Date: Feb 21, 2012
Country: United States
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: 1346036
Issue Date: Apr 28, 2010
Country: Europe
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: IE1346036
Issue Date: Apr 28, 2010
Country: Ireland
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: GB1346036
Issue Date: Apr 28, 2010
Country: United Kingdom
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: DK1346036
Issue Date: Apr 28, 2010
Country: Denmark
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: BE1346036
Issue Date: Apr 28, 2010
Country: Belgium
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Helper Virus-Free Herpes Virus Amplicon Particles and Uses Thereof
Patent #: 2002246625
Issue Date: Apr 24, 2008
Country: Australia
Invented By: William J Bowers, Stephen Dewhurst, Thomas G Evans, Howard J Federoff, John G Frelinger, Peter K Hocknell, Joseph D Rosenblatt, Khaled A Tolba, Richard A Willis

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 2,800,176
Issue Date: Aug 28, 2018
Country: Canada
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 2011258465
Issue Date: Mar 30, 2017
Country: Australia
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 6086326
Issue Date: Feb 10, 2017
Country: Japan
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: ZL201180036376.2
Issue Date: Feb 10, 2016
Country: China, People's Republic of
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 603644
Issue Date: Feb 03, 2015
Country: New Zealand
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Patent #: 8,846,909
Issue Date: Sep 30, 2014
Country: United States
Invented By: Stephen Dewhurst, Harris A Gelbard, Val S Goodfellow, Colin J Loweth, Satheesh Babu Ravula, Torsten Wiemann

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 3022298
Issue Date: Jun 19, 2019
Country: Europe
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: FR3022298
Issue Date: Jun 19, 2019
Country: France
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 602014048
Issue Date: Jun 19, 2019
Country: Germany
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: GB3022298
Issue Date: Jun 19, 2019
Country: United Kingdom
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 10,323,231
Issue Date: Jun 18, 2019
Country: United States
Invented By: Andrew Cox, Stephen Dewhurst, John J Treanor

Patent Title: Attenuated Influenza Vaccines and Uses Thereof
Patent #: 9,878,032
Issue Date: Jan 30, 2018
Country: United States
Invented By: Andrew Cox, Stephen Dewhurst, Baek Kim, John J Treanor

Patent Title: Antigenic Mimics of Discontinuous Epitopes of Pathogens Recognized by Broadly Neutralizing Antibodies
Patent #: 8,961,977
Issue Date: Feb 24, 2015
Country: United States
Invented By: Stephen Dewhurst, Mark A Sullivan

Patent Title: AVB3 Integrin-Binding Polypeptide Monobodies and Their Use
Patent #: 2002307146
Issue Date: May 17, 2007
Country: Australia
Invented By: Stephen Dewhurst, Shohei Koide, Akiko Koide, Michelle L Miller, Julie Richards Gunzler

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Publications

Journal Articles

11/5/2018
Chamberlain J, Sortino K, Sethna P, Bae A, Lanier R, Bambara RA, Dewhurst S. "Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via Both Non-Obligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus." Antimicrobial agents and chemotherapy.. 2018 Nov 5; Epub 2018 Nov 05.

2018
Mathew E, Zhu H, Connelly SM, Sullivan MA, Brewer MG, Piepenbrink MS, Kobie JJ, Dewhurst S, Dumont ME. "Display of the HIV envelope protein at the yeast cell surface for immunogen development." PloS one.. 2018 13(10):e0205756. Epub 2018 Oct 18.

9/19/2017
Sheik DA, Dewhurst S, Yang J. "Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission." Accounts of chemical research.. 2017 Sep 19; 50(9):2159-2166. Epub 2017 Aug 15.

Books & Chapters

2003
Chapter Title: Various reprinted forms, including Biosafety guidelines and policies
Book Title: Medical Laboratory Management: Forms, Checklists and Guidelines
Author List: Dewhurst, S.
Published By: Aspen Publishers 2003 in Gaithersburg, MD

1991
Chapter Title: Simian immunodeficiency virus (SIV) from old world monkeys
Book Title: The Human Retroviruses
Author List: Contag, C.H., Dewhurst, S., Viglianti, G.A., and Mullins, J.I.
Edited By: Gallo, R.C., and Gilbert, J.
Published By: Academic Press 1991 in Orlando, FL

1990
Chapter Title: Proviral DNA cloning.
Book Title: Techniques in HIV research
Author List: Overbaugh, J., Dewhurst, S., and Mullins, J.I.
Edited By: Aldovini, A., and Walker, B. D.
Published By: Stockton Press 1990 in New York.

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