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Roman A. Eliseev, M.D., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-5635

Office: (585) 276-3396

Fax: (585) 275-1121

Research Labs

Our primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells.

Visit Our primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells. Lab Website

Faculty Appointments



The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases.

Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.



Undergraduate/Medical | Russian State Medical University (RSMU)

MD | Russia-Russian State Medical Univ

Graduate | University of Rochester School of Medicine

MS | University of Rochester School of Medicine

PhD | Univ Rochester Sch Med/Dent

Post-doctoral Training & Residency

07/01/2003 - 03/30/2005
Center for Musculoskeletal Research


2009 - 2011
CTSI KL2 Career Award
Sponsor: NCRR/NIH

2004 - 2007
Wilmot Cancer Research Fellowship
Sponsor: Wilmot Foundation

NIH Travel Scholarship
Sponsor: Keystone Symposia

Graduate Student Society Research Award
Sponsor: University of Rochester SMD

Young Investigator Award
Sponsor: Frontiers in Mitochondrial Research

Young Investigator Award
Sponsor: Frontiers of Mitochondrial Research

1993 - 1995
Moscow Mayor's Honorary Scholarship
Sponsor: Russian State Medical University

1987 - 1988
Freshman Competitive Scholarship
Sponsor: Russian State Medical University

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Patent Title: Use of Cyclophilin D Inhibitors to Treat or Prevent Bone Disorders
Patent #: 9,833,467
Issue Date: Dec 05, 2017
Country: United States
Invented By: Roman A Eliseev


Journal Articles

Hollenberg AM, Smith CO, Shum LC, Awad H, Eliseev RA. "Lactate Dehydrogenase Inhibition with Oxamate Exerts Bone Anabolic Effect." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 Jul 30; Epub 2020 Jul 30.

Shares BH, Smith CO, Sheu TJ, Sautchuk R, Schilling K, Shum LC, Paine A, Huber A, Gira E, Brown E, Awad H, Eliseev RA. "Inhibition of the mitochondrial permeability transition improves bone fracture repair." Bone.. 2020 Apr 28; :115391. Epub 2020 Apr 28.

Shares BH, Busch M, White N, Shum L, Eliseev RA. "Active mitochondria support osteogenic differentiation by stimulating ?-catenin acetylation." The Journal of biological chemistry.. 2018 Oct 12; 293(41):16019-16027. Epub 2018 Aug 27.