CONTACT INFORMATIONCREDENTIALSAWARDSPATENTSPUBLICATIONSRoman A. Eliseev, M.D., Ph.D.Contact InformationPhone NumbersAdministrative: (585) 273-5635Office: (585) 276-3396Fax: (585) 275-1121Research LabsOur primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells.Visit Our primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells. Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 665Rochester, NY 14642Faculty AppointmentsAssociate Professor - Department of Orthopaedics , Center for Musculoskeletal Research (SMD) Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - JointAssociate Professor - Department of Pharmacology and Physiology (SMD) - JointBiographyResearchThe main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases. Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.CredentialsEducation1987-1995Undergraduate/Medical | Russian State Medical University (RSMU)1995MD | Russia-Russian State Medical UnivMedicine1996-2002Graduate | University of Rochester School of Medicine1999MS | University of Rochester School of Medicine2002PhD | Univ Rochester Sch Med/DentBiochemistryPost-doctoral Training & Residency07/01/2003 - 03/30/2005Center for Musculoskeletal ResearchAwards2009 - 2011CTSI KL2 Career AwardSponsor: NCRR/NIH2004 - 2007Wilmot Cancer Research FellowshipSponsor: Wilmot Foundation2002NIH Travel ScholarshipSponsor: Keystone Symposia2001Graduate Student Society Research AwardSponsor: University of Rochester SMD2000Young Investigator AwardSponsor: Frontiers in Mitochondrial Research1998Young Investigator AwardSponsor: Frontiers of Mitochondrial Research1993 - 1995Moscow Mayor's Honorary ScholarshipSponsor: Russian State Medical University1987 - 1988Freshman Competitive ScholarshipSponsor: Russian State Medical UniversityVIEW ALL expand_morePatentsPatent Title: Use of Cyclophilin D Inhibitors to Treat or Prevent Bone Disorders Patent #: 9,833,467 Issue Date: Dec 05, 2017 Country: United States Invented By: Roman A EliseevPublicationsJournal Articles6/2022Sautchuk R, Eliseev RA. "Cell energy metabolism and bone formation." Bone reports.. 2022 Jun; 16:101594. Epub 2022 May 27. 5/30/2022Sautchuk R, Kalicharan BH, Escalera-Rivera K, Jonason JH, Porter GA, Awad HA, Eliseev RA. "Transcriptional regulation of Cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation." eLife.. 2022 May 30; 11Epub 2022 May 30. 10/22/2021Tow BD, Deb A, Neupane S, Patel S, Reed M, Loper AB, Eliseev RA, Knollmann BC, Györke S, Liu B. "SR-mitochondria crosstalk shapes Ca signaling to impact pathophenotype in disease models marked by dysregulated intracellular Ca release." Cardiovascular research.. 2021 Oct 22; Epub 2021 Oct 22. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Roman A. Eliseev, M.D., Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Roman A. Eliseev, M.D., Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.