Research Bio
The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases.
Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.
| CTSI KL2 Career Award | NCRR/NIH |
2009 - 2011 |
| Wilmot Cancer Research Fellowship | Wilmot Foundation |
2004 - 2007 |
| NIH TRavel Scholarship | Keystone Symposia |
2002 |
| Graduate Student Society Research Award | University of Rochester SMD |
2001 |
| Young Investigator Award | Frontiers in Mitochondrial Research |
2000 |
| Young Investigator Award | Frontiers of Mitochondrial Research |
1998 |
| Moscow Mayor's Honorary Scholarship | Russian State Medical University |
1993 - 1995 |
| Freshman Competitive Scholarship | Russian State Medical University |
1987 - 1988 |
2013 Nov 15
Giang AH, Raymond T, Brookes P, Demesy-Bentley K, Schwarz E, O'Keefe R, Eliseev R. "Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect." The Journal of biological chemistry. 2013 Nov 15; 288(46):33303-11. Epub 2013 Oct 07. |
2012 Apr
Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. "Targeting radioresistant osteosarcoma cells with parthenolide." Journal of cellular biochemistry. 2012 Apr; 113(4):1282-91. |
2011 Jun 24
Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley KL, Eliseev RA. "Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication." The Journal of biological chemistry. 2011 Jun 24; 286(25):22331-8. Epub 2011 May 02. |
2010 Jul 1
Shapovalov Y, Benavidez D, Zuch D, Eliseev RA. "Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma." International journal of cancer. Journal international du cancer. 2010 Jul 1; 127(1):67-76. |
2009 Apr 10
Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE. "Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect." The Journal of biological chemistry. 2009 Apr 10; 284(15):9692-9. Epub 2009 Feb 19. |
