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Roman A. Eliseev, M.D., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-5635

Office: (585) 276-3396

Fax: (585) 275-1121

Research Labs

Our primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells.

Visit Our primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells. Lab Website

Faculty Appointments

Biography

Research

The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases.

Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.

Credentials

Education

1987-1995
Undergraduate/Medical | Russian State Medical University (RSMU)

1995
MD | Russia-Russian State Medical Univ
Medicine

1996-2002
Graduate | University of Rochester School of Medicine

1999
MS | University of Rochester School of Medicine

2002
PhD | Univ Rochester Sch Med/Dent
Biochemistry

Post-doctoral Training & Residency

07/01/2003 - 03/30/2005
Center for Musculoskeletal Research

Awards

2009 - 2011
CTSI KL2 Career Award
Sponsor: NCRR/NIH

2004 - 2007
Wilmot Cancer Research Fellowship
Sponsor: Wilmot Foundation

2002
NIH Travel Scholarship
Sponsor: Keystone Symposia

2001
Graduate Student Society Research Award
Sponsor: University of Rochester SMD

2000
Young Investigator Award
Sponsor: Frontiers in Mitochondrial Research

1998
Young Investigator Award
Sponsor: Frontiers of Mitochondrial Research

1993 - 1995
Moscow Mayor's Honorary Scholarship
Sponsor: Russian State Medical University

1987 - 1988
Freshman Competitive Scholarship
Sponsor: Russian State Medical University

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Patents

Patent Title: Use of Cyclophilin D Inhibitors to Treat or Prevent Bone Disorders
Patent #: 9,833,467
Issue Date: Dec 05, 2017
Country: United States
Invented By: Roman A Eliseev

Publications

Journal Articles

2/13/2023
Sautchuk R, Yu C, McArthur M, Massie C, Brookes PS, Porter GA, Awad H, Eliseev RA. "ROLE OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN BONE METABOLISM AND AGING." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2023 Feb 13; Epub 2023 Feb 13.

6/2022
Sautchuk R, Eliseev RA. "Cell energy metabolism and bone formation." Bone reports.. 2022 Jun; 16:101594. Epub 2022 May 27.

5/30/2022
Sautchuk R, Kalicharan BH, Escalera-Rivera K, Jonason JH, Porter GA, Awad HA, Eliseev RA. "Transcriptional regulation of Cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation." eLife.. 2022 May 30; 11Epub 2022 May 30.

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