Skip to main content
Explore URMC

URMC Logo

menu

Roman A. Eliseev, M.D., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-5635

Office: (585) 276-3396

Fax: (585) 275-1121

Research Labs

Our primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells.

Lab: (585) 275-4030

Visit Lab Website

Faculty Appointments

Biography

Research

The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases.

Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.

Credentials

Education

1987-1995
Undergraduate/Medical | Russian State Medical University (RSMU)

1995
MD | Russia-Russian State Medical Univ
Medicine

1996-2002
Graduate | University of Rochester School of Medicine

1999
MS | University of Rochester School of Medicine

2002
PhD | Univ Rochester Sch Med/Dent
Biochemistry

Post-doctoral Training & Residency

07/01/2003 - 03/30/2005
Center for Musculoskeletal Research

Awards

2009 - 2011
CTSI KL2 Career Award
Sponsor: NCRR/NIH

2004 - 2007
Wilmot Cancer Research Fellowship
Sponsor: Wilmot Foundation

2002
NIH TRavel Scholarship
Sponsor: Keystone Symposia

2001
Graduate Student Society Research Award
Sponsor: University of Rochester SMD

2000
Young Investigator Award
Sponsor: Frontiers in Mitochondrial Research

1998
Young Investigator Award
Sponsor: Frontiers of Mitochondrial Research

1993 - 1995
Moscow Mayor's Honorary Scholarship
Sponsor: Russian State Medical University

1987 - 1988
Freshman Competitive Scholarship
Sponsor: Russian State Medical University

VIEW ALL expand_more

Publications

Journal Articles

8/27/2018
Shares BH, Busch M, White N, Shum L, Eliseev RA. "Active mitochondria support osteogenic differentiation by stimulating ?-catenin acetylation." The Journal of biological chemistry.. 2018 Aug 27; Epub 2018 Aug 27.

12/2017
Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ. "PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism." Journal of cellular biochemistry.. 2017 Dec 0; 118(12):4383-4393. Epub 2017 May 31.

1/15/2016
Shum LC, White NS, Mills BN, de Mesy Bentley KL, Eliseev RA. "Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation." Stem cells and development.. 2016 Jan 15; 25(2):114-22. Epub 2015 Dec 10.

VIEW ALL PUBLICATIONS