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Roman A. Eliseev, M.D., Ph.D.

Contact Information

Phone Numbers

Fax: (585) 275-1121

Office: (585) 276-3396

Research Labs

Our primary focus is the role of mitochondria in regulation of cell fate in normal stem cells and in cancer cells.

Lab: (585) 276-5610

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Research Network

Biography

Research

The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases. Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.

Credentials

Faculty Appointments

Education

1995
MD | Russia-Russian State Medical Univ
Medicine

1999
MS | University of Rochester School of Medicine

1996-2002
Graduate | University of Rochester School of Medicine

1987-1995
Undergraduate/Medical | Russian State Medical University (RSMU)

2002
PhD | Univ Rochester Sch Med/Dent
Biochemistry

Awards

2009 - 2011
CTSI KL2 Career Award
Sponsor: NCRR/NIH

2004 - 2007
Wilmot Cancer Research Fellowship
Sponsor: Wilmot Foundation

2002
NIH TRavel Scholarship
Sponsor: Keystone Symposia

2001
Graduate Student Society Research Award
Sponsor: University of Rochester SMD

2000
Young Investigator Award
Sponsor: Frontiers in Mitochondrial Research

1998
Young Investigator Award
Sponsor: Frontiers of Mitochondrial Research

1993 - 1995
Moscow Mayor's Honorary Scholarship
Sponsor: Russian State Medical University

1987 - 1988
Freshman Competitive Scholarship
Sponsor: Russian State Medical University

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Publications

Journal Articles

11/15/2013
Giang AH, Raymond T, Brookes P, Demesy-Bentley K, Schwarz E, O'Keefe R, Eliseev R. "Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect." The Journal of biological chemistry.. 2013 Nov 15; 288(46):33303-11. Epub 2013 Oct 07.

4/2012
Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. "Targeting radioresistant osteosarcoma cells with parthenolide." Journal of cellular biochemistry.. 2012 Apr 0; 113(4):1282-91.

6/24/2011
Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley KL, Eliseev RA. "Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication." The Journal of biological chemistry.. 2011 Jun 24; 286(25):22331-8. Epub 2011 May 02.

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