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Chawnshang Chang, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-9994

Fax: (585) 756-4133

Research Labs

The George H. Whipple Lab for Cancer Research was established in 1997 with the recruitment of Dr. Chawnshang Chang as the Founder and current Director.

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Research Network

Biography

Dr. Chang is Director of the George H. Whipple Laboratory for Cancer Research. He is an internationally-recognized expert in the role of androgen receptor in prostate cancer and other organs and diseases. Androgens (steroid hormones) control the development and function of male reproductive tissues, and also influence other organs and tissues, such as skin, skeletal muscle, bone marrow, hair follicles, and brain. Androgen regulates gene expression through the androgen receptor. In 1988, Dr. Chang became the first scientist to clone the complete human and rat androgen receptors. (Science, 1988; PNAS, 1988). He then applied recombinant techniques to overexpress a large quantity of androgen receptor (AR) and used it to produce the first monoclonal antibody to the androgen receptor (Endo., 1989). The successful cloning of the androgen receptor and the generation of the first androgen receptor monoclonal antibody were groundbreaking. Dr. Chang has continued his research in this field; has had more than 200 papers published on the roles of AR, TR2 and TR4; and has served as a mentor to numerous graduate students, postdoctoral fellows, and junior faculty.

Professional Background

Dr. Chawnshang Chang grew up in Taiwan, receiving his Bachelor of Science degree from the National Taiwan University in 1978. Like many students before him, he made the trip across the Pacific Ocean to enter graduate school in the U.S., and earned his Ph.D. degree from the University of Chicago in 1985. As Professor Shutsung Liao's student, he cloned and characterized two androgen target genes. The first was Glutathione S-transferase, which represented the first isolated androgen-repressed gene (JBC, 1987) and the second was Spermine-binding protein, the first isolated androgen early-response gene (JBC, 1987). With this solid training in cloning techniques and the encouragement from his mentor, Dr. Liao, he remained as a post doctorate fellow in Dr. Liao's lab to investigate what was the biggest challenge in the field of Andrology; the cloning of the androgen receptor. In 1988, Chawnshang succeeded in becoming the first scientist to clone the complete human and rat androgen receptors. (Science, 1988; PNAS, 1988). He then applied recombinant techniques to overexpress a large quantity of androgen receptor (AR) and used it to produce the first monoclonal antibody to the androgen receptor (Endo., 1989). The successful cloning of the androgen receptor and the generation of the first androgen receptor monoclonal antibody was not only truly groundbreaking, but also represented one of the most important contributions in the field of Andrology. Over the next 20 years, he continued his research and had more than 200 paper published on the fields of AR, TR2 and TR4. Want to know more about his achievement? Please go to the web site of his lab (http://www.urmc.rochester.edu/ChangARLab/chang.html) for details.

Research

The George H. Whipple Lab for Cancer Research's interest is mainly in the sex hormones/nuclear receptors and Vitamin D/E effects on the prostate/bladder cancer and other hormone-related diseases. Additional information on publications and details of Dr. Chawnshang Chang's research can be obtained from his lab website listed below.

Credentials

Faculty Appointments

Education

1978
BS | National Taiwan University
Agriculture Chemistry

1985
PhD | University of Chicago
Biochemistry & Molecular Biology

Awards

2003
The Milheim Award for Excellence in Cancer Research from Milheim Foundation

2002
Dr. Chien-Tien Hsu Memorial Lecture/Award at 2002 Annual Meeting of OBGYN

2001
Dr. S.T.Huang-Chan memorial Lecture/Award, University of Hong Kong.

2001
Who's Who in America

2001
President Award for Outstanding Andrology Research, The highest honor from The Chinese Andrology Association for the studies of Androgens and Androgen Receptor.

2000
President Award for Outstanding Andrology Research, The highest honor from The Taiwanese Andrology Association for the studies of Androgens and Androgen Receptor.

1999
Davey Memorial Award for Outstanding Cancer Research, University of Rochester.

1999
President Award for Outstanding Urology Research, The highest honor from The Urology Association of Taiwan for the Contribution in Androgen Receptor and Prostate Cancer.

1998
Jiepimg Wu Award, for Outstanding Achievement in Urology (The highest honor for Chinese-Urology Researcher). Beijing, China.

1998
George Hoyt Whipple Lecture, University of Rochester, Rochester, NY

1998
Scholar of the Year, The highest honor from The Taiwanese Osteoporosis Association for Outstanding Contribution in Sex hormones and Osteoporosis.

1996
Award with Honorary Fellow from The Japan Society of Andrology (The 2nd Non-Japanese ever awarded such honor)

1995 - 1997
Blowity-Ridgeway Award in Andrology from Blowity-Ridgeway Foundation

1992
Tokyo Society of Medical Science and University of Tokyo Lecturer

1991 - 1997
CapCure Award (6 times) for Excellence in Prostate Cancer Research

1991 - 1994
American Cancer Society Junior Professorship in Cancer Research

1990
Outstanding Young Investigator Award from Cancer Research Foundation

1989
Andrew Melon Award for Outstanding Young Faculty in USA from Andrew Melon Foundation

1988
The Ayerst Award for Outstanding Young Endocrinologist from the Endocrine Society

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Publications

Journal Articles

10/13/2015
Chen Y, Sun Y, Rao Q, Xu H, Li L, Chang C. "Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status." Oncotarget. 2015 Oct 13; 6(31):31203-15.

9/22/2015
Ou Z, Wang Y, Liu L, Li L, Yeh S, Qi L, Chang C. "Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals." Oncotarget. 2015 Sep 22; 6(28):26065-78.

5/20/2015
Xie H, Li L, Zhu G, Dang Q, Ma Z, He D, Chang L, Song W, Chang HC, Krolewski JJ, Nastiuk KL, Yeh S, Chang C. "Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-?1/Smad/MMP9 signals." Oncotarget. 2015 May 20; 6(14):12326-39.

Books & Chapters

2005
Book Title: Prostate Cancer: Basic Mechanisms and Therapeutic Approaches
Author List: Chang, et al
Published By: World Scientific2005

2005
Chapter Title: "Study of androgen receptor roles in prostate cancer using mice lacking functional prostate androgen receptor"
Book Title: Prostate Cancer: Basic Mechanisms and Therapeutic Approaches.
Author List: Wu C, Yeh S, Xu Q, Yang Z, Chang P, Yu Y, and Chang C
Edited By: (Chang C ed).
Published By: World Scientific. USA.2005

2005
Chapter Title: "Hormonal therapy for prostate cancer: clinical and experimental evidence."
Book Title: Prostate Cancer: Basic Mechanisms and Therapeutic Approaches.
Author List: Miyamoto, H.; and Chang, C
Edited By: (Chang C ed).
Published By: World Scientific. USA.2005

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