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Shu-Yuan Yeh, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-2750

Faculty Appointments

Biography

Research

Dr. Yeh's research projects focus mainly on studying the roles of the estrogen receptor (ER) and androgen receptor (AR) in urological diseases, including prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH), and in male fertility. Dr. Yeh's lab has successfully utilized a broad range of research strategies, with in vitro biochemistry and molecular biology and in vivo animal models, to delineate the biological roles of the AR and ER. In the earlier stages of her career, Dr. Yeh focused on the mechanistic study of the roles of AR and AR associated proteins in androgen responsive and hormonal refractory prostate cancer. Dr. Yeh was the first scientist to clone AR associated protein in 1996, and to create and report on AR knockout (ARKO) mice using the cre-loxP strategy in 2002. The floxed AR mouse has now been successfully applied to knock out the AR gene in selective types of cells, including cells in prostate, testis, bladder, liver, brain, and others. Continuing with her success, Dr. Yeh's lab now has established genetically engineered ERalpha knockout (ERaKO) mice using this cre-loxP strategy.

Dr. Yeh has published papers to validate the usage of Cre-LoxP ERaKO mice and found the defects of prostate ductal morphogenesis and male fertility in this established ERaKO mice model. This cre-loxP ERaKO model represents a more complete ERaKO mouse model and is being used to delineate ERa roles in urological diseases in Dr. Yeh's lab. Furthermore, the lab has identified new ER binding proteins and ER target genes involved in disease progression.

Overall, Dr. Yeh's research strength is in hormone receptors, mechanisms of tumor suppressor and animal model-related studies in prostate cancer and urological disorders. To date, Dr. Yeh has published 78 peer-reviewed papers and 17 review articles on urological diseases. Currently, Dr. Yeh's research projects are supported by the NCI and the Department of Defense.

Credentials

Education

1988
BS | National Taiwan University
Medical Biotechnology/Immunology

1991
MS | National Taiwan University
Biochemical Science

1996
PhD | Univ Wisconsin-Madison
Endocrinology/Molecular Oncology

Awards

2019
AUA Best Poster
Sponsor: AUA

2012
SBUR Best Poster award
Sponsor: SBUR

2007
AUA Best Poster
Sponsor: AUA

2005 - 2006
Outstanding publication award in Department of Pathology
Sponsor: University of Rochester

2003
Traveling Award for Outstanding Oral Presentation
Sponsor: 85th Endocrine Annual Meeting
Location: Philadelphia

2001
Outstanding Young Investigator Award
Sponsor: AACR Steroid Receptor Symposium:

1999
NIH Postdoctoral Fellowship

1997
Travel Award for Outstanding Oral Presentation

1996
Keystone Meeting Travel Award for Outstanding Oral Presentation

1996
CaPCURE Research Award

1995
CaPCURE Research Award
Sponsor: CaPCURE

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Patents

Patent Title: Creation of Female Mice without Androgen Receptor and Creation
Patent #: 531,223
Issue Date: Dec 14, 2006
Country: New Zealand
Invented By: Chawnshang Chang, Shu-Yuan Yeh

Publications

Journal Articles

11/2108
Xiao Y; Sun Y; Liu G1; Zhao J; Gao Y; Yeh S; Gong L; Chang C. "Androgen receptor (AR)/miR-520f-3p/SOX9 signaling is involved in altering hepatocellular carcinoma (HCC) cell sensitivity to the Sorafenib therapy under hypoxia via increasing cancer stem cells phenotype." Cancer Letter. 2108; .

9/10/2019
Chen J, Chou F, Yeh S, Ou Z, Shyr C, Huang C, Xiang Z, Sun Y, Messing E, Zu X, Chang C. "Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated G?i protein/MAPK/MMP9 intracellular signaling." Oncogene.. 2019 Sep 10; Epub 2019 Sep 10.

6/24/2019
Huang CP, Chen J, Chen CC, Liu G, Zhang Y, Messing E, Yeh S, Chang C. "ASC-J9® increases the bladder cancer chemotherapy efficacy via altering the androgen receptor (AR) and NF-?B survival signals." Journal of experimental & clinical cancer research : CR.. 2019 Jun 24; 38(1):275. Epub 2019 Jun 24.

Books & Chapters

2012
Chapter Title: Differential Functions of Stromal and Epithelial Androgen Receptor in Prostate Cancer Before and After Castration Resistant Stage. Advances in Rapid Sex-Steroid Action, New Challenges and New Chances
Book Title: Breast and Prostate Cancers
Author List: Lee SO, Lai KP, Yeh S, Chang C.
Published By: Springer 2012

2010
Chapter Title: Estrogens and Estrogen Receptors in Prostate Development, Estrogenization, and Carcinogenesis
Book Title: Female Sex Hormones and Cancers
Author List: Chen M and Yeh S*
Edited By: George G. Chen
Published By: Nova Science Publishers Inc 2010

2009
Chapter Title: Differential Roles of Androgen Receptor in Prostate Development and Cancer Progression
Book Title: Androgen Action in Prostate Cancer
Author List: Yeh S, Niu Y, Miyamoto H, Chang T, Chang C.
Edited By: Tindall D and Mohler J
Published By: World Scientific Publishing 2009

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