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Helene McMurray, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-6940

Research Labs

Biography

Research

Dr. Helene R. McMurray, Ph.D., is currently head of the Bioinformatics Consulting and Education Service of the Edward G. Miner Library the University of Rochester Medical Center (URMC), as well as holding the post of Assistant Professor of Biomedical Genetics at URMC.

Dr. McMurray is a cancer systems biologist with expertise in genetics, genomics, bioinformatics, biostatistics, and cell and molecular biology. She received her Bachelor of Science degree from Cornell University in 1998 and her Doctor of Philosophy from the University of Rochester, School of Medicine and Dentistry in 2004.

During her post-doctoral training with Dr. Hartmut "Hucky" Land, a leader of research into molecular mechanisms driving malignant cell transformation, Dr. McMurray identified critical gene regulatory architecture that distinguishes cancerous from non-cancerous cells (McMurray et al., Nature, 2008). Reliance on this architecture appears to be a general feature of cancer cells, as it plays a role in diverse types of cancer (Ashton et al., Cell Stem Cell, 2012). The genes involved not only represent a unique source of intervention targets, but their expression signature can also be accessed using chemical genomics to identify CRG-modulating agents with anti-cancer effects (Sampson, McMurray et al., Oncogene, 2013). Recently, Dr. McMurray's laboratory has discovered a cancer-specific role for such genes in the aggressive, hard-to-treat triple-negative sub-type of breast cancers, including identification of novel pharmacologic agents with anti-BLBC activity (Walters et al., in revision).

Credentials

Education

1998
BS | Cornell University
Biological Science

2003
PhD | University of Rochester School of Medicine & Dentistry
Microbiology

Awards

2014
The Graduate Student Society Faculty Award
Sponsor: Graduate Student Society
Location: University of Rochester School of Medicine and Dentistry

2008
Wilson A. Stone Memorial Award
Location: University of Texas, M. D. Anderson Cancer Center, Houston, TX

2008
Outstanding Poster by a Post-Doctoral Fellow, University Day in Genetics
Sponsor: University of Rochester Post-Doctoral Association
Location: University of Rochester, Rochester, NY

2003 - 2006
Postdoctoral Fellowship
Sponsor: National Institutes of Health
Location: James P. Wilmot Cancer Center, University of Rochester, School o

2002
GSS Merit Award
Sponsor: Graduate Student Society
Location: University of Rochester, Rochester, NY

2001 - 2003
Pre-Doctoral Fellowship
Sponsor: National Institutes of Health
Location: Center for Oral Biology, University of Rochester, School of Medi

1996 - 1997
Cornell Tradition Summer Research Fellowship
Location: Cornell University, Ithaca, NY

1994 - 1998
Cornell Tradition Fellowship
Location: Cornell University, Ithaca, NY

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Publications

Journal Articles

8/15/2014
McCall MN, McMurray H, Land H, Almudevar A. "On non-detects in qPCR data." Bioinformatics.. 2014 Aug 15; 30(16):2310-6. Epub 2014 Apr 23.

8/15/2013
Sampson ER, McMurray HR, Hassane DC, Newman L, Salzman P, Jordan CT, Land H. "Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery." Oncogene.. 2013 Aug 15; 32(33):3809-18. Epub 2012 Sep 10.

2013
Tran V, McCall MN, McMurray HR, Almudevar A. "On the underlying assumptions of threshold Boolean networks as a model for genetic regulatory network behavior." Frontiers in genetics. 2013 4:263. Epub 2013 Dec 11.

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