Dr. Cameron cares for patients in the Coronary Care Unit as well as patients in the office who have general cardiac and vascular problems including post-heart attack care, high blood pressure and cholesterol, heart failure, valvular heart disease, aneurysms, arrhythmias and conduction disorders, syncope, peripheral arterial and venous disease. He is board certified in Internal Medicine, Vascular Medicine, and Cardiovascular Disease.
Dr. Cameron trained initially as a pharmacologist at the University of Edinburgh in Scotland which is his home country. He completed postgraduate training in the same discipline at the University of Rochester, then postdoctoral fellowship training in clinical chemistry at the Johns Hopkins Hospital, Department of Pathology, in Baltimore where he published multiple scientific manuscripts on cardiac biomarkers in ischemic disease.
Dr. Cameron then qualified in medicine at Upstate Medical University in Syracuse, later serving as an internal medicine resident at the New York Presbyterian Hospital-Cornell in New York City. He finally completed a five-year integrated clinical and research fellowship in cardiology and vascular medicine at the University of Rochester. He was mentored in platelet biology by Dr. Craig Morrell who is a national expert in this discipline. Dr. Cameron initiated an innovative vascular assessment referral clinic for local optometrists called Vascular Assessment in Patients for Ocular Reasons (VAPOR). He was also the founding member of the University of Rochester Pulmonary Embolism Response Team (PERT). Dr. Cameron has a clinical and academic interest in thrombotic emergencies and presently serves on the University of Rochester faculty as a physician investigator.
Dr. Cameron specializes in both cardiac and vascular disease with admitting privileges at Strong Memorial Hospital where he cares for patients in the Coronary Care Unit. He has documented COCATS Level II training in echocardiography, nuclear cardiology, and vascular interpretation. He is board certified in Internal Medicine through the ABIM, Vascular Medicine through the ABVM, and Cardiovascular Disease through the ABIM.
Our laboratory has funding from the National Institute of Heath to study signal transduction pathways in the cardiovascular system as they relate to thrombotic and ischemic diseases. Our research focus is mostly basic and translational in nature. We are particularly interested in identifying existing and novel platelet signaling pathways in myocardial ischemia and in peripheral vascular disorders such as advanced peripheral artery disease (PAD), chronic venous insufficiency (CVI), and aortic aneurysmal disease. An overarching theme of our laboratory is personalized medicine where we aim to better define platelet function in disease states, paying close attention to post-receptor signal transduction pathways.
Platelets are small anucleate blood particles which play an important role in thrombosis, hemostasis, and inflammation. When patients are treated with anti-platelet drugs, some do not derive expected benefits or they experience off-target adverse events. We have initiated several lines of investigation that show the megakaryocyte-derived platelet phenotype may be fundamentally different in various diseases.
Project 1: Using a murine model of myocardial infarction, we have shown that platelet RNA and the platelet proteome as well as platelet agonist responsiveness are different in the post-myocardial infarct environment. A career-development grant was awarded to study the role of ERK5 and related protein kinases in changing platelet function in ischemic disease. We began enrolling patients with ST-segment elevation myocardial infarction (STEMI) and non ST-segment elevation myocardial infarction (NSTEMI) in July of 2016 to study this phenomenon immediately when the patient arrives in the emergency department at Strong Memorial Hospital.
Project 2: Using a murine model of abdominal aortic aneurysm (AAA) and, along with our colleagues in vascular surgery and cardiac surgery at the University of Rochester, we are studying platelet function both as a consequence of aortic disease and in promoting aortic disease progression. We are using a proteomic approach to identify changes in signaling properties in platelets and in the aortic wall of patients with AAA.
Project 3: Using a murine model of critical limb ischemia (CLI) and various models mimicking the human condition of hypoxia, we have identified two important signal transduction mechanisms which lead to dysregulated platelet behavior. This may in part explain why patients with PAD are predisposed to heart attack and stroke. We recently extended our studies to human platelets from PAD patients with our colleagues in vascular surgery at the University of Rochester and in the Department of Pathology at the Johns Hopkins Hospital.
Project 4: It is well-documented that patients who are exposed to inhaled pollutants are predisposed to adverse cardiovascular events. Using platelets taken from patients with acute myocardial infarction, we are working with our colleagues in environmental medicine and public health at the University of Rochester to study the role of particulate matter and environmental pollutants in changing platelet function and promoting thrombosis These studies may reveal protective mechanisms that could be employed to prevent adverse cardiac events caused by pollutants.
We utilize contemporary cell biology, biochemistry, molecular biology, and animal models to address these questions. We work closely with our colleagues in clinical cardiology, cardiac surgery, and vascular surgery. Our overall goal is to evaluate gaps in clinical care, identify viable signaling pathways in human tissue for drug intervention, and then finally to utilize animal models to test the working hypothesis. We are a friendly, collaborative laboratory with a keen interest in the career development of all laboratory members.
URMC Quality and Safety Certificate of Recognition - Pulmonary Embolism Response Team
Sponsor: Quality of Care Committee
Location: Rochester, NY
NIH K08 Career Development Award
Fellow of the Society of Vascular Medicine
Jay D. Coffman MD Young Investigator Award in Vascular Medicine (2nd Place)
Sponsor: Society of Vascular Medicine
Fellow of the American College of Cardiology
Best of AHA Abstracts
Sponsor: American Heart Association
Abstract and Travel Award, First Place
Sponsor: American College of Cardiology (NY State)
Abstract Merit Badge (top 20%)
Sponsor: International Society of Thrombosis and Hemostasis
Abstract and Travel Award (top 10%)
Sponsor: American Heart Association (ATVB)
Platelet Colloquium Career Investigator Award
Sponsor: University of Kentucky
Society of Vascular Medicine Scholarship
Sponsor: Fellows Vascular Conference Scholarship
Abstract Award (NY State), Second Place
Sponsor: American College of Cardiology
2013 - 2019
NIH LRP (NHLBI)
Sponsor: National Institute of Health
Postdoctoral Research Award (1st place)
Sponsor: Aab CVRI Scientific Advisory Board
2011 - 2012
Multiple "Strong Star" nominations and Hall of Fame citation from patients and colleagues for exceptional clinical care
Sponsor: Strong Memorial Hospital/University of Rochester
Hospitalist award for best resident (honorable mention)
Sponsor: Weill-Cornell Medical Ctr.
Herbert Lourie, MD Graduation Award for gentility, thoughtfulness, philanthropy, compassion, commitment to academic excellence.
Sponsor: SUNY Upstate Medical University
Arnold Gold Humanism Honor Society for excellence in humanistic clinical care, leadership, compassion and dedication to service.
American College of Physicians NY Upstate Scientific Conference: First Place
Sponsor: Medical Student Research
Alpha Omega Alpha Research Award – First Place
Sponsor: Podium Presenters. SUNY Upstate
Young Investigator's Award - awarded with distinction
Sponsor: Paul E. Standjord
Distinguished Abstract Award (top 25 out of 837 selected abstracts)
Sponsor: National Academy of Clinical Biochemistry
Pathology Young Investigator's Award for excellence in basic research – highest scoring winner
Sponsor: Johns Hopkins Hospital
Location: Baltimore, Maryland
Pathology Young Investigator's Award for excellence in clinical research
Sponsor: Johns Hopkins Hospital
Location: Baltimore, Maryland
Dean's Award for the Most Innovative PhD Thesis
Sponsor: University of Rochester
Location: Rochester, NY
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Morris J, Mix D, Cameron SJ. "Medical management of Acute Aortic Syndromes". Current Treatment Options in Cardiovascular Medicine. 2017; 19 (4)(29).
Croft DP, Cameron SJ, Morrell CN, Lowenstein CJ, Ling FS,
Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-
Morrison K, Evans KA, Chalupa D, Rich Q. "Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients." Environmental Research. 2017; 154: 352–361.
Yang M, Vasque-Vivar JM, Cameron SJ, Morrell CN, Silverstein R. "Platelet CD36 Induces ERK5 Activation through a Redox-Regulated Signaling Pathway to Promote a Prothrombotic Phenotype." Blood. 2017; : 1-2.
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