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David J. Topham, Ph.D.


Showing all 191 journal articles & 1 books available

Journal Articles

Villamayor L, Rivero V, López-García D, Topham DJ, Martínez-Sobrido L, Nogales A, DeDiego ML. "Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation." Frontiers in immunology.. 2023 14:1105309. Epub 2023 Jan 30.

Yu J, Tycksen E, Yang W, Mariani TJ, Bhattacharya S, Falsey AR, Topham DJ, Storch GA. "Use of Host Response to Refine the Diagnosis of Group A Streptococcal Pharyngitis." Journal of the Pediatric Infectious Diseases Society.. 2022 Sep 25; Epub 2022 Sep 25.

McDavid A, Laniewski N, Grier A, Gill AL, Kessler HA, Huyck H, Carbonell E, Holden-Wiltse J, Bandyopadhyay S, Carnahan J, Dylag AM, Topham DJ, Falsey AR, Caserta MT, Pryhuber GS, Gill SR, Scheible KM. "Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy." iScience.. 2022 Apr 15; 25(4):104007. Epub 2022 Mar 01.

Moritzky SA, Richards KA, Glover MA, Krammer F, Chaves FA, Topham DJ, Branche A, Nayak JL, Sant AJ. "The negative effect of pre-existing immunity on influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history." The Journal of infectious diseases.. 2022 Feb 24; Epub 2022 Feb 24.

Embong AK, Nguyen-Contant P, Wang J, Kanagaiah P, Chaves FA, Fitzgerald TF, Zhou Q, Kosoy G, Branche AR, Miller BL, Zand MS, Sangster MY, Topham DJ. "Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 Individuals." Pathogens.. 2022 Jan 29; 11(2)Epub 2022 Jan 29.

McCall MN, Chu CY, Wang L, Benoodt L, Thakar J, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Qiu X, Mariani TJ. "A systems genomics approach uncovers molecular associates of RSV severity." PLoS computational biology.. 2021 Dec 28; 17(12):e1009617. Epub 2021 Dec 28.

Young BE, Seppo AE, Diaz N, Rosen-Carole C, Nowak-Wegrzyn A, Cruz Vasquez JM, Ferri-Huerta R, Nguyen-Contant P, Fitzgerald T, Sangster MY, Topham DJ, Järvinen KM. "Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA Vaccination." JAMA pediatrics.. 2021 Nov 10; Epub 2021 Nov 10.

Yee Mon KJ, Zhu H, Daly CWP, Vu LT, Smith NL, Patel R, Topham DJ, Scheible K, Jambo K, Le MTN, Rudd BD, Grimson A. "MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response." Cell reports.. 2021 Nov 9; 37(6):109969.

Nguyen-Contant P, Sangster MY, Topham DJ. "Squalene-Based Influenza Vaccine Adjuvants and Their Impact on the Hemagglutinin-Specific B Cell Response." Pathogens.. 2021 Mar 17; 10(3)Epub 2021 Mar 17.

Wang L, Chu CY, McCall MN, Slaunwhite C, Holden-Wiltse J, Corbett A, Falsey AR, Topham DJ, Caserta MT, Mariani TJ, Walsh EE, Qiu X. "Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants." BMC medical genomics.. 2021 Feb 25; 14(1):57. Epub 2021 Feb 25.

Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CDW, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan CL, Caffé B, Sangster MY, Topham D, McGuire MA, Seppo A, McGuire MK. "Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19." mBio.. 2021 Feb 9; 12(1)Epub 2021 Feb 09.

Lorbach JN, Fitzgerald T, Nolan C, Nolting JM, Treanor JJ, Topham DJ, Bowman AS. "Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States." Viruses.. 2021 Jan 18; 13(1)Epub 2021 Jan 18.

Reilly EC, Sportiello M, Emo KL, Amitrano AM, Jha R, Kumar ABR, Laniewski NG, Yang H, Kim M, Topham DJ. "CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection." Frontiers in immunology.. 2021 12:728669. Epub 2021 Sep 09.

Nguyen-Contant P, Embong AK, Topham DJ, Sangster MY. "Analysis of Antigen-Specific Human Memory B Cell Populations Based on In Vitro Polyclonal Stimulation." Current protocols in immunology / edited by John E. Coligan ... [et al.]. 2020 Dec; 131(1):e109.

Alon R, Sportiello M, Kozlovski S, Kumar A, Reilly EC, Zarbock A, Garbi N, Topham DJ. "Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19." Nature reviews. Immunology.. 2020 Nov 19; Epub 2020 Nov 19.

Zent CS, Brady MT, Delage C, Strawderman M, Laniewski N, Contant PN, Kanagaiah P, Sangster MY, Barr PM, Chu CC, Topham DJ, Friedberg JW. "Short term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial BTK inhibitor therapy for CLL or lymphoplasmacytic lymphoma." Leukemia.. 2020 Oct 30; Epub 2020 Oct 30.

Nguyen-Contant P, Embong AK, Kanagaiah P, Chaves FA, Yang H, Branche AR, Topham DJ, Sangster MY. "S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit." mBio.. 2020 Sep 25; 11(5)Epub 2020 Sep 25.

Steiner DJ, Cognetti JS, Luta EP, Klose AM, Bucukovski J, Bryan MR, Schmuke JJ, Nguyen-Contant P, Sangster MY, Topham DJ, Miller BL. "Array-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patients." Biosensors & bioelectronics.. 2020 Sep 21; 169:112643. Epub 2020 Sep 21.

Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CD, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan C, Caffe B, Sangster MY, Topham DJ, McGuire MA, Seppo A, McGuire MK. "COVID-19 and human milk: SARS-CoV-2, antibodies, and neutralizing capacity." medRxiv : the preprint server for health sciences.. 2020 Sep 18; Epub 2020 Sep 18.

Grier A, Gill AL, Kessler HA, Corbett A, Bandyopadhyay S, Java J, Holden-Wiltse J, Falsey AR, Topham DJ, Mariani TJ, Caserta MT, Walsh EE, Gill SR. "Temporal Dysbiosis of Infant Nasal Microbiota Relative to Respiratory Syncytial Virus Infection." The Journal of infectious diseases.. 2020 Sep 14; Epub 2020 Sep 14.

Chu CY, Qiu X, McCall MN, Wang L, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Pryhuber GS, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Mariani TJ. "Airway gene expression correlates of RSV disease severity and microbiome composition in infants." The Journal of infectious diseases.. 2020 Sep 14; Epub 2020 Sep 14.

Gouma S, Kim K, Weirick ME, Gumina ME, Branche A, Topham DJ, Martin ET, Monto AS, Cobey S, Hensley SE. "Middle-aged individuals may be in a perpetual state of H3N2 influenza virus susceptibility." Nature communications.. 2020 Sep 11; 11(1):4566. Epub 2020 Sep 11.

Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ. "Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans." NPJ vaccines.. 2020 Aug 26; 5(1):77. Epub 2020 Aug 26.

Thakar J, Qian Y, Benoodt L, Roumanes D, Qiu X, Laniewski N, Chu C, Slaunwhite C, Wang L, Mandava A, Chang I, Falsey AR, Caserta MT, Mariani TJ, Scheuermann RH, Walsh EE, Topham DJ. "Unbiased analysis of peripheral blood mononuclear cells reveals CD4 T cell response to RSV matrix protein." Vaccine: X.. 2020 Aug 7; 5:100065. Epub 2020 Apr 21.

Lim K, Kim TH, Trzeciak A, Amitrano AM, Reilly EC, Prizant H, Fowell DJ, Topham DJ, Kim M. "In situ neutrophil efferocytosis shapes T cell immunity to influenza infection." Nature immunology.. 2020 Aug 3; Epub 2020 Aug 03.

Vom Steeg LG, Dhakal S, Woletsadik YA, Park HS, Mulka KR, Reilly EC, Topham DJ, Klein SL. "Androgen receptor signaling in the lungs mitigates inflammation and improves the outcome of influenza in mice." PLoS pathogens.. 2020 Jul 9; 16(7):e1008506. Epub 2020 Jul 09.

McDavid A, Corbett AM, Dutra JL, Straw AG, Topham DJ, Pryhuber GS, Caserta MT, Gill SR, Scheible KM, Holden-Wiltse J. "Eight practices for data management to enable team data science." Journal of clinical and translational science.. 2020 Jun 23; 5(1):e14. Epub 2020 Jun 23.

Anderson CS, Sangster MY, Yang H, Mariani TJ, Chaudhury S, Topham DJ. "Implementing sequence-based antigenic distance calculation into immunological shape space model." BMC bioinformatics.. 2020 Jun 19; 21(1):256. Epub 2020 Jun 19.

Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, Yang H, Oakes PW, Topham DJ. "T integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection." Proceedings of the National Academy of Sciences of the United States of America.. 2020 Jun 2; 117(22):12306-12314. Epub 2020 May 21.

Meilleur CE, Memarnejadian A, Shivji AN, Benoit JM, Tuffs SW, Mele TS, Singh B, Dikeakos JD, Topham DJ, Mu HH, Bennink JR, McCormick JK, Haeryfar SMM. "Discordant rearrangement of primary and anamnestic CD8+ T cell responses to influenza A viral epitopes upon exposure to bacterial superantigens: Implications for prophylactic vaccination, heterosubtypic immunity and superinfections." PLoS pathogens.. 2020 May; 16(5):e1008393. Epub 2020 May 20.

Moore KA, Ostrowsky JT, Mehr AJ, Osterholm MT, . "Influenza response planning for the centers of excellence for influenza research and surveillance: Science preparedness for enhancing global health security." Influenza and other respiratory viruses.. 2020 Apr 19; Epub 2020 Apr 19.

Topham DJ. "Serendipity: Reflections on Being Mentored by Dr. Peter Doherty." Viral immunology.. 2020 Apr; 33(3):137-142.

Martinez-Sobrido L, Blanco-Lobo P, Rodriguez L, Fitzgerald T, Zhang H, Nguyen P, Anderson CS, Holden-Wiltse J, Bandyopadhyay S, Nogales A, DeDiego ML, Wasik BR, Miller BL, Henry C, Wilson PC, Sangster MY, Treanor JJ, Topham DJ, Byrd-Leotis L, Steinhauer DA, Cummings RD, Luczo JM, Tompkins SM, Sakamoto K, Jones CA, Steel J, Lowen AC, Danzy S, Tao H, Fink AL, Klein SL, Wohlgemuth N, Fenstermacher KJ, El Najjar F, Pekosz A, Sauer L, Lewis MK, Shaw-Saliba K, Rothman RE, Liu ZY, Chen KF, Parrish CR, Voorhees IEH, Kawaoka Y, Neumann G, Chiba S, Fan S, Hatta M, Kong H, Zhong G, Wang G, Uccellini MB, García-Sastre A, Perez DR, Ferreri LM, Herfst S, Richard M, Fouchier R, Burke D, Pattinson D, Smith DJ, Meliopoulos V, Freiden P, Livingston B, Sharp B, Cherry S, Dib JC, Yang G, Russell CJ, Barman S, Webby RJ, Krauss S, Danner A, Woodard K, Peiris M, Perera RAPM, Chan MCW, Govorkova EA, Marathe BM, Pascua PNQ, Smith G, Li YT, Thomas PG, Schultz-Cherry S. "Characterizing Emerging Canine H3 Influenza Viruses." PLoS pathogens.. 2020 Apr; 16(4):e1008409. Epub 2020 Apr 14.

Smith A, Rodriguez L, El Ghouayel M, Nogales A, Chamberlain JM, Sortino K, Reilly E, Feng C, Topham DJ, Martínez-Sobrido L, Dewhurst S. "A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus." Journal of virology.. 2020 Jan 31; 94(4)Epub 2020 Jan 31.

Emo K, Reilly EC, Sportiello M, Yang H, Topham DJ. "T cell and chemokine receptors differentially control CD8 T cell motility behavior in the infected airways immediately before and after virus clearance in a primary infection." PloS one.. 2020 15(8):e0227157. Epub 2020 Aug 20.

Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ. "Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans." NPJ vaccines.. 2020 5:77. Epub 2020 Aug 26.

Veazey JM, Eliseeva SI, Hillman SE, Stiles K, Smyth TR, Morrissey CE, Tillotson EJ, Topham DJ, Chapman TJ, Georas SN. "Inhibiting Protein Kinase D Promotes Airway Epithelial Barrier Integrity in Mouse Models of Influenza A Virus Infection." Frontiers in immunology.. 2020 11:580401. Epub 2020 Dec 14.

Topham DJ, DeDiego ML, Nogales A, Sangster MY, Sant A. "Immunity to Influenza Infection in Humans." Cold Spring Harbor perspectives in medicine.. 2019 Dec 30; Epub 2019 Dec 30.

Henry C, Palm AE, Utset HA, Huang M, Ho IY, Zheng NY, Fitzgerald T, Neu KE, Chen YQ, Krammer F, Treanor JJ, Sant AJ, Topham DJ, Wilson PC. "Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine: a Comparative Study." Journal of virology.. 2019 Nov 1; 93(21)Epub 2019 Oct 15.

Topham DJ, Reilly EC, Emo KL, Sportiello M. "Formation and Maintenance of Tissue Resident Memory CD8+ T Cells after Viral Infection." Pathogens.. 2019 Oct 18; 8(4)Epub 2019 Oct 18.

Rodriguez L, Blanco-Lobo P, Reilly EC, Maehigashi T, Nogales A, Smith A, Topham DJ, Dewhurst S, Kim B, Martínez-Sobrido L. "Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines." Viruses.. 2019 Oct 10; 11(10)Epub 2019 Oct 10.

Gouma S, Zost SJ, Parkhouse K, Branche A, Topham DJ, Cobey S, Hensley SE. "Comparison of human H3N2 antibody responses elicited by egg-based, cell-based, and recombinant protein-based influenza vaccines during the 2017-2018 season." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2019 Oct 9; Epub 2019 Oct 09.

Sangster MY, Nguyen PQT, Topham DJ. "Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection." Pathogens.. 2019 Sep 28; 8(4)Epub 2019 Sep 28.

Sonawane AR, Tian L, Chu CY, Qiu X, Wang L, Holden-Wiltse J, Grier A, Gill SR, Caserta MT, Falsey AR, Topham DJ, Walsh EE, Mariani TJ, Weiss ST, Silverman EK, Glass K, Liu YY. "Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection." Scientific reports.. 2019 Sep 25; 9(1):13824. Epub 2019 Sep 25.

DeDiego ML, Nogales A, Martinez-Sobrido L, Topham DJ. "Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication." mBio.. 2019 Aug 27; 10(4)Epub 2019 Aug 27.


Gaylo-Moynihan A, Prizant H, Popovic M, Fernandes NRJ, Anderson CS, Chiou KK, Bell H, Schrock DC, Schumacher J, Capece T, Walling BL, Topham DJ, Miller J, Smrcka AV, Kim M, Hughson A, Fowell DJ. "Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites." Immunity.. 2019 Aug 20; 51(2):298-309.e6. Epub 2019 Aug 06.

Caserta MT, Yang H, Bandyopadhyay S, Qiu X, Gill SR, Java J, McDavid A, Falsey AR, Topham DJ, Holden-Wiltse J, Scheible K, Pryhuber G. "Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants." The Journal of pediatrics.. 2019 Jul 31; Epub 2019 Jul 31.

Walsh EE, Mariani TJ, Chu C, Grier A, Gill SR, Qiu X, Wang L, Holden-Wiltse J, Corbett A, Thakar J, Benoodt L, McCall MN, Topham DJ, Falsey AR, Caserta MT. "Aims, Study Design, and Enrollment Results From the Assessing Predictors of Infant Respiratory Syncytial Virus Effects and Severity Study." JMIR research protocols.. 2019 Jun 6; 8(6):e12907. Epub 2019 Jun 06.

Zhang Y, Bandyopadhyay G, Topham DJ, Falsey AR, Qiu X. "Highly efficient hypothesis testing methods for regression-type tests with correlated observations and heterogeneous variance structure." BMC bioinformatics.. 2019 Apr 15; 20(1):185. Epub 2019 Apr 15.

Tesini BL, Kanagaiah P, Wang J, Hahn M, Halliley JL, Chaves FA, Nguyen PQT, Nogales A, DeDiego ML, Anderson CS, Ellebedy AH, Strohmeier S, Krammer F, Yang H, Bandyopadhyay S, Ahmed R, Treanor JJ, Martinez-Sobrido L, Golding H, Khurana S, Zand MS, Topham DJ, Sangster MY. "Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus." Journal of virology.. 2019 Feb 6; Epub 2019 Feb 06.

Henry C, Zheng NY, Huang M, Cabanov A, Rojas KT, Kaur K, Andrews SF, Palm AE, Chen YQ, Li Y, Hoskova K, Utset HA, Vieira MC, Wrammert J, Ahmed R, Holden-Wiltse J, Topham DJ, Treanor JJ, Ertl HC, Schmader KE, Cobey S, Krammer F, Hensley SE, Greenberg H, He XS, Wilson PC. "Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals." Cell host & microbe.. 2019 Jan 24; Epub 2019 Jan 24.

Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML. "Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins." Viruses.. 2018 Dec 12; 10(12)Epub 2018 Dec 12.

Grier A, McDavid A, Wang B, Qiu X, Java J, Bandyopadhyay S, Yang H, Holden-Wiltse J, Kessler HA, Gill AL, Huyck H, Falsey AR, Topham DJ, Scheible KM, Caserta MT, Pryhuber GS, Gill SR. "Neonatal gut and respiratory microbiota: coordinated development through time and space." Microbiome.. 2018 Oct 26; 6(1):193. Epub 2018 Oct 26.

DeDiego ML, Chiem K, Topham DJ. "Directed selection of amino acid changes in the influenza hemagglutinin and neuraminidase affecting protein antigenicity." Vaccine.. 2018 Oct 15; 36(43):6383-6392. Epub 2018 Sep 14.

Nogales A, Martinez-Sobrido L, Chiem K, Topham DJ, DeDiego ML. "Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans." Journal of virology.. 2018 Oct 1; 92(19)Epub 2018 Sep 12.

Zhang H, Henry C, Anderson CS, Nogales A, DeDiego ML, Bucukovski J, Martinez-Sobrido L, Wilson PC, Topham DJ, Miller BL. "Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza." Analytical chemistry.. 2018 Aug 7; 90(15):9583-9590. Epub 2018 Jul 20.

Topham DJ, Nguyen P, Sangster MY. "Pandemic influenza vaccines: what they have taught us about B cell immunology." Current opinion in immunology.. 2018 Aug; 53:203-208. Epub 2018 Jun 26.

Branche AR, Yang H, Java J, Wiltse-Holden J, Topham DJ, Peasley M, Frost MR, Nahm MH, Falsey AR. "Effect of prior vaccination on carriage rates of Streptococcus pneumoniae in older adults: A longitudinal surveillance study." Vaccine.. 2018 Jul 5; 36(29):4304-4310. Epub 2018 Jun 02.

Roumanes D, Falsey AR, Quataert S, Secor-Socha S, Lee FE, Yang H, Bandyopadhyay S, Holden-Wiltse J, Topham DJ, Walsh EE. "T-Cell Responses in Adults During Natural Respiratory Syncytial Virus Infection." The Journal of infectious diseases.. 2018 Jul 2; 218(3):418-428.

DiPiazza A, Laniewski N, Rattan A, Topham DJ, Miller J, Sant AJ. "CD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection." Journal of virology.. 2018 Jul 1; 92(13)Epub 2018 Jun 13.

Walsh EE, Wang L, Falsey AR, Qiu X, Corbett A, Holden-Wiltse J, Mariani TJ, Topham DJ, Caserta MT. "Virus-Specific Antibody, Viral Load, and Disease Severity in Respiratory Syncytial Virus Infection." The Journal of infectious diseases.. 2018 Jun 20; 218(2):208-217.

Chen YQ, Wohlbold TJ, Zheng NY, Huang M, Huang Y, Neu KE, Lee J, Wan H, Rojas KT, Kirkpatrick E, Henry C, Palm AE, Stamper CT, Lan LY, Topham DJ, Treanor J, Wrammert J, Ahmed R, Eichelberger MC, Georgiou G, Krammer F, Wilson PC. "Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies." Cell.. 2018 Apr 5; 173(2):417-429.e10.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML. "Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain." Scientific reports.. 2018 Mar 6; 8(1):4265. Epub 2018 Mar 06.

Scheible KM, Emo J, Laniewski N, Baran AM, Peterson DR, Holden-Wiltse J, Bandyopadhyay S, Straw AG, Huyck H, Ashton JM, Tripi KS, Arul K, Werner E, Scalise T, Maffett D, Caserta M, Ryan RM, Reynolds AM, Ren CL, Topham DJ, Mariani TJ, Pryhuber GS. "T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy." JCI insight.. 2018 Feb 22; 3(4)Epub 2018 Feb 22.

Anderson CS, McCall PR, Stern HA, Yang H, Topham DJ. "Antigenic cartography of H1N1 influenza viruses using sequence-based antigenic distance calculation." BMC bioinformatics.. 2018 Feb 12; 19(1):51. Epub 2018 Feb 12.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML. "Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain." Scientific reports.. 2018 Jan 5; 8(1):276. Epub 2018 Jan 05.

Yang H, Holden-Wiltse J, Topham DJ, Treanor J. "Maximum Likelihood Estimation of Titer via a Power Family of Four-Parameter Logistic Model." Journal of biopharmaceutical statistics.. 2018 28(3):492-500. Epub 2017 Sep 05.

Topham DJ, Reilly EC. "Tissue-Resident Memory CD8 T Cells: From Phenotype to Function." Frontiers in immunology.. 2018 9:515. Epub 2018 Mar 26.

Wang J, Hilchey SP, DeDiego M, Perry S, Hyrien O, Nogales A, Garigen J, Amanat F, Huertas N, Krammer F, Martinez-Sobrido L, Topham DJ, Treanor JJ, Sangster MY, Zand MS. "Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice." PloS one.. 2018 13(4):e0193680. Epub 2018 Apr 11.

Nogales A, Chauché C, DeDiego ML, Topham DJ, Parrish CR, Murcia PR, Martínez-Sobrido L. "The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression." Journal of virology.. 2017 Nov 15; 91(22)Epub 2017 Oct 27.

Mariani TJ, Qiu X, Chu CY, Wang L, Thakar J, Holden-Wiltse J, Corbett A, Topham DJ, Falsey AR, Caserta MT, Walsh EE. "Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants." The Journal of infectious diseases.. 2017 Nov 15; 216(8):1027-1037.

Capece T, Walling BL, Lim K, Kim KD, Bae S, Chung HL, Topham DJ, Kim M. "A novel intracellular pool of LFA-1 is critical for asymmetric CD8 T cell activation and differentiation." The Journal of cell biology.. 2017 Nov 6; 216(11):3817-3829. Epub 2017 Sep 27.

Anderson CS, Ortega S, Chaves FA, Clark AM, Yang H, Topham DJ, DeDiego ML. "Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain." Scientific reports.. 2017 Nov 6; 7(1):14614. Epub 2017 Nov 06.

Nogales A, Rodriguez L, DeDiego ML, Topham DJ, Martínez-Sobrido L. "Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus." Journal of virology.. 2017 Sep 1; 91(17)Epub 2017 Aug 10.

Clark AM, Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML. "Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses." Journal of virology.. 2017 Sep 1; 91(17)Epub 2017 Aug 10.

Bhattacharya S, Rosenberg AF, Peterson DR, Grzesik K, Baran AM, Ashton JM, Gill SR, Corbett AM, Holden-Wiltse J, Topham DJ, Walsh EE, Mariani TJ, Falsey AR. "Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness." Scientific reports.. 2017 Jul 26; 7(1):6548. Epub 2017 Jul 26.

Zhang Y, Topham DJ, Thakar J, Qiu X. "FUNNEL-GSEA: FUNctioNal ELastic-net regression in time-course gene set enrichment analysis." Bioinformatics.. 2017 Jul 1; 33(13):1944-1952.

Ramani S, Neill FH, Ferreira J, Treanor JJ, Frey SE, Topham DJ, Goodwin RR, Borkowski A, Baehner F, Mendelman PM, Estes MK, Atmar RL. "B-Cell Responses to Intramuscular Administration of a Bivalent Virus-Like Particle Human Norovirus Vaccine." Clinical and vaccine immunology : CVI.. 2017 May; 24(5)Epub 2017 May 05.

Rodriguez L, Nogales A, Reilly EC, Topham DJ, Murcia PR, Parrish CR, Martinez Sobrido L. "A live-attenuated influenza vaccine for H3N2 canine influenza virus." Virology.. 2017 Apr; 504:96-106. Epub 2017 Feb 03.

Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML. "NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses." Journal of virology.. 2017 Mar 1; 91(5)Epub 2017 Feb 14.

Caserta MT, Qiu X, Tesini B, Wang L, Murphy A, Corbett A, Falsey AR, Holden-Wiltse J, Walsh EE. "Development of a Global Respiratory Severity Score for Respiratory Syncytial Virus Infection in Infants." The Journal of infectious diseases.. 2017 Mar 1; 215(5):750-756.

Nogales A, Rodriguez L, Chauché C, Huang K, Reilly EC, Topham DJ, Murcia PR, Parrish CR, Martínez-Sobrido L. "Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 Vaccine." Journal of virology.. 2017 Feb 15; 91(4)Epub 2017 Jan 31.

Clark AM, DeDiego ML, Anderson CS, Wang J, Yang H, Nogales A, Martinez-Sobrido L, Zand MS, Sangster MY, Topham DJ. "Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins." PloS one.. 2017 12(11):e0188267. Epub 2017 Nov 16.

DeDiego ML, Nogales A, Lambert-Emo K, Martinez-Sobrido L, Topham DJ. "NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses." Journal of virology.. 2016 Nov 1; 90(21):9693-9711. Epub 2016 Oct 14.

Lambert Emo K, Hyun YM, Reilly E, Barilla C, Gerber S, Fowell D, Kim M, Topham DJ. "Live Imaging of Influenza Infection of the Trachea Reveals Dynamic Regulation of CD8+ T Cell Motility by Antigen." PLoS pathogens.. 2016 Sep; 12(9):e1005881. Epub 2016 Sep 19.

Nogales A, DeDiego ML, Topham DJ, Martínez-Sobrido L. "Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines." Journal of virology.. 2016 Jul 15; 90(14):6291-6302. Epub 2016 Jun 24.

Henry Dunand CJ, Leon PE, Huang M, Choi A, Chromikova V, Ho IY, Tan GS, Cruz J, Hirsh A, Zheng NY, Mullarkey CE, Ennis FA, Terajima M, Treanor JJ, Topham DJ, Subbarao K, Palese P, Krammer F, Wilson PC. "Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection." Cell host & microbe.. 2016 Jun 8; 19(6):800-13.

DeDiego ML, Anderson CS, Yang H, Holden-Wiltse J, Fitzgerald T, Treanor JJ, Topham DJ. "Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection." Immunology.. 2016 Jun; 148(2):160-73. Epub 2016 Mar 30.

Yang H, Baker SF, González ME, Topham DJ, Martínez-Sobrido L, Zand M, Holden-Wiltse J, Wu H. "An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein." Journal of biopharmaceutical statistics.. 2016 26(3):409-20. Epub 2015 May 26.

Anderson CS, DeDiego ML, Topham DJ, Thakar J. "Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection." Computational and mathematical methods in medicine.. 2016 2016:7686081. Epub 2016 Feb 14.

Anderson CS, DeDiego ML, Thakar J, Topham DJ. "Novel Sequence-Based Mapping of Recently Emerging H5NX Influenza Viruses Reveals Pandemic Vaccine Candidates." PloS one.. 2016 11(8):e0160510. Epub 2016 Aug 05.

Reilly EC, Lambert-Emo K, Topham DJ. "The Effects of Acute Neutrophil Depletion on Resolution of Acute Influenza Infection, Establishment of Tissue Resident Memory (TRM), and Heterosubtypic Immunity." PloS one.. 2016 11(10):e0164247. Epub 2016 Oct 14.

Scheible KM, Emo J, Yang H, Holden-Wiltse J, Straw A, Huyck H, Misra S, Topham DJ, Ryan RM, Reynolds AM, Mariani TJ, Pryhuber GS. "Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants." Clinical immunology : the official journal of the Clinical Immunology Society.. 2015 Dec; 161(2):65-74. Epub 2015 Jul 29.

Lim K, Hyun YM, Lambert-Emo K, Topham DJ, Kim M. "Visualization of integrin Mac-1 in vivo." Journal of immunological methods.. 2015 Nov; 426:120-7. Epub 2015 Sep 02.

Halliley JL, Khurana S, Krammer F, Fitzgerald T, Coyle EM, Chung KY, Baker SF, Yang H, Martínez-Sobrido L, Treanor JJ, Subbarao K, Golding H, Topham DJ, Sangster MY. "High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine." The Journal of infectious diseases.. 2015 Oct 15; 212(8):1270-8. Epub 2015 Apr 02.

Lim K, Hyun YM, Lambert-Emo K, Capece T, Bae S, Miller R, Topham DJ, Kim M. "Neutrophil trails guide influenza-specific CD8? T cells in the airways." Science.. 2015 Sep 4; 349(6252):aaa4352.

Boule LA, Winans B, Lambert K, Vorderstrasse BA, Topham DJ, Pavelka MS, Lawrence BP. "Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection." American journal of physiology. Lung cellular and molecular physiology.. 2015 Aug 1; 309(3):L305-13. Epub 2015 Jun 12.

Baker SF, Nogales A, Santiago FW, Topham DJ, Martínez-Sobrido L. "Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA)." Vaccine.. 2015 Jul 9; 33(30):3562-70. Epub 2015 Jun 01.

Wu H, Miao H, Xue H, Topham DJ, Zand M. "Quantifying Immune Response to Influenza Virus Infection via Multivariate Nonlinear ODE Models with Partially Observed State Variables and Time-Varying Parameters." Statistics in biosciences.. 2015 May 1; 7(1):147-166.

Lee AJ, Das SR, Wang W, Fitzgerald T, Pickett BE, Aevermann BD, Topham DJ, Falsey AR, Scheuermann RH. "Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans." Journal of virology.. 2015 May; 89(10):5427-40. Epub 2015 Mar 04.

Tankam P, He Z, Chu YJ, Won J, Canavesi C, Lepine T, Hindman HB, Topham DJ, Gain P, Thuret G, Rolland JP. "Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases." Optics letters.. 2015 Mar 15; 40(6):1113-6.

Sundararajan A, Sangster MY, Frey S, Atmar RL, Chen WH, Ferreira J, Bargatze R, Mendelman PM, Treanor JJ, Topham DJ. "Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine." Vaccine.. 2015 Jan 15; 33(4):568-76. Epub 2014 Nov 22.

Ramon S, Baker SF, Sahler JM, Kim N, Feldsott EA, Serhan CN, Martínez-Sobrido L, Topham DJ, Phipps RP. "The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?" The Journal of immunology : official journal of the American Association of Immunologists.. 2014 Dec 15; 193(12):6031-40. Epub 2014 Nov 12.

Babu TM, Levine M, Fitzgerald T, Luke C, Sangster MY, Jin H, Topham D, Katz J, Treanor J, Subbarao K. "Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine." Vaccine.. 2014 Nov 28; 32(50):6798-804. Epub 2014 Oct 16.

Guo H, Baker S, Martínez-Sobrido L, Topham DJ. "Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus." Journal of virology.. 2014 Oct; 88(20):12006-16. Epub 2014 Aug 06.

Nogales A, Baker SF, Ortiz-Riaño E, Dewhurst S, Topham DJ, Martínez-Sobrido L. "Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development." Journal of virology.. 2014 Sep; 88(18):10525-40. Epub 2014 Jun 25.

Baker SF, Nogales A, Finch C, Tuffy KM, Domm W, Perez DR, Topham DJ, Martínez-Sobrido L. "Influenza A and B virus intertypic reassortment through compatible viral packaging signals." Journal of virology.. 2014 Sep; 88(18):10778-91. Epub 2014 Jul 09.

Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. "Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection." PloS one.. 2014 9(8):e104781. Epub 2014 Aug 29.

Chen J, Pompano RR, Santiago FW, Maillat L, Sciammas R, Sun T, Han H, Topham DJ, Chong AS, Collier JH. "The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation." Biomaterials.. 2013 Nov; 34(34):8776-85. Epub 2013 Aug 13.

Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ. "Inflammation-induced interstitial migration of effector CD4? T cells is dependent on integrin ?V." Nature immunology.. 2013 Sep; 14(9):949-58. Epub 2013 Aug 11.

Fouchier RA, Kawaoka Y, Cardona C, Compans RW, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. "Gain-of-function experiments on H7N9." Science.. 2013 Aug 9; 341(6146):612-3.

Fouchier RA, Kawaoka Y, Cardona C, Compans RW, Fouchier RA, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Kawaoka Y, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. "Avian flu: Gain-of-function experiments on H7N9." Nature.. 2013 Aug 8; 500(7461):150-1.

Baker SF, Guo H, Albrecht RA, García-Sastre A, Topham DJ, Martínez-Sobrido L. "Protection against lethal influenza with a viral mimic." Journal of virology.. 2013 Aug; 87(15):8591-605. Epub 2013 May 29.

Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K. "B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination." Clinical and vaccine immunology : CVI.. 2013 Jun; 20(6):867-76. Epub 2013 Apr 10.

He XS, Sasaki S, Baer J, Khurana S, Golding H, Treanor JJ, Topham DJ, Sangster MY, Jin H, Dekker CL, Subbarao K, Greenberg HB. "Heterovariant cross-reactive B-cell responses induced by the 2009 pandemic influenza virus A subtype H1N1 vaccine." The Journal of infectious diseases.. 2013 Jan 15; 207(2):288-96. Epub 2012 Oct 29.

Yang H, Topham DJ, Holden-Wiltse J, Wu H. "Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays." Journal of biopharmaceutical statistics.. 2013 23(4):921-36.

Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S. "Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection." Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2012 Nov; 81(11):937-49. Epub 2012 Oct 01.

van Helden MJ, van Kooten PJ, Bekker CP, Gröne A, Topham DJ, Easton AJ, Boog CJ, Busch DH, Zaiss DM, Sijts AJ. "Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice." Vaccine.. 2012 Oct 5; 30(45):6382-8. Epub 2012 Aug 29.

van Helden MJ, de Graaf N, Boog CJ, Topham DJ, Zaiss DM, Sijts AJ. "The bone marrow functions as the central site of proliferation for long-lived NK cells." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Sep 1; 189(5):2333-7. Epub 2012 Jul 20.

Chapman LM, Aggrey AA, Field DJ, Srivastava K, Ture S, Yui K, Topham DJ, Baldwin WM, Morrell CN. "Platelets present antigen in the context of MHC class I." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Jul 15; 189(2):916-23. Epub 2012 Jun 15.

Li X, Miao H, Henn A, Topham DJ, Wu H, Zand MS, Mosmann TR. "Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination." Vaccine.. 2012 Jun 29; 30(31):4581-4. Epub 2012 Apr 30.

Santiago FW, Emo KL, Fitzgerald T, Treanor JJ, Topham DJ. "Antigenic and immunogenic properties of recombinant hemagglutinin proteins from H1N1 A/Brisbane/59/07 and B/Florida/04/06 when produced in various protein expression systems." Vaccine.. 2012 Jun 29; 30(31):4606-16. Epub 2012 May 15.

Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY. "Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization." PloS one.. 2012 7(3):e34377. Epub 2012 Mar 23.

Guo H, Topham DJ. "Multiple distinct forms of CD8+ T cell cross-reactivity and specificities revealed after 2009 H1N1 influenza A virus infection in mice." PloS one.. 2012 7(9):e46166. Epub 2012 Sep 27.

Santiago FW, Fitzgerald T, Treanor JJ, Topham DJ. "Vaccination with drifted variants of avian H5 hemagglutinin protein elicits a broadened antibody response that is protective against challenge with homologous or drifted live H5 influenza virus." Vaccine.. 2011 Nov 8; 29(48):8888-97. Epub 2011 Sep 28.

Wu H, Kumar A, Miao H, Holden-Wiltse J, Mosmann TR, Livingstone AM, Belz GT, Perelson AS, Zand MS, Topham DJ. "Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 Nov 1; 187(9):4474-82. Epub 2011 Sep 23.

de Graaf N, van Helden MJ, Textoris-Taube K, Chiba T, Topham DJ, Kloetzel PM, Zaiss DM, Sijts AJ. "PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo." European journal of immunology.. 2011 Apr; 41(4):926-35. Epub 2011 Mar 01.

Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G, Treanor JJ, Topham DJ. "CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses." Vaccine.. 2011 Mar 3; 29(11):2159-68. Epub 2011 Jan 04.

Azadniv M, Bowers WJ, Topham DJ, Crispe IN. "CD4+ T cell effects on CD8+ T cell location defined using bioluminescence." PloS one.. 2011 Jan 20; 6(1):e16222. Epub 2011 Jan 20.

Mace CR, Topham DJ, Mosmann TR, Quataert SA, Treanor JJ, Miller BL. "Label-free, arrayed sensing of immune response to influenza antigens." Talanta.. 2011 Jan 15; 83(3):1000-5. Epub 2010 Nov 10.

Guo H, Santiago F, Lambert K, Takimoto T, Topham DJ. "T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model." Journal of virology.. 2011 Jan; 85(1):448-55. Epub 2010 Oct 27.

Chapman TJ, Lambert K, Topham DJ. "Rapid reactivation of extralymphoid CD4 T cells during secondary infection." PloS one.. 2011 6(5):e20493. Epub 2011 May 27.

Richards KA, Topham D, Chaves FA, Sant AJ. "Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Nov 1; 185(9):4998-5002. Epub 2010 Oct 01.

Guo H, Topham DJ. "Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection." Journal of virology.. 2010 Aug; 84(15):7750-9. Epub 2010 May 26.

Miao H, Hollenbaugh JA, Zand MS, Holden-Wiltse J, Mosmann TR, Perelson AS, Wu H, Topham DJ. "Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus." Journal of virology.. 2010 Jul; 84(13):6687-98. Epub 2010 Apr 21.

Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology.. 2010 May 10; 400(2):224-32. Epub 2010 Feb 25.

Chapman TJ, Topham DJ. "Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Apr 1; 184(7):3841-9. Epub 2010 Mar 03.

Bernard MP, Bancos S, Chapman TJ, Ryan EP, Treanor JJ, Rose RC, Topham DJ, Phipps RP. "Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection." Vaccine.. 2010 Feb 3; 28(5):1363-72. Epub 2009 Nov 24.

Baer J, Santiago F, Yang H, Wu H, Jeanne-Holden-Wiltse , Treanor J, Topham DJ. "B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant." Vaccine.. 2010 Jan 22; 28(4):907-15. Epub 2009 Nov 21.

Lee HY, Topham DJ, Park SY, Hollenbaugh J, Treanor J, Mosmann TR, Jin X, Ward B, Miao H, Holden-Wiltse J, Perelson AS, Zand M, Wu H. "Simulation and prediction of the adaptive immune response to influenza A virus infection." Journal of virology.. 2009 Jul; 83(14):7151-65. Epub 2009 May 13.

Elphick GF, Sarangi PP, Hyun YM, Hollenbaugh JA, Ayala A, Biffl WL, Chung HL, Rezaie AR, McGrath JL, Topham DJ, Reichner JS, Kim M. "Recombinant human activated protein C inhibits integrin-mediated neutrophil migration." Blood.. 2009 Apr 23; 113(17):4078-85. Epub 2009 Feb 24.

Crompton PD, Mircetic M, Weiss G, Baughman A, Huang CY, Topham DJ, Treanor JJ, Sanz I, Lee FE, Durbin AP, Miura K, Narum DL, Ellis RD, Malkin E, Mullen GE, Miller LH, Martin LB, Pierce SK. "The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals." The Journal of immunology : official journal of the American Association of Immunologists.. 2009 Mar 1; 182(5):3318-26.

Lin GH, Sedgmen BJ, Moraes TJ, Snell LM, Topham DJ, Watts TH. "Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease." The Journal of immunology : official journal of the American Association of Immunologists.. 2009 Jan 15; 182(2):934-47.

Kyu SY, Kobie J, Yang H, Zand MS, Topham DJ, Quataert SA, Sanz I, Lee FE. "Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells." Journal of immunological methods.. 2009 Jan 1; 340(1):42-7. Epub 2008 Nov 06.

Bancos S, Bernard MP, Topham DJ, Phipps RP. "Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells." Cellular immunology.. 2009 258(1):18-28. Epub 2009 Apr 05.

Klein I, Cornejo JC, Polakos NK, John B, Wuensch SA, Topham DJ, Pierce RH, Crispe IN. "Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages." Blood.. 2007 Dec 1; 110(12):4077-85. Epub 2007 Aug 09.

Borowski AB, Boesteanu AC, Mueller YM, Carafides C, Topham DJ, Altman JD, Jennings SR, Katsikis PD. "Memory CD8+ T cells require CD28 costimulation." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 Nov 15; 179(10):6494-503.

Richter MV, Topham DJ. "The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 Oct 15; 179(8):5054-63.

Polakos NK, Klein I, Richter MV, Zaiss DM, Giannandrea M, Crispe IN, Topham DJ. "Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 Jul 1; 179(1):201-10.

Richards KA, Chaves FA, Krafcik FR, Topham DJ, Lazarski CA, Sant AJ. "Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin." Journal of virology.. 2007 Jul; 81(14):7608-19. Epub 2007 May 16.

Richter M, Ray SJ, Chapman TJ, Austin SJ, Rebhahn J, Mosmann TR, Gardner H, Kotelianski V, deFougerolles AR, Topham DJ. "Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 Apr 1; 178(7):4506-16.

Treanor J, Wu H, Liang H, Topham DJ. "Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults." Vaccine.. 2006 Nov 17; 24(47-48):6913-23. Epub 2006 Jun 21.

Kessels HW, Schepers K, van den Boom MD, Topham DJ, Schumacher TN. "Generation of T cell help through a MHC class I-restricted TCR." The Journal of immunology : official journal of the American Association of Immunologists.. 2006 Jul 15; 177(2):976-82.

Polakos NK, Cornejo JC, Murray DA, Wright KO, Treanor JJ, Crispe IN, Topham DJ, Pierce RH. "Kupffer cell-dependent hepatitis occurs during influenza infection." The American journal of pathology.. 2006 Apr; 168(4):1169-78; quiz 1404-5.

Topham DJ, Chapman TJ, Richter M. "Lymphoid and extralymphoid CD4 T cells that orchestrate the antiviral immune response." Expert review of clinical immunology.. 2006 Mar; 2(2):267-76.

Divekar AA, Zaiss DM, Lee FE, Liu D, Topham DJ, Sijts AJ, Mosmann TR. "Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells." The Journal of immunology : official journal of the American Association of Immunologists.. 2006 Feb 1; 176(3):1465-73.

Ignatovich F.V.; Topham D.; and Novotny L. "Optical detection of single nanoparticles and viruses." Journal of Selected Topics in Quantum Electronics, Special Issue on Nanophotonics. 2006; 12(6): 1292-1300.

Chapman TJ, Castrucci MR, Padrick RC, Bradley LM, Topham DJ. "Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection." Virology.. 2005 Sep 30; 340(2):296-306.

Aronica MA, Swaidani S, Zhang YH, Mitchell D, Mora AL, McCarthy S, O'Neal J, Topham D, Sheller JR, Boothby M. "Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells." The Journal of allergy and clinical immunology.. 2004 Dec; 114(6):1441-8.

Ray SJ, Franki SN, Pierce RH, Dimitrova S, Koteliansky V, Sprague AG, Doherty PC, de Fougerolles AR, Topham DJ. "The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection." Immunity.. 2004 Feb; 20(2):167-79.

Sangster MY, Riberdy JM, Gonzalez M, Topham DJ, Baumgarth N, Doherty PC. "An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions." The Journal of experimental medicine.. 2003 Oct 6; 198(7):1011-21. Epub 2003 Sep 29.

Topham DJ, Crispe IN. "Contrasting urban and rural lifestyles of memory CD8+ T cells." Immunity.. 2003 May; 18(5):584-6.

Topham DJ, Castrucci MR, Wingo FS, Belz GT, Doherty PC. "The role of antigen in the localization of naive, acutely activated, and memory CD8(+) T cells to the lung during influenza pneumonia." The Journal of immunology : official journal of the American Association of Immunologists.. 2001 Dec 15; 167(12):6983-90.

Topham DJ, Cardin RC, Christensen JP, Brooks JW, Belz GT, Doherty PC. "Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity." The Journal of general virology.. 2001 Aug; 82(Pt 8):1971-81.

Sangster MY, Topham DJ, D'Costa S, Cardin RD, Marion TN, Myers LK, Doherty PC. "Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Feb 15; 164(4):1820-8.

Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN. "SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality." Cell.. 1999 Sep 3; 98(5):609-16.

Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN. "SOCS3 is essential in the regulation of fetal liver erythropoiesis." Cell.. 1999 Sep 3; 98(5):617-27.

Moriggl R, Sexl V, Piekorz R, Topham D, Ihle JN. "Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells." Immunity.. 1999 Aug; 11(2):225-30.

Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN. "Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells." Immunity.. 1999 Feb; 10(2):249-59.

Moriggl R, Marine JC, Topham DJ, Teglund S, Sexl V, McKay C, Piekorz R, Wang D, Parganas E, Yoshimura A, Ihle JN. "Differential roles of cytokine signaling during T-cell development." Cold Spring Harbor symposia on quantitative biology.. 1999 64:389-95.

Topham DJ, Doherty PC. "Longitudinal analysis of the acute Sendai virus-specific CD4+ T cell response and memory." The Journal of immunology : official journal of the American Association of Immunologists.. 1998 Nov 1; 161(9):4530-5.

Brown MP, Topham DJ, Sangster MY, Zhao J, Flynn KJ, Surman SL, Woodland DL, Doherty PC, Farr AG, Pattengale PK, Brenner MK. "Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice." Nature medicine.. 1998 Nov; 4(11):1253-60.

Bunting KD, Galipeau J, Topham D, Benaim E, Sorrentino BP. "Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice." Blood.. 1998 Oct 1; 92(7):2269-79.

Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN. "Jak2 is essential for signaling through a variety of cytokine receptors." Cell.. 1998 May 1; 93(3):385-95.

Topham DJ, Doherty PC. "Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells." Journal of virology.. 1998 Jan; 72(1):882-5.

Topham DJ, Tripp RA, Doherty PC. "CD8+ T cells clear influenza virus by perforin or Fas-dependent processes." The Journal of immunology : official journal of the American Association of Immunologists.. 1997 Dec 1; 159(11):5197-200.

Doherty PC, Hamilton-Easton AM, Topham DJ, Riberdy J, Brooks JW, Cardin RD. "Consequences of viral infections for lymphocyte compartmentalization and homeostasis." Seminars in immunology.. 1997 Dec; 9(6):365-73.

Doherty PC, Topham DJ, Tripp RA, Cardin RD, Brooks JW, Stevenson PG. "Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections." Immunological reviews.. 1997 Oct; 159:105-17.

Tripp RA, Topham DJ, Watson SR, Doherty PC. "Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking." The Journal of immunology : official journal of the American Association of Immunologists.. 1997 Apr 15; 158(8):3716-20.

Topham DJ, Tripp RA, Hamilton-Easton AM, Sarawar SR, Doherty PC. "Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig." The Journal of immunology : official journal of the American Association of Immunologists.. 1996 Oct 1; 157(7):2947-52.

Bright JJ, Topham DJ, Nag B, Lodge PA, Sriram S. "Vaccination with peptides from MHC class II beta chain hypervariable region causes allele-specific suppression of EAE." Journal of neuroimmunology.. 1996 Jul; 67(2):119-24.

Doherty PC, Topham DJ, Tripp RA. "Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory." Immunological reviews.. 1996 Apr; 150:23-44.

Topham DJ, Tripp RA, Sarawar SR, Sangster MY, Doherty PC. "Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium." Journal of virology.. 1996 Feb; 70(2):1288-91.

Fabry Z, Topham DJ, Fee D, Herlein J, Carlino JA, Hart MN, Sriram S. "TGF-beta 2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo." The Journal of immunology : official journal of the American Association of Immunologists.. 1995 Jul 1; 155(1):325-32.

Ewing C, Topham DJ, Doherty PC. "Prevalence and activation phenotype of Sendai virus-specific CD4+ T cells." Virology.. 1995 Jun 20; 210(1):179-85.

Topham DJ, Nag B, Arimilli S, Sriram S. "A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis." Proceedings of the National Academy of Sciences of the United States of America.. 1994 Aug 16; 91(17):8005-9.

Sriram S, Topham DJ, Carroll L, Shenoy M, Adesina A, Craighead JE. "In vivo administration of TNF-alpha prevents EMC-M virus induced viral encephalitis." International immunology.. 1991 Jul; 3(7):641-5.

Topham DJ, Adesina A, Shenoy M, Craighead JE, Sriram S. "Indirect role of T cells in development of polioencephalitis and encephalomyelitis induced by encephalomyocarditis virus." Journal of virology.. 1991 Jun; 65(6):3238-45.

Sriram S, Topham DJ, Huang SK, Rodriguez M. "Treatment of encephalomyocarditis virus-induced central nervous system demyelination with monoclonal anti-T-cell antibodies." Journal of virology.. 1989 Oct; 63(10):4242-8.

Sriram S, Topham DJ, Carroll L. "Haplotype-specific suppression of experimental allergic encephalomyelitis with anti-IA antibodies." The Journal of immunology : official journal of the American Association of Immunologists.. 1987 Sep 1; 139(5):1485-9.

Books & Chapters

Chapter Title: The Role of VLA-1 in Maintaining Virus-specific T cells in Peripheral Non-lymphoid Tissues
Book Title: Effector Memory T cell Subsets in the Extralymphatic Tissue
Author List: David J. Topham, Timothy R. Chapman, Martin Richter, and Joseph A. Hollenbaugh
Edited By: Ilan Bank
Published By: Research Signpost2009 in Kerala, India