Skip to main content

Coronavirus (COVID-19): Visitor Restrictions, Resources, and Updates

Explore URMC
menu

Zheng-Gen Jin, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 276-7698

Office: (585) 276-7691

Fax: (585) 276-9829

Research Labs

Molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that regulate vasomotor tone, but&.

Visit Molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that regulate vasomotor tone, but&. Lab Website

Faculty Appointments

Biography

Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases.

The specific ongoing projects in the lab are: 1) to characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect; 2) to identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction; 3) to define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines.

Research

Research

* Molecular regulation of vascular endothelial function.

Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases.

The specific ongoing projects in the lab are: 1) to characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect; 2) to identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction; 3) to define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines.

Credentials

Education

1987
BS | China - Non-Medical School
Physics

1991
PhD | China - Non-Medical School
Physiology

Publications

Journal Articles

3/3/2020
Zhang S, Kim JY, Xu S, Liu H, Yin M, Koroleva M, Guo J, Pei X, Jin ZG. "Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ." Proceedings of the National Academy of Sciences of the United States of America.. 2020 Mar 3; 117(9):4792-4801. Epub 2020 Feb 19.

1/8/2020
Luo J, Jin FQ, Yin M, Jin ZG. "Regulation of SRF protein stability by an autophagy-dependent pathway." Biochemical and biophysical research communications.. 2020 Jan 8; 521(2):279-284. Epub 2019 Oct 23.

8/1/2019
Xu S, Xu Y, Liu P, Zhang S, Liu H, Slavin S, Kumar S, Koroleva M, Luo J, Wu X, Rahman A, Pelisek J, Jo H, Si S, Miller CL, Jin ZG. "The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis." European heart journal.. 2019 Aug 1; 40(29):2398-2408.

VIEW ALL PUBLICATIONS