CONTACT INFORMATIONBIOGRAPHYCREDENTIALSPUBLICATIONSZheng-Gen Jin, Ph.D.Contact InformationPhone NumbersAdministrative: (585) 276-7698Office: (585) 276-7691Fax: (585) 276-9829Research LabsMolecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that regulate vasomotor tone, but&.Visit Molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that regulate vasomotor tone, but&. Lab WebsiteLocationsAab Cardiovascular Research Institute601 Elmwood AvenueRochester, NY 14642Faculty AppointmentsProfessor - Department of Medicine , Aab Cardiovascular Research Institute (SMD) BiographyDr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases. The specific ongoing projects in the lab are: 1) to characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect; 2) to identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction; 3) to define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines.ResearchResearch * Molecular regulation of vascular endothelial function. Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases. The specific ongoing projects in the lab are: 1) to characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect; 2) to identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction; 3) to define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines.CredentialsEducation1987BS | China - Non-Medical SchoolPhysics1991PhD | China - Non-Medical SchoolPhysiologyPublicationsJournal Articles3/3/2020Zhang S, Kim JY, Xu S, Liu H, Yin M, Koroleva M, Guo J, Pei X, Jin ZG. "Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ." Proceedings of the National Academy of Sciences of the United States of America.. 2020 Mar 3; 117(9):4792-4801. Epub 2020 Feb 19. 1/8/2020Luo J, Jin FQ, Yin M, Jin ZG. "Regulation of SRF protein stability by an autophagy-dependent pathway." Biochemical and biophysical research communications.. 2020 Jan 8; 521(2):279-284. Epub 2019 Oct 23. 8/1/2019Xu S, Xu Y, Liu P, Zhang S, Liu H, Slavin S, Kumar S, Koroleva M, Luo J, Wu X, Rahman A, Pelisek J, Jo H, Si S, Miller CL, Jin ZG. "The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis." European heart journal.. 2019 Aug 1; 40(29):2398-2408. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Zheng-Gen Jin, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Zheng-Gen Jin, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.