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Robert H. Dworkin, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-8214

Fax: (585) 244-7271

Faculty Appointments

Biography

Professional Background

1. Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the U.S. Food and Drug Administration (FDA) [www.acttion.org]
2. Special Government Employee, Center for Drug Evaluation and Research, FDA
3. Professional Advisory Board, American Chronic Pain Association
4. Associate Editor: Pain; Editorial Boards: Canadian Journal of Pain, Journal of Pain

Research

My major research interests are (1) methodologic aspects of analgesic clinical trials and (2) treatment and prevention of chronic neuropathic and musculoskeletal pain. The primary focus of my current research involves the identification of factors that increase the assay sensitivity of randomized clinical trials to detect differences between an efficacious treatment and a placebo control or comparison intervention. In ongoing studies, we are evaluating the research designs and methods, clinical outcome assessments, and statistical analyses used in clinical trials of treatments for acute and chronic pain. These studies and other efforts to improve the efficiency and informativeness of clinical trials of analgesic, addiction, anesthesiology, and peripheral neuropathy interventions are being conducted under the auspices of the ACTTION public-private partnership with the FDA, of which I serve as Director.

Current Funding (as Principal Investigator)
1. NIH/NINDS, U24 NS113850 (9/30/19-8/31/24): Clinical coordinating center for the HEAL initiative early phase pain investigation clinical network.
2. FDA, U01 FD005936 (9/15/16-8/31/21): Analgesic, anesthetic, and addiction clinical trial translations, innovations, opportunities, and networks (ACTTION) public-private partnership.

Credentials

Education

1971
BA | University of Pennsylvania
Psychology, Sociology

1977
PhD | Harvard University
Psychology

Awards

2020
John D. Loeser Award
Sponsor: International Association for the Study of Pain

2018
Founders Award
Sponsor: American Academy of Pain Medicine

2018
Raymond W. Houde Award
Sponsor: Eastern Pain Association

2015
Mitchell B. Max Award for Neuropathic Pain
Sponsor: American Academy of Neurology

2014
John and Emma Bonica Public Service Award
Sponsor: American Pain Society

2011
John J. Bonica Award
Sponsor: Eastern Pain Association

2008
Frontiers in Pain Lecture
Sponsor: McGill University

2007
Advisory Committee Service Award
Sponsor: US Food and Drug Administration

2007
Gunn-Loke Lecture
Sponsor: University of Washington

2005
Wilbert Fordyce Clinical Investigator Award
Sponsor: American Pain Society

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Publications

Journal Articles

4/28/2021
Ward DS, Absalom AR, Aitken LM, Balas MC, Brown DL, Burry L, Colantuoni E, Coursin D, Devlin JW, Dexter F, Dworkin RH, Egan TD, Elliott D, Egerod I, Flood P, Fraser GL, Girard TD, Gozal D, Hopkins RO, Kress J, Maze M, Needham DM, Pandharipande P, Riker R, Sessler DI, Shafer SL, Shehabi Y, Spies C, Sun LS, Tung A, Urman RD. "Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III." Critical care medicine.. 2021 Apr 28; Epub 2021 Apr 28.

4/8/2021
Gewandter JS, Smith SM, Dworkin RH, Turk DC, Gan TJ, Gilron I, Hertz S, Katz NP, Markman JD, Raja SN, Rowbotham MC, Stacey BR, Strain EC, Ward DS, Farrar JT, Kroenke K, Rathmell JP, Rauck R, Brown C, Cowan P, Edwards RR, Eisenach JC, Ferguson M, Freeman R, Gray R, Giblin K, Grol-Prokopczyk H, Haythornthwaite J, Jamison RN, Martel M, McNicol E, Oshinsky M, Sandbrink F, Scholz J, Scranton R, Simon LS, Steiner D, Verburg K, Wasan AD, Wentworth K. "Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: IMMPACT recommendations." Pain.. 2021 Apr 8; Epub 2021 Apr 08.

3/1/2021
Rice ASC, Dworkin RH, Finnerup NB, Attal N, Anand P, Freeman R, Piaia A, Callegari F, Doerr C, Mondal S, Narayanan N, Ecochard L, Flossbach Y, Pandhi S. "Efficacy and safety of EMA401 in peripheral neuropathic pain: results of two randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy." Pain.. 2021 Mar 1; Epub 2021 Mar 01.

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