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Robert H. Dworkin, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-8214

Fax: (585) 244-7271

Faculty Appointments

Biography

Professional Background

1. Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the U.S. Food and Drug Administration (FDA) [www.acttion.org]
2. Special Government Employee, Center for Drug Evaluation and Research, FDA
3. Professional Advisory Board, American Chronic Pain Association
4. Selection Committee, David Sackett Trial of the Year, Society for Clinical Trials
5. Associate Editor: Pain; Editorial Boards: Canadian Journal of Pain, Journal of Pain

Research

My major research interests are (1) methodologic aspects of analgesic clinical trials and (2) treatment and prevention of chronic neuropathic and musculoskeletal pain. The primary focus of our current research involves the identification of factors that increase the assay sensitivity of clinical trials to detect differences between an active and a control or comparison treatment. In ongoing studies, we are examining the relationships between clinical trial results and their research designs, patient characteristics, and outcome measures. This program of research and other efforts to improve the efficiency and informativeness of analgesic clinical trials are being conducted under the auspices of the ACTTION public-private partnership with the FDA. I have also been very interested in the identification of risk factors for the development of chronic pain. One of our major results has been that patients with greater acute pain are more likely to develop chronic pain. This suggests that attenuating acute pain might prevent chronic pain, and an additional focus of my research has involved developing approaches to test this hypothesis.

Current Funding (as Principal Investigator)
1. NIH/NINDS, U24 NS113850 (9/30/19-8/31/24): Clinical coordinating center for the HEAL initiative early phase pain investigation clinical network.
2. FDA, U01 FD005936 (9/15/16-8/31/21): Analgesic, anesthetic, and addiction clinical trial translations, innovations, opportunities, and networks (ACTTION) public-private partnership.

Credentials

Education

1971
BA | University of Pennsylvania
Psychology, Sociology

1977
PhD | Harvard University
Psychology

Awards

2020
John D. Loeser Award
Sponsor: International Association for the Study of Pain

2018
Founders Award
Sponsor: American Academy of Pain Medicine

2018
Raymond W. Houde Award
Sponsor: Eastern Pain Association

2015
Mitchell B. Max Award for Neuropathic Pain
Sponsor: American Academy of Neurology

2014
John and Emma Bonica Public Service Award
Sponsor: American Pain Society

2011
John J. Bonica Award
Sponsor: Eastern Pain Association

2008
Frontiers in Pain Lecture
Sponsor: McGill University

2007
Advisory Committee Service Award
Sponsor: US Food and Drug Administration

2007
Gunn-Loke Lecture
Sponsor: University of Washington

2005
Wilbert Fordyce Clinical Investigator Award
Sponsor: American Pain Society

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Publications

Journal Articles

1/15/2020
Xu A, Larsen B, Baller EB, Cobb Scott J, Sharma V, Adebimpe A, Basbaum AI, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD. "Convergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis." Neuroscience and biobehavioral reviews.. 2020 Jan 15; Epub 2020 Jan 15.

12/13/2019
Gewandter JS, Dworkin RH, Turk DC, Devine EG, Hewitt D, Jensen MP, Katz NP, Kirkwood AA, Malamut R, Markman JD, Vrijens B, Burke L, Campbell JN, Carr DB, Conaghan PG, Cowan P, Doyle MK, Edwards RR, Evans SR, Farrar JT, Freeman R, Gilron I, Juge D, Kerns RD, Kopecky EA, McDermott MP, Niebler G, Patel KV, Rauck R, Rice ASC, Rowbotham M, Sessler NE, Simon LS, Singla N, Skljarevski V, Tockarshewsky T, Vanhove GF, Wasan AD, Witter J. "Improving study conduct and data quality in clinical trials of chronic pain treatments: IMMPACT recommendations." The journal of pain : official journal of the American Pain Society.. 2019 Dec 13; Epub 2019 Dec 13.

10/17/2019
Kleykamp BA, De Santis M, Dworkin RH, Huhn AS, Kampman KM, Montoya ID, Preston KL, Ramey T, Smith SM, Turk DC, Walsh R, Weiss RD, Strain EC. "Craving and opioid use disorder: A scoping review." Drug and alcohol dependence.. 2019 Oct 17; 205:107639. Epub 2019 Oct 17.

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