Robert H. Dworkin, Ph.D.

Robert H. Dworkin, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 604
Rochester, NY 14642

Office: (585) 275-8214
Fax: (585) 244-7271

Professional Bio

Associate Editor, Pain
Editorial Board, Journal of Pain
Editorial Board, Current Pain and Headache Reports
Professional Advisory Board, American Chronic Pain Association
Co-Chair, Acute to Chronic Pain Transition Work Group, Federal Pain Research Strategy
Special Government Employee, Food and Drug Administration
Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the Food and Drug Administration (http://www.acttion.org)

Research Bio

Research Interests:
Methodologic aspects of analgesic clinical trials
Treatment and prevention of chronic pain
Neuropathic pain
Osteoarthritis



My current research focuses on methodologic aspects of acute and chronic pain clinical trials, especially identifying factors that increase the assay sensitivity of a trial to detect differences between an active and a control or comparison treatment. With funding from the US Food and Drug Administration (FDA), we are examining in large databases of acute and chronic pain trials the relationships between study methodologic features and study outcomes and placebo group responses, as well as comparing the responsiveness to treatment effects of different primary and secondary outcome measures. These studies and other efforts to improve the efficiency and informativeness of analgesic clinical trials are being conducted under the auspices of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the FDA, of which I serve as director.

In addition, in collaboration with Dennis Turk at the University of Washington, we are currently conducting a randomized clinical trial of tramadol, cognitive-behavior therapy, and health education alone and in combination for the treatment of fibromyalgia.

I have also been very interested in the identification of risk factors for the development of chronic neuropathic pain. One of our major results has been that patients with greater acute pain are more likely to develop chronic pain. This suggests that attenuating acute pain might prevent chronic pain, and an additional focus of my research has involved developing approaches to test this hypothesis.

Funding

U01 FD005936-01 (9/15/16-8/31/21)
Food and Drug Administration
Analgesic, anesthetic, and addiction clinical trial translations, innovations, opportunities, and networks (ACTTION) public-private partnership
Role: Principal Investigator

HHSF223201400191C (9/30/14-9/29/17)
Food and Drug Administration
Analysis of FDA clinical trial data to improve assay sensitivity and informativeness of analgesic clinical trials
Role: Principal Investigator

1R01 AR059102-01A (9/1/11-7/31/17)
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Combined behavioral and analgesic trial for fibromyalgia (COMBAT-FM)
Role: Principal Investigator

T32 NS007338 (7/1/90-6/30/20)
NIH/National Institute of Neurological Disorders and Stroke
Experimental therapeutics of neurological disease
Role: Preceptor

Awards & Honors (National)

Mitchell B. Max Award for Neuropathic Pain | American Academy of Neurology 2015
John and Emma Bonica Public Service Award | American Pain Society 2014
John J. Bonica Award | Eastern Pain Association 2011
Advisory Committee Service Award | US Food and Drug Administration 2007
Wilbert Fordyce Clinical Investigator Award | American Pain Society 2005

Recent Journal Articles

Showing the 5 most recent journal articles. 238 available »

2016 Nov
Gewandter JS, McDermott MP, McKeown A, Hoang K, Iwan K, Kralovic S, Rothstein D, Gilron I, Katz NP, Raja SN, Senn S, Smith SM, Turk DC, Dworkin RH. "Reporting of cross-over clinical trials of analgesic treatments for chronic pain: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review and recommendations." Pain. 2016 Nov; 157(11):2544-2551.
2016 Sep 12
Williams MR, Ward DS, Carlson D, Cravero J, Dexter F, Lightdale JR, Mason KP, Miner J, Vargo JJ, Berkenbosch JW, Clark RM, Constant I, Dionne R, Dworkin RH, Gozal D, Grayzel D, Irwin MG, Lerman J, O'Connor RE, Pandharipande P, Rappaport BA, Riker RR, Tobin JR, Turk DC, Twersky RS, Sessler DI. "Evaluating Patient-Centered Outcomes in Clinical Trials of Procedural Sedation, Part 1 Efficacy: Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research Recommendations." Anesthesia and analgesia. 2016 Sep 12; Epub 2016 Sep 12.
2016 Sep
Thakur S, Dworkin RH, Freeman R, Gorson KC, Herrmann DN. "Pain in acquired inflammatory demyelinating polyneuropathies." Pain. 2016 Sep; 157(9):1887-94.
2016 Sep
Taylor AM, Phillips K, Patel KV, Turk DC, Dworkin RH, Beaton D, Clauw DJ, Gignac M, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH, Conaghan PG, Cowan P, Farrar JT, Freeman R, Gewandter J, Gilron I, Goli V, Gover TD, Haddox JD, Kerns RD, Kopecky EA, Lee DA, Malamut R, Mease P, Rappaport BA, Simon LS, Singh JA, Smith SM, Strand V, Tugwell P, Vanhove GF, Veasley C, Walco GA, Wasan AD, Witter J. "Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations." Pain. 2016 Sep; 157(9):1836-50.
2016 Sep
Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice AS, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D. "Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations." Pain. 2016 Sep; 157(9):1851-71.

Current Appointments

Professor - Department of Anesthesiology (SMD) - Primary
Professor - Department of Neurology (SMD)
Professor - Department of Psychiatry (SMD)
Professor - Center for Human Experimental Therapeutics

Education

PhD | Harvard University1977
BA | University of Pennsylvania1971