Robert H. Dworkin, Ph.D.

Robert H. Dworkin, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 604
Rochester, NY 14642

Office: (585) 275-8214
Fax: (585) 244-7271

Professional Bio

Associate Editor, Pain
Editorial Board, Journal of Pain
Editorial Board, Current Pain and Headache Reports
Professional Advisory Board, American Chronic Pain Association
Herpes Zoster Working Group, Centers for Disease Control and Prevention
Special Government Employee, Food and Drug Administration
Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the Food and Drug Administration (http://www.acttion.org)

Research Bio

Research Interests:
Methodologic aspects of analgesic clinical trials
Treatment and prevention of chronic pain
Neuropathic pain
Osteoarthritis



My current research focuses on methodologic aspects of acute and chronic pain clinical trials, especially identifying factors that increase the assay sensitivity of a trial to detect differences between an active and a control or comparison treatment. With funding from the US Food and Drug Administration (FDA), we are examining in large databases of acute and chronic pain trials the relationships between study methodologic features and study outcomes and placebo group responses, as well as comparing the responsiveness to treatment effects of different primary and secondary outcome measures. These studies and other efforts to improve the efficiency and informativeness of analgesic clinical trials are being conducted under the auspices of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the FDA, of which I serve as director.

In addition, in collaboration with Dennis Turk at the University of Washington, we are currently conducting a randomized clinical trial of tramadol, cognitive-behavior therapy, and health education alone and in combination for the treatment of fibromyalgia.

I have also been very interested in the identification of risk factors for the development of chronic neuropathic pain. One of our major results has been that patients with greater acute pain are more likely to develop chronic pain. This suggests that attenuating acute pain might prevent chronic pain, and an additional focus of my research has involved developing approaches to test this hypothesis.

Funding

HHSF223201400191C (9/30/14-9/29/17)
Food and Drug Administration
Analysis of FDA clinical trial data to improve assay sensitivity and informativeness of analgesic clinical trials
Role: Principal Investigator

U01 FD004187-01 (9/15/11-8/31/16)
Food and Drug Administration
Analgesic clinical trial innovations, opportunities, and networks (ACTION)
Role: Principal Investigator

1R01 AR059102-01A (9/1/11-7/31/16)
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Combined behavioral and analgesic trial for fibromyalgia (COMBAT-FM)
Role: Principal Investigator

T32 NS007338 (7/1/90-6/30/20)
NIH/National Institute of Neurological Disorders and Stroke
Experimental therapeutics of neurological disease
Role: Preceptor

Awards & Honors (National)

Mitchell B. Max Award for Neuropathic Pain | American Academy of Neurology 2015
John and Emma Bonica Public Service Award | American Pain Society 2014
John J. Bonica Award | Eastern Pain Association 2011
Advisory Committee Service Award | US Food and Drug Administration 2007
Wilbert Fordyce Clinical Investigator Award | American Pain Society 2005

Recent Journal Articles

Showing the 5 most recent journal articles. 230 available »

2016 Jul 30
Chowdhry AK, Dworkin RH, McDermott MP. "Meta-analysis with missing study-level sample variance data." Statistics in medicine. 2016 Jul 30; 35(17):3021-32. Epub 2016 Feb 16.
2016 Jul 22
Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, McArthur Mb JC, McDermott MP, Rappaport BA, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R. "Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy." Muscle & nerve. 2016 Jul 22; Epub 2016 Jul 22.
2016 Jul 19
Gewandter JS, McDermott MP, McKeown A, Hoang K, Iwan K, Kralovic S, Rothstein D, Gilron I, Katz NP, Raja SN, Senn S, Smith SM, Turk DC, Dworkin RH. "Reporting of cross-over clinical trials of analgesic treatments for chronic pain: ACTTION systematic review and recommendations." Pain. 2016 Jul 19; Epub 2016 Jul 19.
2016 May 5
Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice AS, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D. "Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations." Pain. 2016 May 5; Epub 2016 May 05.
2016 May
Smith SM, Amtmann D, Askew RL, Gewandter JS, Hunsinger M, Jensen MP, McDermott MP, Patel KV, Williams M, Bacci ED, Burke LB, Chambers CT, Cooper SA, Cowan P, Desjardins P, Etropolski M, Farrar JT, Gilron I, Huang IZ, Katz M, Kerns RD, Kopecky EA, Rappaport BA, Resnick M, Strand V, Vanhove GF, Veasley C, Versavel M, Wasan AD, Turk DC, Dworkin RH. "Pain intensity rating training: results from an exploratory study of the ACTTION PROTECCT system." Pain. 2016 May; 157(5):1056-64.

Current Appointments

Professor - Department of Anesthesiology (SMD) - Primary
Professor - Department of Neurology (SMD)
Professor - Department of Psychiatry (SMD)
Professor - Center for Human Experimental Therapeutics

Education

PhD | Harvard University1977
BA | University of Pennsylvania1971