Skip to main content
Explore URMC

URMC Logo

menu

Robert H. Dworkin, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-8214

Fax: (585) 244-7271

Biography

Professional Background

1. Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the Food and Drug Administration (FDA) [www.acttion.org]
2. Special Government Employee, FDA
3. Professional Advisory Board, American Chronic Pain Association
4. Associate Editor, Pain
5. Editorial Boards: Journal of Pain; Canadian Journal of Pain; Current Pain and Headache Reports

Research

My major research interests are (1) methodologic aspects of analgesic clinical trials and (2) treatment and prevention of chronic neuropathic and musculoskeletal pain. The primary focus of our current research involves the identification of factors that increase the assay sensitivity of clinical trials to detect differences between an active and a control or comparison treatment. In ongoing studies, we are examining the relationships between clinical trial results and their research designs, patient characteristics, and outcome measures. This program of research and other efforts to improve the efficiency and informativeness of analgesic clinical trials are being conducted under the auspices of the ACTTION public-private partnership with the FDA. In addition, in collaboration with Dennis Turk at the University of Washington, we are currently conducting a randomized clinical trial of tramadol, cognitive-behavior therapy, and health education alone and in combination for the treatment of fibromyalgia. I have also been very interested in the identification of risk factors for the development of chronic pain. One of our major results has been that patients with greater acute pain are more likely to develop chronic pain. This suggests that attenuating acute pain might prevent chronic pain, and an additional focus of my research has involved developing approaches to test this hypothesis.

Current Funding (as Principal Investigator)
1. FDA, U01 FD005936-01 (9/15/16-8/31/21): Analgesic, anesthetic, and addiction clinical trial translations, innovations, opportunities, and networks (ACTTION) public-private partnership
2. FDA, HHSF223201400191C (9/30/14-9/29/19): Analysis of FDA clinical trial data to improve assay sensitivity and informativeness of analgesic clinical trials
3. NIH/NIAMS, R01 AR059102-01A (9/1/11-7/31/18): Combined behavioral and analgesic trial for fibromyalgia (COMBAT-FM)

Credentials

Faculty Appointments

Education

1971
BA | University of Pennsylvania
Psychology, Sociology

1977
PhD | Harvard University
Psychology

Awards

2015
Mitchell B. Max Award for Neuropathic Pain
Sponsor: American Academy of Neurology

2014
John and Emma Bonica Public Service Award
Sponsor: American Pain Society

2011
John J. Bonica Award
Sponsor: Eastern Pain Association

2007
Advisory Committee Service Award
Sponsor: US Food and Drug Administration

2005
Wilbert Fordyce Clinical Investigator Award
Sponsor: American Pain Society

VIEW ALL expand_more

Publications

Journal Articles

8/2017
Ward DS, Williams MR, Turk DC, Dworkin RH, Sessler DI, Dexter F, . "Recommendations for Procedural Sedation Clinical Trials." Anesthesia and analgesia.. 2017 Aug 0; 125(2):703-704.

7/26/2017
Gewandter JS, Freeman R, Kitt RA, Cavaletti G, Gauthier LR, McDermott MP, Mohile NA, Mohlie SG, Smith AG, Tejani MA, Turk DC, Dworkin RH. "Chemotherapy-induced peripheral neuropathy clinical trials: Review and recommendations." Neurology.. 2017 Jul 26; Epub 2017 Jul 26.

7/18/2017
Gewandter JS, McDermott MP, Kitt RA, Chaudari J, Koch JG, Evans SR, Gross RA, Markman JD, Turk DC, Dworkin RH. "Interpretation of CIs in clinical trials with non-significant results: systematic review and recommendations." BMJ open.. 2017 Jul 18; 7(7):e017288. Epub 2017 Jul 18.

VIEW ALL PUBLICATIONS