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Robert H. Dworkin, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-8214

Faculty Appointments

Biography

Professional Background

1. Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the U.S. Food and Drug Administration (FDA) [www.acttion.org]
2. Special Government Employee, Center for Drug Evaluation and Research, FDA
3. Professional Advisory Board, American Chronic Pain Association
4. Associate Editor: Pain; Editorial Boards: Canadian Journal of Pain, Journal of Pain

Research

My major research interests are (1) methodologic aspects of analgesic clinical trials and (2) treatment and prevention of chronic neuropathic and musculoskeletal pain. The primary focus of my current research involves the identification of factors that increase the assay sensitivity of randomized clinical trials to detect differences between an efficacious treatment and a placebo control or comparison intervention. In ongoing studies, we are evaluating the research designs and methods, clinical outcome assessments, and statistical analyses used in clinical trials of treatments for acute and chronic pain. These studies and other efforts to improve the efficiency and informativeness of clinical trials of analgesic, anesthetic, and addiction interventions are being conducted under the auspices of the ACTTION public-private partnership with the FDA, of which I serve as Director.

Current Funding
1. FDA, U01FD007474 (9/1/21-8/31/22): Analgesic, anesthetic, and addiction clinical trial translations, innovations, opportunities, and networks (ACTTION) public-private partnership (PD/PI)
2. NIH/NINDS, U24 NS113850 (9/30/19-8/31/24): Clinical coordinating center for the HEAL initiative early phase pain investigation clinical network (MPI: 2019-2021; Co-I: 2021-2024)

Credentials

Education

1971
BA | University of Pennsylvania
Psychology, Sociology

1977
PhD | Harvard University
Psychology

Awards

2020
John D. Loeser Prize for Distinguished Lifetime Achievement in the Clinical Science of Pain
Sponsor: International Association for the Study of Pain

2018
Founders Award
Sponsor: American Academy of Pain Medicine

2018
Raymond W. Houde Award
Sponsor: Eastern Pain Association

2015
Mitchell B. Max Award for Neuropathic Pain
Sponsor: American Academy of Neurology

2014
John and Emma Bonica Public Service Award
Sponsor: American Pain Society

2011
John J. Bonica Award
Sponsor: Eastern Pain Association

2008
Frontiers in Pain Lecture
Sponsor: McGill University

2007
Advisory Committee Service Award
Sponsor: US Food and Drug Administration

2007
Gunn-Loke Lecture
Sponsor: University of Washington

2005
Wilbert Fordyce Clinical Investigator Award
Sponsor: American Pain Society

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Publications

Journal Articles

5/13/2022
Henn AT, Larsen B, Frahm L, Xu A, Adebimpe A, Scott JC, Linguiti S, Sharma V, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Habel U, Eickhoff SB, Eickhoff CR, Wagels L, Satterthwaite TD. "Structural imaging studies of patients with chronic pain: an anatomic likelihood estimate meta-analysis." Pain.. 2022 May 13; Epub 2022 May 13.

4/7/2022
Kleykamp BA, Ferguson MC, McNicol E, Bixho I, Matthews M, Turk DC, Dworkin RH, Strain EC. "A comparison of registered and published primary outcomes in clinical trials of opioid use disorder: ACTTION review and recommendations." Drug and alcohol dependence.. 2022 Apr 7; 236:109447. Epub 2022 Apr 07.

3/1/2022
Conaghan PG, Dworkin RH, Schnitzer TJ, Berenbaum F, Bushmakin AG, Cappelleri JC, Viktrup L, Abraham L. "WOMAC Meaningful Within-Patient Change: Results from Three Studies of Tanezumab in Patients with Moderate-To-Severe Osteoarthritis of the Hip or Knee." The Journal of rheumatology.. 2022 Mar 1; Epub 2022 Mar 01.

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