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Lianping Xing, B.Med., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5892

Office: (585) 273-4090

Fax: (585) 756-4468

Biography

Research

The major focus of my research is to study the regulation of bone cell function in inflammatory bone loss using combinations of genetically modified animals, in vivo imaging technologies, histology and in vitro cellular and molecular approaches. I have two established research programs which are funded by NIH to investigate the molecular mechanisms mediating increased osteoclastic bone resorption and reduced osteoblastic bone formation in animal models of rheumatoid arthritis (RA). Patients with RA suffer from joint inflammation and bone erosion as well as systemic osteoporosis. In one program, we are investigating the mechanism by which pro-inflammatory cytokine TNF affects joint tissue injury in RA through the regulation of function of osteoclasts and precursors. In another program, we are investigating the role of ubiquitin-mediated proteasomal degradation in osteoblast function in RA. Currently, we are testing the hypothesis that an inflammatory bone marrow environment increases proteasome-mediated protein degradation in mesenchymal stem cells and inhibits their differentiation to osteoblast precursors, accounting for inflammation-mediated bone loss. The ultimate goal of our research is to provide pre-clinical information that is useful for developing agents that improve bone health in patients with chronic inflammatory disorders.

Credentials

Faculty Appointments

Education

1977
MD | China-Fourth Military Medical Univ, Xian
Medicine

1985
MS | China-Fourth Military Medical Univ, Xian
Internal Medicine

1994
PhD | Penn State University
Cell and Molecular Biology

Awards

2000
Travel Award, ASBMR (50 selected from a pool of 2000 abstracts)

2000
Young Investigator Award, ORS (20 selected from a pool of 1000 abstracts)

1997
Most Outstanding Abstract Award, ASBMR (one selected from a pool of 2000 abstracts)

1996
Young Investigator Award, ASBMR (50 selected from a pool of 2000 abstracts)

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Patents

Title: Method to Identify Patients That Will Likely Respond to Anti-TNF Therapy
U.S. Serial #: 14/761,408
Filed: Jan 10, 2014
Invented By: BrendanBoyce, ChristopherRitchlin, LianpingXing, YanXiu

Publications

Journal Articles

1/2013
Li J, Ju Y, Bouta EM, Xing L, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, Schwarz EM. "Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow." Arthritis and rheumatism.. 2013 Jan 0; 65(1):130-8.

11/2012
Takahata M, Maher JR, Juneja SC, Inzana J, Xing L, Schwarz EM, Berger AJ, Awad HA. "Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk." Arthritis and rheumatism.. 2012 Nov 0; 64(11):3649-59.

6/2012
Ju Y, Rahimi H, Li J, Wood RW, Xing L, Schwarz EM. "Validation of 3-dimensional ultrasound versus magnetic resonance imaging quantification of popliteal lymph node volume as a biomarker of erosive inflammatory arthritis in mice." Arthritis and rheumatism.. 2012 Jun 0; 64(6):2048-50. Epub 2012 Feb 21.

Books & Chapters

2001
Chapter Title: Bone
Book Title: Yearbook of Science and Technology
Author List: Boyce BF and Xing L.
Published By: McGraw-Hill2001 in New York

2001
Chapter Title: Bone Cell Apoptosis
Book Title: Principles of Bone Biology
Author List: Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C.
Edited By: Blezikian, J. P., Raisz, L. G., and Rodan, G. A.
Published By: Academic Press2001 in San Diego

1998
Chapter Title: Apoptosis in Bone Cells.
Book Title: Novel Approaches to Treatment of Osteoporosis
Author List: Boyce, B.F.; Hughes, D.E.; Wright, K.R.; Xing, L.; Dai, A.
Edited By: Russell, R.G.G.; Skerry, T.M.
Published By: Kollenkirchen U.1998

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