Lianping Xing, B.Med., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5892

Office: (585) 273-4090

Fax: (585) 756-4468

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Biography

Research

The major focus of my research is to study the regulation of bone cell function in inflammatory bone loss using combinations of genetically modified animals, in vivo imaging technologies, histology and in vitro cellular and molecular approaches. I have two established research programs which are funded by NIH to investigate the molecular mechanisms mediating increased osteoclastic bone resorption and reduced osteoblastic bone formation in animal models of rheumatoid arthritis (RA). Patients with RA suffer from joint inflammation and bone erosion as well as systemic osteoporosis. In one program, we are investigating the mechanism by which pro-inflammatory cytokine TNF affects joint tissue injury in RA through the regulation of function of osteoclasts and precursors. In another program, we are investigating the role of ubiquitin-mediated proteasomal degradation in osteoblast function in RA. Currently, we are testing the hypothesis that an inflammatory bone marrow environment increases proteasome-mediated protein degradation in mesenchymal stem cells and inhibits their differentiation to osteoblast precursors, accounting for inflammation-mediated bone loss. The ultimate goal of our research is to provide pre-clinical information that is useful for developing agents that improve bone health in patients with chronic inflammatory disorders.

Credentials

Education

1977
MD | China-Fourth Military Medical Univ, Xian
Medicine

1985
MS | China-Fourth Military Medical Univ, Xian
Internal Medicine

1994
PhD | Penn State University
Cell and Molecular Biology

Awards

2000
Travel Award, ASBMR (50 selected from a pool of 2000 abstracts)

2000
Young Investigator Award, ORS (20 selected from a pool of 1000 abstracts)

1997
Most Outstanding Abstract Award, ASBMR (one selected from a pool of 2000 abstracts)

1996
Young Investigator Award, ASBMR (50 selected from a pool of 2000 abstracts)

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Patents

Patent Title: Methods and Compositions for Treating Inflammatory Conditions
Patent #: 8,580,755
Issue Date: Nov 12, 2013
Country: United States
Invented By: Brendan Boyce, Edward Michael Schwarz, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: 3371203
Issue Date: Feb 26, 2020
Country: Europe
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: FR3371203
Issue Date: Feb 26, 2020
Country: France
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: DE3371203
Issue Date: Feb 26, 2020
Country: Germany
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: GB3371203
Issue Date: Feb 26, 2020
Country: United Kingdom
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

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Publications

Journal Articles

2022
Lin X, Zhang H, Liu J, Wu CL, McDavid A, Boyce BF, Xing L. "Aged Callus Skeletal Stem/Progenitor Cells Contain an Inflammatory Osteogenic Population With Increased IRF and NF-?B Pathways and Reduced Osteogenic Potential." Frontiers in molecular biosciences.. 2022 9:806528. Epub 2022 Jun 09.

9/2/2020
Sun S, Tao J, Sedghizadeh PP, Cherian P, Junka AF, Sodagar E, Xing L, Boeckman RK, Srinivasan V, Yao Z, Boyce BF, Lipe B, Neighbors JD, Russell G, McKenna CE, Ebetino FH. "Bisphosphonates for delivering drugs to bone." British journal of pharmacology.. 2020 Sep 2; Epub 2020 Sep 02.

6/25/2020
Lin X, Zhang H, Boyce BF, Xing L. "Ubiquitination of interleukin-1? is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH." The Journal of biological chemistry.. 2020 Jun 25; Epub 2020 Jun 25.

Books & Chapters

2001
Chapter Title: Bone Cell Apoptosis
Book Title: Principles of Bone Biology
Author List: Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C.
Edited By: Blezikian, J. P., Raisz, L. G., and Rodan, G. A.
Published By: Academic Press 2001 in San Diego

2001
Chapter Title: Bone
Book Title: Yearbook of Science and Technology
Author List: Boyce BF and Xing L.
Published By: McGraw-Hill 2001 in New York

1998
Chapter Title: Apoptosis in Bone Cells.
Book Title: Novel Approaches to Treatment of Osteoporosis
Author List: Boyce, B.F.; Hughes, D.E.; Wright, K.R.; Xing, L.; Dai, A.
Edited By: Russell, R.G.G.; Skerry, T.M.
Published By: Kollenkirchen U. 1998

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