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Lianping Xing, B.Med., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5892

Office: (585) 273-4090

Fax: (585) 756-4468

Faculty Appointments



The major focus of my research is to study the regulation of bone cell function in inflammatory bone loss using combinations of genetically modified animals, in vivo imaging technologies, histology and in vitro cellular and molecular approaches. I have two established research programs which are funded by NIH to investigate the molecular mechanisms mediating increased osteoclastic bone resorption and reduced osteoblastic bone formation in animal models of rheumatoid arthritis (RA). Patients with RA suffer from joint inflammation and bone erosion as well as systemic osteoporosis. In one program, we are investigating the mechanism by which pro-inflammatory cytokine TNF affects joint tissue injury in RA through the regulation of function of osteoclasts and precursors. In another program, we are investigating the role of ubiquitin-mediated proteasomal degradation in osteoblast function in RA. Currently, we are testing the hypothesis that an inflammatory bone marrow environment increases proteasome-mediated protein degradation in mesenchymal stem cells and inhibits their differentiation to osteoblast precursors, accounting for inflammation-mediated bone loss. The ultimate goal of our research is to provide pre-clinical information that is useful for developing agents that improve bone health in patients with chronic inflammatory disorders.



MD | China-Fourth Military Medical Univ, Xian

MS | China-Fourth Military Medical Univ, Xian
Internal Medicine

PhD | Penn State University
Cell and Molecular Biology


Travel Award, ASBMR (50 selected from a pool of 2000 abstracts)

Young Investigator Award, ORS (20 selected from a pool of 1000 abstracts)

Most Outstanding Abstract Award, ASBMR (one selected from a pool of 2000 abstracts)

Young Investigator Award, ASBMR (50 selected from a pool of 2000 abstracts)

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Patent Title: Methods and Compositions for Treating Inflammatory Conditions
Patent #: 8,580,755
Issue Date: Nov 12, 2013
Country: United States
Invented By: Brendan Boyce, Edward M Schwarz, Lianping Xing


Journal Articles

Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT. "Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells." Cancer cell.. 2018 Oct 8; 34(4):659-673.e6. Epub 2018 Sep 27.

Huang QQ, Birket R, Doyle RE, Haines GK, Perlman H, Shi B, Homan P, Xing L, Pope RM. "Association of Increased F4/80 Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells." Arthritis & rheumatology.. 2017 Sep 0; 69(9):1762-1771. Epub 2017 Aug 01.

Sun W, Zhang H, Wang H, Chiu YG, Ritchlin CT, Kiernan A, Boyce BF, Xing L. "Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 Jul 0; 32(7):1469-1480. Epub 2017 Apr 10.

Books & Chapters

Chapter Title: Bone
Book Title: Yearbook of Science and Technology
Author List: Boyce BF and Xing L.
Published By: McGraw-Hill 2001 in New York

Chapter Title: Bone Cell Apoptosis
Book Title: Principles of Bone Biology
Author List: Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C.
Edited By: Blezikian, J. P., Raisz, L. G., and Rodan, G. A.
Published By: Academic Press 2001 in San Diego

Chapter Title: Apoptosis in Bone Cells.
Book Title: Novel Approaches to Treatment of Osteoporosis
Author List: Boyce, B.F.; Hughes, D.E.; Wright, K.R.; Xing, L.; Dai, A.
Edited By: Russell, R.G.G.; Skerry, T.M.
Published By: Kollenkirchen U. 1998