Skip to main content
Explore URMC

URMC Logo

menu

Lianping Xing, B.Med., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5892

Office: (585) 273-4090

Fax: (585) 756-4468

Biography

Research

The major focus of my research is to study the regulation of bone cell function in inflammatory bone loss using combinations of genetically modified animals, in vivo imaging technologies, histology and in vitro cellular and molecular approaches. I have two established research programs which are funded by NIH to investigate the molecular mechanisms mediating increased osteoclastic bone resorption and reduced osteoblastic bone formation in animal models of rheumatoid arthritis (RA). Patients with RA suffer from joint inflammation and bone erosion as well as systemic osteoporosis. In one program, we are investigating the mechanism by which pro-inflammatory cytokine TNF affects joint tissue injury in RA through the regulation of function of osteoclasts and precursors. In another program, we are investigating the role of ubiquitin-mediated proteasomal degradation in osteoblast function in RA. Currently, we are testing the hypothesis that an inflammatory bone marrow environment increases proteasome-mediated protein degradation in mesenchymal stem cells and inhibits their differentiation to osteoblast precursors, accounting for inflammation-mediated bone loss. The ultimate goal of our research is to provide pre-clinical information that is useful for developing agents that improve bone health in patients with chronic inflammatory disorders.

Credentials

Faculty Appointments

Education

1977
MD | China-Fourth Military Medical Univ, Xian
Medicine

1985
MS | China-Fourth Military Medical Univ, Xian
Internal Medicine

1994
PhD | Penn State University
Cell and Molecular Biology

Awards

2000
Travel Award, ASBMR (50 selected from a pool of 2000 abstracts)

2000
Young Investigator Award, ORS (20 selected from a pool of 1000 abstracts)

1997
Most Outstanding Abstract Award, ASBMR (one selected from a pool of 2000 abstracts)

1996
Young Investigator Award, ASBMR (50 selected from a pool of 2000 abstracts)

VIEW ALL expand_more

Publications

Journal Articles

7/2017
Sun W, Zhang H, Wang H, Chiu YG, Ritchlin CT, Kiernan A, Boyce BF, Xing L. "Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 Jul 0; 32(7):1469-1480. Epub 2017 Apr 10.

6/2017
Bouta EM, Kuzin I, de Mesy Bentley K, Wood RW, Rahimi H, Ji RC, Ritchlin CT, Bottaro A, Xing L, Schwarz EM. "Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress." Arthritis & rheumatology.. 2017 Jun 0; 69(6):1187-1193. Epub 2017 Apr 04.

6/2017
Lawal RA, Zhou X, Batey K, Hoffman CM, Georger MA, Radtke F, Hilton MJ, Xing L, Frisch BJ, Calvi LM. "The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 Jun 0; 32(6):1320-1331. Epub 2017 Mar 09.

Books & Chapters

2001
Chapter Title: Bone
Book Title: Yearbook of Science and Technology
Author List: Boyce BF and Xing L.
Published By: McGraw-Hill2001 in New York

2001
Chapter Title: Bone Cell Apoptosis
Book Title: Principles of Bone Biology
Author List: Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C.
Edited By: Blezikian, J. P., Raisz, L. G., and Rodan, G. A.
Published By: Academic Press2001 in San Diego

1998
Chapter Title: Apoptosis in Bone Cells.
Book Title: Novel Approaches to Treatment of Osteoporosis
Author List: Boyce, B.F.; Hughes, D.E.; Wright, K.R.; Xing, L.; Dai, A.
Edited By: Russell, R.G.G.; Skerry, T.M.
Published By: Kollenkirchen U.1998

VIEW ALL PUBLICATIONS