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Lynne Elizabeth Maquat, Ph.D.


Showing all 171 journal articles & 0 books available

Journal Articles

Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE. "PGC-1? senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII." Molecular cell.. 2023 Jan 19; 83(2):186-202.e11.

Kurosaki T, Mitsutomi S, Hewko A, Akimitsu N, Maquat LE. "Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells." Molecular cell.. 2022 Nov 1; Epub 2022 Nov 01.

Cho H, Abshire ET, Popp MW, Pröschel C, Schwartz JL, Yeo GW, Maquat LE. "AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay." Molecular cell.. 2022 Jun 3; Epub 2022 Jun 03.

Maquat L, Johnson R, Valadkhan S, Carninci P. "Lessons from the functional characterization of lncRNAs: introduction to mammalian genome special issue." Mammalian genome : official journal of the International Mammalian Genome Society.. 2022 May 9; Epub 2022 May 09.

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X. "Noncoding RNAs: biology and applications-a Keystone Symposia report." Annals of the New York Academy of Sciences.. 2021 Nov 17; Epub 2021 Nov 17.

Kurosaki T, Sakano H, Pröschel C, Wheeler J, Hewko A, Maquat LE. "NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome." Genome biology.. 2021 Nov 16; 22(1):317. Epub 2021 Nov 16.

Kurosaki T, Imamachi N, Pröschel C, Mitsutomi S, Nagao R, Akimitsu N, Maquat LE. "Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay." Nature cell biology.. 2021 Jan; 23(1):40-48. Epub 2021 Jan 08.

Rambout X, Maquat LE. "NCBP3: A Multifaceted Adaptive Regulator of Gene Expression." Trends in biochemical sciences.. 2020 Oct 5; Epub 2020 Oct 05.

Rambout X, Maquat LE. "The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing." Genes & development.. 2020 Sep 1; 34(17-18):1113-1127.

Zheng D, Cho H, Wang W, Rambout X, Tian B, Maquat LE. "3'READS+RIP defines differential Staufen1 binding to alternative 3'UTR isoforms and reveals structures and sequence motifs influencing binding and polysome association." RNA.. 2020 Aug 12; Epub 2020 Aug 12.

Popp MW, Cho H, Maquat LE. "Viral subversion of nonsense-mediated mRNA decay." RNA.. 2020 Jul 22; Epub 2020 Jul 22.

Rambout X, Cho H, Maquat LE. "Transcriptional Coactivator PGC-1? Binding to Newly Synthesized RNA via CBP80: A Nexus for Co- and Posttranscriptional Gene Regulation." Cold Spring Harbor symposia on quantitative biology.. 2020 Apr 15; Epub 2020 Apr 15.

Maquat LE. "Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty." Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2020 Mar 30; 375(1795):20190344. Epub 2020 Feb 10.

Wolin SL, Maquat LE. "Cellular RNA surveillance in health and disease." Science.. 2019 Nov 15; 366(6467):822-827. Epub 2019 Nov 14.

Kurosaki T, Popp MW, Maquat LE. "Publisher Correction: Quality and quantity control of gene expression by nonsense-mediated mRNA decay." Nature reviews. Molecular cell biology.. 2019 Apr 26; Epub 2019 Apr 26.

Kurosaki T, Popp MW, Maquat LE. "Quality and quantity control of gene expression by nonsense-mediated mRNA decay." Nature reviews. Molecular cell biology.. 2019 Apr 16; Epub 2019 Apr 16.

Kim YK, Maquat LE. "UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond." RNA.. 2019 Jan 17; Epub 2019 Jan 17.

Elbarbary, R.A. and Maquat, L.E. "Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro." Methods: MicroRNA biogenesis, identification, function and decay. 2019; 152: 18-22.

Kurosaki, T., Myers, J. and Maquat, L.E. "Defining nonsense-mediated mRNA decay intermediates in human cells." Methods: Biochemical and next generation sequencing approaches to study RNA regulation. 2019; .

Kurosaki T, Myers JR, Maquat LE. "Defining nonsense-mediated mRNA decay intermediates in human cells." Methods : a companion to Methods in enzymology.. 2018 Dec 19; Epub 2018 Dec 19.

Kurosaki T, Miyoshi K, Myers JR, Maquat LE. "Publisher Correction: NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides." Nature structural & molecular biology.. 2018 Nov; 25(11):1059.

Kurosaki T, Miyoshi K, Myers JR, Maquat LE. "NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides." Nature structural & molecular biology.. 2018 Oct; 25(10):940-950. Epub 2018 Oct 01.

Elbarbary R, Maquat LE. "Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro." Methods : a companion to Methods in enzymology.. 2018 May 17; Epub 2018 May 17.

Rambout X, Dequiedt F, Maquat LE. "Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing." Chemical reviews.. 2018 Apr 25; 118(8):4339-4364. Epub 2017 Dec 18.

Walter NG, Maquat LE. "Introduction-RNA: From Single Molecules to Medicine." Chemical reviews.. 2018 Apr 25; 118(8):4117-4119.

Cho H, Rambout X, Gleghorn ML, Nguyen PQT, Phipps CR, Miyoshi K, Myers JR, Kataoka N, Fasan R, Maquat LE. "Transcriptional coactivator PGC-1? contains a novel CBP80-binding motif that orchestrates efficient target gene expression." Genes & development.. 2018 Apr 1; 32(7-8):555-567. Epub 2018 Apr 13.

Kurosaki T, Maquat LE. "Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation." Nature structural & molecular biology.. 2018 Apr; 25(4):299-301.

Popp MW, Maquat LE. "Nonsense-mediated mRNA Decay and Cancer." Current opinion in genetics & development.. 2018 Feb; 48:44-50. Epub 2017 Nov 07.

Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M, Maquat LE. "Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay." Proceedings of the National Academy of Sciences of the United States of America.. 2018 Jan 30; 115(5):968-973. Epub 2018 Jan 16.

Kurosaki T, Hoque M, Maquat LE. "Identifying Cellular Nonsense-Mediated mRNA Decay (NMD) Targets: Immunoprecipitation of Phosphorylated UPF1 Followed by RNA Sequencing (p-UPF1 RIP-Seq)." Methods in molecular biology.. 2018 1720:175-186.

Elbarbary RA, Miyoshi K, Hedaya O, Myers JR, Maquat LE. "UPF1 helicase promotes TSN-mediated miRNA decay." Genes & development.. 2017 Jul 15; 31(14):1483-1493. Epub 2017 Aug 21.

Elbarbary RA, Maquat LE. "Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism." Nature structural & molecular biology.. 2017 Jun 6; 24(6):496-498.

Elbarbary RA, Miyoshi K, Myers JR, Du P, Ashton JM, Tian B, Maquat LE. "Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G/S phase transition." Science.. 2017 May 26; 356(6340):859-862.

Gleghorn ML, Zhao J, Turner DH, Maquat LE. "Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation." Nucleic acids research.. 2016 Sep 30; 44(17):8417-24. Epub 2016 Jun 10.

Popp MW, Maquat LE. "Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine." Cell.. 2016 Jun 2; 165(6):1319-1322.

Maquat LE. "Eukaryotic antisense ahead of its time." Nature reviews. Molecular cell biology.. 2016 Apr; 17(4):204. Epub 2016 Feb 24.

Elbarbary RA, Maquat LE. "Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock." Genes & development.. 2016 Mar 1; 30(5):487-8.

Elbarbary RA, Lucas BA, Maquat LE. "Retrotransposons as regulators of gene expression." Science.. 2016 Feb 12; 351(6274):aac7247. Epub 2016 Feb 11.

Kurosaki T, Maquat LE. "Nonsense-mediated mRNA decay in humans at a glance." Journal of cell science.. 2016 Feb 1; 129(3):461-7. Epub 2016 Jan 19.

Elbarbary RA, Maquat LE. "CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention." Genes & development.. 2015 Apr 1; 29(7):687-9.

Maquat LE. "The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences." RNA.. 2015 Apr; 21(4):488-9.

Popp MW, Maquat LE. "Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics." Nature communications.. 2015 Mar 26; 6:6632. Epub 2015 Mar 26.

Popp MW, Maquat LE. "RNA. A TRICK'n way to see the pioneer round of translation." Science.. 2015 Mar 20; 347(6228):1316-7.

Jackson KL, Dayton RD, Orchard EA, Ju S, Ringe D, Petsko GA, Maquat LE, Klein RL. "Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis." Gene therapy.. 2015 Jan; 22(1):20-8. Epub 2014 Nov 06.

Gong C, Maquat LE. "Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells." Methods in molecular biology.. 2015 1206:81-6.

Kurosaki T, Li W, Hoque M, Popp MW, Ermolenko DN, Tian B, Maquat LE. "A post-translational regulatory switch on UPF1 controls targeted mRNA degradation." Genes & development.. 2014 Sep 1; 28(17):1900-16.

Gleghorn ML, Maquat LE. "'Black sheep' that don't leave the double-stranded RNA-binding domain fold." Trends in biochemical sciences.. 2014 Jul; 39(7):328-40. Epub 2014 Jun 19.

Popp MW, Maquat LE. "Defective secretory-protein mRNAs take the RAPP." Trends in biochemical sciences.. 2014 Apr; 39(4):154-6. Epub 2014 Mar 03.

Popp MW, Maquat LE. "The dharma of nonsense-mediated mRNA decay in mammalian cells." Molecules and cells.. 2014 Jan; 37(1):1-8. Epub 2014 Jan 27.

Elbarbary RA, Maquat LE. "Dodging two bullets with one dsRNA-binding protein." Cell cycle.. 2014 13(3):345-6. Epub 2013 Dec 13.

Belfort M, Marraffini L, Macfarlan T, Boeke J, Slotkin K, Malik H, Maquat L. "Mobile DNA: an evolving field." Mobile DNA. 2014 5:16. Epub 2014 Jun 05.

Gong C, Tang Y, Maquat LE. "mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay." Nature structural & molecular biology.. 2013 Oct; 20(10):1214-20. Epub 2013 Sep 22.

Elbarbary RA, Li W, Tian B, Maquat LE. "STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown." Genes & development.. 2013 Jul 1; 27(13):1495-510.

Wang J, Lucas BA, Maquat LE. "New gene expression pipelines gush lncRNAs." Genome biology.. 2013 May 24; 14(5):117. Epub 2013 May 24.

Wang J, Gong C, Maquat LE. "Control of myogenesis by rodent SINE-containing lncRNAs." Genes & development.. 2013 Apr 1; 27(7):793-804. Epub 2013 Apr 04.

Gleghorn ML, Gong C, Kielkopf CL, Maquat LE. "Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay." Nature structural & molecular biology.. 2013 Apr; 20(4):515-24. Epub 2013 Mar 24.

Trcek T, Sato H, Singer RH, Maquat LE. "Temporal and spatial characterization of nonsense-mediated mRNA decay." Genes & development.. 2013 Mar 1; 27(5):541-51. Epub 2013 Feb 21.

Kurosaki T, Maquat LE. "Rules that govern UPF1 binding to mRNA 3' UTRs." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Feb 26; 110(9):3357-62. Epub 2013 Feb 12.

Park E, Gleghorn ML, Maquat LE. "Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Jan 8; 110(2):405-12. Epub 2012 Dec 20.

Park E, Maquat LE. "Staufen-mediated mRNA decay." Wiley interdisciplinary reviews. RNA.. 2013 4(4):423-35. Epub 2013 May 16.

Wei-Lin Popp M, Maquat LE. "Organizing principles of mammalian nonsense-mediated mRNA decay." Annual review of genetics. 2013 47:139-65.

Gong C, Popp MW, Maquat LE. "Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes." Methods : a companion to Methods in enzymology.. 2012 Oct; 58(2):88-93. Epub 2012 Jul 10.

Schoenberg DR, Maquat LE. "Regulation of cytoplasmic mRNA decay." Nature reviews. Genetics.. 2012 Mar 6; 13(4):246-59. Epub 2012 Mar 06.

Hwang J, Maquat LE. "Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question." Current opinion in genetics & development.. 2011 Aug; 21(4):422-30.

Gong C, Maquat LE. ""Alu"strious long ncRNAs and their role in shortening mRNA half-lives." Cell cycle.. 2011 Jun 15; 10(12):1882-3. Epub 2011 Jun 15.

Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S, Ringe D, Petsko GA. "A yeast model of FUS/TLS-dependent cytotoxicity." PLoS biology.. 2011 Apr; 9(4):e1001052. Epub 2011 Apr 26.

Gleghorn ML, Maquat LE. "UPF1 learns to relax and unwind." Molecular cell.. 2011 Mar 18; 41(6):621-3.

Gong C, Maquat LE. "lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements." Nature.. 2011 Feb 10; 470(7333):284-8.

Hwang J, Sato H, Tang Y, Matsuda D, Maquat LE. "UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps." Molecular cell.. 2010 Aug 13; 39(3):396-409. Epub 2010 Aug 05.

Maquat LE, Tarn WY, Isken O. "The pioneer round of translation: features and functions." Cell.. 2010 Aug 6; 142(3):368-74.

Maquat LE, Hwang J, Sato H, Tang Y. "CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter." Cold Spring Harbor symposia on quantitative biology.. 2010 75:127-34. Epub 2011 Mar 29.

Maquat LE, Gong C. "Gene expression networks: competing mRNA decay pathways in mammalian cells." Biochemical Society transactions.. 2009 Dec; 37(Pt 6):1287-92.

Sato H, Maquat LE. "Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta." Genes & development.. 2009 Nov 1; 23(21):2537-50.

Schoenberg DR, Maquat LE. "Re-capping the message." Trends in biochemical sciences.. 2009 Sep; 34(9):435-42. Epub 2009 Sep 02.

Gong C, Kim YK, Woeller CF, Tang Y, Maquat LE. "SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs." Genes & development.. 2009 Jan 1; 23(1):54-66. Epub 2008 Dec 18.

Isken O, Maquat LE. "Telomeric RNAs as a novel player in telomeric integrity." F1000 biology reports. 2009 1:90. Epub 2009 Nov 26.

Isken O, Maquat LE. "The multiple lives of NMD factors: balancing roles in gene and genome regulation." Nature reviews. Genetics.. 2008 Sep; 9(9):699-712.

Saltzman AL, Kim YK, Pan Q, Fagnani MM, Maquat LE, Blencowe BJ. "Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay." Molecular and cellular biology.. 2008 Jul; 28(13):4320-30. Epub 2008 Apr 28.

Woeller CF, Gaspari M, Isken O, Maquat LE. "NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA." EMBO reports.. 2008 May; 9(5):446-51. Epub 2008 Mar 28.

Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE. "Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay." Cell.. 2008 Apr 18; 133(2):314-27.

Sato H, Hosoda N, Maquat LE. "Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay." Molecular cell.. 2008 Feb 1; 29(2):255-62.

Maquat LE, Kiledjian M. "RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface." Methods in enzymology.. 2008 448:xxi-xxii.

Maquat LE, Arraiano CM. "RNA turnover in prokaryotes, archaea and organelles. Preface." Methods in enzymology.. 2008 447:xxiii-xxiv.

Maquat LE, Kiledjian M. "RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface." Methods in enzymology.. 2008 449:xvii-xviii.

Matsuda D, Sato H, Maquat LE. "Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells." Methods in enzymology.. 2008 449:177-201.

Matsuda D, Hosoda N, Kim YK, Maquat LE. "Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA." Nature structural & molecular biology.. 2007 Oct; 14(10):974-9. Epub 2007 Sep 16.

Isken O, Maquat LE. "Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function." Genes & development.. 2007 Aug 1; 21(15):1833-56.

Kim YK, Furic L, Parisien M, Major F, DesGroseillers L, Maquat LE. "Staufen1 regulates diverse classes of mammalian transcripts." The EMBO journal.. 2007 Jun 6; 26(11):2670-81. Epub 2007 May 17.

Kuzmiak HA, Maquat LE. "Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges." Trends in molecular medicine.. 2006 Jul; 12(7):306-16. Epub 2006 Jun 16.

Hosoda N, Lejeune F, Maquat LE. "Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails." Molecular and cellular biology.. 2006 Apr; 26(8):3085-97.

Pan Q, Saltzman AL, Kim YK, Misquitta C, Shai O, Maquat LE, Frey BJ, Blencowe BJ. "Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression." Genes & development.. 2006 Jan 15; 20(2):153-8.

Hosoda N, Kim YK, Lejeune F, Maquat LE. "CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells." Nature structural & molecular biology.. 2005 Oct; 12(10):893-901. Epub 2005 Sep 25.

Lejeune F, Maquat LE. "Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells." Current opinion in cell biology.. 2005 Jun; 17(3):309-15.

Maquat LE. "Nonsense-mediated mRNA decay in mammals." Journal of cell science.. 2005 May 1; 118(Pt 9):1773-6.

Gao Q, Das B, Sherman F, Maquat LE. "Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Mar 22; 102(12):4258-63. Epub 2005 Mar 07.

Kim YK, Furic L, Desgroseillers L, Maquat LE. "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay." Cell.. 2005 Jan 28; 120(2):195-208.

Valencia-Sánchez MA, Maquat LE. "An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA." Trends in cell biology. 2004 Nov; 14(11):594-7.

Lejeune F, Ranganathan AC, Maquat LE. "eIF4G is required for the pioneer round of translation in mammalian cells." Nature structural & molecular biology.. 2004 Oct; 11(10):992-1000. Epub 2004 Sep 07.

Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT. "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells." Molecular cell.. 2004 Jun 4; 14(5):585-98.

Chiu SY, Lejeune F, Ranganathan AC, Maquat LE. "The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex." Genes & development.. 2004 Apr 1; 18(7):745-54. Epub 2004 Apr 01.

Maquat LE. "Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics." Nature reviews. Molecular cell biology.. 2004 Feb; 5(2):89-99.

Lejeune F, Maquat LE. "Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells." Methods in molecular biology.. 2004 257:115-24.

Lejeune F, Li X, Maquat LE. "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities." Molecular cell.. 2003 Sep; 12(3):675-87.

Arraiano CM, Maquat LE. "Post-transcriptional control of gene expression: effectors of mRNA decay." Molecular microbiology.. 2003 Jul; 49(1):267-76.

Chiu SY, Serin G, Ohara O, Maquat LE. "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1." RNA.. 2003 Jan; 9(1):77-87.

Stevens A, Wang Y, Bremer K, Zhang J, Hoepfner R, Antoniou M, Schoenberg DR, Maquat LE. "Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon." Proceedings of the National Academy of Sciences of the United States of America.. 2002 Oct 1; 99(20):12741-6. Epub 2002 Sep 19.

Maquat LE. "NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on." Genes & development.. 2002 Jul 15; 16(14):1743-53.

Lejeune F, Ishigaki Y, Li X, Maquat LE. "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling." The EMBO journal.. 2002 Jul 1; 21(13):3536-45.

Maquat LE. "Molecular biology. Skiing toward nonstop mRNA decay." Science.. 2002 Mar 22; 295(5563):2221-2.

Maquat LE. "Nonsense-mediated mRNA decay." Current biology : CB.. 2002 Mar 19; 12(6):R196-7.

Maquat LE. "RNA-protein interactions: insight into gene function." Methods : a companion to Methods in enzymology.. 2002 Feb; 26(2):93-4.

Sun, X.; Maquat, L.E. ;. "Nonsense-Mediated Decay: Assaying for Effects on Selenoprotein mRNAs" . In Methods in Enzymology. Protein Sensors of Reactive Oxygen Species: Selenoproteins, Thioredoxin, Thiol Enzymes, and Proteins, eds. H. Sies, L. Packer, Academic Press. 2002; 347(3): 49-57.

Sun X, Maquat LE. "Nonsense-mediated decay: assaying for effects on selenoprotein mRNAs." Methods in enzymology.. 2002 347:49-57.

Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. "New ways of initiating translation in eukaryotes." Molecular and cellular biology.. 2001 Dec; 21(23):8238-46.

Ishigaki Y, Li X, Serin G, Maquat LE. "Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20." Cell.. 2001 Sep 7; 106(5):607-17.

Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein." The Journal of biological chemistry.. 2001 Jun 22; 276(25):22709-14. Epub 2001 Apr 30.

Sun X, Li X, Moriarty PM, Henics T, LaDuca JP, Maquat LE. "Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues." Molecular biology of the cell.. 2001 Apr; 12(4):1009-17.

Maquat LE, Li X. "Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay." RNA.. 2001 Mar; 7(3):445-56.

Maquat LE, Carmichael GG. "Quality control of mRNA function." Cell.. 2001 Jan 26; 104(2):173-6.

Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE. "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)." Molecular and cellular biology.. 2001 Jan; 21(1):209-23.

Maquat LE. "The power of point mutations." Nature genetics.. 2001 Jan; 27(1):5-6.

Pal M, Ishigaki Y, Nagy E, Maquat LE. "Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway." RNA.. 2001 Jan; 7(1):5-15.

Maquat LE. "Evidence that selenium deficiency results in the cytoplasmic decay of GPx1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction." BioFactors (Oxford, England). 2001 14(1-4):37-42.

Maquat LE, Serin G. "Nonsense-mediated mRNA decay: insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3, and Upf3X proteins." Cold Spring Harbor symposia on quantitative biology.. 2001 66:313-20.

Le Hir H, Izaurralde E, Maquat LE, Moore MJ. "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions." The EMBO journal.. 2000 Dec 15; 19(24):6860-9.

Sun X, Moriarty PM, Maquat LE. "Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position." The EMBO journal.. 2000 Sep 1; 19(17):4734-44.

Le Hir H, Moore MJ, Maquat LE. "Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions." Genes & development.. 2000 May 1; 14(9):1098-108.

Valentin C, Cohen-Solal M, Maquat L, Horányi M, Inselt-Kovács M, Hollán S. "Identical germ-line mutations in the triosephosphate isomerase alleles of two brothers are associated with distinct clinical phenotypes." Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie. 2000 Mar; 323(3):245-50.

Sun X, Maquat LE. "mRNA surveillance in mammalian cells: the relationship between introns and translation termination." RNA.. 2000 Jan; 6(1):1-8.

Zhang J, Sun X, Qian Y, LaDuca JP, Maquat LE. "At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation." Molecular and cellular biology.. 1998 Sep; 18(9):5272-83.

Sun X, Perlick HA, Dietz HC, Maquat LE. "A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells." Proceedings of the National Academy of Sciences of the United States of America.. 1998 Aug 18; 95(17):10009-14.

Zhang J, Sun X, Qian Y, Maquat LE. "Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm." RNA.. 1998 Jul; 4(7):801-15.

Nagy E, Maquat LE. "A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance." Trends in biochemical sciences.. 1998 Jun; 23(6):198-9.

Moriarty PM, Reddy CC, Maquat LE. "Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA." Molecular and cellular biology.. 1998 May; 18(5):2932-9.

Moriarty PM, Reddy CC, Maquat LE. "The presence of an intron within the rat gene for selenium-dependent glutathione peroxidase 1 is not required to protect nuclear RNA from UGA-mediated decay." RNA.. 1997 Dec; 3(12):1369-73.

Zhang J, Maquat LE. "Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells." The EMBO journal.. 1997 Feb 17; 16(4):826-33.

Maquat LE. "Defects in RNA splicing and the consequence of shortened translational reading frames." American journal of human genetics.. 1996 Aug; 59(2):279-86.

Zhang J, Maquat LE. "Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing." RNA.. 1996 Mar; 2(3):235-43.

Stephenson LS, Maquat LE. "Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes." Biochimie.. 1996 78(11-12):1043-7.

Maquat LE. "When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells." RNA.. 1995 Jul; 1(5):453-65.

Nesic D, Zhang J, Maquat LE. "Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells." Molecular and cellular biology.. 1995 Jan; 15(1):488-96.

Belgrader P, Cheng J, Zhou X, Stephenson LS, Maquat LE. "Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life." Molecular and cellular biology.. 1994 Dec; 14(12):8219-28.

Cheng J, Belgrader P, Zhou X, Maquat LE. "Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance." Molecular and cellular biology.. 1994 Sep; 14(9):6317-25.

Belgrader P, Maquat LE. "Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping." Molecular and cellular biology.. 1994 Sep; 14(9):6326-36.

Nesic D, Maquat LE. "Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation." Genes & development.. 1994 Feb 1; 8(3):363-75.

Nesic D, Cheng J, Maquat LE. "Sequences within the last intron function in RNA 3'-end formation in cultured cells." Molecular and cellular biology.. 1993 Jun; 13(6):3359-69.

Chang ML, Artymiuk PJ, Wu X, Hollán S, Lammi A, Maquat LE. "Human triosephosphate isomerase deficiency resulting from mutation of Phe-240." American journal of human genetics.. 1993 Jun; 52(6):1260-9.

Cheng J, Maquat LE. "Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA." Molecular and cellular biology.. 1993 Mar; 13(3):1892-902.

Belgrader P, Cheng J, Maquat LE. "Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA." Proceedings of the National Academy of Sciences of the United States of America.. 1993 Jan 15; 90(2):482-6.

Lim SK, Maquat LE. "Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini." The EMBO journal.. 1992 Sep; 11(9):3271-8.

Lim SK, Sigmund CD, Gross KW, Maquat LE. "Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products." Molecular and cellular biology.. 1992 Mar; 12(3):1149-61.

Maquat LE. "Nuclear mRNA export." Current opinion in cell biology.. 1991 Dec; 3(6):1004-12.

Boyer TG, Maquat LE. "Modulation of human triosephosphate isomerase gene transcription by serum." The Journal of biological chemistry.. 1991 Jul 15; 266(20):13350-4.

Boyer TG, Maquat LE. "Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter." The Journal of biological chemistry.. 1990 Nov 25; 265(33):20524-32.

Cheng J, Fogel-Petrovic M, Maquat LE. "Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA." Molecular and cellular biology.. 1990 Oct; 10(10):5215-25.

Cheng J, Mielnicki LM, Pruitt SC, Maquat LE. "Nucleotide sequence of murine triosephosphate isomerase cDNA." Nucleic acids research.. 1990 Jul 25; 18(14):4261.

Lim S, Mullins JJ, Chen CM, Gross KW, Maquat LE. "Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice." The EMBO journal.. 1989 Sep; 8(9):2613-9.

Boyer TG, Krug JR, Maquat LE. "Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase." The Journal of biological chemistry.. 1989 Mar 25; 264(9):5177-87.

Daar IO, Maquat LE. "Premature translation termination mediates triosephosphate isomerase mRNA degradation." Molecular and cellular biology.. 1988 Feb; 8(2):802-13.

Daar IO, Artymiuk PJ, Phillips DC, Maquat LE. "Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme." Proceedings of the National Academy of Sciences of the United States of America.. 1986 Oct; 83(20):7903-7.

Baumann H, Maquat LE. "Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene." Molecular and cellular biology.. 1986 Jul; 6(7):2551-61.

Brown JR, Daar IO, Krug JR, Maquat LE. "Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family." Molecular and cellular biology.. 1985 Jul; 5(7):1694-706.

Maquat LE, Kinniburgh AJ. "A beta zero-thalassemic beta-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells." Nucleic acids research.. 1985 Apr 25; 13(8):2855-67.

Maquat LE, Chilcote R, Ryan PM. "Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man." The Journal of biological chemistry.. 1985 Mar 25; 260(6):3748-53.

Kinniburgh AJ, Maquat LE, Schedl T, Rachmilewitz E, Ross J. "mRNA-deficient beta o-thalassemia results from a single nucleotide deletion." Nucleic acids research.. 1982 Sep 25; 10(18):5421-7.

Maquat LE, Kinniburgh AJ, Rachmilewitz EA, Ross J. "Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia." Cell.. 1981 Dec; 27(3 Pt 2):543-53.

Maquat LE, Kinniburgh AJ, Beach LR, Honig GR, Lazerson J, Ershler WB, Ross J. "Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia." Proceedings of the National Academy of Sciences of the United States of America.. 1980 Jul; 77(7):4287-91.

Maquat LE, Reznikoff WS. "lac Promoter mutation Pr115 generates a new transcription initiation point." Journal of molecular biology.. 1980 May 25; 139(3):551-6.

Maquat LE, Thornton K, Reznikoff WS. "lac Promoter mutations located downstream from the transcription start site." Journal of molecular biology.. 1980 May 25; 139(3):537-49.

Patient RK, Hardies SC, Larson JE, Inman RB, Maquat LE, Wells RD. "Influence of A-T content on the fractionation of DNA restriction fragments by RPC-5 column chromatography." The Journal of biological chemistry.. 1979 Jun 25; 254(12):5548-54.

Maquat LE, Reznikoff WS. "In vitro analysis of the Escherichia coli RNA polymerase interaction with wild-type and mutant lactose promoters." Journal of molecular biology.. 1978 Nov 15; 125(4):467-90.