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Shannon Patrick Hilchey, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-2187

Biography

Professional Background

Research Associate Professor of Medicie with extensive research experience in the pharmaceutical industry, clinical GLP laboratory and academic environments. My major areas of research expertise are in the evaluation of immune responses to malignant tumors as well as the development of cancer vaccines and therapies. I have extensive experience developing and implementing assays characterizing cellular and humoral immune responses for both preclinical and clinical studies.

Research

My areas of domain expertise include T and B cell immunology, flow cytometric phenotyping of lymphocytes, human translational research studies in oncology and immunology, and data analysis. My experience with human tissues includes not only phenotypic characterization of cellular subsets by flow cytometry, but also the development and application of various in vitro functional immunological assays, which requires significant expertise, as cell numbers are typically limiting when working with primary human tissues. In particular, as the Technical Director of the Lymphoma Lab at the James P. Wilmot Cancer Center from 2004-2013, I developed, applied, and published several T cell and B cell functional assays utilizing very small cell numbers from fine needle aspirates obtained during routine lymph node biopsies of lymphoma patients. From 2013 to the present I have been a research team leader for the University of Rochester Center for Biodefense Immune Modeling, leading multidisciplinary experimental-modeling hybrid teams for this several NIH funded projects. I oversee the implementation of reproducibility and rigor requirements, data integrity, human subjects review requirements and certification and budgets. My responsibilities also include all aspects of experimental design, execution, and analysis. Lastly, throughout my tenure at the University of Rochester, I have successfully collaborated with a number of other researchers and produced several peer-reviewed publications.

Credentials

Faculty Appointments

Education

1997
PhD | SUNY Coll at Buffalo
Biological Science

1992
BS | SUNY Coll at Buffalo
Biological Science

Awards

2003
Porter Anderson Immunobiology Fellow

2002
Recipient of a 2002 Wyeth Above and Beyond Award for Research Excellence

2002
Nominated for the 2002 Wyeth Eagles Leadership Development Program

2000
NIH Postdoctoral Fellowship Recipient, 2000

1998
NYS Breast Cancer Research and Educational Postdoctoral Fellowship Recipient, 1998

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Publications

Journal Articles

2016
Nedelkovska H, Rosenberg AF, Hilchey SP, Hyrien O, Burack WR, Quataert SA, Baker CM, Azadniv M, Welle SL, Ansell SM, Kim M, Bernstein SH. "Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node." PloS one. 2016 11(5):e0155347. Epub 2016 May 26.

2/2015
Kiebala M, Skalska J, Casulo C, Brookes PS, Peterson DR, Hilchey SP, Dai Y, Grant S, Maggirwar SB, Bernstein SH. "Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach." Experimental hematology.. 2015 Feb 0; 43(2):89-99. Epub 2014 Oct 22.

2015
Wang J, Hilchey SP, Hyrien O, Huertas N, Perry S, Ramanunninair M, Bucher D, Zand MS. "Multi-Dimensional Measurement of Antibody-Mediated Heterosubtypic Immunity to Influenza." PloS one. 2015 10(6):e0129858. Epub 2015 Jun 23.

Books & Chapters

1997
Chapter Title: Indirect Effects of DNA Sequence on Transcriptional Activation by Prokaryotic DNA Binding Proteins.
Book Title: Nucleic Acids & Molecular Biology
Author List: Hilchey, S.P., Xu, J., Koudelka, G.B.
Published By: Mechanisms in Transcription1997

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