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Patricia J. Sime, M.D.

Pulmonary

Contact Information

Phone Numbers

Office: (585) 275-4161

Fax: (585) 273-1171

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Professional Background

Modulation of Pulmonary Inflammation using Gene Transfer Techniques

Research

The Sime lab is focused on studying pulmonary disease and pathologic processes in the lung. Our 2 primary areas of focus include lung scarring, and smoking related diseases such as chronic obstructive pulmonary disease (COPD). Lung scarring, or pulmonary fibrosis, can be caused by environmental exposures such as silica, asbestos, and radiation, or develop of unknown reasons (Idiopathic pulmonary fibrosis). We are interested in studying the cellular mechanisms involved in the pathogenesis of pulmonary fibrosis to identify novel therapeutic targets. We are also interested in studying the effects of cigarette and biomass smoke exposure in the lung. Our lab is investigating the mechanisms by which cigarette smoke leads to lung pathologies such as COPD, and dampened anti-viral responses in the lung. Biomass smoke exposure is another common environmental exposure, especially in the developing world, that is associated with lung infection and disease. For our smoking-related projects, we utilize a state-of-the-art smoking facility in the MRBX to expose cells and mice to biomass or cigarette smoke.

Credentials

Faculty Appointments

Specialties

  • Internal Medicine - American Board of Internal Medicine
  • Pulmonary Disease - American Board of Internal Medicine

Education

1984
BS | UK-U Edinburgh Fac Med
Pathology

1988
MD | UK-U Edinburgh Fac Med
Medicine

Post-doctoral Training & Residency

08/01/1989 - 02/28/1991
Residency in Internal Medicine at Western General Hospitals

03/01/1991 - 02/28/1992
Residency in Internal Medicine at Borders General Hospital

11/1/1993 - 02/28/1998
Fellowship in Internal Medicine: Pulmonary Disease at Mcmaster Univ, Canada

08/01/1988 - 07/31/1989
Internship in at Royal Infirmary of Edinburgh

03/01/1998 - 09/30/1999
Fellowship in Internal Medicine: Pulmonary Disease at Royal Infirmary of Edinburgh

03/01/1992 - 11/01/1993
Fellowship in Internal Medicine: Pulmonary Disease at Royal Infirmary of Edinburgh

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Patents

Title: Methods of Diagnosing and Treating Fibrosis
U.S. Serial #: 14/814,238
Filed: Jul 30, 2015
Invented By: SteveGeoras, JiaGuo, XinLin, PatriciaSime

Title: LDH Inhibitors as Treatment for Fibrosis and for Fibrotic-Related Disorders
U.S. Serial #: 14/718,933
Filed: May 21, 2015
Invented By: R. MatthewKottmann, RichardPhipps, PatriciaSime

Title: Methods of Diagnosing and Treating Fibrosis
U.S. Serial #: 13/126,875
Filed: Nov 02, 2009
Invented By: SteveGeoras, JiaGuo, XinLin, PatriciaSime

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Publications

Journal Articles

5/2017
Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES, . "An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis." American journal of respiratory cell and molecular biology.. 2017 May 0; 56(5):667-679.

4/2017
Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA. "Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells." American journal of respiratory cell and molecular biology.. 2017 Apr 0; 56(4):453-464.

2/9/2017
Kim N, Thatcher TH, Sime PJ, Phipps RP. "Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients." JCI insight.. 2017 Feb 9; 2(3):e88588. Epub 2017 Feb 09.

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