Brendan F. Boyce, M.B.Ch.B.

Pathology

Contact Information

Phone Numbers

Appointment: (585) 275-1959

Administrative: (585) 275-1959

Office: (585) 275-5837

Fax: (585) 276-2832

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Not Accepting New Patients

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Faculty Appointments

Professor (Part-Time) - Department of Pathology and Laboratory Medicine (SMD)
Professor (Part-Time) - Center for Musculoskeletal Research - Joint
Professor - Department of Orthopaedics (SMD) - Joint

Biography

Professor, Pathology & Laboratory Medicine. An internationally recognized expert in bone biology, osteoporosis, and metabolic bone disease, Dr. Boyce is also a diagnostic surgical pathologist with a sub-specialty interest in bone and soft tissue pathology. He served as Director of Surgical Patholgy from 1999-2007, Director of Anatomic Pathology from 2007-13 and Vice Chair for Anatomic Pathology 2013-2016 . His research laboratory studies regulatory mechanisms controlling osteoblast and osteoclast function, in particular where there is the potential of opening up new therapeutic pathways for preventing or treating osteoporosis. He was the first to report osteoclast apoptosis in 1996, and has been funded continuously since then to study the osteoclast, which is essential for bone modeling and remodeling and mediates bone loss in common bone diseases, including rheumatoid arthritis and postmenopausal osteoporosis.

Research

The major focus of research in my lab is study of the regulation of the formation, activation and survival of osteoclasts, the cells that resorb bone. In recent years, many genes have been identified as regulators of these aspects of osteoclast function, and our studies presently are focused on the roles of NF-kappaB and src tyrosine kinase in osteoclasts. My colleague, Dr. Lianping Xing, and I, along with members of the Center for Musculoskeletal Research at the University, are studying the roles of these gene products in the increased bone resorption and decreased bone formation that characterize a number of bone diseases, including postmenopausal osteoporosis, inflammatory joint disease, metastatic bone disease and loosening of joint prostheses. We are also studying the effects of a number of potential drug development compounds developed by ARIAD Pharmaceuticals on bone resorption and bone formation, using a number of models of human bone diseases. NF-kappaB also appears to regulate chondrocyte differentiation, and we are studying its role in endochondral ossification. We acknowledge funding from the National Institutes of Health to support our studies.

Credentials

Education

1972
MD (M.B., Ch.B.) | UK-U Glasgow Fac Med
Medicine

1979
M.R.C. Path | Royal College of Pathologists

1991
F. R.C. Path | Royal College of Pathologists

Post-doctoral Training & Residency

07/19/1979 - 09/30/1982
Fellowship in Pathology at Royal Infirmary

08/01/1973 - 07/18/1979
Residency in Pathology at Royal Infirmary

02/01/1973 - 07/31/1973
Internship in General Surgery at Royal Infirmary

07/01/1972 - 01/31/1973
Internship in General Medicine at Western Infirmary

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Awards

2011 - 2013
Secretary/Treasurer, American Society for Bone & Mineral Research

2010 - Present
Treasurer, United States Biological Stain Commission

2010 - 2013
Member, Executive Committee, American Society for Bone & Mineral Research
Sponsor: ASBMR

2010 - 2011
Secretary/Treasurer-Elect, American Society for Bone & Mineral Research
Sponsor: ASBMR

2009 - 2012
Treasurer, International Society of Bone Morphometry
Sponsor: ISBM

2009
Chair, Gordon Research Conference on Bones and Teeth

2007
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab)

2007
Vice Chair, Gordon Research Conference on Bone and Teeth

2005
Young Investigator of Year Award from International Society of Bone Morphometry to Dr. Zhenqiang Yao (post-doc fellow in my lab)

2005
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab)

2003 - 2006
Secretary/Treasurer, Association of Osteobiology

2002 - 2006
President International Society of Bone Morphometry

2001 - 2007
Council Member Association of Osteobiology

2000
Travel Award From American Society for Bone and Mineral Research to Dr. Lianping Xing from my lab

1999 - Present
Member, Board of Directors International Society of Bone Morphometry

1999
New Investigator Award From Orthopaedic Research Society to Dr. Lianping Xing (post-doctoral fellow in my lab)

1998
Travel Award From American Society for Bone and Mineral Research to Dr. Sheela Rani (post-doctoral fellow in my lab)

1997
Most Outstanding Abstract of Mtg President's Award fr. Amer. Soc Bone & Min Res Drs L Xing, G Franzoso, U Siebenlist & BF Boyce

1996
Young Investigator of Year Award fr Amer. Society for Bone & Mineral Research to Dr. Lianping Xing (post-doc fellow in my lab)

1993
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Hong Chen (post-doc fellow in my lab)

1986 - 1987
Pathological Society Travel Award (London, England)

1986 - 1987
McCunn Trust Traveling Fellowship (Glasgow, Scotland)

1986 - 1987
Peel International Research Fellowship (London, England)

1977
Jean Mackintosh Traveling Research Fellowship (Glasgow, Scotland)

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Publications

Journal Articles

12/3/2018
Sun W, Meednu N, Rosenberg A, Rangel-Moreno J, Wang V, Glanzman J, Owen T, Zhou X, Zhang H, Boyce BF, Anolik JH, Xing L. "B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation." Nature communications.. 2018 Dec 3; 9(1):5127. Epub 2018 Dec 03.

9/10/2018
Wang H, Xiao L, Tao J, Srinivasan V, Boyce BF, Ebetino FH, Oyajobi BO, Boeckman RK, Xing L. "Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice." Pharmaceutics.. 2018 Sep 10; 10(3)Epub 2018 Sep 10.

7/11/2018
Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, , Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. "Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue." Arthritis research & therapy.. 2018 Jul 11; 20(1):139. Epub 2018 Jul 11.

Books & Chapters

2014
Chapter Title: RANKL-based osteoclastogenic assay from murine bone marrow cells.
Book Title: Skeletal Development and Repair: Methods and Protocols
Author List: Xing L, Boyce BF.
Edited By: Matthew J. Hilton
Published By: Springer Link, Humana Press 2014

2013
Chapter Title: Bone and Immune Cell Interactions
Book Title: Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism
Author List: Boyce BF
Published By: Wiley-Blackwell 2013

2012
Chapter Title: Biology of Bone and Cartilage
Book Title: Genetics of Bone Biology and Skeletal Disease
Author List: Boyce BF, Zuscik MJ, Xing L.
Edited By: Drs. Thakker, Whyte, Eisman and Igarashi
Published By: Elsevier 2012

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