Brendan F. Boyce, M.B.Ch.B.

Contact Information

Phone Numbers

Appointment: (585) 275-3202

Administrative: (585) 275-5892

Office: (585) 275-5837

Fax: (585) 276-2832

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Not Accepting New Patients

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Faculty Appointments

Professor (Part-Time) - Department of Pathology and Laboratory Medicine (SMD)
Professor (Part-Time) - Center for Musculoskeletal Research - Joint
Professor (Part-Time) - Department of Orthopaedics (SMD) - Joint

Patient Care Setting

Pathology

Biography

Professor, Pathology & Laboratory Medicine. An internationally recognized expert in bone biology, osteoporosis, and metabolic bone disease, Dr. Boyce is also a diagnostic surgical pathologist with a sub-specialty interest in bone and soft tissue pathology. He served as Director of Surgical Pathology from 1999-2007, Director of Anatomic Pathology from 2007-13 and Vice Chair for Anatomic Pathology 2013-2016. His research laboratory studies regulatory mechanisms controlling osteoblast and osteoclast formation and function, in particular where there is the potential for development of new therapeutics for preventing or treating osteoporosis. He was the first to report osteoclast apoptosis in 1996, and has been funded continuously since then by the NIH to study the mechanisms that regulate the formation and activation of osteoclasts, which are essential for bone modeling and remodeling and mediate bone loss in common bone diseases, including rheumatoid arthritis and postmenopausal and age-related osteoporosis.

Research

The major focus of research in my lab is study of the role of NF-kappaB signaling in the regulation of formation, activation and survival of osteoclasts, the cells that resorb bone, and in the formation of osteoblasts, the cells that make new bone matrix. In the past 26 years since we discovered with colleagues at the NIH that NF-kappaB signaling is essential for osteoclast formation, many genes have been identified as regulators of these aspects of osteoclast function. Our studies presently are focused on the roles of NF-kappaB signaling in age-related bone loss. My colleagues, Dr. Lianping Xing and Zhenqiang Yao, and I, along with members of the Center for Musculoskeletal Research at the University Medical Center, are studying how increased NF-kappaB signaling mediates the increased bone resorption and decreased bone formation that characterize a number of bone diseases, including postmenopausal and age-related osteoporosis, inflammatory joint disease, and metastatic bone disease. We are also studying how to repurpose a number of FDA-approved drugs and small molecules that we have shown can interfere with aberrantly enhanced NF-kappaB signaling to prevent bone resorption and stimulate bone formation, using a number of models of human bone diseases. We acknowledge funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging at the National Institutes of Health and New York State for support of our studies.

Credentials

Education

1972
MBBCH | University of Glasgow (United Kingdom)

Post-doctoral Training & Residency

07/19/1979 - 09/30/1982
Fellowship in Pathology at Glasgow Royal Infirmary (United Kingdom)

02/01/1973 - 07/31/1973
Internship in Surgery (General Surgery) at Glasgow Royal Infirmary (United Kingdom)

08/01/1973 - 07/18/1979
Residency in Pathology at Glasgow Royal Infirmary (United Kingdom)

07/01/1972 - 01/31/1973
Internship in Internal Medicine at Western Infirmary (Scotland)

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Awards

2011 - 2013
Secretary/Treasurer, American Society for Bone & Mineral Research

2010 - Present
Treasurer, United States Biological Stain Commission

2010 - 2013
Member, Executive Committee, American Society for Bone & Mineral Research
Sponsor: ASBMR

2010 - 2011
Secretary/Treasurer-Elect, American Society for Bone & Mineral Research
Sponsor: ASBMR

2009 - 2012
Treasurer, International Society of Bone Morphometry
Sponsor: ISBM

2009
Chair, Gordon Research Conference on Bones and Teeth

2007
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab)

2007
Vice Chair, Gordon Research Conference on Bone and Teeth

2005
Young Investigator of Year Award from International Society of Bone Morphometry to Dr. Zhenqiang Yao (post-doc fellow in my lab)

2005
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab)

2003 - 2006
Secretary/Treasurer, Association of Osteobiology

2002 - 2006
President International Society of Bone Morphometry

2001 - 2007
Council Member Association of Osteobiology

2000
Travel Award From American Society for Bone and Mineral Research to Dr. Lianping Xing from my lab

1999 - Present
Member, Board of Directors International Society of Bone Morphometry

1999
New Investigator Award From Orthopaedic Research Society to Dr. Lianping Xing (post-doctoral fellow in my lab)

1998
Travel Award From American Society for Bone and Mineral Research to Dr. Sheela Rani (post-doctoral fellow in my lab)

1997
Most Outstanding Abstract of Mtg President's Award fr. Amer. Soc Bone & Min Res Drs L Xing, G Franzoso, U Siebenlist & BF Boyce

1996
Young Investigator of Year Award fr Amer. Society for Bone & Mineral Research to Dr. Lianping Xing (post-doc fellow in my lab)

1993
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Hong Chen (post-doc fellow in my lab)

1986 - 1987
Pathological Society Travel Award (London, England)

1986 - 1987
McCunn Trust Traveling Fellowship (Glasgow, Scotland)

1986 - 1987
Peel International Research Fellowship (London, England)

1977
Jean Mackintosh Traveling Research Fellowship (Glasgow, Scotland)

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Patents

Patent Title: Phosphonate-Chloroquine Conjugates and Methods Using Same
Patent #: 10,660,884
Issue Date: May 26, 2020
Country: United States
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Zhenqiang Yao

Patent Title: Methods and Compositions for Treating Inflammatory Conditions
Patent #: 8,580,755
Issue Date: Nov 12, 2013
Country: United States
Invented By: Brendan Boyce, Edward Michael Schwarz, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: 3371203
Issue Date: Feb 26, 2020
Country: Europe
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: FR3371203
Issue Date: Feb 26, 2020
Country: France
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: DE3371203
Issue Date: Feb 26, 2020
Country: Germany
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Patent Title: Bortezomib Conjugates and Methods Using Same
Patent #: GB3371203
Issue Date: Feb 26, 2020
Country: United Kingdom
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

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Publications

Journal Articles

1/11/2023
Li J, Yao Z, Liu X, Duan R, Yi X, Ayoub A, Sanders JO, Mesfin A, Xing L, Boyce BF. "TGF?1CCR5 neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice." Nature communications.. 2023 Jan 11; 14(1):159. Epub 2023 Jan 11.

10/16/2022
Dong Q, Xiu Y, Wang Y, Hodgson C, Borcherding N, Jordan C, Buchanan J, Taylor E, Wagner B, Leidinger M, Holman C, Thiele DJ, O'Brien S, Xue HH, Zhao J, Li Q, Meyerson H, Boyce BF, Zhao C. "HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia." Nature communications.. 2022 Oct 16; 13(1):6107. Epub 2022 Oct 16.

9/16/2022
Yao Z, Boyce BF. "TGF? priming promotes TNF-induced bone erosion: a promising new target in RA?" Nature reviews. Rheumatology.. 2022 Sep 16; Epub 2022 Sep 16.

Books & Chapters

2018
Chapter Title: Biology of Bone and Cartilage
Book Title: Genetics of Bone Biology and Skeletal Disease
Author List: Boyce BF, Zuscik MJ, Xing L
Edited By: IN: Drs. Thakker, Whyte, Eisman and Igarashi (editors)
Published By: Elsevier. 2018

2014
Chapter Title: RANKL-based osteoclastogenic assay from murine bone marrow cells.
Book Title: Skeletal Development and Repair: Methods and Protocols
Author List: Xing L, Boyce BF.
Edited By: Matthew J. Hilton
Published By: Springer Link, Humana Press 2014

2013
Chapter Title: Bone and Immune Cell Interactions
Book Title: Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism
Author List: Boyce BF
Published By: Wiley-Blackwell 2013

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