Brendan F. Boyce, M.B.Ch.B.

Brendan F. Boyce, M.B.Ch.B.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 275-5837
Fax: (585) 276-2832
Administrative: (585) 275-1959

Research Bio

The major focus of research in my lab is study of the regulation of the formation, activation and survival of osteoclasts, the cells that resorb bone. In recent years, many genes have been identified as regulators of these aspects of osteoclast function, and our studies presently are focused on the roles of NF-kappaB and src tyrosine kinase in osteoclasts. My colleague, Dr. Lianping Xing, and I, along with members of the Center for Musculoskeletal Research at the University, are studying the roles of these gene products in the increased bone resorption and decreased bone formation that characterize a number of bone diseases, including postmenopausal osteoporosis, inflammatory joint disease, metastatic bone disease and loosening of joint prostheses.

We are also studying the effects of a number of potential drug development compounds developed by ARIAD Pharmaceuticals on bone resorption and bone formation, using a number of models of human bone diseases. NF-kappaB also appears to regulate chondrocyte differentiation, and we are studying its role in endochondral ossification. We acknowledge funding from the National Institutes of Health to support our studies.

Awards & Honors (Local)

Secretary/Treasurer, American Society for Bone & Mineral Research 2011 - 2013
Treasurer, United States Biological Stain Commission 2010 - Present
Member, Executive Committee, American Society for Bone & Mineral Research | ASBMR 2010 - 2013
Secretary/Treasurer-Elect, American Society for Bone & Mineral Research | ASBMR 2010 - 2011
Chair, Gordon Research Conference on Bones and Teeth 2009
Treasurer, International Society of Bone Morphometry | ISBM 2009 - 2012
Vice Chair, Gordon Research Conference on Bone and Teeth 2007
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab) 2007
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab) 2005
Young Investigator of Year Award from International Society of Bone Morphometry to Dr. Zhenqiang Yao (post-doc fellow in my lab) 2005
Secretary/Treasurer, Association of Osteobiology 2003 - 2006
President International Society of Bone Morphometry 2002 - 2006
Council Member Association of Osteobiology 2001 - 2007
Travel Award From American Society for Bone and Mineral Research to Dr. Lianping Xing from my lab 2000
Member, Board of Directors International Society of Bone Morphometry 1999 - Present
New Investigator Award From Orthopaedic Research Society to Dr. Lianping Xing (post-doctoral fellow in my lab) 1999
Travel Award From American Society for Bone and Mineral Research to Dr. Sheela Rani (post-doctoral fellow in my lab) 1998
Most Outstanding Abstract of Mtg President's Award fr. Amer. Soc Bone & Min Res Drs L Xing, G Franzoso, U Siebenlist & BF Boyce 1997
Young Investigator of Year Award fr Amer. Society for Bone & Mineral Research to Dr. Lianping Xing (post-doc fellow in my lab) 1996
Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Hong Chen (post-doc fellow in my lab) 1993
Peel International Research Fellowship (London, England) 1986 - 1987
Pathological Society Travel Award (London, England) 1986 - 1987
McCunn Trust Traveling Fellowship (Glasgow, Scotland) 1986 - 1987
Jean Mackintosh Traveling Research Fellowship (Glasgow, Scotland) 1977

Patents

Neutralizing Rat Monoclonal Antibody Specific for Mouse Vascular Endothelial Growth Factor Receptor (VEGFR)-2 (DC101) Reduces Joint Damage in Chronic Inflammatory Arthritis

United States Serial NO.: 12/389,193
Filed Date: February 19, 2009
Title: Methods and Compositions for Treating Inflammatory Conditions
Invented by: Lianping Xing, Brendan Boyce, Edward Schwarz
Neutralizing Rat Monoclonal Antibody Specific for Mouse Vascular Endothelial Growth Factor Receptor (VEGFR)-2 (DC101) Reduces Joint Damage in Chronic Inflammatory Arthritis

United States Serial NO.: 14/068,823
Filed Date: October 31, 2013
Title: Methods and Compositions for Treating Inflammatory Conditions
Invented by: Lianping Xing, Brendan Boyce, Edward Schwarz
TRAF3 Protein Levels in Peripheral Blood Monocytes Predict which Patients with Rheumatoid Arthritis and Psoriatic Arthritis will Respond to Anti-TNF Therapy

United States Serial NO.: 14/761,408
Filed Date: January 10, 2014
Title: Method to Identify Patients That Will Likely Respond to Anti-TNF Therapy
Invented by: Brendan Boyce, Lianping Xing, Christopher Ritchlin, Yan Xiu

Recent Journal Articles

Showing the 5 most recent journal articles. 186 available »

2016 Sep
Zhang H, Sun W, Li X, Wang M, Boyce BF, Hilton MJ, Xing L. "Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation." Bone. 2016 Sep; 90:80-9. Epub 2016 Jun 04.
2016 Mar 12
Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, Xu H, Wood RW, Schwarz EM, Boyce BF, Wang Y, Xing L. "Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice." Arthritis research & therapy. 2016 Mar 12; 18:62. Epub 2016 Mar 12.
2016 Mar
Krieger NS, Yao Z, Kyker-Snowman K, Kim MH, Boyce BF, Bushinsky DA. "Increased bone density in mice lacking the proton receptor OGR1." Kidney international. 2016 Mar; 89(3):565-73. Epub 2016 Jan 06.
2016
Zhang L, Chang M, Beck CA, Schwarz EM, Boyce BF. "Analysis of new bone, cartilage, and fibrosis tissue in healing murine allografts using whole slide imaging and a new automated histomorphometric algorithm." Bone research. 2016 4:15037. Epub 2016 Jan 19.
2015 Jul
Boyce BF. "Whole slide imaging: uses and limitations for surgical pathology and teaching." Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2015 Jul; 90(5):321-30. Epub 2015 Apr 22.

Current Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary
Professor - Department of Orthopaedics (SMD)

Specialties

Anatomic Pathology - American Board of Pathology

Education

F. R.C. Path | Royal College of Pathologists1991
M.R.C. Path | Royal College of Pathologists1979
MD (M.B., Ch.B.) | Medicine | UK-U Glasgow Fac Med1972

Post-Doctoral Training & Residency

Fellowship in Pathology at Royal Infirmary07/19/1979 - 09/30/1982
Residency in Pathology at Royal Infirmary08/01/1973 - 07/18/1979
Internship in General Surgery at Royal Infirmary02/01/1973 - 07/31/1973
Internship in General Medicine at Western Infirmary07/01/1972 - 01/31/1973