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Chen Yan, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 276-7698

Office: (585) 276-7704

Fax: (585) 276-1530

Research Labs

Research * Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system.

Lab: (585) 276-7713

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Biography

Dr. Yan was born and grew up in Shanghai, China. She received her Bachelors and Masters degrees in the field of Biochemistry and Genetics, respectively, from Fudan University, Shanghai, China. Her PhD research was done in the lab of Dr. Joseph A. Beavo in Department of Pharmacology at the University of Washington in Seattle, WA USA. Her postdoctoral training was done with Dr. Bradford C. Berk in the Cardiology Unit of the University of Washington. Currently Dr. Yan is an associate professor in Aab Cardiovascular Research Institute, University of Rochester, School of Medicine and Dentistry. Her research focuses on a family of enzymes called phosphodiesterases (PDE) that degrade second messengers, diffusible signaling molecules that are rapidly generated and activate proteins within the cell to exert a cellular response. By inhibiting PDEs one can amplify cellular responses. One successful example is Viagra, which inhibits a specific PDE. Altered second messenger signaling and PDE activity/expression have been implicated in a variety of cardiovascular diseases such as hypertension, atherosclerosis and heart failure. Understanding the role of PDEs in cardiovascular diseases may provide new therapeutic information for the treatment of cardiovascular diseases. To date, Dr. Yan has published over 80 research and review articles and has recently received an American Heart Association Established Investigator Award.

Professional Background

Dr. Chen Yan received her Bachelor of Science degree in Biochemistry in 1983 and Master's degree in Human/Medical Genetics from the Fudan University in 1983. She received her Ph.D. degree in molecular pharmacology from the University of Washington (UW), Seattle in 1996 and performed her postdoctoral training in molecular cardiology, also at UW. She was recruited to the University of Rochester as a Research Assistant Professor in December 1998. She currently is a assistant professor.

Research

General Research Interests: Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system. Second messenger cyclic nucleotides (cAMP and cGMP) regulate many signaling pathways in the cardiovascular system. For example, the vascular tone, smooth muscle cell growth, and cardiac muscle contractility are all regulated by cyclic nucleotide signaling. We are interested in phosphodiesterases (PDEs), the enzymes that break down cyclic nucleotides and thus control the amplitude, duration, and compartmentalization of cyclic nucleotide signaling in the cell. It has become increasingly clear that cyclic nucleotide degradation by PDEs is not a constitutive function of the cell, but rather a highly regulated one controlled by different mechanisms in different physiological and pathological circumstances. PDE regulation and function is further complicated by the fact that there are more than 50 individual PDEs belonging to 11 different PDE families, yet our understanding of the physiological function of each PDE is far from complete. PDEs have been demonstrated to be good pharmacological targets for therapeutic agents due to the presence of multiple structurally different, tissue-specific, differentially regulated, and functionally distinct isozymes. Several drugs, such as Viagra, have been shown to have unique specific effects via selectively inhibit individual PDE isozymes. Our focus has been on determining the regulation and function of individual PDE isozymes in cardiovascular diseases such as hypertension, atherosclerosis, heart failure, and cardiovascular inflammatory diseases. Ongoing and future studies using in vitro and in vivo approaches will focus on the various roles of PDEs in cardiovascular physiology and pathology, which may provide new therapeutic information for tissue specific interventions in cardiovascular diseases.

Credentials

Faculty Appointments

Education

1983
BS | Department of Biology, Fudan University
Biochemistry

1986
MS | Genetic Institute, Fudan University
Genetics

1996
Ph.D. | University of Washington
Pharmacology

Awards

2007 - 2011
American Heart Association Established Investigator Award

1997 - 1998
NIH Postdoctoral Fellowship

1994 - 1996
Fellowship for Advanced Predoctoral Training in Pharmacology/Toxicology of Pharmaceutical Research & Manufactures of America Foundation

1979 - 1982
Shanghai City Honor (Sanhao) Student (top 0.1% students who display the overall well-roundedness). Received this award for three consecutive years.

1979 - 1982
Honor (Sanhao) Student of Fudan University (top 2% of students who display the best all round development of morality, intelligence, and physique). Received this award for three consecutive years.

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Patents

Title: Method and Compositions For Treatment or Prevention of Inflammatory Conditions
U.S. Serial #: 14/970,028
Filed: Dec 15, 2015
Invented By: BradfordBerk, Kye-ImJeon, Jian-DongLi, XiangbinXu, ChenYan

Title: Method and Compositions For Treatment or Prevention of Inflammatory Conditions
U.S. Serial #: 14/191,219
Filed: Feb 26, 2014
Invented By: BradfordBerk, Kye-ImJeon, Jian-DongLi, XiangbinXu, ChenYan

Title: Method and Compositions For Treatment or Prevention of Inflammatory Conditions
U.S. Serial #: 12/678,352
Filed: Sep 16, 2008
Invented By: BradfordBerk, Kye-ImJeon, Jian-DongLi, XiangbinXu, ChenYan

Title: Method and Compositions for Treatment or Prevention of Inflammatory Conditions
U.S. Serial #: 200880117461.X
Filed: Sep 16, 2008
Invented By: BradfordBerk, Kye-ImJeon, Jian-DongLi, XiangbinXu, ChenYan

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Publications

Journal Articles

10/12/2007
Surapisitchat J, Jeon KI, Yan C, Beavo JA. "Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3." Circulation research.. 2007 Oct 12; 101(8):811-8. Epub 2007 Aug 17.

8/2007
Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA, Li JD. "Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections." Immunity.. 2007 Aug 0; 27(2):349-60.

7/6/2007
Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC. "Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing." Circulation research.. 2007 Jul 6; 101(1):97-105. Epub 2007 May 24.

Books & Chapters

2006
Chapter Title: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases.
Book Title: Cyclic Nucleotide Phosphodiesterases in Health and Disease
Author List: Yan C, Nagel DJ, Jeon K
Edited By: Joseph Beavo, Sharron Francis, and Miles Houslay
Published By: CRC Press2006

2005
Chapter Title: Determination of Ca2+/Calmodulin-Stimulated Phosphodiesterase Activity in Intact Cells
Book Title: Methods Mol Biol
Author List: Yan C.
Published By: N/A2005

2003
Chapter Title: Identification of secreted oxidative stress-induced factors (SOXF) and associated proteins: proteomics in vascular biology
Book Title: In Proteomic and Genomic Analysis of Cardiovascular Disease
Author List: Jin Z-G, Liao D-F, Yan C, and Berk BC
Edited By: Jennifer Van Eyk and Michael J. Dunn
Published By: Wiley-VCH publishers2003

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